JP2015506369A - 安定化された水性抗体組成物 - Google Patents
安定化された水性抗体組成物 Download PDFInfo
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- JP2015506369A JP2015506369A JP2014553812A JP2014553812A JP2015506369A JP 2015506369 A JP2015506369 A JP 2015506369A JP 2014553812 A JP2014553812 A JP 2014553812A JP 2014553812 A JP2014553812 A JP 2014553812A JP 2015506369 A JP2015506369 A JP 2015506369A
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- Prior art keywords
- aqueous solution
- ethyleneimine
- alkyl
- antibody
- mpeg
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Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39591—Stabilisation, fragmentation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
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- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Peptides Or Proteins (AREA)
- Compositions Of Macromolecular Compounds (AREA)
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| US201261592323P | 2012-01-30 | 2012-01-30 | |
| US61/592,323 | 2012-01-30 | ||
| PCT/GB2013/050211 WO2013114112A2 (en) | 2012-01-30 | 2013-01-30 | Stabilized aqueous antibody compositions |
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| JP2015506369A true JP2015506369A (ja) | 2015-03-02 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| JP7357540B2 (ja) | 2017-03-06 | 2023-10-06 | アレコル リミテッド | 液体医薬組成物 |
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| ES2705538T3 (es) | 2012-01-30 | 2019-03-25 | Arecor Ltd | Composiciones acuosas de anticuerpo estabilizadas |
| MX2018009967A (es) * | 2016-02-19 | 2018-11-09 | Avery Dennison Corp | Metodos en dos etapas para procesar adhesivos y composiciones relacionadas. |
| GB201613896D0 (en) | 2016-08-12 | 2016-09-28 | Arecor Ltd | Novel composition |
| US11608357B2 (en) | 2018-08-28 | 2023-03-21 | Arecor Limited | Stabilized antibody protein solutions |
| EP3372241A1 (en) | 2017-03-06 | 2018-09-12 | Ares Trading S.A. | Liquid pharmaceutical composition |
| WO2020055679A2 (en) * | 2018-09-10 | 2020-03-19 | Dow Global Technologies Llc | A composition comprising a protein and a polyalkoxy fatty acyl surfactant |
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| US5824784A (en) | 1994-10-12 | 1998-10-20 | Amgen Inc. | N-terminally chemically modified protein compositions and methods |
| US5990237A (en) | 1997-05-21 | 1999-11-23 | Shearwater Polymers, Inc. | Poly(ethylene glycol) aldehyde hydrates and related polymers and applications in modifying amines |
| DE19726186A1 (de) | 1997-06-20 | 1998-12-24 | Boehringer Ingelheim Int | Komplexe für den Transport von Nukleinsäure in höhere eukaryotische Zellen |
| DE19933024C2 (de) | 1999-07-15 | 2003-03-13 | Medinnova Ges Med Innovationen | Kationische Blockcopolymere |
| US6652886B2 (en) | 2001-02-16 | 2003-11-25 | Expression Genetics | Biodegradable cationic copolymers of poly (alkylenimine) and poly (ethylene glycol) for the delivery of bioactive agents |
| US7524938B2 (en) * | 2003-04-04 | 2009-04-28 | Yeda Research And Development Co., Ltd. | Antibodies and pharmaceutical compositions containing same useful for inhibiting activity of metalloproteins |
| CA2536120A1 (en) | 2003-06-30 | 2005-02-10 | Canji, Inc. | Polymer encapsulation of adenoviruses |
| US7022214B2 (en) | 2004-01-21 | 2006-04-04 | Bio-Rad Laboratories, Inc. | Carrier ampholytes of high pH range |
| TW200719913A (en) * | 2005-03-08 | 2007-06-01 | Pharmacia & Upjohn Co Llc | Anti-madcam antibody compositions |
| US20090011004A1 (en) | 2005-12-30 | 2009-01-08 | Philadelphia Health & Education Corp., D/B/A/ Drexel University Of College Of Medicine | Improved carriers for delivery of nucleic acid agents to cells and tissues |
| GB0700523D0 (en) | 2007-01-11 | 2007-02-21 | Insense Ltd | The Stabilisation Of Proteins |
| US20080312174A1 (en) | 2007-06-05 | 2008-12-18 | Nitto Denko Corporation | Water soluble crosslinked polymers |
| CA2737407A1 (en) | 2008-09-24 | 2010-04-01 | Stabilitech Ltd. | Method for preserving polypeptides using a sugar and polyethyleneimine |
| AU2009319856A1 (en) * | 2008-11-28 | 2010-06-03 | Abbvie Inc. | Stable antibody compositions and methods for stabilizing same |
| RU2600847C2 (ru) * | 2010-05-10 | 2016-10-27 | Интас Биофармасьютикалс Лимитед | Жидкий состав полипептидов, содержащих fc-домен иммуноглобулина |
| US20130209465A1 (en) * | 2010-07-30 | 2013-08-15 | Arecor Ltd. | Stabilized Aqueous Antibody Compositions |
| ES2705538T3 (es) | 2012-01-30 | 2019-03-25 | Arecor Ltd | Composiciones acuosas de anticuerpo estabilizadas |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JP7357540B2 (ja) | 2017-03-06 | 2023-10-06 | アレコル リミテッド | 液体医薬組成物 |
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| US12016922B2 (en) | 2024-06-25 |
| EP2809350B1 (en) | 2018-10-17 |
| CA2861402C (en) | 2021-10-12 |
| US20200138946A1 (en) | 2020-05-07 |
| US10532098B2 (en) | 2020-01-14 |
| CA2861402A1 (en) | 2013-08-08 |
| CN104203282A (zh) | 2014-12-10 |
| IN2014DN06121A (enExample) | 2015-08-14 |
| US20150010548A1 (en) | 2015-01-08 |
| EP2809350A2 (en) | 2014-12-10 |
| WO2013114112A2 (en) | 2013-08-08 |
| WO2013114112A3 (en) | 2013-11-07 |
| ES2705538T3 (es) | 2019-03-25 |
| DK2809350T3 (en) | 2019-01-28 |
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