JP2015113330A - Skin care film - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a skin care film having an excellent skin-following property.SOLUTION: A skin care film comprises a film that satisfies a density of 1.3-1.9 g/cm, a thickness of 5-50 μm, a tensile elasticity of 200-600 MPa and a tensile elongation of 60-150%.

Description

  The present invention relates to a skin care film.

  Conventionally, skin care films in which an ointment is carried on a film have been widely used for medical purposes. By applying an ointment to the film in advance and sticking it to the skin, it is possible to improve unsanitary conditions when applying with bare hands, manage dosage, and prevent transfer to clothes and other parts. . On the other hand, the above-mentioned skin care film has problems such as an uncomfortable feeling when applied to the skin and a decrease in mechanical strength due to the transfer of the ointment.

  In order to solve such a problem, Patent Documents 1 and 2 propose a skin care film using a film in which a tension feeling that may occur when the bent portion is bent and stretched is reduced by extending at a bent portion such as a joint. Has been.

Japanese Patent No. 4616542 Japanese Patent No. 3400026

  However, with the techniques described in Patent Documents 1 and 2, it is not possible to obtain a film that fits along the skin when applied to the skin and can be applied without a sense of incongruity.

  This invention is made | formed in view of the subject which said prior art has, and aims at providing the skin care film excellent in the along-skin property.

In order to solve the above-mentioned problems, the present inventors have made extensive studies and have completed the present invention. That is, the present invention is as follows.
[1]
A skin care film having a film satisfying a density of 1.3 to 1.9 g / cm ³ , a thickness of 5 to 50 μm, a tensile elastic modulus of 200 to 600 MPa, and a tensile elongation of 60 to 150%.
[2]
The skin care film according to [1], further comprising an ointment in contact with the surface of the film.
[3]
The skin care film according to [1] or [2], wherein a critical surface tension obtained by a Zisman plot at 20 ° C. of the film is 35 to 50 mN / m.
[4]
The skin care film according to any one of [1] to [3], wherein the main component of the film is a vinylidene chloride copolymer.
[5]
100 to 10 parts by mass of a vinylidene chloride copolymer satisfying a mass average molecular weight of 70,000 to 140,000 and a vinylidene chloride monomer unit of 75 to 96% by mass, and a mixture of a fatty acid ester and an epoxidized compound of 1 to 10 mass. A skin care film according to any one of [1] to [4].
[6]
The skin care film according to any one of [2] to [5], wherein the ointment contains at least one of paraffin wax and liquid paraffin.

  ADVANTAGE OF THE INVENTION According to this invention, when affixed on skin, the skin care film excellent in the along-skin property which can be affixed along a skin without a strange feeling can be provided.

  Hereinafter, a mode for carrying out the present invention (hereinafter abbreviated as “this embodiment”) will be described in detail. In addition, this invention is not limited to the following embodiment, It can implement by changing variously within the range of the summary.

The skin care film of this embodiment has a film satisfying a density of 1.3 to 1.9 g / cm ³ , a thickness of 5 to 50 μm, a tensile elastic modulus of 200 to 600 MPa, and a tensile elongation of 60 to 150%. Since it is comprised in this way, the skin care film of this embodiment is familiar along skin when it affixes on skin, and is affixed without discomfort. That is, the skin care film of the present embodiment can exhibit excellent along-skin properties.

The film in the present embodiment satisfies a density of 1.3 to 1.9 g / cm ³ , a thickness of 5 to 50 μm, a tensile elastic modulus of 200 to 600 MPa, and a tensile elongation of 60 to 150%. By setting it within this range, there is no fear of conforming to the skin and tearing when it is pasted, it has a waist and is easy to handle, and can withstand some practical deformation. From the viewpoint of further enhancing the above effects, preferable ranges are a density of 1.5 to 1.8 g / cm ³ , a thickness of 10 to 20 μm, a tensile elastic modulus of 400 to 600 MPa, and a tensile elongation of 100 to 140%. In addition, about the said density, thickness, a tensile elasticity modulus, and tensile elongation, it can obtain | require by the method as described in the Example mentioned later. Moreover, the film in the present embodiment is controlled to have the desired physical properties (density, tensile elastic modulus, tensile elongation) of the present embodiment by appropriately adjusting the constituent components and degree of polymerization of the polymer constituting the film. be able to.

  The material and shape of the film in the present embodiment are not particularly limited as long as the above-described conditions are satisfied. For example, the film in the present embodiment may be subjected to surface treatment such as corona treatment or plasma treatment, perforation, printing, adhesive coating, or the like. Moreover, you may be comprised by the multilayer containing a some film and nonwoven fabric in the range of the conditions mentioned above.

  The skin care film of this embodiment may further have an ointment that contacts the surface of the film. In the present specification, the term “ointment” refers to a semi-solid substance that does not flow at room temperature but has spreadability and does not have a freezing point or has a freezing point of −10 ° C. or lower. Examples of the ointment include, but are not limited to, an oleaginous ointment, a water-soluble ointment, and an emulsion ointment. Examples of the oily ointment include, but are not limited to, petrolatum, plastibase, simple ointment, and zinc white ointment. Examples of the water-soluble ointment include, but are not limited to, macrogol ointment. Examples of the emulsion ointment include, but are not limited to, hydrogel ointment.

  In the present embodiment, the ointment may be purified, combined with different types of ointments, and further added with an adhesive, various additives, pharmacologically active ingredients, and the like. Examples of additives include, but are not limited to, stabilizers, surfactants, antioxidants, preservatives, pH adjusters, and fragrances. Examples of pharmacologically active ingredients include, but are not limited to, bactericidal disinfectants, vitamins, anti-inflammatory analgesics, antiviral agents, antibiotic preparations, and the like.

  The ointment in this embodiment preferably contains at least one of paraffin wax and liquid paraffin, and more preferably contains petrolatum or plastibase. In addition to the above, examples of the ointment in the present embodiment include, but are not limited to, mineral oil, medical paraffin, baby oil, and the like.

  In the present embodiment, if necessary, a release material may be provided so that the ointment does not transfer, or the skin care film may be folded in half with the ointment inside, and the periphery may be sealed. . The release material is not limited to the following, but for example, a film, paper, nonwoven fabric, woven fabric, knitted fabric or the like that has been subjected to a release treatment with a silicone resin or a fluororesin can be used. The preferable thickness range of the release material is 10 to 1000 μm.

The ointment in this embodiment is preferably applied to the substrate with a basis weight of 1 to 100 g / cm ² . When the basis weight is 1 g / cm ² or more, the ointment tends to be applied more uniformly. When the basis weight is 100 g / cm ² or less, the skin care film is excessively applied to the skin. There exists a tendency which can reduce a sticky feeling effectively. The basis weight can be obtained by cutting the skin care film into a 10 cm square, measuring the weight, and reducing the weight of the film alone and then dividing it by the area.

  In the present embodiment, the application method is not limited to the following, and for example, a coating machine such as a hot melt coating machine, a die coater, a bar coater, or a roll coater can be used. The application pattern of the ointment is not limited to the following, but an application pattern such as a linear shape, a dot shape, a spiral shape, or a checkered shape can be adopted.

If it is a film satisfying a density of 1.3 to 1.9 g / cm ³ , a thickness of 5 to 50 μm, a tensile elastic modulus of 200 to 600 MPa and a tensile elongation of 60 to 150%, it is suitably used as the skin care film of the present embodiment. Furthermore, it is more preferable to use a film having a critical surface tension of 35 to 50 mN / m determined by a Zisman plot at 20 ° C. as the skin care film of this embodiment. That is, it is preferable that the critical surface tension of the film in the present embodiment determined by a Zisman plot at 20 ° C. is 35 to 50 mN / m. When the critical surface tension is in the above range, the ointment tends to be familiar with the film surface, and the ointment tends to stay on the film surface over time. More preferably, it is the range of 38-42 mN / m, and when it exists in the said range, it exists in the tendency which becomes easy to maintain the uniformity of coating more favorably.

  The film in the present embodiment is not limited to the following. For example, polyolefins such as polyvinylidene chloride, polyethylene and polypropylene, polyesters such as polyethylene terephthalate, ethylene / vinyl alcohol copolymer, ethylene / vinyl acetate copolymer Polyamide, polyurethane and the like can be applied as the material. These can be used alone or in appropriate combination. Among those described above, a film containing a vinylidene chloride copolymer as a main component can be particularly preferably used. That is, the main component of the film in this embodiment is preferably a vinylidene chloride copolymer. Since a film containing a vinylidene chloride copolymer as a main component is difficult to be impregnated with an ointment, it tends to maintain better mechanical strength. In addition, the “main component” in this specification typically means 50% by mass or more.

  The vinylidene chloride copolymer preferably has a mass average molecular weight of 70,000 to 140,000 and a vinylidene chloride monomer unit of 75 to 96% by mass. When the mass average molecular weight is within this range, the film can be easily stretched and a crack-free film can be easily produced. When the vinylidene chloride monomer unit is within this range, the crystallinity of the film is good, the fusion after molding tends to be hindered, and the handleability is improved. In addition, a mass average molecular weight can be calculated | required by the method as described in the Example mentioned later.

  Moreover, it is more preferable to add a total of 1 to 10 parts by mass of a mixture of a fatty acid ester and an epoxidized compound with respect to 100 parts by mass of the vinylidene chloride copolymer. Fatty acid esters have the effect of plasticizing the resin to improve extrudability. Examples of compatible fatty acid esters that do not cause phase separation with a composition containing a polyvinylidene chloride copolymer include, but are not limited to, dibutyl sebacate, acetyltributyl citrate, glycerin diacetomonolaurate, and the like. Is mentioned.

  That is, from the above-mentioned viewpoint, the film in this embodiment has a mass average molecular weight of 70,000 to 140,000 and vinylidene chloride copolymer 100 parts by mass satisfying 75 to 96% by mass of vinylidene chloride monomer units, and fatty acid esters. It is preferable that 1-10 mass parts of mixtures with an epoxidized compound are included.

  The epoxidized compound has an effect of preventing the vinylidene chloride copolymer from yellowing due to hydrochloric acid generated by thermal degradation during extrusion. Examples of the epoxidized compound include, but are not limited to, epoxidized soybean oil, epoxidized linseed oil, bisphenol A diglycidyl ether, epoxidized octyl stearate, and epoxidized palm oil.

  Furthermore, the form of the skin care film of the present embodiment is not particularly limited, and may be a form wound in a roll and housed in a decorative box, or a sheet cut out and packaged to a certain size. Furthermore, you may perform sterilization processing, such as a gamma ray, an electron beam, and ethylene oxide gas, as needed.

Although it does not specifically limit as a manufacturing method of the skin care film which concerns on this embodiment, For example, the petrolatum is apply | coated to the film obtained by the inflation method with 30 g / cm < ² > of fabric weight with a hot-melt coating machine, and the obtained skin care An example is a method in which the film is slit to a width of 100 mm, and further wound around a small-diameter paper tube having a diameter of 30 mm, and then stored in a decorative box.

  Next, the present embodiment will be described more specifically with reference to examples and comparative examples. However, the present embodiment is not limited to the following examples unless it exceeds the gist.

  Density, thickness, tensile modulus, tensile elongation of film, proportion of vinylidene chloride monomer unit in vinylidene chloride copolymer when vinylidene chloride copolymer is included as a film component, mass average molecular weight, manufactured The along-skin property of the skin care film and the transferability of the ointment were measured by the following methods. When an ointment was applied, it was removed and evaluated using a solvent in which the ointment was dissolved.

(1) Density Based on the measurement method of the density and specific gravity of JISK7112 plastic and non-foamed plastic, it was measured using the method A underwater substitution method.

(2) Thickness Based on the JISK7130 plastic film and sheet thickness measuring method, the thickness was measured using the thickness test method B1 method of the sample.

(3) Tensile modulus Measured according to ASTM-D882. That is, the skin care film of each example was cut into a width of 10 mm and a length of 100 mm along the MD and TD directions, respectively, and measured at a tensile speed of 5 mm / min. A tangent line is drawn on the obtained stress-strain graph to calculate a value obtained by converting the stress value at the time of 2% elongation into the thickness of the sample, and the average value of five measurements is taken as a measured value, and the MD direction and the TD direction are calculated. The average value was taken as the value of tensile modulus. The trade name “AUTOGRAPH AG-IS” (manufactured by Shimadzu Corporation) was used for the measuring apparatus.

(4) Tensile elongation Measured according to ASTM-D882. That is, the skin care film was cut into a width of 10 mm and a length of 100 mm along the MD and TD directions, respectively, and measured at a tensile speed of 300 mm / min. The average value was the measured value, and the average value in the MD direction and the TD direction was the tensile elongation value. The trade name “AUTOGRAPH AG-IS” (manufactured by Shimadzu Corporation) was used for the measurement.

(5) Ratio of vinylidene chloride monomer unit in vinylidene chloride copolymer It was measured using a high resolution proton nuclear magnetic resonance measuring apparatus ( ¹ H-NMR: α-400 manufactured by JEOL Ltd.). At this time, in the case where components other than the vinylidene chloride copolymer were contained, the measurement was carried out after removing in advance. For example, in the case of fatty acid esters and epoxy compounds, measurement samples were obtained as follows.

  A measurement sample was obtained by reprecipitating 1 g of a film mainly composed of vinylidene chloride copolymer with 20 ml of tetrahydrofuran and 80 ml of methanol. A solution obtained by dissolving 5% of this measurement sample in deuterated tetrahydrofuran was measured by 400 MHz H-NMR under a measurement temperature of about 27 ° C. The vinylidene chloride monomer unit was calculated using a specific chemical shift based on tetramethylsilane in the spectrum.

For example, when the copolymer resin with vinylidene chloride resin is vinyl chloride, it is derived from the solvent from the peak between 3.50 to 4.20 ppm, 2.80 to 3.50 ppm, and 2.00 to 2.80 ppm. The integral values obtained by subtracting the peaks were obtained as the following formulas as (A), (B), and (C), respectively.
VDC content (% by mass) = {97.0 × ((A) + (B) / 2) × 100} / {97.0 × ((A) + (B) / 2) + 62.5 × (( C) + (B) / 2)}

  Further, when the copolymer resin is other than vinyl chloride, it was calculated from the integral value of the specific chemical shift according to this.

(6) Mass average molecular weight It measured using the gel permeation chromatograph (GPC) method. More specifically, a film containing a vinylidene chloride copolymer as a main component was dissolved in 0.05% by mass in tetrahydrofuran, and measurement was performed using monodisperse polystyrene having a known molecular weight as a standard substance. As a measuring device, Tosoh Co., Ltd. 8000 series <trade name> was used. The column used two GMH6 (3/8 inch x 60 cm) manufactured by Tosoh Corporation in series, and tetrahydrofuran was used as the developing solvent.

(7) Skin alignment The skin care film was sampled in a 40 mm square and pasted on the forearms of 10 men and 10 women in their 20s to 40s, and the skin alignment was determined by sensory evaluation. The number of people judged to be uncomfortable was determined as follows. In addition, it was evaluated that feeling a sense of urgency, a foreign body feeling, etc. was equivalent to the above-mentioned “discomfort”.
○: 16 or more people have no discomfort △: 10 to 15 people have no discomfort ×: 9 people or less have no discomfort

(8) Ointment transferability Vaseline was applied to the film before application of petrolatum and 30 g / cm ² , and after aging for 1 week under conditions of room temperature 23 ° C. ± 1 ° C. and humidity 50% ± 2%. Evaluation was based on the amount of change in the tensile strength of the film.

Measurement of tensile strength was in accordance with ASTM-D882. The sample film used was a skin care film cut into a width of 10 mm and a length of 100 mm along the MD and TD directions, respectively. The tensile speed was 300 mm / min, the average value of five measurements was taken as the measured value, and the average value in the MD and TD directions was taken as the tensile strength value. The trade name “AUTOGRAPH AG-IS” (manufactured by Shimadzu Corporation) was used for the measurement. The obtained results were evaluated according to the following criteria.
○: Change in tensile strength is less than 5% Δ: Change in tensile strength is 5% or more and less than 20% ×: Change in tensile strength is 20% or more

(9) Critical surface tension The contact angle for a liquid having a known surface tension used in the Zisman plot was measured, and the surface tension was plotted on the x-axis and cos θ of the contact angle was plotted on the y-axis. The value obtained by extrapolating the straight line obtained based on the above plot to cos θ = 1 was defined as the critical surface tension. As the liquid having a known surface tension, n-alkanes such as heptane, decane, alcohols such as ethanol, ethylene glycol, and alkyl halides such as 1-chlorohexane and 1-chlorooctane were used. For the measurement, a contact angle meter DM-501 (Kyowa Interface Science Co., Ltd.) was used.

[Example 1]
Vinylidene chloride-vinyl chloride copolymer (vinylidene chloride monomer unit content / vinyl chloride monomer unit content = 80% by mass / 20% by mass, mass average molecular weight 120,000, expressed as “PVDC” in Table 1 ) 3 parts by weight of dibutyl sebacate as fatty acid esters, 4 parts by weight of acetyltributyl citrate, 2 parts by weight of epoxidized soybean oil as an epoxidized compound for 100 parts by weight, and mixed for 5 minutes with a Henschel mixer did. The obtained mixture was extruded into a tubular shape with a melt extruder, supercooled in a cold water bath at about 10 ° C., passed through 35 ° C. water, stretched at 30 ° C., 3.0 times in the longitudinal (MD) direction, and width (TD) ) A tubular film obtained by biaxial stretching of 4.0 times in the direction was folded with a pinch roll to produce a flat and long film for skin care film having a thickness of 40 μm. The evaluation results of film properties are shown in Table 1.

[Example 2]
2.5 parts by mass of acetyltributyl citrate with respect to 100 parts by mass of vinylidene chloride-vinyl chloride copolymer (vinylidene chloride content / vinyl chloride content = 90 mass% / 10 mass%, mass average molecular weight 70,000), 0.5 parts by mass of epoxidized soybean oil was added and mixed in the same manner. The obtained mixture was stretched and wound up in the same manner as in Example 1 to prepare a flat long double-ply film original fabric having a thickness of 20 μm. Thereafter, it was peeled off to a single film using a slitter to form a 10 μm film. The obtained results are shown in Table 1.

[Example 3]
40% by mass of calcium carbonate (average particle size 0.2 μm) is added to polyethylene (low density polyethylene, density 0.9 g / cm ³ , expressed as “PE” in Table 1) and mixed, and the mixture is mixed with a melt extruder. The film was extruded to form a bubble and wound up to prepare a film having a thickness of 20 μm. The obtained results are shown in Table 1.

[Example 4]
Vaseline (Iwaki white petrolatum north white) was applied to the film obtained in the same manner as in Example 1 with a basis weight of 30 g / cm ² using a hot melt coater. The obtained results are shown in Table 1.

[Example 5]
A plastic base (Plastic base manufactured by Taisho Toyama Pharmaceutical Co., Ltd.) was applied to the film obtained in the same manner as in Example 1 with a basis weight of 50 g / cm ² using a hot melt coating machine. The obtained results are shown in Table 1.

[Example 6]
Lanolin (Crano Lanolin) was applied to a film obtained in the same manner as in Example 1 with a basis weight of 3 g / cm ² using a hot melt coater. The obtained results are shown in Table 1.

[Example 7]
Macrogol ointment (Macrogol ointment manufactured by Shiseido Pharmaceutical Co., Ltd.) was applied to the film obtained in the same manner as in Example 1 at a basis weight of 80 g / cm ² using a hot melt coater. The obtained results are shown in Table 1.

[Example 8]
Vaseline (Iwaki white petrolatum north white) was applied to the film obtained in the same manner as in Example 2 with a basis weight of 30 g / cm ² using a hot melt coater. The obtained results are shown in Table 1.

[Example 9]
Vaseline (Iwaki white petrolatum north white) was applied to the film obtained in the same manner as in Example 3 with a basis weight of 30 g / cm ² using a hot melt coater. The obtained results are shown in Table 1.

[Comparative Example 1]
Polyethylene (linear low density polyethylene, density 0.9 g / cm ³ ) was extruded into a cylindrical shape with a melt extruder to form bubbles and wound up to produce a film having a thickness of 10 μm. The obtained results are shown in Table 1.

[Comparative Example 2]
Polytetrafluoroethylene (indicated as “PTFE” in Table 1, PTFE fine powder) was paste extruded, rolled and fired to obtain a film having a thickness of 50 μm.

[Comparative Example 3]
A film having a thickness of 3 μm was obtained in the same manner as in Example 1. The obtained results are shown in Table 1.

[Comparative Example 4]
A film having a thickness of 70 μm was obtained in the same manner as in Example 1. The obtained results are shown in Table 1.

[Comparative Example 5]
6 nylon (indicated as “Ny” in Table 1) was extruded with a melt extruder and biaxially stretched to obtain a film having a thickness of 25 μm. The obtained results are shown in Table 1.

[Comparative Example 6]
A film was collected in the same manner as in Example 1 except that no inflation was performed. The obtained results are shown in Table 1.

  INDUSTRIAL APPLICABILITY The present invention can provide a skin care film excellent in along-skin properties that conforms to the skin when applied to the skin, and further can provide a skin care film that maintains mechanical strength without the ointment shifting. In particular, it is useful in applications that require a strict level of performance in terms of the along-skin property of the skin.

Claims (6)

A skin care film having a film satisfying a density of 1.3 to 1.9 g / cm ³ , a thickness of 5 to 50 μm, a tensile elastic modulus of 200 to 600 MPa, and a tensile elongation of 60 to 150%.   The skin care film according to claim 1, further comprising an ointment in contact with the surface of the film.   The skin care film of Claim 1 or 2 whose critical surface tension calculated | required by the Zisman plot in 20 degreeC of the said film is 35-50 mN / m.   The skin care film according to any one of claims 1 to 3, wherein a main component of the film is a vinylidene chloride copolymer.   100 to 10 parts by mass of a vinylidene chloride copolymer satisfying a mass average molecular weight of 70,000 to 140,000 and a vinylidene chloride monomer unit of 75 to 96% by mass, a mixture of a fatty acid ester and an epoxidized compound, 1 to 10 mass The skin care film as described in any one of Claims 1-4 containing a part.   The skin care film according to any one of claims 2 to 5, wherein the ointment contains at least one of paraffin wax and liquid paraffin.