JP2015101566A - Tooth whitening agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a tooth whitening agent excellent in prompt effectiveness of a tooth whitening effect and an effect of providing gloss to the tooth.SOLUTION: The tooth whitening agent contains the following composition (A) and (B) separately in order to apply the composition (A) and (B) to the tooth by turns. (A) is a composition containing 0.1 mass% or more to 30 mass% or less of phytic acid or a salt thereof in terms of acid, not containing a polyvalent metal cation or containing less than 0.1 mole times to the phytic acid or the salt thereof, and having pH of 4.5 or more to 7 or less at 25°C. (B) is a composition containing 0.01 mass% or more to 15 mass% or less of peroxide, and having pH of 4.5 or more to 6.5 or less at 25°C.

Description

  The present invention relates to a tooth whitening agent for applying two types of compositions to teeth alternately.

  In addition to tartar and plaque, human teeth are colored by the adhesion of various colored materials to the surface, and gloss is also reduced. These reductions in coloring and gloss are not cosmetically desirable, and various means for whitening teeth have been developed.

  Under these circumstances, peroxides are known to have an effect of bleaching or removing coloring deposited on the teeth, and the use thereof is effective for whitening the teeth. For example, a composition that can contain a peroxide and a polyphosphate such as tripolyphosphate or tetrapolyphosphate (Patent Document 1), a bleaching active substance such as peroxide, a linear polyphosphate, phytic acid, etc. It has been reported that the use of a composition containing the polyphosphorylated compound (Patent Document 2) can remove tooth stains or prevent stains while whitening teeth.

  In addition, means for applying treatments in multiple stages to enhance the whitening effect of the teeth is also disclosed. For example, a composition containing an organic acid such as malic acid and / or an inorganic acid, and a composition containing a peroxide. (Patent Document 3) and a method of pretreatment with a condensed phosphate aqueous solution when using a tooth bleaching material containing hydrogen peroxide (Patent Document 4).

  On the other hand, peroxides are generally known to cause pain and irritation such as puncture and penetration in the oral cavity, and compositions aimed at improving this have been reported (for example, patents). Reference 5).

JP-T-2006-504776 Special table 2009-531425 gazette JP 2008-201732 A Japanese Patent Laid-Open No. 2003-2815 Special table 2009-531414 gazette

Thus, when whitening teeth using peroxide, it is desired to reduce pain and irritation by shortening the application time as much as possible.
However, as described in Patent Documents 1 and 2, when a polyphosphate and a peroxide are contained in one composition, the application time must be extended in order to obtain sufficient tooth whitening effect. There is a tendency to reduce pain and irritation. On the other hand, as described in Patent Documents 3 to 4, a composition containing an organic acid such as malic acid and / or an inorganic acid is allowed to act separately from the composition containing a peroxide. If a pretreatment with an acid salt is performed, there is a possibility that the whitening effect of the teeth by the peroxide itself is reduced. In addition, as the application time of the peroxide is extended by the present inventors, the teeth become white, but the possibility of damaging the tooth surface increases. It was also found that there is a tendency to be damaged.

  Therefore, the present invention relates to an excellent tooth whitening agent that suppresses the formation of irregularities on the surface of the tooth and ensures the gloss of the tooth while being excellent in the immediate effect of the whitening effect of the tooth.

  Therefore, the present inventors analyzed the components in a minute solid product with a thickness of less than several μm attached or deposited on the tooth surface in more detail, and found that not only calcium phosphates but also organic substances were included. I found Furthermore, the present inventors have disclosed phytic acid and peroxide not specifically shown in any of the above-mentioned documents for the fine solid product on the tooth surface resulting from the mixing of the organic substance and calcium phosphates. Whitening agent that alternately acts on the teeth, i.e., a specific weakly acidic composition containing phytic acid and a specific weakly acidic composition containing peroxide, which are separated into teeth. If you use a tooth whitening agent to apply, it will effectively remove inorganic stains such as calcium phosphates and organic stains, shorten the application time, and have excellent whitening effect and damage to the tooth surface It was found that the natural gloss of the teeth can be secured and the present invention has been completed.

That is, the present invention includes the following composition (A) and composition (B):
Composition (A) containing phytic acid or a salt thereof in an acid conversion amount of 0.1% by mass or more and 30% by mass or less and not containing a polyvalent metal cation or 0.1 times that of phytic acid or a salt thereof A composition containing less than a mole and having a pH of 4.5 or more and 7 or less at 25 ° C., and a composition (B) peroxide of 0.01% by mass or more and 15% by mass or less, and a pH at 25 ° C. of 4 It is related with the tooth whitening agent for isolate | separating and providing the composition which is 0.5 or more and 6.5 or less, and applying a composition (A) and a composition (B) to a tooth | gear alternately.

The present invention also includes the following composition (A) and composition (B):
Composition (A) containing phytic acid or a salt thereof in an acid conversion amount of 0.1% by mass or more and 30% by mass or less and not containing a polyvalent metal cation or 0.1 times that of phytic acid or a salt thereof A composition containing less than a mole and having a pH of 4.5 or more and 7 or less at 25 ° C., and a composition (B) peroxide of 0.01% by mass or more and 15% by mass or less, and a pH at 25 ° C. of 4 It is related with the whitening method of the tooth which applies the composition which is .5 or more and 6.5 or less to a tooth alternately.

  According to the tooth whitening agent of the present invention, it is possible to quickly remove minute dirt or solid products adhering to or accumulating on the surface of the tooth, and to exhibit an immediate effect of the tooth-beautifying effect, and to shorten the application time. It is also possible to secure the beautiful gloss inherent in the teeth by realizing the above.

Hereinafter, the present invention will be described in detail.
In the present invention, the fine dirt or solid product adhering or depositing on the tooth surface means a solid matter having a thickness of less than several μm adhering to and accumulating on the tooth surface, and such solid matter is an inorganic substance. And an aggregate mainly composed of an organic substance, and each aggregate includes a layered or sea-island structure. This minute solid product is mainly formed by the adhesion of proteins, calcium, phosphorus, and other components in saliva, and is thought to be formed by the accumulation of deposits. Adhesion and deposition are promoted due to deterioration of the internal environment and the like, and are easily generated, and are difficult to remove by a normal brushing process. According to the tooth whitening agent of the present invention, it acts suitably on an aging tooth whose yellowing has increased and its luster has been lost, and whiteness and luster can be improved within a short period of time.

  The tooth whitening agent of the present invention is provided for separating the composition (A) and the composition (B) and applying these compositions to the teeth alternately. The composition (A) and the composition (B) are applied alternately to the teeth, and then the composition (A) and the composition (B) are applied alternately to the teeth, and this is repeated many times. Can do. Since the tooth whitening agent of the present invention exhibits an immediate effect of the tooth whitening effect, use for a short period of time, for example, applying the composition (A) and the composition (B) alternately to the teeth multiple times. It is possible to obtain white teeth while preventing loss of gloss of the teeth only by repeating over a long period. The order in which these compositions are applied to the teeth is not particularly limited. After the composition (A) is first applied to the teeth, the composition (B) may be applied to the teeth. After applying (B) to the teeth, the composition (A) may be applied to the teeth. From the viewpoint of shortening the time for applying the composition (B) to the teeth and ensuring sufficient gloss of the teeth, the composition (A) is first applied to the teeth, and then the composition (B) is applied to the teeth. It is preferable to apply. From the viewpoint of reducing irritation caused by the composition (B) and preventing the reduction of tooth gloss, the application time of the composition (A) and the composition (B) is the application time of the composition (A). Is preferably longer than the application time of the composition (B).

  In the tooth whitening agent of the present invention, the composition (A) and the composition (B) are provided separately from each other without mixing these compositions before applying to the teeth. Means that these compositions are present in a separate manner so that can be applied to the teeth in turn. Therefore, for example, as described later, when these compositions are both a dentifrice composition such as a toothpaste or a liquid oral composition such as a mouthwash, they are filled in separate containers in a state of being separated from each other. In addition, when these compositions are sheet agents as described later, each sheet agent includes a plurality of layers, and includes an embodiment in which one laminated sheet agent is formed in a close contact state. Moreover, in this invention, a sheet agent is an agent provided with the single layer or multiple layers which consist of a composition (A) and / or composition (B) used with the tooth whitening agent of this invention, and is a thin plate shape which has a softness | flexibility. It is said to be used by directly sticking to the tooth surface and having the property of being dissolved by saliva in the oral cavity after the application or the property of elution of the active ingredient. In particular, an agent having a plurality of layers is also referred to as a laminated sheet agent.

The composition (A) provided in the tooth whitening agent of the present invention contains phytic acid or a salt thereof in an amount of 0.1% by mass to 30% by mass in terms of acid. Phytic acid or a salt thereof has an excellent tooth whitening effect and gloss-imparting effect, and is applied to the tooth alternately with a composition (B) containing a peroxide, which will be described later. Effectively removes accumulated fine dirt or solid products to promote the whitening effect of peroxides, and exhibits excellent whitening effect on teeth even when used for a short period of time, while enhancing the gloss imparting effect Can be achieved. Phytic acid is also called myo-inositol hexaphosphate, and is an inositol phosphate ester compound. Among various phosphoric acid compounds, phytic acid or a salt thereof is particularly excellent in the gloss imparting effect.
Examples of the salt include alkali metal salts such as sodium and potassium, ammonium salts, and the like, and one or more selected from these are preferable, and alkali metal salts are preferable from the viewpoint of taste and smell.

The content of phytic acid or a salt thereof in the composition (A) is an acid-converted amount in the composition (A) from the viewpoint of sufficiently exerting a whitening effect and a gloss-imparting effect due to a fine solid product removing effect. It is 0.1 mass% or more, Preferably it is 0.2 mass% or more, More preferably, it is 0.3 mass% or more. The content of phytic acid or a salt thereof in the composition (A) is 30 in terms of acid equivalent in the composition (A) from the viewpoint of smoothening the tooth surface and improving the gloss and taste and squeaking. It is not more than mass%, preferably not more than 20 mass%. Further, when the composition (A) has a form to be applied after being gradually dissolved and diluted after being applied to a tooth like a sheet, the content of phytic acid or a salt thereof is contained in the composition (A). When the acid conversion amount is preferably 18% by mass or less and the composition (A) has a form such as a dentifrice composition such as a toothpaste or a liquid oral composition such as a mouthwash. The content of phytic acid or a salt thereof is preferably 5% by mass or less, more preferably 3% by mass or less, in terms of acid. The content of phytic acid or a salt thereof in the composition (A) is 0.1% by mass or more and 30% by mass or less in terms of acid in the composition (A), preferably 0.2 to When it is 20% by mass and the composition (A) is a sheet, it is preferably 0.2 to 18% by mass in terms of acid, and the composition (A) is a dentifrice composition or liquid. When it is a composition for oral cavity, it is 0.2-5 mass% more preferably in acid conversion amount, More preferably, it is 0.2-3 mass%.
The content of phytic acid or a salt thereof in the composition (A) is measured after neutralization with potassium hydroxide or sodium hydroxide, and the total amount is converted to an acid. Moreover, content of phytic acid or its salt in a composition (A) in case a composition (A) is a sheet agent means the value in dry mass.

  The composition (A) is one in which the content of the polyvalent metal cation is kept low. Since the polyvalent metal cation makes phytic acid insoluble or reduces the effect of removing the solid product, the content of the polyvalent metal cation is kept low in order to prevent a decrease in the effect. Its content is measured by ICP emission spectrometry (ICP emission analyzer: Perkin Elmer Optima 5300 DV), and the total amount of polyvalent metal cations is less than 0.1-fold mol with respect to phytic acid or a salt thereof. 0.02 times mole or less is preferable and 0.01 times mole or less is more preferable. That is, it is desirable not to add an agent mainly supplying a polyvalent metal cation such as aluminum, calcium, magnesium, iron, zinc, etc., and it does not contain a polyvalent metal cation unless it is inevitably mixed. May be.

  In addition to cationic antibacterial agents that are polyvalent cations other than polyvalent metal cations, adsorbents such as zeolite and activated carbon reduce the solid product removal effect by phytic acid or its salts, and thus the composition (A ) Is preferably less than 0.001% by mass, more preferably 0.0001% by mass or less, and it is preferably not contained unless it is inevitably mixed.

  The composition (A) has a pH of 4.5 or more and 7 or less. In this way, by adjusting the pH of the composition (A) in the weakly acidic region, when the composition is applied to the oral cavity, the enamel surface and the enamel trabecular space are particularly reached. Effectively works on inorganic dirt to remove fine solid products, and suppresses the decalcification of the tooth surface to fully exhibit the immediate whitening effect and gloss imparting effect. The immediate effect of the whitening effect by the peroxide contained in the product (B) can be ensured, and the gloss reduction by the composition (B) can be suppressed. The pH of the composition (A) is 4.5 or more and preferably 4.8 or more from the viewpoint of providing an immediate whitening effect and a gloss imparting effect, and the composition (A) is a dentifrice. In the case of a composition or liquid oral composition, it is more preferably 5 or more. The pH of the composition (A) is 7 or less, preferably 6.5 or less, more preferably 6.2 or less, from the viewpoint of sufficiently exerting the whitening effect and the gloss-imparting effect by removing the solid product. is there. Moreover, pH of a composition (A) is 4.5-7, Preferably it is 4.5-6.5, More preferably, it is 4.8-6.2.

  Further, the composition (A) includes a fluoride ion supply compound such as sodium fluoride, potassium fluoride, and ammonium fluoride within a range (content, dosage form, etc.) that does not inhibit the gloss-imparting effect of phytic acid or a salt thereof. , And fluorides such as sodium monofluorophosphate. The composition (A) is a fluorine atom equivalent amount of fluoride in the composition (A) from the viewpoint of further enhancing the whitening effect and gloss imparting effect by phytic acid or a salt thereof, preferably less than 500 ppm. When it is contained in an amount that becomes 200 ppm or less, more preferably, it is contained in an amount that becomes 100 ppm or less, more preferably, it is contained in an amount that becomes 50 ppm or less, and inevitably mixed. It is preferable not to contain fluoride.

The pH of the composition (A) is a pH measured at 25 ° C., for example, when the composition is a highly viscous composition such as a toothpaste or when the composition is used as a sheet. Therefore, a composition having a high viscosity, such as a dentifrice composition such as a toothpaste, has a pH of the composition measured by diluting the composition 4 times by weight with water. When the composition (A) is used as a sheet agent, the surface of the sheet agent comprising the composition (A) is inclined at 45 degrees with respect to the horizontal plane, and the sheet agent has a hole in the surface. After dripping the water which does not melt | dissolve, for example, 0.1-0.5g, the dripped water is rapidly collect | recovered using 45 degree | times inclination, for example, by compact pH meter-712 (Horiba, Ltd.) etc. Measure the pH. Regarding the pH of the composition (A), the value obtained by such a measurement method is the application of the tooth whitening agent of the present invention to the oral cavity, assuming a state in which the composition (A) acts, When the composition (A) is a dentifrice composition such as a toothpaste, it is considered to be diluted in the oral cavity, and when the composition (A) is a sheet, it is applied to the teeth. It takes into account that it is gradually dissolved and diluted.
In addition, in the sheet agent, the pH value of the undiluted solution before forming the sheet agent and the pH value measured for the dropped water after dropping purified water on the sheet agent as described above are substantially the same. From this, the pH of the stock solution before forming the sheet is taken as the pH of the composition (A). Moreover, the liquid oral composition with a low viscosity like a mouthwash or a liquid dentifrice uses the value which measured pH of the undiluted | stock solution as pH of a composition (A). In any case, the water is purified water, and distilled water or ion exchange water is used.

  In order to adjust the pH of the composition (A) to the above range, it is preferable to use a pH adjuster. As the pH adjuster, the whitening effect and the gloss imparting effect by phytic acid or a salt thereof are not inhibited, and the tooth As long as it can suppress the decalcification of organic acids, organic acid salts such as acetic acid, fumaric acid, malic acid, lactic acid, gluconic acid, tartaric acid, inorganic acids such as phosphoric acid other than condensed phosphoric acid, phytic acid and condensed phosphoric acid, hydrochloric acid, sulfuric acid, etc. Examples include hydroxides such as acid salts and sodium hydroxide, ammonia or aqueous ammonia, lower alkanolamines, basic amino acids such as arginine and lysine, and these may be used alone or in combination of two or more. Good. Among these pH adjusters, the content of organic acid and inorganic acid (excluding phytic acid) is the acid-converted amount of phytic acid or its salt from the viewpoint of not inhibiting the whitening effect and gloss imparting effect of phytic acid or its salt. It is preferable that it is 5 mass parts or less with respect to 100 mass parts of content, and also it is preferable that it is 1 mass part or less. In the case where a condensed phosphate such as an alkali metal salt of condensed phosphoric acid is used as the pH adjuster of the composition (A), phytic acid or a salt thereof is used from the viewpoint of not inhibiting the gloss-imparting effect of phytic acid or a salt thereof. The content is preferably equimolar or less, more preferably 0.5 mol or less, and the mass ratio of the phytic acid or its salt to the acid-converted content is (condensed phosphate / phytin). Acid) is preferably 0.5 or less, more preferably 0.2 or less, and even more preferably 0.1 or less.

  The composition (B) provided in the tooth whitening agent of the present invention contains 0.01% by mass to 15% by mass of peroxide. Peroxide has an excellent whitening effect, and by applying to the teeth alternately with the composition (A), effective and efficient whitening combined with the solid product removal effect of phytic acid or its salt. The effect is achieved, and an excellent whitening effect can be exhibited even after a short period of use. Moreover, since it becomes possible to shorten the application time of a peroxide, the glossiness reduction of a tooth | gear can be suppressed and the outstanding gloss imparting effect by a phytic acid or its salt can be hold | maintained favorably. Examples of the peroxide include one or more selected from hydrogen peroxide, urea peroxide, calcium peroxide, and carbamide peroxide. Among these, hydrogen peroxide is preferable from the viewpoint of ensuring a whitening effect due to short-term use.

The content of the peroxide in the composition (B) is 0. 0 in the composition (B) from the viewpoint of exhibiting an excellent whitening effect and sufficiently exhibiting the whitening effect by phytic acid or a salt thereof. It is 01 mass% or more, preferably 0.1 mass% or more, more preferably 0.2 mass% or more. The content of the peroxide in the composition (B) is 15 in the composition (B) from the viewpoint of securing the gloss imparting effect by phytic acid or a salt thereof and suppressing the irritation and the like to enhance the feeling of use. When the composition (B) is a sheet agent, it is preferably 12% by mass or less, more preferably 10% by mass or less, and preferably 5% by mass or more. When the product (B) is a dentifrice composition such as a toothpaste or a liquid oral composition such as a mouthwash, it is preferably 3% by mass or less, more preferably 2% by mass or less. The content of the peroxide in the composition (B) is 0.01% by mass or more and 15% by mass or less in the composition (B), preferably 0.1 to 12% by mass, more Preferably it is 0.2-10 mass%. Furthermore, when the composition (B) is a sheet agent, it is preferably 5 to 12% by mass, more preferably 5 to 10% by mass in the composition (B). When the composition (B) is a dentifrice composition such as a toothpaste or a liquid oral composition such as a mouthwash, the peroxide content is preferably in the composition (B). Is 0.1-3 mass%, More preferably, it is 0.2-2 mass%.
In addition, content of the peroxide in a composition (B) in case a composition (B) is a sheet agent means the value in dry mass.

The composition (B) has a pH of 4.5 or more and 6.5 or less. The composition (A) and the composition (B) may have substantially the same pH because the composition (A) and the composition (B) are separated from each other. The products (A) and (B) will be applied individually to the oral cavity, specifically to the teeth, and the whitening effect on the teeth will be higher than those obtained by mixing the compositions (A) and (B). In addition, loss of tooth gloss can be prevented. In particular, when the composition (A) is applied to a tooth, the inorganic dirt deposited or volumed in the vicinity of the tooth surface is effectively removed, or the inorganic dirt of the deposited or volumed dirt is removed, whereby the composition The effect of removing dirt by (B) can be improved, the whitening effect can be immediately and sufficiently exhibited, damage to the teeth can be suppressed, and gloss can be secured.
For these reasons, in the present invention, the composition (B) not only exhibits the whitening effect by hydrogen peroxide itself, but also functions as a component that promotes and enhances the effect of the composition (A). The pH of the composition (B) is 4.5 or more, and preferably 4.8 or more, from the viewpoint of providing an immediate whitening effect and gloss imparting effect by the composition (A). The pH of the composition (B) is 6.5 or less, preferably 6 or less, and preferably 5.5 or less from the viewpoint of sufficiently exerting the whitening effect and the gloss imparting effect of the composition (A). It is preferable. Moreover, pH of a composition (B) is 4.5-6.5, Preferably it is 4.5-6, More preferably, it is 4.5-5.5, More preferably, it is 4. 8 to 5.5.

  The pH of the composition (B) is a pH measured at 25 ° C., and is a value determined by the same measurement method as the pH of the composition (A). Water is also purified water, and distilled water or ion exchange water is used. In order to adjust the pH of the composition (B), it is preferable to use a pH adjuster. As the pH adjuster, it is possible to suppress the decalcification of the teeth without inhibiting the whitening effect and the gloss imparting effect. In range, organic acid salts such as acetic acid, fumaric acid, malic acid, lactic acid, gluconic acid and tartaric acid, inorganic acid salts such as phosphoric acid other than phytic acid, hydrochloric acid and sulfuric acid, hydroxide such as sodium hydroxide, ammonia or Examples include basic aqueous amino acids such as aqueous ammonia, lower alkanolamines, arginine, and lysine, and these may be used singly or in combination of two or more. Among these pH adjusters, the content of the organic acid and the inorganic acid is 0.5% from the content of the peroxide (organic acid and inorganic acid / peroxide) from the viewpoint of not inhibiting the whitening effect. Or less, more preferably 0.2 or less, and still more preferably 0.1 or less.

  The composition (B) may further contain a fluoride. By containing such a fluoride, it is difficult to dissolve in an acid and remineralization can be achieved, so that teeth can be strengthened together with a whitening effect and a gloss imparting effect having an immediate effect. In the composition (A), the fluoride is preferably contained within a range that does not impair the gloss-imparting effect of phytic acid or a salt thereof. It is good to make it contain in a thing (B).

Examples of the fluoride include fluoride ion supply compounds such as sodium fluoride, potassium fluoride, and ammonium fluoride, and fluorides such as sodium monofluorophosphate as described above. Among these, from the viewpoint of strengthening teeth, one or more selected from sodium fluoride, sodium monofluorophosphate, and ammonium fluoride are preferable. The content of the fluoride in the composition (B) is preferably 0.001% by mass or more, more preferably 0 in terms of fluorine atom in the composition (B) from the viewpoint of increasing the amount of fluorine uptake. 0.005% by mass or more. The content of fluoride in the composition (B) is a fluorine atom equivalent amount in the composition (B) from the viewpoint of not inhibiting the effect of the composition (A) applied to the teeth alternately with the composition (B). Preferably, it is 0.5 mass% or less, More preferably, it is 0.2 mass% or less, More preferably, it is 0.1 mass% or less. Further, the content of fluoride in the composition (B) is preferably 0.001 to 0.5% by mass, more preferably 0.005 to 0.2% by mass in terms of fluorine atom, Preferably it is 0.005-0.1 mass%.
In addition, content of the fluoride in a composition (B) in case a composition (B) is a sheet agent means the value in dry mass.

  In addition, when a composition (B) contains a fluoride, from a viewpoint which does not inhibit the effect of the composition (A) applied to a tooth alternately with the composition (B), the composition (B) is first made into a tooth. After application, the composition (A) is preferably applied to the teeth, which can then be applied repeatedly to the teeth alternately.

  In addition to the composition (A) and the composition (B), the tooth whitening agent of the present invention may further include a composition (C) containing a fluoride. At this time, it is preferable to apply the composition (C) to the teeth after applying the composition (A) and the composition (B) to the teeth. From the viewpoint of further enhancing the effect of the composition (C), the composition It is preferable to apply the composition (B) after applying the product (A), and then apply the composition (C). From the viewpoint of enhancing the effect of the composition (A), the composition (B) is preferably used. It is preferable to apply the composition (A) after the application, and then apply the composition (C). This can also be repeated and applied to the teeth. Thereby, a composition (A) can be made to act first before a composition (C), and it can reduce effectively that the effect of a composition (A) is inhibited by fluoride.

The content of fluoride in the composition (C) is preferably 0.001% by mass or more, more preferably 0 in terms of fluorine atom, in the composition (C) from the viewpoint of increasing the amount of fluorine uptake. 0.005% by mass or more. The content of fluoride in the composition (C) is preferably 0 in terms of fluorine atom in the composition (C) from the viewpoint of effectively applying to the teeth without inhibiting the effect of the composition (A). It is 0.5 mass% or less, More preferably, it is 0.2 mass% or less, More preferably, it is 0.1 mass% or less. Further, the content of fluoride in the composition (C) is preferably 0.001 to 0.5% by mass in terms of fluorine atom in the composition (C), more preferably 0.005 to 0. 0.2 mass%, and more preferably 0.005-0.1 mass%.
In addition, content of the fluoride in a composition (C) in case a composition (C) is a sheet agent so that it may mention later means the value in dry mass.

  In addition to the above components, the composition (A) and the composition (B), or the composition (C) used as necessary include, for example, a foaming agent, a foaming aid, an abrasive, a wetting agent, a thickening agent, Gelling agents, binders, sweeteners, preservatives, bactericides, medicinal ingredients, pigments, dyes, fragrances, etc. can be included as appropriate, and polyethylene glycol, a conventionally used whitening component, is used in combination. You can also.

  The composition (A) and the composition (B), or the composition (C) to be used as necessary, are prepared in a dosage form such as a solution, a gel, or a paste. Agent), a dentifrice composition having a form such as a toothpaste, a coating composition such as a gel or an ointment that adheres to the tooth, and a liquid oral composition having a form such as a liquid dentifrice or mouthwash It can also be a composition. Alternatively, it may be a coating material obtained by impregnating a cloth or fiber with these compositions, an oral hygiene tool such as dental floss impregnated with these compositions, or a food such as chewing gum, troche, or candy. Furthermore, it is good also as a laminated sheet agent which forms the sheet agent containing these compositions, laminate | stacks each sheet agent, and comprises these as integral. In addition, the form which these compositions have may be the same form mutually, and a different form may be sufficient as them. For example, the composition (A) may be a dentifrice, and the composition (B) may be a liquid dentifrice or a mouthwash, and vice versa. From the viewpoint of applying for a long time, at least the composition (A) is preferably a sheet agent, more preferably both the composition (A) and the composition (B) are sheet agents, and the composition (A) It is more preferable that the sheet material and the sheet material of the component (B) are laminated and the sheet material is integrally provided. From the viewpoint of ease of use, it is preferable that both or one of the composition (A) and the composition (B) is a mouthwash or a toothpaste.

  In any of these dosage forms, polyethylene glycol, propylene glycol, glycerin, sorbitol, maltitol, xylitol, lactitol and the like can be contained for the purpose of a wetting agent or a thickening agent.

Further, as a thickener for a liquid oral composition or a gelling agent for a gel-like composition, as a binder for a dentifrice composition (paste-like composition), and further using a liquid composition as a sheet agent As a gelling agent in forming carboxymethylcellulose sodium, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropylcellulose, carboxyvinyl polymer, xanthan gum, carrageenan, sodium alginate, pullulan, guar gum, sodium chondroitin sulfate, etc. More than seeds can be included. Among these, for the composition (A), cellulose such as sodium carboxymethylcellulose, hydroxyethylcellulose, hydroxymethylcellulose, etc. from the viewpoint of sufficiently exerting the gloss-imparting effect of phytic acid or a salt thereof, and the feeling of use and stability. It is preferable to contain a non-cellulosic binder such as a system binder, xanthan gum, pullulan and guar gum, and it is preferable to use a cellulose binder and a non-cellulosic binder together.
For example, when a high salt concentration is obtained due to a buffer solution system, it is preferable to contain one or more kinds selected from nonionic polymers, that is, hydroxyethyl cellulose, guar gum, hydroxypropyl cellulose, pullulan and the like.

  In the case where any of the composition (A) and the composition (B) or the composition (C) used as needed is a dentifrice composition, the viscosity at 25 ° C. is sufficient from the viewpoint of sufficient gloss-imparting effect. Is preferably 500 to 10000 dPa · s, more preferably 1000 to 7000 dPa · s, and still more preferably 1200 to 5000 dPa · s. Here, the viscosity is measured by using a helipath type viscometer (VISCOMETER TVB-10 Toki Sangyo) at a measurement temperature of 25 ° C., with a rotor TC, a rotational speed of 2.5 r / min, and a measurement condition of 1 minute. be able to.

When any of the composition (A) and the composition (B) or the composition (C) used as necessary is a dentifrice composition such as a toothpaste, a granule can be blended. . From the viewpoint of effectively removing organic solid stains that are firmly deposited or deposited in the vicinity of the tooth surface to remove fine solid products and promote gloss formation, the disintegration strength is 10 g / g in the absence of granules or in a dry state. It is preferable to contain granules that are not more than one, preferably those having a disintegration strength of 10 g / piece or less in the presence of moisture, and it is preferable that they are not substantially contained. Moreover, it is also possible to contain an abrasive within a range that does not impair the gloss forming effect of the present invention. For example, it is preferable to use a silica-based abrasive such as hydrous silica, anhydrous silica, or silica gel.
In addition, when any of the composition (A) and the composition (B) or the composition (C) used as necessary is a sheet agent, the content of each of the components in each of these compositions is dry. It selects suitably on the basis of the value in mass.

  In order to apply the composition (A) and the composition (B) provided in the tooth whitening agent of the present invention or the composition (C) provided as necessary to the teeth, it may be applied as it is, Both are included when applied in a state diluted with water or saliva. In the case of a liquid oral composition such as a mouthwash, it is applied to the tooth without dilution, and in the case of a sheet agent in which a sheet layer is formed and laminated from the liquid composition, it is directly applied to the tooth surface. It is applied by sticking and dissolving the sheet. On the other hand, in the case of a dentifrice composition or the like, in application by a toothbrush or the like, it is generally applied in a state diluted to about 4 times by mass with saliva.

Either or both of the composition (A) and the composition (B) provided in the tooth whitening agent of the present invention are preferably a sheet agent, and the effect of tooth whitening and gloss imparting effects can be achieved in a shorter period of time. From the standpoint of obtaining it, it is preferable that at least the composition (A) is a sheet agent. When the composition (A) is a sheet agent, the thickness of the sheet agent of the composition (A) is preferably 200 μm from the viewpoint of dissolving the sheet agent in an appropriate time and obtaining appropriate flexibility as the sheet agent. Or less, more preferably 100 μm or less, and preferably 10 μm or less, from the viewpoint of obtaining a whitening effect and a gloss-imparting effect of a tooth by short-term use, and from the viewpoint of ease of use and manufacturability. It is above, More preferably, it is 15 micrometers or more, More preferably, it is 20 micrometers or more. When the composition (B) is a sheet agent, the thickness of the sheet agent of the composition (B) is preferably 100 μm or less from the viewpoint of dissolving it in an appropriate time and ensuring an appropriate flexibility as a sheet. More preferably, it is 50 μm or less, more preferably 20 μm or less, preferably 1 μm or more, more preferably 5 μm or more, and further preferably 7 μm or more.
In addition, when the composition (C) is a sheet agent, the thickness of the sheet agent of the composition (C) is preferably 100 μm or less from the viewpoint of dissolving in an appropriate time and obtaining appropriate flexibility as the sheet agent. More preferably, it is 50 μm or less, more preferably 20 μm or less, preferably 1 μm or more, more preferably 5 μm or more, and further preferably 7 μm or more.

When both the composition (A) and the composition (B) provided in the tooth whitening agent of the present invention are used as a sheet, when the sheet is applied to a tooth, first, phytic acid or a salt thereof is pH 4.5 or more. From the viewpoint of allowing the peroxide to sufficiently act in an environment of pH 4.5 or more and 6.5 or less, and then sufficiently acting in an environment of 7 or less, the sheet that constitutes the surface on the side to be affixed to the tooth Is preferably a sheet of the composition (A).
In this case, the thickness ratio (Bt / At) of the sheet agent of the composition (B) and the sheet agent of the composition (A) is preferably 1/10 to 1/1, more preferably 1 / 9 to 1/2, more preferably 1/8 to 1/3.

  In the case of forming a laminated sheet comprising the composition (A), the composition (B), and, if necessary, the composition (C) as a sheet, and laminating these sheets together. By laminating a coating sheet (X) that is further poorly water-soluble on the surface opposite to the layer to be applied to the tooth so that the side to be applied to the tooth is first dissolved in saliva and applied to the tooth. It is preferable to form a laminated sheet agent comprising all of these integrally. By providing the coating sheet agent (X), when a tooth whitening agent is applied to the tooth, it is effectively prevented from being dissolved by saliva from the composition constituting the layer opposite to the layer applied to the tooth. be able to. The coating sheet agent (X) that is slightly water-soluble may be a component that dissolves or decomposes by saliva, but the composition (A), the composition (B), and the composition (C) provided as necessary. ) Is a sheet agent that remains in a state of covering the teeth without dissolving or decomposing even after being dissolved or decomposed, or a sheet agent that does not dissolve or decompose. The coated sheet agent (X) is thicker than the composition (A), the composition (B), the sheet agent of the composition (C) provided as necessary, or a component such as a polymer constituting the sheet agent. Is different. The component of the covering sheet agent (X) is one selected from cellulose acetate phthalate, polyvinyl acetate, ethyl cellulose, polymethyl methacrylate, methacryloylethyl betaine-methacrylate copolymer, methacrylic acid copolymer and aminoalkyl methacrylate copolymer. Alternatively, two or more kinds of polymers or copolymers may be mentioned. From the viewpoint of increasing the adhesion with the composition (A), the composition (B), and if necessary, the composition (C), and from the viewpoint of availability, ethyl cellulose. Cellulose acetate phthalate is preferred. In addition, the content of a polymer or copolymer such as ethyl cellulose and cellulose acetate phthalate in these coating sheet agents (X) is a dry mass, preferably 40 to 95 mass%, more preferably 50 to 90 mass. %. The thickness of the covering sheet agent (X) is preferably 40 μm or less, 0.5 μm or more, and 1 μm or more from the viewpoint of securing appropriate flexibility as a sheet.

  Further, when a plurality of sheet agents are selected from the composition (A), the composition (B), the composition (C), and the coated sheet agent (X) and a single laminated sheet is laminated, the sheet agent An intermediate sheet (Y) may be sandwiched between the sheet and the sheet. Such an intermediate sheet agent (Y) can be sandwiched between any sheet agents. For example, by having the intermediate sheet agent (Y) between the sheet agent of the composition (A) and the sheet agent of the composition (B), the composition (A) and the composition (B) It is easy to separate and form these compositions without mixing, and it becomes easy to improve the stability of the pH of the composition (A) and the composition (B) during storage, After the sheet material is dissolved and the component contained therein is released into the oral cavity, it is then easy to dissolve the other sheet agent and release the component contained therein into the oral cavity.

  The material of the intermediate sheet (Y) is preferably a nonionic polymer such as pullulan, hydroxyethyl cellulose, guar gum, hydroxypropyl cellulose, etc. from the viewpoint of enhancing the followability to other sheet agents. ) And the sheet agent of the composition (B), cellulose acetate phthalate, polyvinyl acetate, ethyl cellulose, polymethyl methacrylate, methacryloylethyl betaine-methacrylate are used from the viewpoint of enhancing the separability of these compositions. One or more (co) polymers selected from a copolymer, a methacrylic acid copolymer and an aminoalkyl methacrylate copolymer are preferred.

The thickness of the intermediate sheet (Y) is preferably from the viewpoint of effectively preventing dissolution of the layer from the surface opposite to the surface to be applied to the tooth and preferentially dissolving from the surface to be applied to the tooth. Is 1 μm or more, more preferably 5 μm or more, and even more preferably 10 μm or more. The thickness of the intermediate sheet is preferably 100 μm or less, more preferably 50 μm or less, and further preferably 30 μm, from the viewpoint of ease of use by the user.
The intermediate sheet agent (Y) preferably has a pH of 6.5 to 7.0.

  When the composition (A), the composition (B), and if necessary, the composition (C) is used as a sheet, and the laminated sheet is provided with a covering sheet (X) or an intermediate sheet (Y), Also about a sheet agent, it is preferable to contain a plasticizer as needed from a viewpoint which provides moderate rigidity and a softness | flexibility, and a viewpoint which ensures favorable moldability. As such a plasticizer, for example, one or more selected from phthalic acid esters, adipic acid esters, trimellitic acid esters, citric acid esters, and fatty acid esters are preferable.

  As described above, for example, a laminate comprising a plurality of sheet agents selected from the composition (A), the composition (B), the composition (C), the covering sheet agent (X) and the intermediate sheet agent (Y). In the case of a sheet agent, the total thickness of the sheet agent is preferably 10 μm or more, from the viewpoint of enhancing the followability to the teeth when applied, and from the viewpoint of realizing the immediate whitening effect and the gloss imparting effect, More preferably, it is 20 micrometers or more, More preferably, it is 30 micrometers or more, Preferably it is 1000 micrometers or less, More preferably, it is 500 micrometers or less, More preferably, it is 100 micrometers or less.

<Method for producing sheet agent>
The method for producing a sheet preparation includes a step of adjusting a stock solution further containing water in the composition (A) and / or a stock solution further containing water in the composition (B), A process of coating on a base material such as a polyethylene terephthalate (PET) film that has been subjected to a mold release process or the like while considering the thickness, and further a process of drying. And a sheet | seat agent can be obtained by peeling bases, such as PET film. When both the composition (A) and the composition (B) are used as sheet agents and these are laminated to form one laminated sheet agent, after forming each of the two sheet agents and laminating them, for example, It is preferable to provide a step of forming a two-layer structure by pressure bonding using a heated pressure device.

In the case where the composition (C) is used as a sheet agent, the production method is the same as the above except that it includes a step of preparing a stock solution in which water is further added to the composition (C). Further, when a poorly water-soluble sheet agent is further provided, it may be a production method including a step of applying any one of the above stock solutions using the poorly water-soluble sheet agent as a base material. After forming, the covering sheet agent (X) may be laminated and pressure-bonded.
In addition, when the intermediate sheet agent is sandwiched, the intermediate sheet agent (Y) may be appropriately sandwiched between the sheet agent and then laminated, and then, for example, may be provided with a pressure bonding process using a heated pressure device. It is also possible to provide a step of laminating and pressure-bonding the other sheet agent after the step of applying any of the stock solutions using the intermediate sheet agent as a base material.

Using the tooth whitening agent of the present invention, the composition (A) and the composition (B), or the composition (C) provided as necessary, are applied to the oral cavity of a person. When the composition (A) or the composition (B) is a dentifrice composition such as a toothpaste or a liquid oral composition such as a mouthwash, the application time of the tooth whitening agent of the present invention is as follows. The application time is preferably 10 seconds or longer, more preferably 30 seconds or longer, further preferably 1 minute or longer, preferably 8 minutes or shorter, more preferably 4 minutes or shorter. When the composition (A) and the composition (B) are dentifrice compositions such as toothpastes or liquid oral compositions such as mouthwashes, the compositions (A) and (B) The total time for continuous application once is preferably 20 seconds or more, more preferably 1 minute or more, further preferably 2 minutes or more, preferably 10 minutes or less, and more preferably 5 minutes or less. When the composition (A) or the composition (B) is a sheet agent, the application time of each composition is preferably 1 minute or longer, preferably 3 minutes or longer, and 1 hour or shorter. Preferably, 30 minutes or less is more preferable, and 20 minutes or less is more preferable. Further, the time from the end of application of any one of the compositions to the start of application of the composition applied subsequently is preferably within 3 minutes, more preferably within 1 minute, 30 Preferably it is within seconds.
Moreover, when the composition (A) and the composition (B) are sheet agents and are two or more sheet agents each having one layer, the application time of the sheet agent may be 1 minute or more. It is preferably 5 minutes or more, more preferably 10 minutes or more, and preferably 90 minutes or less, more preferably 60 minutes or less, and even more preferably 30 minutes or less from the viewpoint of ease of use by the user.
In addition, the application time of a sheet agent is good also as time (dissolution time) until all a sheet agent melt | dissolves in water. The time until all of the sheet is dissolved in water is the time from when water is applied to the sheet at a rate of 0.1 g / min until the amount of components contained in the sheet does not increase in water. Means the value.

  In this way, by applying the composition (A), the composition (B), and optionally the composition (C) to the teeth, a fine solid product of less than a few μm on the tooth enamel surface is selectively selected. Since it can be removed, the tooth enamel surface can be smoothed to a few μm while suppressing damage to the tooth enamel itself, and the reflected light from the enamel surface can be increased, resulting in a natural gloss of the tooth itself. Can be obtained. That is, in addition to the immediate whitening effect, an excellent gloss imparting effect can be realized. Moreover, when applied 1 to 5 times a day, preferably 1 week or more, for example 4 weeks or less, that is, even if it is repeatedly used over a long period of time, the application time per time can be shortened. Therefore, damage to the enamel surface of the tooth can be suppressed, and a more natural glossy and glossy tooth can be obtained.

  Hereinafter, the present invention will be specifically described based on examples. In addition, unless otherwise indicated in a table | surface, content of each component shows the mass%.

[Examples 1-2]
As shown in Table 1, a liquid composition test solution x and a liquid composition test solution y containing phytic acid or peroxide were prepared. Specifically, it was prepared by dissolving phytic acid or condensed phosphoric acid in purified water and adjusting the pH of each test solution with a pH adjuster. None of the test solutions contain any polyvalent metal cation, and the polyvalent metal cations such as magnesium, aluminum, and calcium in the test solution are less than 0.02 moles compared to phytic acid as measured by IPC emission spectrometry. Met. In addition, pH of each test solution is a measured value of 25 degreeC and a stock solution.

Next, at room temperature (25 ° C.), the extracted tooth was washed with ion-exchanged water and first immersed in the test solution x for 2.5 minutes. Next, the extracted tooth taken out from the test solution x was immersed in the test solution y for 2.5 minutes, the extracted tooth taken out from the test solution y was washed with ion-exchanged water, and immersed in artificial saliva for about 3 hours. This was regarded as one process, and the process was repeated three times. The extracted teeth were human teeth that were not treated to remove dirt due to polishing or the like. Artificial saliva is an aqueous solution containing calcium chloride (1.0 mM), potassium hydrogen phosphate (0.9 mM), HEPES (4- (2-hydroxyethyl) -1-piperazine etheric acid) (2.0 mM) and water. What adjusted pH = 7 with potassium oxide was used.
About the tooth | gear after extraction (extraction tooth | gear), evaluation of the whitening of a tooth | gear and evaluation of the surface state of a tooth | gear were performed according to the following method.

<Evaluation of teeth whitening>
By measuring b * according to the following method, the whiteness of the treated tooth (extracted tooth) was evaluated.
Specifically, the digital camera D1x (Nikon) and lens are installed in combination with Ai AF Micro Nikkor 105mm F2.8D, and the strobe emission is a wireless remote speedlight SB-R200 (all manufactured by Nikon). It was. The photographed image was expressed in L * a * b * color system using Adobe Photoshop (manufactured by Adobe Systems), and the value of b * before treatment with the test solution and b * after treatment were measured. Next, Δb * was determined as the difference {(b * after treatment) − (b * before treatment)} between the b * before and after the treatment. The smaller Δb *, that is, the larger the absolute value of Δb *, the greater the whiteness.
The results are shown in Table 1.

<< Evaluation of tooth surface condition >>
About the tooth | gear (extraction tooth | gear) after the said process, the surface state of a tooth | gear is evaluated by observing with the naked eye with a magnifying glass (magnification 10 times). `` Smooth '' means that the tooth surface has no irregularities and is judged to be a smooth surface, while those that have no irregularities on the tooth surface have been judged to lack some smoothness. “No irregularities” and those with irregularities on the tooth surface were evaluated as “unevenness”.
The results are shown in Table 1.

[Comparative Examples 1-4]
As shown in Table 1, liquid composition test solutions containing phytic acid and / or hydrogen peroxide were prepared. None of the test solutions contain any polyvalent metal cation, and the polyvalent metal cations such as magnesium, aluminum, and calcium in the test solution are less than 0.02 moles compared to phytic acid as measured by IPC emission spectrometry. Met. In addition, pH of each test solution is a measured value of 25 degreeC and a stock solution.

Next, in Comparative Examples 1 to 3, the extracted teeth were washed with ion-exchanged water at room temperature (25 ° C.), immersed in the prepared test solution for 5 minutes, and then the extracted teeth removed from the test solution were ion-exchanged water. And then immersed in artificial saliva for about 3 hours. This was treated as one time and repeated up to 3 times. The extracted teeth and artificial saliva were the same as in Example 1.
Each treatment (extraction tooth) was evaluated in the same manner as in Example 1.
In Comparative Example 4, the extracted tooth was used in the same manner as in Example 1, and then the same treatment was performed on the test solution x and the test solution y, and then the treated tooth (extracted tooth) was used. Therefore, the whitening of the teeth and the surface condition of the teeth were evaluated.
The results are shown in Table 1.

[Example 3]
As shown in Table 2, a test solution x, a test solution y, and a test solution z of a liquid composition containing pyrophosphoric acid, phytic acid, or peroxide were prepared. The test solution y does not contain a polyvalent metal cation, and the polyvalent metal cations such as magnesium, aluminum, and calcium in the test solution y are less than 0.02 times mol of phytic acid as measured by IPC emission spectrometry. Met. In addition, pH of each test solution is a measured value of 25 degreeC and a stock solution.
Next, using the extracted tooth in the same manner as in Example 1, the test was first immersed in the test solution x for 1.5 minutes, and then the extracted tooth taken out from the test solution x was immersed in the test solution y for 2 minutes. The extracted tooth taken out from y was immersed in the test solution z for 1.5 minutes. Next, the extracted tooth taken out from the test solution z was washed with ion-exchanged water and immersed in artificial saliva for about 3 hours. This was regarded as one process, and the process was repeated three times. The extracted teeth were human teeth that were not treated to remove dirt due to polishing or the like.
Using the treated tooth (extracted tooth), evaluation of whitening of the tooth and evaluation of the surface condition of the tooth were performed according to the above-described methods.
The results are shown in Table 2.

  According to the results of Tables 1 and 2, it was confirmed that Comparative Example 1 in which a composition containing only a peroxide was applied alone had a high whitening effect, but the tooth surface was uneven, and only phytic acid was used. Comparative Example 2 in which the composition containing it was applied alone, Comparative Example 3 in which the composition containing phytic acid and peroxide was applied alone, and comparison in which the composition containing sodium pyrophosphate and phytic acid were applied alternately In Example 4, although the tooth surface was generally smooth, the whitening effect was not immediately effective. On the other hand, in Examples 1 to 3, the tooth whitening effect excellent in the short-term treatment was confirmed as compared with these comparative examples while the tooth surface was smooth.

[Example 4]
As shown in Table 3, a stock solution containing a peroxide was prepared, and a sheet y (thickness 8 μm, basis weight 9 g / m ² ) was produced by blending pullulan. Similarly, a stock solution containing phytic acid was prepared, and pullulan was blended to produce a sheet x (thickness 55 μm, basis weight 72 g / m ² ), which was laminated on one side of the sheet y. Further, a layer containing 65% ethyl cellulose and 35% polyethylene glycol (PEG 600) was laminated on the surface of the sheet y. None of the stock solutions was mixed with a polyvalent cation, and the polyvalent cations such as magnesium, aluminum, and calcium in the stock solution were less than 0.02 moles compared to phytic acid as measured by IPC emission spectrometry. In addition, pH of each sheet | seat is a measured value by a stock solution, and the thickness of the sheet | seat x and y was determined on the basis that it melt | dissolves all at the time of 10 minutes after sticking.

Next, at room temperature (25 ° C.), the extracted tooth is washed with ion-exchanged water, and the laminated sheet is applied so that the surface on which the sheet x is exposed is in contact with the tooth. A 20 mm square sponge (manufactured by INOAC, continuous porous sponge MAPS K001) to which artificial saliva is immediately supplied at a rate of 0.1 g / min is brought into contact from the side opposite to the side in contact with the teeth. Thereafter, the remaining sheet material was removed by light brushing, and then immersed in artificial saliva for about 3 hours. This was treated as one time and repeated up to 3 times. The extracted teeth and artificial saliva were the same as in Example 1.
For the treated tooth (extracted tooth), the whitening of the tooth and the evaluation of the surface condition of the tooth were evaluated in the same manner as in Example 1, and the gloss of the tooth was evaluated according to the following method.
The results are shown in Table 3.

<Evaluation of tooth gloss>
About the tooth | gear (extracted tooth) after the said process, the glossiness of the tooth | gear was evaluated by measuring a brightness | luminance according to the following method.
Specifically, a method of measuring the surface reflected light intensity from image analysis using polarized light was used. As a device for taking images for evaluation, the camera is a digital camera D2x (made by Nikon), the lens is Ai AF Micro Nikkor 105mm F2.8D, and the flash emission is Wireless Remote Speedlight SB-R200 (all made by Nikon). What was installed in combination was used. Photographing was carried out by placing a plastic polarizing plate (manufactured by Edmond) in front of the light emitting part of the speedlight and the lens so that the transmission axes intersected 30 degrees. For the captured image, the average brightness of the highlight portion was determined using Adobe Photoshop (manufactured by Adobe Systems). Luminance means that the larger the value, the higher the gloss. A difference in luminance before and after the treatment with the test solutions x and y (luminance after treatment-luminance before treatment) was obtained as Δ luminance. The larger the Δ luminance value obtained, the higher the gloss.

  From the results of Table 3, when the composition (A) and the composition (B) are each formed into a sheet agent laminated as a sheet layer, it is possible to provide an excellent tooth whitening effect with immediate effect. It was confirmed that the gloss imparting effect was excellent.

[Example 5]
As shown in Table 4, a toothpaste x and a toothpaste y containing phytic acid or peroxide were prepared by mixing each component. By applying the toothpaste y after applying the obtained toothpaste x in the oral cavity, an excellent tooth whitening effect and gloss imparting effect can be obtained.

[Example 6]
As shown in Table 5, a mouthwash x and a mouthwash y containing phytic acid or peroxide were prepared by mixing the components. After applying the obtained mouthwash x to the oral cavity, the mouthwash solution y is applied to obtain excellent tooth whitening effect and gloss imparting effect.

Claims (7)

The following composition (A) and composition (B):
Composition (A) containing phytic acid or a salt thereof in an acid conversion amount of 0.1% by mass or more and 30% by mass or less and not containing a polyvalent metal cation or 0.1 times that of phytic acid or a salt thereof A composition containing less than a mole and having a pH of 4.5 or more and 7 or less at 25 ° C., and a composition (B) peroxide of 0.01% by mass or more and 15% by mass or less, and a pH at 25 ° C. of 4 A tooth whitening agent for separately providing a composition of 5 or more and 6.5 or less, and applying the composition (A) and the composition (B) to the teeth alternately.   The tooth whitening agent according to claim 1, wherein the composition (A) contains fluoride in an amount that is less than 500 ppm in terms of fluorine atoms, or does not contain fluoride.   The tooth whitening agent according to claim 1 or 2, wherein the tooth whitening agent is a laminated sheet agent integrally comprising a sheet agent formed from the composition (A) and a sheet agent formed from the composition (B).   The tooth whitening agent of any one of Claims 1-3 for applying a composition (B) to a tooth | gear after applying a composition (A) first to a tooth | gear.   The tooth whitening agent according to any one of claims 2 to 4, wherein the fluoride is one or more selected from sodium fluoride, sodium monofluorophosphate, and ammonium fluoride. The following composition (A) and composition (B):
Composition (A) containing phytic acid or a salt thereof in an acid conversion amount of 0.1% by mass or more and 30% by mass or less and not containing a polyvalent metal cation or 0.1 times that of phytic acid or a salt thereof A composition containing less than a mole and having a pH of 4.5 or more and 7 or less at 25 ° C., and a composition (B) peroxide of 0.01% by mass or more and 15% by mass or less, and a pH at 25 ° C. of 4 A method for whitening teeth, in which a composition that is not less than 5 and not more than 6.5 is alternately applied to teeth.   The method for whitening teeth according to claim 6, wherein the composition (A) is first applied to the teeth, and then the composition (B) is applied to the teeth.