DK2809350T3 - STABILIZED Aqueous Antibody Preparations - Google Patents

STABILIZED Aqueous Antibody Preparations Download PDF

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Publication number
DK2809350T3
DK2809350T3 DK13703468.2T DK13703468T DK2809350T3 DK 2809350 T3 DK2809350 T3 DK 2809350T3 DK 13703468 T DK13703468 T DK 13703468T DK 2809350 T3 DK2809350 T3 DK 2809350T3
Authority
DK
Denmark
Prior art keywords
antibody
protein
aqueous solution
ethyleneimine
oligomer
Prior art date
Application number
DK13703468.2T
Other languages
Danish (da)
English (en)
Inventor
Guy Casy
Barry Kingston Derham
Jan Jezek
Nikki Royle
Original Assignee
Arecor Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arecor Ltd filed Critical Arecor Ltd
Application granted granted Critical
Publication of DK2809350T3 publication Critical patent/DK2809350T3/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Peptides Or Proteins (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
DK13703468.2T 2012-01-30 2013-01-30 STABILIZED Aqueous Antibody Preparations DK2809350T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261592323P 2012-01-30 2012-01-30
PCT/GB2013/050211 WO2013114112A2 (en) 2012-01-30 2013-01-30 Stabilized aqueous antibody compositions

Publications (1)

Publication Number Publication Date
DK2809350T3 true DK2809350T3 (en) 2019-01-28

Family

ID=47681959

Family Applications (1)

Application Number Title Priority Date Filing Date
DK13703468.2T DK2809350T3 (en) 2012-01-30 2013-01-30 STABILIZED Aqueous Antibody Preparations

Country Status (9)

Country Link
US (2) US10532098B2 (enExample)
EP (1) EP2809350B1 (enExample)
JP (1) JP2015506369A (enExample)
CN (1) CN104203282A (enExample)
CA (1) CA2861402C (enExample)
DK (1) DK2809350T3 (enExample)
ES (1) ES2705538T3 (enExample)
IN (1) IN2014DN06121A (enExample)
WO (1) WO2013114112A2 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2705538T3 (es) 2012-01-30 2019-03-25 Arecor Ltd Composiciones acuosas de anticuerpo estabilizadas
MX2018009967A (es) * 2016-02-19 2018-11-09 Avery Dennison Corp Metodos en dos etapas para procesar adhesivos y composiciones relacionadas.
GB201613896D0 (en) 2016-08-12 2016-09-28 Arecor Ltd Novel composition
US11608357B2 (en) 2018-08-28 2023-03-21 Arecor Limited Stabilized antibody protein solutions
EP3372241A1 (en) 2017-03-06 2018-09-12 Ares Trading S.A. Liquid pharmaceutical composition
EP3372242A1 (en) 2017-03-06 2018-09-12 Ares Trading S.A. Liquid pharmaceutical composition
WO2020055679A2 (en) * 2018-09-10 2020-03-19 Dow Global Technologies Llc A composition comprising a protein and a polyalkoxy fatty acyl surfactant

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5824784A (en) 1994-10-12 1998-10-20 Amgen Inc. N-terminally chemically modified protein compositions and methods
US5990237A (en) 1997-05-21 1999-11-23 Shearwater Polymers, Inc. Poly(ethylene glycol) aldehyde hydrates and related polymers and applications in modifying amines
DE19726186A1 (de) 1997-06-20 1998-12-24 Boehringer Ingelheim Int Komplexe für den Transport von Nukleinsäure in höhere eukaryotische Zellen
DE19933024C2 (de) 1999-07-15 2003-03-13 Medinnova Ges Med Innovationen Kationische Blockcopolymere
US6652886B2 (en) 2001-02-16 2003-11-25 Expression Genetics Biodegradable cationic copolymers of poly (alkylenimine) and poly (ethylene glycol) for the delivery of bioactive agents
US7524938B2 (en) * 2003-04-04 2009-04-28 Yeda Research And Development Co., Ltd. Antibodies and pharmaceutical compositions containing same useful for inhibiting activity of metalloproteins
CA2536120A1 (en) 2003-06-30 2005-02-10 Canji, Inc. Polymer encapsulation of adenoviruses
US7022214B2 (en) 2004-01-21 2006-04-04 Bio-Rad Laboratories, Inc. Carrier ampholytes of high pH range
TW200719913A (en) * 2005-03-08 2007-06-01 Pharmacia & Upjohn Co Llc Anti-madcam antibody compositions
US20090011004A1 (en) 2005-12-30 2009-01-08 Philadelphia Health & Education Corp., D/B/A/ Drexel University Of College Of Medicine Improved carriers for delivery of nucleic acid agents to cells and tissues
GB0700523D0 (en) 2007-01-11 2007-02-21 Insense Ltd The Stabilisation Of Proteins
US20080312174A1 (en) 2007-06-05 2008-12-18 Nitto Denko Corporation Water soluble crosslinked polymers
CA2737407A1 (en) 2008-09-24 2010-04-01 Stabilitech Ltd. Method for preserving polypeptides using a sugar and polyethyleneimine
AU2009319856A1 (en) * 2008-11-28 2010-06-03 Abbvie Inc. Stable antibody compositions and methods for stabilizing same
RU2600847C2 (ru) * 2010-05-10 2016-10-27 Интас Биофармасьютикалс Лимитед Жидкий состав полипептидов, содержащих fc-домен иммуноглобулина
US20130209465A1 (en) * 2010-07-30 2013-08-15 Arecor Ltd. Stabilized Aqueous Antibody Compositions
ES2705538T3 (es) 2012-01-30 2019-03-25 Arecor Ltd Composiciones acuosas de anticuerpo estabilizadas

Also Published As

Publication number Publication date
US12016922B2 (en) 2024-06-25
EP2809350B1 (en) 2018-10-17
CA2861402C (en) 2021-10-12
US20200138946A1 (en) 2020-05-07
US10532098B2 (en) 2020-01-14
CA2861402A1 (en) 2013-08-08
CN104203282A (zh) 2014-12-10
IN2014DN06121A (enExample) 2015-08-14
US20150010548A1 (en) 2015-01-08
EP2809350A2 (en) 2014-12-10
JP2015506369A (ja) 2015-03-02
WO2013114112A2 (en) 2013-08-08
WO2013114112A3 (en) 2013-11-07
ES2705538T3 (es) 2019-03-25

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