JP2015221794A5 - - Google Patents
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- Publication number
- JP2015221794A5 JP2015221794A5 JP2015098334A JP2015098334A JP2015221794A5 JP 2015221794 A5 JP2015221794 A5 JP 2015221794A5 JP 2015098334 A JP2015098334 A JP 2015098334A JP 2015098334 A JP2015098334 A JP 2015098334A JP 2015221794 A5 JP2015221794 A5 JP 2015221794A5
- Authority
- JP
- Japan
- Prior art keywords
- opioid
- palmitoylethanolamide
- medicament according
- micronized
- medicament
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229950007031 palmidrol Drugs 0.000 claims description 19
- HXYVTAGFYLMHSO-UHFFFAOYSA-N palmitoyl ethanolamide Chemical compound CCCCCCCCCCCCCCCC(=O)NCCO HXYVTAGFYLMHSO-UHFFFAOYSA-N 0.000 claims description 19
- 238000011282 treatment Methods 0.000 claims description 7
- 241001465754 Metazoa Species 0.000 claims description 3
- 239000000203 mixture Substances 0.000 claims description 3
- 229940005483 opioid analgesics Drugs 0.000 claims description 3
- 239000008194 pharmaceutical composition Substances 0.000 claims description 3
- 230000000202 analgesic effect Effects 0.000 claims description 2
- 230000001934 delay Effects 0.000 claims description 2
- 208000024891 symptom Diseases 0.000 claims description 2
- 239000003814 drug Substances 0.000 claims 11
- BQJCRHHNABKAKU-KBQPJGBKSA-N morphine Chemical compound O([C@H]1[C@H](C=C[C@H]23)O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O BQJCRHHNABKAKU-KBQPJGBKSA-N 0.000 claims 4
- 239000002245 particle Substances 0.000 claims 4
- 230000037396 body weight Effects 0.000 claims 2
- OROGSEYTTFOCAN-DNJOTXNNSA-N codeine Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)=C[C@H](O)[C@@H]1OC1=C2C3=CC=C1OC OROGSEYTTFOCAN-DNJOTXNNSA-N 0.000 claims 2
- 239000007903 gelatin capsule Substances 0.000 claims 2
- OROGSEYTTFOCAN-UHFFFAOYSA-N hydrocodone Natural products C1C(N(CCC234)C)C2C=CC(O)C3OC2=C4C1=CC=C2OC OROGSEYTTFOCAN-UHFFFAOYSA-N 0.000 claims 2
- 229960005181 morphine Drugs 0.000 claims 2
- JVLBPIPGETUEET-WIXLDOGYSA-O (3r,4r,4as,7ar,12bs)-3-(cyclopropylmethyl)-4a,9-dihydroxy-3-methyl-2,4,5,6,7a,13-hexahydro-1h-4,12-methanobenzofuro[3,2-e]isoquinoline-3-ium-7-one Chemical compound C([N@+]1(C)[C@@H]2CC=3C4=C(C(=CC=3)O)O[C@@H]3[C@]4([C@@]2(O)CCC3=O)CC1)C1CC1 JVLBPIPGETUEET-WIXLDOGYSA-O 0.000 claims 1
- USSIQXCVUWKGNF-UHFFFAOYSA-N 6-(dimethylamino)-4,4-diphenylheptan-3-one Chemical compound C=1C=CC=CC=1C(CC(C)N(C)C)(C(=O)CC)C1=CC=CC=C1 USSIQXCVUWKGNF-UHFFFAOYSA-N 0.000 claims 1
- GVGLGOZIDCSQPN-PVHGPHFFSA-N Heroin Chemical compound O([C@H]1[C@H](C=C[C@H]23)OC(C)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4OC(C)=O GVGLGOZIDCSQPN-PVHGPHFFSA-N 0.000 claims 1
- JAQUASYNZVUNQP-USXIJHARSA-N Levorphanol Chemical compound C1C2=CC=C(O)C=C2[C@]23CCN(C)[C@H]1[C@@H]2CCCC3 JAQUASYNZVUNQP-USXIJHARSA-N 0.000 claims 1
- WJBLNOPPDWQMCH-MBPVOVBZSA-N Nalmefene Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=C)O)CC1)O)CC1CC1 WJBLNOPPDWQMCH-MBPVOVBZSA-N 0.000 claims 1
- BRUQQQPBMZOVGD-XFKAJCMBSA-N Oxycodone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(OC)C2=C5[C@@]13CCN4C BRUQQQPBMZOVGD-XFKAJCMBSA-N 0.000 claims 1
- UQCNKQCJZOAFTQ-ISWURRPUSA-N Oxymorphone Chemical compound O([C@H]1C(CC[C@]23O)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O UQCNKQCJZOAFTQ-ISWURRPUSA-N 0.000 claims 1
- 229930013930 alkaloid Natural products 0.000 claims 1
- 229960001736 buprenorphine Drugs 0.000 claims 1
- RMRJXGBAOAMLHD-IHFGGWKQSA-N buprenorphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]11CC[C@]3([C@H](C1)[C@](C)(O)C(C)(C)C)OC)CN2CC1CC1 RMRJXGBAOAMLHD-IHFGGWKQSA-N 0.000 claims 1
- IFKLAQQSCNILHL-QHAWAJNXSA-N butorphanol Chemical compound N1([C@@H]2CC3=CC=C(C=C3[C@@]3([C@]2(CCCC3)O)CC1)O)CC1CCC1 IFKLAQQSCNILHL-QHAWAJNXSA-N 0.000 claims 1
- 229960001113 butorphanol Drugs 0.000 claims 1
- 229960004126 codeine Drugs 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 229960002069 diamorphine Drugs 0.000 claims 1
- XYYVYLMBEZUESM-UHFFFAOYSA-N dihydrocodeine Natural products C1C(N(CCC234)C)C2C=CC(=O)C3OC2=C4C1=CC=C2OC XYYVYLMBEZUESM-UHFFFAOYSA-N 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000007938 effervescent tablet Substances 0.000 claims 1
- 239000000839 emulsion Substances 0.000 claims 1
- 229950004155 etorphine Drugs 0.000 claims 1
- CAHCBJPUTCKATP-FAWZKKEFSA-N etorphine Chemical compound O([C@H]1[C@@]2(OC)C=C[C@@]34C[C@@H]2[C@](C)(O)CCC)C2=C5[C@]41CCN(C)[C@@H]3CC5=CC=C2O CAHCBJPUTCKATP-FAWZKKEFSA-N 0.000 claims 1
- 229960002428 fentanyl Drugs 0.000 claims 1
- PJMPHNIQZUBGLI-UHFFFAOYSA-N fentanyl Chemical compound C=1C=CC=CC=1N(C(=O)CC)C(CC1)CCN1CCC1=CC=CC=C1 PJMPHNIQZUBGLI-UHFFFAOYSA-N 0.000 claims 1
- 239000008187 granular material Substances 0.000 claims 1
- LLPOLZWFYMWNKH-CMKMFDCUSA-N hydrocodone Chemical compound C([C@H]1[C@H](N(CC[C@@]112)C)C3)CC(=O)[C@@H]1OC1=C2C3=CC=C1OC LLPOLZWFYMWNKH-CMKMFDCUSA-N 0.000 claims 1
- 229960000240 hydrocodone Drugs 0.000 claims 1
- WVLOADHCBXTIJK-YNHQPCIGSA-N hydromorphone Chemical compound O([C@H]1C(CC[C@H]23)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O WVLOADHCBXTIJK-YNHQPCIGSA-N 0.000 claims 1
- 229960001410 hydromorphone Drugs 0.000 claims 1
- 229960003406 levorphanol Drugs 0.000 claims 1
- 229960001797 methadone Drugs 0.000 claims 1
- 229960002921 methylnaltrexone Drugs 0.000 claims 1
- 229960000805 nalbuphine Drugs 0.000 claims 1
- NETZHAKZCGBWSS-CEDHKZHLSA-N nalbuphine Chemical compound C([C@]12[C@H]3OC=4C(O)=CC=C(C2=4)C[C@@H]2[C@]1(O)CC[C@@H]3O)CN2CC1CCC1 NETZHAKZCGBWSS-CEDHKZHLSA-N 0.000 claims 1
- 229960005297 nalmefene Drugs 0.000 claims 1
- UZHSEJADLWPNLE-GRGSLBFTSA-N naloxone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(O)C2=C5[C@@]13CCN4CC=C UZHSEJADLWPNLE-GRGSLBFTSA-N 0.000 claims 1
- 229960004127 naloxone Drugs 0.000 claims 1
- DQCKKXVULJGBQN-XFWGSAIBSA-N naltrexone Chemical compound N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=O)O)CC1)O)CC1CC1 DQCKKXVULJGBQN-XFWGSAIBSA-N 0.000 claims 1
- 229960003086 naltrexone Drugs 0.000 claims 1
- -1 narolphine Chemical compound 0.000 claims 1
- 229940127240 opiate Drugs 0.000 claims 1
- 229960002085 oxycodone Drugs 0.000 claims 1
- 229960005118 oxymorphone Drugs 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000829 suppository Substances 0.000 claims 1
- 239000003826 tablet Substances 0.000 claims 1
- LLPOLZWFYMWNKH-UHFFFAOYSA-N trans-dihydrocodeinone Natural products C1C(N(CCC234)C)C2CCC(=O)C3OC2=C4C1=CC=C2OC LLPOLZWFYMWNKH-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITMI2014A000876 | 2014-05-14 | ||
| ITMI20140876 | 2014-05-14 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015221794A JP2015221794A (ja) | 2015-12-10 |
| JP2015221794A5 true JP2015221794A5 (https=) | 2018-06-14 |
| JP6563685B2 JP6563685B2 (ja) | 2019-08-21 |
Family
ID=51179022
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015098334A Active JP6563685B2 (ja) | 2014-05-14 | 2015-05-13 | オピオイドと組み合わせたパルミトイルエタノールアミドの使用 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US9801836B2 (https=) |
| EP (1) | EP2944309B1 (https=) |
| JP (1) | JP6563685B2 (https=) |
| KR (1) | KR102507891B1 (https=) |
| CN (1) | CN105079811B (https=) |
| AR (1) | AR100444A1 (https=) |
| AU (1) | AU2015202575B9 (https=) |
| BR (1) | BR102015011079A2 (https=) |
| CA (1) | CA2891049C (https=) |
| CY (1) | CY1121773T1 (https=) |
| DK (1) | DK2944309T3 (https=) |
| ES (1) | ES2731729T3 (https=) |
| HU (1) | HUE044915T2 (https=) |
| PL (1) | PL2944309T3 (https=) |
| PT (1) | PT2944309T (https=) |
| SM (1) | SMT201900345T1 (https=) |
| TR (1) | TR201908936T4 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2968345T3 (es) * | 2015-05-21 | 2024-05-09 | Scisparc Ltd | Combinaciones de oxicodona y palmitoiletanolamina de N-aciletanolamina para reducir los efectos secundarios asociados a los opioides |
| PH12018000077B1 (en) | 2017-07-05 | 2021-07-09 | Frimline Private Ltd | A pharmaceutical composition for neuropathic pain |
| PH12018000227A1 (en) | 2017-09-05 | 2019-03-11 | Frimline Private Ltd | A pharmaceutical composition for improving or preventing progression of chronic kidney disease |
| PH12021551384A1 (en) * | 2019-01-02 | 2022-03-28 | Celagenex Res India Pvt Ltd | Synergistic nutritional compositions for pain management |
| EP4681710A1 (en) * | 2024-07-18 | 2026-01-21 | EPITECH GROUP S.p.A. | 2-pentadecyl-2-oxazoline as an opioid adjuvant to prevent or treat hyperalgesia |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IT1271266B (it) | 1994-12-14 | 1997-05-27 | Valle Francesco Della | Impiego terapeutico di ammidi di acidi mono e bicarbossilici con amminoalcoli,selettivamente attive sul recettore periferico dei cannabinoidi |
| ATE290858T1 (de) | 1999-08-06 | 2005-04-15 | Innovet Italia Srl | N-palmitoylethanolamid-enthaltende pharmazeutische zusammensetzungen und deren verwendung in der veterinärmedizin |
| JP2004536854A (ja) * | 2001-07-18 | 2004-12-09 | ユニリーバー・ナームローゼ・ベンノートシヤープ | 頭髪及び／または頭皮のトリートメント組成物 |
| US20050245557A1 (en) * | 2003-10-15 | 2005-11-03 | Pain Therapeutics, Inc. | Methods and materials useful for the treatment of arthritic conditions, inflammation associated with a chronic condition or chronic pain |
| JP2012522004A (ja) * | 2009-03-27 | 2012-09-20 | アボット・ラボラトリーズ | カンナビノイド受容体リガンドである化合物 |
| ES2547133T5 (es) * | 2009-09-07 | 2019-02-15 | Epitech Group S P A | Composición que contiene palmitoiletanolamida ultramicronizada |
-
2015
- 2015-05-04 ES ES15166284T patent/ES2731729T3/es active Active
- 2015-05-04 PL PL15166284T patent/PL2944309T3/pl unknown
- 2015-05-04 DK DK15166284.8T patent/DK2944309T3/da active
- 2015-05-04 PT PT15166284T patent/PT2944309T/pt unknown
- 2015-05-04 TR TR2019/08936T patent/TR201908936T4/tr unknown
- 2015-05-04 SM SM20190345T patent/SMT201900345T1/it unknown
- 2015-05-04 EP EP15166284.8A patent/EP2944309B1/en active Active
- 2015-05-04 HU HUE15166284 patent/HUE044915T2/hu unknown
- 2015-05-12 CA CA2891049A patent/CA2891049C/en active Active
- 2015-05-13 AU AU2015202575A patent/AU2015202575B9/en active Active
- 2015-05-13 KR KR1020150066492A patent/KR102507891B1/ko active Active
- 2015-05-13 JP JP2015098334A patent/JP6563685B2/ja active Active
- 2015-05-13 US US14/711,112 patent/US9801836B2/en active Active
- 2015-05-13 CN CN201510243856.6A patent/CN105079811B/zh active Active
- 2015-05-14 AR ARP150101502A patent/AR100444A1/es unknown
- 2015-05-14 BR BR102015011079A patent/BR102015011079A2/pt not_active IP Right Cessation
-
2019
- 2019-05-29 CY CY20191100565T patent/CY1121773T1/el unknown
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