JP2015509360A5 - - Google Patents
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- Publication number
- JP2015509360A5 JP2015509360A5 JP2014556093A JP2014556093A JP2015509360A5 JP 2015509360 A5 JP2015509360 A5 JP 2015509360A5 JP 2014556093 A JP2014556093 A JP 2014556093A JP 2014556093 A JP2014556093 A JP 2014556093A JP 2015509360 A5 JP2015509360 A5 JP 2015509360A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- population
- tissue
- human
- syndecan
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims 26
- 238000000034 method Methods 0.000 claims 14
- 102000003711 Syndecan-2 Human genes 0.000 claims 5
- 108090000054 Syndecan-2 Proteins 0.000 claims 5
- 210000001519 tissue Anatomy 0.000 claims 5
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 4
- 238000002955 isolation Methods 0.000 claims 4
- 210000005260 human cell Anatomy 0.000 claims 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 2
- 241001465754 Metazoa Species 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000035475 disorder Diseases 0.000 claims 2
- 210000004962 mammalian cell Anatomy 0.000 claims 2
- 210000000130 stem cell Anatomy 0.000 claims 2
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 1
- 102000008186 Collagen Human genes 0.000 claims 1
- 108010035532 Collagen Proteins 0.000 claims 1
- 102000008100 Human Serum Albumin Human genes 0.000 claims 1
- 108091006905 Human Serum Albumin Proteins 0.000 claims 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 1
- 210000000577 adipose tissue Anatomy 0.000 claims 1
- 230000002491 angiogenic effect Effects 0.000 claims 1
- 238000003556 assay Methods 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 210000000845 cartilage Anatomy 0.000 claims 1
- 229920001436 collagen Polymers 0.000 claims 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 claims 1
- 210000004696 endometrium Anatomy 0.000 claims 1
- 210000004700 fetal blood Anatomy 0.000 claims 1
- 229920002674 hyaluronan Polymers 0.000 claims 1
- 229960003160 hyaluronic acid Drugs 0.000 claims 1
- 235000015110 jellies Nutrition 0.000 claims 1
- 239000008274 jelly Substances 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 230000002188 osteogenic effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000002953 phosphate buffered saline Substances 0.000 claims 1
- 210000002826 placenta Anatomy 0.000 claims 1
- 210000002027 skeletal muscle Anatomy 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 210000002536 stromal cell Anatomy 0.000 claims 1
- 210000002435 tendon Anatomy 0.000 claims 1
- 210000003954 umbilical cord Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1202319.8 | 2012-02-10 | ||
| GBGB1202319.8A GB201202319D0 (en) | 2012-02-10 | 2012-02-10 | Stromal stem cells |
| PCT/EP2013/052692 WO2013117761A1 (en) | 2012-02-10 | 2013-02-11 | Stromal stem cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015509360A JP2015509360A (ja) | 2015-03-30 |
| JP2015509360A5 true JP2015509360A5 (https=) | 2015-07-02 |
| JP5829765B2 JP5829765B2 (ja) | 2015-12-09 |
Family
ID=45929927
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014556093A Active JP5829765B2 (ja) | 2012-02-10 | 2013-02-11 | 間質幹細胞 |
Country Status (22)
| Country | Link |
|---|---|
| US (10) | US11230700B2 (https=) |
| EP (4) | EP2758523B1 (https=) |
| JP (1) | JP5829765B2 (https=) |
| KR (1) | KR102124837B1 (https=) |
| CN (1) | CN104302763B (https=) |
| AU (1) | AU2013217870B2 (https=) |
| BR (1) | BR112014019277A8 (https=) |
| CA (1) | CA2863821C (https=) |
| CY (1) | CY1116365T1 (https=) |
| DK (1) | DK2758523T3 (https=) |
| ES (3) | ES2959833T3 (https=) |
| GB (1) | GB201202319D0 (https=) |
| HR (1) | HRP20150594T1 (https=) |
| HU (1) | HUE026480T2 (https=) |
| IN (1) | IN2014KN01777A (https=) |
| PL (1) | PL2758523T3 (https=) |
| PT (1) | PT2758523E (https=) |
| RS (1) | RS54073B1 (https=) |
| RU (1) | RU2636551C2 (https=) |
| SI (1) | SI2758523T1 (https=) |
| SM (1) | SMT201500147B (https=) |
| WO (1) | WO2013117761A1 (https=) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201202319D0 (en) | 2012-02-10 | 2012-03-28 | Orbsen Therapeutics Ltd | Stromal stem cells |
| JP6438457B2 (ja) | 2013-04-16 | 2018-12-12 | オルブセン セラピューティクス リミテッド | シンデカン−２の医療用途 |
| EP3074506A1 (en) | 2014-02-12 | 2016-10-05 | National University of Ireland, Galway | Selection and use of stem cells |
| KR101690872B1 (ko) | 2014-08-19 | 2016-12-29 | 이화여자대학교 산학협력단 | 편도 유래 중간엽 줄기세포로부터 인슐린 분비 세포의 분화 방법 |
| US9716660B2 (en) * | 2014-12-11 | 2017-07-25 | Intel Corporation | Hierarchical enforcement of service flow quotas |
| KR101686315B1 (ko) | 2015-01-09 | 2016-12-13 | 이화여자대학교 산학협력단 | 편도 유래 중간엽 줄기세포로부터 슈반 세포의 분화 방법 |
| WO2016123163A2 (en) | 2015-01-27 | 2016-08-04 | Kardiatonos, Inc. | Biomarkers of vascular disease |
| US10124038B2 (en) | 2015-03-20 | 2018-11-13 | Orbsen Therapeutics Limited | Modulators of syndecan-2 and uses thereof |
| EP3402489B1 (en) * | 2016-01-15 | 2021-06-09 | Orbsen Therapeutics Limited | Sdc-2 exosome compositions and methods of isolation and use |
| CN106177918A (zh) * | 2016-09-30 | 2016-12-07 | 广州赛莱拉干细胞科技股份有限公司 | 一种间充质干细胞注射液及其制备方法和应用 |
| WO2018220442A2 (en) * | 2017-05-30 | 2018-12-06 | Orbsen Therapeutics Limited | Stromal stem cell therapeutics and methods of use |
| CA3069805A1 (en) * | 2017-07-14 | 2019-01-17 | Orbsen Therapeutics Limited | Cd39 stromal stem cells methods of isolation and use |
| MX2022003465A (es) | 2019-09-23 | 2022-06-16 | Univ Pennsylvania | Anticuerpo monoclonal contra proteína de activación de fibroblasto canino de reacción cruzada con proteína de activación de fibroblasto (fap) de ratón y humana. |
| US12116418B2 (en) * | 2019-09-23 | 2024-10-15 | The Trustees Of The University Of Pennsylvania | Disrupting tumor tissues by targeting fibroblast activation protein (FAP) |
| WO2022179518A1 (en) * | 2021-02-25 | 2022-09-01 | Rosas Ivan O | Anti-fibrotic peptides and uses thereof |
| CN116334214A (zh) * | 2023-04-04 | 2023-06-27 | 暨南大学附属第一医院（广州华侨医院） | 一种用于急性心肌梗死和稳定性心绞痛鉴别的生物标志物的ceRNA调控网络及其应用 |
| IT202300007497A1 (it) * | 2023-04-18 | 2024-10-18 | Comecer Spa | Isolatore per colture cellulari derivate da un tessuto perinatale e metodo di isolamento di almeno una tipologia di cellule da un tessuto perinatale |
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| US5726058A (en) | 1992-12-01 | 1998-03-10 | Jalkanen; Markku | Syndecan stimulation of cellular differentiation |
| WO1997034605A1 (en) | 1996-03-21 | 1997-09-25 | Mayo Foundation For Medical Education And Research | Use of nicotine to treat liver disease |
| AU749675B2 (en) * | 1998-03-13 | 2002-07-04 | Mesoblast International Sarl | Uses for human non-autologous mesenchymal stem cells |
| AU4221399A (en) | 1998-05-29 | 1999-12-13 | Osiris Therapeutics, Inc. | Human cd45+ and/or fibroblast + mesenchymal stem cells |
| AU5723601A (en) | 2000-04-25 | 2001-11-07 | Osiris Therapeutics Inc | Joint repair using mesenchymal stem cells |
| US7442390B2 (en) * | 2000-06-05 | 2008-10-28 | University Of South Florida | Method for enhancing engraftment of cells using mesenchymal progenitor cells |
| WO2002087609A1 (en) | 2001-05-01 | 2002-11-07 | The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Identification of a cell surface receptor for papillomaviruses |
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| WO2003062386A2 (en) | 2002-01-18 | 2003-07-31 | Regents Of The University Of Minnesota | Syndecans and angiogenesis |
| WO2004003179A1 (en) | 2002-06-27 | 2004-01-08 | The University Of Queensland | Differentiation modulating agents and uses therefor |
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2012
- 2012-02-10 GB GBGB1202319.8A patent/GB201202319D0/en not_active Ceased
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2013
- 2013-02-11 KR KR1020147025152A patent/KR102124837B1/ko active Active
- 2013-02-11 EP EP13707295.5A patent/EP2758523B1/en active Active
- 2013-02-11 EP EP18190005.1A patent/EP3492584B1/en active Active
- 2013-02-11 BR BR112014019277A patent/BR112014019277A8/pt not_active Application Discontinuation
- 2013-02-11 ES ES18190005T patent/ES2959833T3/es active Active
- 2013-02-11 ES ES15158384T patent/ES2697780T3/es active Active
- 2013-02-11 DK DK13707295.5T patent/DK2758523T3/da active
- 2013-02-11 RU RU2014136711A patent/RU2636551C2/ru active
- 2013-02-11 EP EP15158384.6A patent/EP2902482B1/en active Active
- 2013-02-11 CA CA2863821A patent/CA2863821C/en active Active
- 2013-02-11 HU HUE13707295A patent/HUE026480T2/en unknown
- 2013-02-11 AU AU2013217870A patent/AU2013217870B2/en active Active
- 2013-02-11 ES ES13707295.5T patent/ES2539186T3/es active Active
- 2013-02-11 US US14/377,597 patent/US11230700B2/en active Active
- 2013-02-11 PT PT137072955T patent/PT2758523E/pt unknown
- 2013-02-11 JP JP2014556093A patent/JP5829765B2/ja active Active
- 2013-02-11 WO PCT/EP2013/052692 patent/WO2013117761A1/en not_active Ceased
- 2013-02-11 EP EP23176834.2A patent/EP4257203A3/en active Pending
- 2013-02-11 PL PL13707295T patent/PL2758523T3/pl unknown
- 2013-02-11 RS RS20150392A patent/RS54073B1/sr unknown
- 2013-02-11 SI SI201330036T patent/SI2758523T1/sl unknown
- 2013-02-11 HR HRP20150594TT patent/HRP20150594T1/hr unknown
- 2013-02-11 CN CN201380019351.0A patent/CN104302763B/zh active Active
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2014
- 2014-08-22 IN IN1777KON2014 patent/IN2014KN01777A/en unknown
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2015
- 2015-06-08 CY CY20151100502T patent/CY1116365T1/el unknown
- 2015-06-25 SM SM201500147T patent/SMT201500147B/xx unknown
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2016
- 2016-04-01 US US15/089,435 patent/US10907131B2/en active Active
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2018
- 2018-06-14 US US16/009,048 patent/US11142747B2/en active Active
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2019
- 2019-09-05 US US16/562,206 patent/US10920197B2/en active Active
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2021
- 2021-09-09 US US17/470,492 patent/US11926848B2/en active Active
- 2021-12-01 US US17/540,067 patent/US11434471B2/en active Active
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2023
- 2023-06-05 US US18/329,455 patent/US11952589B2/en active Active
- 2023-06-05 US US18/329,435 patent/US11884936B2/en active Active
- 2023-06-05 US US18/329,469 patent/US11952590B2/en active Active
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2024
- 2024-03-07 US US18/599,002 patent/US20240209319A1/en active Pending
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