JP2015500247A5 - - Google Patents
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- Publication number
- JP2015500247A5 JP2015500247A5 JP2014545038A JP2014545038A JP2015500247A5 JP 2015500247 A5 JP2015500247 A5 JP 2015500247A5 JP 2014545038 A JP2014545038 A JP 2014545038A JP 2014545038 A JP2014545038 A JP 2014545038A JP 2015500247 A5 JP2015500247 A5 JP 2015500247A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- optionally substituted
- formula
- alkyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 19
- 238000000034 method Methods 0.000 claims 13
- 125000000217 alkyl group Chemical group 0.000 claims 12
- 229910052751 metal Inorganic materials 0.000 claims 7
- 239000002184 metal Substances 0.000 claims 7
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 7
- 125000003118 aryl group Chemical group 0.000 claims 6
- 150000004696 coordination complex Chemical class 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 239000003446 ligand Substances 0.000 claims 5
- 125000006711 (C2-C12) alkynyl group Chemical group 0.000 claims 4
- 125000000753 cycloalkyl group Chemical group 0.000 claims 4
- 229910052736 halogen Inorganic materials 0.000 claims 4
- 150000002367 halogens Chemical class 0.000 claims 4
- 125000004404 heteroalkyl group Chemical group 0.000 claims 4
- 125000001072 heteroaryl group Chemical group 0.000 claims 4
- 125000005842 heteroatom Chemical group 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- QGJOPFRUJISHPQ-UHFFFAOYSA-N Carbon disulfide Chemical compound S=C=S QGJOPFRUJISHPQ-UHFFFAOYSA-N 0.000 claims 3
- 238000006243 chemical reaction Methods 0.000 claims 3
- 229910021645 metal ion Inorganic materials 0.000 claims 3
- 125000006710 (C2-C12) alkenyl group Chemical group 0.000 claims 2
- DPOPAJRDYZGTIR-UHFFFAOYSA-N Tetrazine Chemical compound C1=CN=NN=N1 DPOPAJRDYZGTIR-UHFFFAOYSA-N 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 150000001345 alkine derivatives Chemical class 0.000 claims 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims 2
- 150000001540 azides Chemical class 0.000 claims 2
- 125000000852 azido group Chemical group *N=[N+]=[N-] 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 125000006297 carbonyl amino group Chemical group [H]N([*:2])C([*:1])=O 0.000 claims 2
- 239000003153 chemical reaction reagent Substances 0.000 claims 2
- 125000004093 cyano group Chemical group *C#N 0.000 claims 2
- 150000002527 isonitriles Chemical class 0.000 claims 2
- 125000005647 linker group Chemical group 0.000 claims 2
- 229910052697 platinum Inorganic materials 0.000 claims 2
- ZWZVWGITAAIFPS-UHFFFAOYSA-N thiophosgene Chemical compound ClC(Cl)=S ZWZVWGITAAIFPS-UHFFFAOYSA-N 0.000 claims 2
- 229910052688 Gadolinium Inorganic materials 0.000 claims 1
- 150000008065 acid anhydrides Chemical class 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 229910052793 cadmium Inorganic materials 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 229910052733 gallium Inorganic materials 0.000 claims 1
- 229910052738 indium Inorganic materials 0.000 claims 1
- 229910052741 iridium Inorganic materials 0.000 claims 1
- FPYJFEHAWHCUMM-UHFFFAOYSA-N maleic anhydride Chemical compound O=C1OC(=O)C=C1 FPYJFEHAWHCUMM-UHFFFAOYSA-N 0.000 claims 1
- 229910052748 manganese Inorganic materials 0.000 claims 1
- 229910052753 mercury Inorganic materials 0.000 claims 1
- 150000002739 metals Chemical class 0.000 claims 1
- 229910052759 nickel Inorganic materials 0.000 claims 1
- 229910052763 palladium Inorganic materials 0.000 claims 1
- 229910052702 rhenium Inorganic materials 0.000 claims 1
- 229910052707 ruthenium Inorganic materials 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000006850 spacer group Chemical group 0.000 claims 1
- 229910052719 titanium Inorganic materials 0.000 claims 1
- 229910052721 tungsten Inorganic materials 0.000 claims 1
- 229910052720 vanadium Inorganic materials 0.000 claims 1
- 229910052725 zinc Inorganic materials 0.000 claims 1
- 0 CNCC*CNC Chemical compound CNCC*CNC 0.000 description 5
- QUZHZQZSVNOGAH-UHFFFAOYSA-N CC(CNC)(CNC)CNP Chemical compound CC(CNC)(CNC)CNP QUZHZQZSVNOGAH-UHFFFAOYSA-N 0.000 description 1
- SWHXRXCXOQNNHZ-KRWDZBQOSA-N C[C@]1(CNCCNCN(CNCCNC)CCNCCCNCC1)N Chemical compound C[C@]1(CNCCNCN(CNCCNC)CCNCCCNCC1)N SWHXRXCXOQNNHZ-KRWDZBQOSA-N 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161567262P | 2011-12-06 | 2011-12-06 | |
| US61/567,262 | 2011-12-06 | ||
| PCT/AU2012/001484 WO2013082656A1 (en) | 2011-12-06 | 2012-12-06 | Cage amine ligands for metallo-radiopharmaceuticals |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015500247A JP2015500247A (ja) | 2015-01-05 |
| JP2015500247A5 true JP2015500247A5 (enExample) | 2016-01-28 |
| JP6047581B2 JP6047581B2 (ja) | 2016-12-21 |
Family
ID=48573413
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014545038A Active JP6047581B2 (ja) | 2011-12-06 | 2012-12-06 | 金属放射性医薬品のためのケージアミン配位子 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US9457107B2 (enExample) |
| EP (2) | EP2788353B1 (enExample) |
| JP (1) | JP6047581B2 (enExample) |
| AU (1) | AU2012350147B2 (enExample) |
| DK (1) | DK2788353T3 (enExample) |
| ES (1) | ES2924289T3 (enExample) |
| PT (1) | PT2788353T (enExample) |
| WO (1) | WO2013082656A1 (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9457107B2 (en) | 2011-12-06 | 2016-10-04 | The University Of Melbourne | Cage amine ligands for metallo-radiopharmaceuticals |
| WO2013181697A1 (en) * | 2012-06-05 | 2013-12-12 | The University Of Melbourne | Bicyclo[6.1.0]non-4-yne compounds suitable for use as linkers in biological applications |
| US9597643B1 (en) * | 2013-10-22 | 2017-03-21 | U.S. Department Of Energy | Surface functionalization of metal organic frameworks for mixed matrix membranes |
| US9422286B2 (en) * | 2014-01-27 | 2016-08-23 | Washington University | Metal-binding bifunctional compounds as diagnostic agents for Alzheimer's disease |
| DK3634965T3 (da) | 2017-06-06 | 2023-05-01 | Clarity Pharmaceuticals Ltd | Radiofarmaceutiske lægemidler, radiobilleddannelsesmidler og anvendelser deraf |
| AU2019251767B2 (en) * | 2018-04-11 | 2024-07-11 | Clarity Pharmaceuticals Ltd | Targeting compounds and methods for their production |
| US11738100B2 (en) | 2018-04-11 | 2023-08-29 | Clarity Pharmaceuticals Limited | Formulations and kits for radiotherapy and diagnostic imaging |
| TW202426433A (zh) | 2022-09-23 | 2024-07-01 | 瑞士商紐利迪姆股份公司 | 成纖維細胞活化蛋白（ｆａｐ）抑制劑、ｆａｐ結合物及其診斷與治療用途 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0001719A1 (en) | 1977-10-26 | 1979-05-02 | The Australian National University | Metal complexes, their preparation and production of hydrogen peroxide therewith |
| WO1995031202A1 (en) | 1994-05-17 | 1995-11-23 | Commonwealth Scientific And Industrial Research Organisation | Cage compounds, processes for their preparation and their use as antiviral agents |
| EP1331012A1 (en) | 2002-01-29 | 2003-07-30 | BRACCO IMAGING S.p.A. | Responsive paramagnetic MRI contrast agents |
| FI20031528A0 (fi) | 2003-10-17 | 2003-10-17 | Ctt Cancer Targeting Tech Oy | Terapeuttinen liposomikoostumus ja menetelmä sen valmistamiseksi |
| US9701694B2 (en) * | 2008-12-02 | 2017-07-11 | The University Of Melbourne | Nitrogen-containing macrocyclic conjugates as radiopharmaceuticals |
| WO2010121133A2 (en) * | 2009-04-17 | 2010-10-21 | The General Hospital Corporation | Multimodal imaging of fibrin |
| US9457107B2 (en) | 2011-12-06 | 2016-10-04 | The University Of Melbourne | Cage amine ligands for metallo-radiopharmaceuticals |
-
2012
- 2012-12-06 US US14/363,219 patent/US9457107B2/en active Active
- 2012-12-06 JP JP2014545038A patent/JP6047581B2/ja active Active
- 2012-12-06 AU AU2012350147A patent/AU2012350147B2/en active Active
- 2012-12-06 DK DK12856044.8T patent/DK2788353T3/da active
- 2012-12-06 WO PCT/AU2012/001484 patent/WO2013082656A1/en not_active Ceased
- 2012-12-06 EP EP12856044.8A patent/EP2788353B1/en active Active
- 2012-12-06 PT PT128560448T patent/PT2788353T/pt unknown
- 2012-12-06 ES ES12856044T patent/ES2924289T3/es active Active
- 2012-12-06 EP EP22173377.7A patent/EP4063369A1/en active Pending
-
2016
- 2016-08-18 US US15/240,836 patent/US9861714B2/en active Active
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