JP2015172587A5 - - Google Patents
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- JP2015172587A5 JP2015172587A5 JP2015094454A JP2015094454A JP2015172587A5 JP 2015172587 A5 JP2015172587 A5 JP 2015172587A5 JP 2015094454 A JP2015094454 A JP 2015094454A JP 2015094454 A JP2015094454 A JP 2015094454A JP 2015172587 A5 JP2015172587 A5 JP 2015172587A5
- Authority
- JP
- Japan
- Prior art keywords
- gfap
- marker
- sbdp
- binding agent
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 102100012570 GFAP Human genes 0.000 claims 10
- 101700069447 GFAP Proteins 0.000 claims 10
- 239000003550 marker Substances 0.000 claims 10
- 239000011230 binding agent Substances 0.000 claims 7
- 206010070976 Craniocerebral injury Diseases 0.000 claims 6
- 208000005765 Traumatic Brain Injury Diseases 0.000 claims 6
- 206010022114 Injury Diseases 0.000 claims 4
- 238000004166 bioassay Methods 0.000 claims 4
- 230000000926 neurological Effects 0.000 claims 4
- 102100004938 MAP2 Human genes 0.000 claims 3
- 101700017358 MAP2 Proteins 0.000 claims 3
- 101710039851 METAP1D Proteins 0.000 claims 3
- 101710012506 METAP2 Proteins 0.000 claims 3
- 238000005259 measurement Methods 0.000 claims 3
- 239000000523 sample Substances 0.000 claims 3
- 239000012472 biological sample Substances 0.000 claims 2
- 208000001183 Brain Injury Diseases 0.000 claims 1
- 206010061255 Ischaemia Diseases 0.000 claims 1
- 102000004965 antibodies Human genes 0.000 claims 1
- 108090001123 antibodies Proteins 0.000 claims 1
- 239000000758 substrate Substances 0.000 claims 1
Claims (10)
- 対象の外傷性脳傷害の重篤度を決定するために、第１の時点で前記対象から得られた試料中のＧＦＡＰの量と、ＭＡＰ−２、ＳＢＤＰ−１５０、ＳＢＤＰ−１４５またはＳＢＤＰ−１２０から選択される第２のマーカーの量とを測定する方法であって、前記第１の時点でのＧＦＡＰおよび第２のマーカーの量の測定が、傷害後の７２時間以内に行われる、方法。
- 前記脳傷害の重篤度が、外傷性脳傷害がない、軽度の外傷性脳傷害、中等度の外傷性脳傷害である、請求項１に記載の方法。
- 前記外傷性脳傷害の重篤度が重篤な外傷性脳傷害である、請求項１に記載の方法。
- 前記第１の時点でのＧＦＡＰおよび第２のマーカーの量の測定が傷害後の２４時間以内に行われる、請求項１に記載の方法。
- 前記第１の時点でのＧＦＡＰおよび第２のマーカーの量の測定が傷害後の２時間以内に行われる、請求項１に記載の方法。
- 対象の神経学的状態を決定するために、第１の時点で得られた試料中のＧＦＡＰの量と、ＭＡＰ−２、ＳＢＤＰ−１５０、ＳＢＤＰ−１４５またはＳＢＤＰ−１２０から選択される第２のマーカーの量とを測定する方法であって、前記第１の時点でのＧＦＡＰおよび第２のマーカーの量の測定が、傷害後の７２時間以内に行われる、方法。
- 前記神経学的状態が虚血である、請求項６に記載の方法。
- ＧＦＡＰおよび第２のマーカーが同じ試料中にある、請求項１または６に記載の方法。
- 対象の神経学的状態を決定するためのアッセイであって、
前記対象から単離された生体試料を保持するための基材、ＧＦＡＰ特異的結合剤および第２のマーカー特異的結合剤を含み、それにより、前記ＧＦＡＰ特異的結合剤および第２のマーカー特異的結合剤と生体試料の一部分との反応が前記対象の神経学的状態のエビデンスとなる、アッセイであって、
第２のマーカーは、ＭＡＰ−２、ＳＢＤＰ−１５０、ＳＢＤＰ−１４５またはＳＢＤＰ−１２０から選択される、
アッセイ。 - 前記ＧＦＡＰ特異的結合剤または第２のマーカー特異的結合剤が抗体である、請求項９に記載のアッセイ。
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US21872709P | 2009-06-19 | 2009-06-19 | |
| US61/218,727 | 2009-06-19 | ||
| US34518810P | 2010-05-17 | 2010-05-17 | |
| US61/345,188 | 2010-05-17 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012516369A Division JP5875514B2 (ja) | 2009-06-19 | 2010-06-21 | 神経学的状態のバイオマーカーアッセイ |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017007752A Division JP6408041B2 (ja) | 2009-06-19 | 2017-01-19 | 神経学的状態のバイオマーカーアッセイ |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2015172587A JP2015172587A (ja) | 2015-10-01 |
| JP2015172587A5 true JP2015172587A5 (ja) | 2015-12-10 |
Family
ID=43357089
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012516369A Active JP5875514B2 (ja) | 2009-06-19 | 2010-06-21 | 神経学的状態のバイオマーカーアッセイ |
| JP2015094454A Pending JP2015172587A (ja) | 2009-06-19 | 2015-05-01 | 神経学的状態のバイオマーカーアッセイ |
| JP2017007752A Active JP6408041B2 (ja) | 2009-06-19 | 2017-01-19 | 神経学的状態のバイオマーカーアッセイ |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012516369A Active JP5875514B2 (ja) | 2009-06-19 | 2010-06-21 | 神経学的状態のバイオマーカーアッセイ |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017007752A Active JP6408041B2 (ja) | 2009-06-19 | 2017-01-19 | 神経学的状態のバイオマーカーアッセイ |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US20130029859A1 (ja) |
| EP (2) | EP2443461A4 (ja) |
| JP (3) | JP5875514B2 (ja) |
| AU (1) | AU2010262952B2 (ja) |
| CA (1) | CA2766057A1 (ja) |
| WO (1) | WO2010148391A2 (ja) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8492107B2 (en) | 2004-04-15 | 2013-07-23 | University Of Florida Research Foundation, Inc. | Neural proteins as biomarkers for nervous system injury and other neural disorders |
| NO2324360T3 (ja) | 2008-08-11 | 2018-06-30 | ||
| EP2478360B1 (en) * | 2009-09-14 | 2018-06-27 | Banyan Biomarkers, Inc. | Autoantibody markers for diagnosis of traumatic brain injury |
| US9682132B2 (en) | 2010-01-26 | 2017-06-20 | Banyan Biomarkers, Inc | Compositions and methods relating to argininosucccinate synthetase |
| CA2809737A1 (en) * | 2010-04-01 | 2011-10-06 | Banyan Biomarkers, Inc. | Markers and assays for detection of neurotoxicity |
| WO2013138509A1 (en) | 2012-03-13 | 2013-09-19 | The Johns Hopkins University | Citrullinated brain and neurological proteins as biomarkers of brain injury or neurodegeneration |
| WO2015009907A1 (en) * | 2013-07-17 | 2015-01-22 | The Johns Hopkins University | A multi-protein biomarker assay for brain injury detection and outcome |
| US20170023591A1 (en) * | 2014-04-07 | 2017-01-26 | Iron Horse Diagnostics, Inc. | Traumatic Brain Injury and Neurodegenerative Biomarkers, Methods, and Systems |
| AU2015330355B2 (en) * | 2014-10-06 | 2021-09-23 | Fundacio Hospital Universitari Vall D'hebron - Institut De Recerca | Markers and their use in brain injury |
| EP3479121A4 (en) * | 2016-06-30 | 2020-03-11 | Brainbox Solutions, Inc. | LEVELS OF CIRCULATING BIOMARKERS FOR DIAGNOSING AND STRATIFYING THE RISK OF TRAUMATIC CEREBRAL DAMAGE |
| EP3519824A1 (en) * | 2016-10-03 | 2019-08-07 | Abbott Laboratories | Improved methods of assessing uch-l1 status in patient samples |
| CN106568750B (zh) * | 2016-10-31 | 2019-12-03 | 陕西脉元生物科技有限公司 | 一种基于荧光能量共振转移法的gfap检测方法 |
| CN110494752A (zh) * | 2017-03-23 | 2019-11-22 | 雅培实验室 | 用早期生物标记物泛素羧基末端水解酶l1帮助诊断测定人受试者创伤性脑损伤程度的方法 |
| US11016092B2 (en) | 2017-03-23 | 2021-05-25 | Abbott Laboratories | Methods for aiding in the diagnosis and determination of the extent of traumatic brain injury in a human subject using the early biomarker ubiquitin carboxy-terminal hydrolase L1 |
| BR112019021612A2 (pt) * | 2017-04-15 | 2020-05-12 | Abbott Laboratories | Métodos para auxiliar o diagnóstico hiperagudo e determinação de traumatismo crânioencefálico em um indivíduo humano com o uso de biomarcadores precoces |
| EP3635407A1 (en) * | 2017-04-28 | 2020-04-15 | Abbott Laboratories | Methods for aiding in the hyperacute diagnosis and determination of traumatic brain injury using early biomarkers on at least two samples from the same human subject |
| US11709168B2 (en) | 2017-05-23 | 2023-07-25 | Brainbox Solutions, Inc. | Biomarker levels and neuroimaging for detecting, monitoring and treating brain injury or trauma |
| CN110651190A (zh) | 2017-05-25 | 2020-01-03 | 雅培实验室 | 用早期生物标记物帮助确定是否对已遭受或可能已遭受头部损伤的人受试者执行成像的方法 |
| US11129564B2 (en) * | 2017-05-30 | 2021-09-28 | Abbott Laboratories | Methods for aiding in diagnosing and evaluating a mild traumatic brain injury in a human subject using cardiac troponin I |
| US11169159B2 (en) | 2017-07-03 | 2021-11-09 | Abbott Laboratories | Methods for measuring ubiquitin carboxy-terminal hydrolase L1 levels in blood |
| US11016105B2 (en) | 2017-12-09 | 2021-05-25 | Abbott Laboratories | Methods for aiding in diagnosing and evaluating a traumatic brain injury in a human subject using a combination of GFAP and UCH-L1 |
| CN111094983A (zh) * | 2017-12-09 | 2020-05-01 | 雅培实验室 | 使用胶质细胞原纤维酸性蛋白(gfap)和/或泛素羧基末端水解酶l1(uch-l1)帮助诊断和评价已遭受骨科损伤并已遭受或可能已遭受头部损伤诸如轻度创伤性脑损伤(tbi)的患者的方法 |
| JP7437303B2 (ja) | 2017-12-29 | 2024-02-22 | アボット・ラボラトリーズ | 外傷性脳損傷を診断及び査定するための、新規のバイオマーカー及び方法 |
| KR102072563B1 (ko) * | 2018-06-27 | 2020-02-03 | 가톨릭대학교 산학협력단 | Dpysl2를 포함하는 인터넷 게임 장애 진단용 바이오마커 및 그의 용도 |
| KR102464243B1 (ko) * | 2020-04-01 | 2022-11-08 | 프리시젼바이오 주식회사 | 외상성 뇌손상 바이오마커 검출용 시분해 형광분석 측방유동 분석장치 및 이를 이용한 외상성 뇌손상 바이오마커 측정방법 |
| KR102357260B1 (ko) * | 2020-12-10 | 2022-02-08 | 주식회사 레피겐엠디 | 마이크로rna를 이용한 당뇨병성 신경병증의 예측 및 진단 방법 및 이를 위한 키트 |
| CN113238045B (zh) * | 2021-04-27 | 2021-12-28 | 南方医科大学南方医院 | Crmp2及抗crmp2抗体的应用 |
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| JP2763958B2 (ja) | 1990-06-11 | 1998-06-11 | ネクスター ファーマスーティカルズ，インコーポレイテッド | 核酸リガンド |
| US5660985A (en) | 1990-06-11 | 1997-08-26 | Nexstar Pharmaceuticals, Inc. | High affinity nucleic acid ligands containing modified nucleotides |
| US5567588A (en) | 1990-06-11 | 1996-10-22 | University Research Corporation | Systematic evolution of ligands by exponential enrichment: Solution SELEX |
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| US5683867A (en) | 1990-06-11 | 1997-11-04 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: blended SELEX |
| US5637459A (en) | 1990-06-11 | 1997-06-10 | Nexstar Pharmaceuticals, Inc. | Systematic evolution of ligands by exponential enrichment: chimeric selex |
| US5496938A (en) | 1990-06-11 | 1996-03-05 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligands to HIV-RT and HIV-1 rev |
| US6011020A (en) | 1990-06-11 | 2000-01-04 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligand complexes |
| US7427490B2 (en) * | 2001-08-20 | 2008-09-23 | Biosite Incorporated | Diagnostic markers of stroke and cerebral injury and methods of use thereof |
| WO2003032894A2 (en) * | 2001-10-12 | 2003-04-24 | Pfizer Products Inc. | Method of monitoring neuroprotective treatment |
| EP2348317B1 (en) * | 2002-09-11 | 2014-12-03 | University Of Florida Research Foundation, Inc. | Detection of traumatic brain injury using alpha II spectrin break-down products (SBDP) |
| EP2341350B1 (en) * | 2003-09-20 | 2017-11-08 | Electrophoretics Limited | Diagnostic method for brain damage-related disorders based on detection of dj-1 |
| EP1519194A1 (en) * | 2003-09-24 | 2005-03-30 | Roche Diagnostics GmbH | Use of gfap for identification of intracerebral hemorrhage |
| ES2482142T3 (es) | 2004-04-15 | 2014-08-01 | University Of Florida Research Foundation, Inc. | Proteínas neurales como biomarcadores para lesiones del sistema nervioso y otros trastornos neurales |
| WO2008008819A2 (en) * | 2006-07-11 | 2008-01-17 | University Of Florida Research Foundation, Inc. | Diagnosis and treatment of neurological inflammation |
| US20100159486A1 (en) * | 2006-11-01 | 2010-06-24 | George Mason Intellectual Properties, Inc. | Biomarkers for neurological conditions |
| US8293489B2 (en) * | 2007-01-31 | 2012-10-23 | Henkin Robert I | Methods for detection of biological substances |
| JP2009052933A (ja) * | 2007-08-24 | 2009-03-12 | Rakuno Gakuen | プリオン病の検出方法及び診断キット |
| JP2011511301A (ja) * | 2008-02-04 | 2011-04-07 | バンヤン・バイオマーカーズ・インコーポレイテッド | 脳損傷を診断または治療するための方法 |
| NO2324360T3 (ja) * | 2008-08-11 | 2018-06-30 | ||
| EP2478360B1 (en) * | 2009-09-14 | 2018-06-27 | Banyan Biomarkers, Inc. | Autoantibody markers for diagnosis of traumatic brain injury |
-
2010
- 2010-06-21 AU AU2010262952A patent/AU2010262952B2/en active Active
- 2010-06-21 WO PCT/US2010/039335 patent/WO2010148391A2/en active Application Filing
- 2010-06-21 EP EP10790319A patent/EP2443461A4/en not_active Ceased
- 2010-06-21 US US13/379,164 patent/US20130029859A1/en not_active Abandoned
- 2010-06-21 CA CA2766057A patent/CA2766057A1/en not_active Abandoned
- 2010-06-21 EP EP18162020.4A patent/EP3355059A3/en not_active Withdrawn
- 2010-06-21 JP JP2012516369A patent/JP5875514B2/ja active Active
-
2015
- 2015-05-01 JP JP2015094454A patent/JP2015172587A/ja active Pending
-
2017
- 2017-01-19 JP JP2017007752A patent/JP6408041B2/ja active Active
- 2017-02-23 US US15/441,183 patent/US20190064187A1/en not_active Abandoned
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