JP2015073848A - Liquid transfer device - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a liquid transfer device capable of adjusting a liquid level in a drip chamber to effectively preventing emission of bubbles without stopping a liquid transfer operation.SOLUTION: A liquid transfer device 1 includes: an accumulation bag 4 for accumulating liquid L containing a blood component; a puncture needle connection part 5 for ejecting the liquid L; a liquid feed line 10 for communicating the accumulation bag 4 with the puncture needle connection part 5; a heater 31 for heating the liquid L that passes; a liquid feed pump P1 for pressure-feeding the liquid L that passes through the liquid feed line 10; a drip chamber 7 that captures bubbles contained in the liquid L that has passed through the heater 31; a bubble return line 15 which communicates a bubble discharge port 7a of the drip chamber 7 with the accumulation bag 4, and through which the captured bubbles pass; and a liquid level adjusting pump P2 for pressure-feeding at least one of the bubbles and the liquid L that pass through the bubble return line 15.

Description

  The present invention relates to a liquid transfer apparatus for transferring a liquid containing blood components such as whole blood and blood products stored at a low temperature while heating.

  Liquids such as blood products required for patient treatment are stored at low temperatures to maintain their function. When introducing the liquid into the patient, it is necessary to heat the liquid to an appropriate temperature in order to reduce the burden on the patient. In particular, when urgently required to introduce the liquid, it is necessary to simultaneously perform the heating of the liquid and the pumping with a pump, and an apparatus for that purpose is known (Patent Document 1). In this type of device, a drip chamber (also referred to as an “air trap”) is provided in the middle of the path through which the liquid passes, and bubbles generated in the liquid are captured by the drip chamber to prevent introduction into the patient. .

JP 2010-172708 A

  However, in the conventional apparatus, when the liquid level in the drip chamber decreases, bubbles may escape from the drip chamber. Each time, it is necessary to stop the operation and remove the bubbles that have escaped from the drip chamber. There is. In particular, when the liquid is transferred while warming, bubbles are easily generated, so the frequency of stopping the operation is increased, and the efficiency is very poor.

  The present invention aims to solve the above-described problems, and provides a liquid transfer device that can effectively prevent bubbles from falling out by adjusting the liquid level in the drip chamber without stopping the liquid transfer operation. The purpose is to do.

  The liquid transfer device of the present invention includes a liquid storage unit that stores a liquid containing a blood component, a liquid discharge unit that discharges the liquid, a liquid supply line that connects the liquid storage unit and the liquid discharge unit, and a liquid supply line. A heating unit for heating the liquid passing therethrough, a liquid feeding pump for pumping the liquid passing through the liquid feeding line, and a bubble provided in the liquid passing through the heating unit are provided on the liquid feeding line. A drip chamber, an upper part of the drip chamber and a liquid reservoir, a bubble return line through which bubbles trapped in the drip chamber pass, and a liquid level that pumps fluid trapped in the drip chamber and passing through the bubble return line The liquid feed line includes an upstream line that communicates between the liquid storage unit and the drip chamber, and a downstream line that communicates between the drip chamber and the liquid discharge unit.

  According to the present invention, even if bubbles are included in the liquid that has passed through the heating unit, the bubbles can be captured by the drip chamber. Furthermore, the position of the liquid level in the drip chamber can be adjusted by pumping the trapped bubbles to the liquid storage unit with the liquid level adjustment pump, and the liquid level can be prevented from being lowered more than necessary. As a result, it is possible to effectively prevent the bubbles trapped in the drip chamber from dropping without stopping the operation.

  Moreover, it is preferable to further have an upstream detector for detecting bubbles in the liquid passing through the upstream line. By providing a detector in the upstream line, the presence or absence of bubbles in the liquid passing through the upstream line can be monitored. By detecting bubbles in the liquid passing through the upstream line, it is possible to monitor the inflow of bubbles into the drip chamber, which is effective in preventing the outflow of bubbles due to a drop in the liquid level in the drip chamber.

  In addition, the upstream line includes a heated portion heated by the heating portion, an introduction portion that connects the heated portion and the liquid storage portion, and bubble detection that connects the heated portion and the drip chamber. The upstream detector is preferably disposed along the bubble detection unit. Bubbles that are likely to be generated by heating the liquid can be detected appropriately, and bubbles flowing into the drip chamber can be effectively monitored.

  Moreover, it is preferable to further have a downstream detector that detects bubbles in the liquid passing through the downstream line. By detecting bubbles in the liquid passing through the downstream line, the outflow of bubbles from the drip chamber can be effectively monitored.

  Also, an additional bubble return line that connects the downstream line and the liquid storage unit, and a liquid discharge unit side that is downstream of the connection part between the downstream line and the additional bubble return line, opens and closes the downstream line. It is preferable to further include a main clamp that performs and an auxiliary clamp that opens and closes the additional bubble return line. By providing the main clamp, even if the liquid that has passed through the drip chamber contains bubbles, closing the main clamp prevents the liquid containing the bubbles from being discharged from the liquid discharge unit. be able to. When the downstream line is opened by the main clamp, the additional bubble return line is closed by the sub clamp, and when the downstream line is closed, the additional bubble return line is opened to substantially perform the liquid transfer operation. There is no need to stop it.

  The downstream detector preferably has a first downstream detector disposed along the downstream line between the drip chamber and the communication portion. When bubbles are detected by the first downstream detector, the downstream line is closed by the main clamp, and the additional bubble return line is opened by the sub clamp, so that bubbles are contained without stopping the liquid transfer operation. It is possible to effectively prevent the discharged liquid from being discharged from the liquid discharge portion. Furthermore, since the liquid containing bubbles can be returned to the liquid storage part via the additional bubble return line, the liquid containing bubbles can be reused without being discarded.

  Moreover, it is preferable that a downstream detector has a 2nd downstream detector arrange | positioned along between the connection part of a downstream line, and the main clamp. Even if the first downstream side detector cannot detect the bubbles for some reason, the second downstream side detector can detect the bubbles, so that the liquid containing the bubbles may be discharged from the liquid discharge unit. Can be reduced.

  In addition, a control unit is further provided for controlling a liquid feed flow rate at which the liquid is transferred by the liquid feed pump and a return flow rate at which the fluid passing through the bubble return line is transferred by the liquid level adjustment pump. It is preferable to control the driving of the liquid feeding pump and the driving of the liquid level adjustment pump so that the return flow rate is reduced. By controlling the liquid feed pump and the liquid level adjustment pump by the control unit, it is possible to predict and prevent the liquid level in the drip chamber from decreasing. As a result, it is possible to effectively prevent the bubbles trapped in the drip chamber from dropping without stopping the operation.

  The liquid level adjustment pump further includes a control unit that controls a return flow rate for transferring the fluid passing through the bubble return line, and the control unit is configured to control the liquid level adjustment pump based on the value detected by the upstream detector. It is preferable to control the drive. Since the upstream detector detects bubbles in the liquid transferred to the drip chamber, the liquid level in the drip chamber is more than necessary by controlling the drive of the liquid level adjustment pump based on this detection value. It can prevent effectively that it falls.

  Further, the control unit further controls the opening and closing of the downstream line by the main clamp and the opening and closing of the additional bubble return line by the sub clamp, and the control unit is configured to detect when no bubbles are detected by the first downstream detector. Control the main clamp to open the downstream line, and if a bubble is detected by the first downstream detector, control the main clamp to close the downstream line and control the secondary clamp to return the additional bubble It is preferable to open the line. If comprised in this way, discharge | emission from the liquid discharge part of the liquid in which a bubble is contained can be suppressed effectively, without stopping the liquid transfer operation.

  The liquid feed pump is preferably provided on the introduction part side, which is upstream from the heated part. When the liquid feed pump is provided on the downstream side of the heated portion, there is a possibility that a negative pressure acts on the heated portion by suction of the liquid feed pump. At this time, when the heated portion has flexibility, the flow path of the heated portion is partially narrowed by the negative pressure, and the flow rate is reduced. However, in the above configuration, since the liquid feed pump is provided on the upstream side of the warmed portion, a positive pressure is applied to the warmed portion so that the flow path is expanded, so that it is efficient. The liquid can be transferred to

  It is preferable to further include an empty detector for detecting bubbles in the liquid passing through the introduction part. By providing the sky detector, it is possible to detect bubbles in the liquid passing through the introducing portion. Thereby, the presence or absence of the liquid stored in the liquid storage part can be monitored.

  The upstream detector preferably detects the volume of bubbles contained in the liquid passing through the upstream line. Moreover, it is preferable that a downstream detector detects the volume of the bubble contained in the liquid which passes a downstream line. By detecting the volume of bubbles, it is possible to monitor bubbles based on quantitative values, and it is effective in preventing liquid containing bubbles from being discharged from the liquid discharge part without stopping the liquid transfer operation. It is.

  According to the present invention, it is possible to effectively prevent bubbles from falling out by adjusting the liquid level in the drip chamber without stopping the liquid transfer operation.

It is explanatory drawing for demonstrating one Embodiment of the liquid transfer apparatus of this invention.

  Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the drawings. The “liquid” used in the present embodiment broadly intends a liquid containing blood components such as red blood cells, white blood cells, or platelets, such as whole blood preparations for blood transfusion, red blood cell preparations, platelet preparations, plasma preparations, Contains blood products.

  The liquid transfer device according to the present embodiment is a device that introduces a liquid such as a blood product into a patient during treatment. In particular, when an emergency is required, the liquid stored in a refrigerator is pumped while being heated to an appropriate temperature. Device.

  As shown in FIG. 1, the liquid transfer device 1 includes a liquid circuit 2 also called a blood circuit and a drive warming device 3. The liquid circuit 2 includes a tube made of vinyl chloride, for example, and forms a flow path through which the liquid L passes. The liquid circuit 2 is installed at a predetermined position of the driving and heating device 3, and the liquid L in the liquid circuit 2 is transferred by driving the driving and heating device 3, and the liquid L passing through the liquid circuit 2 is appropriately transferred. It is warmed. In this embodiment, an example in which the liquid circuit 2 is installed and used in the drive heating device 3 will be described as an example. However, the drive heating device is an embodiment in which a flow path corresponding to the liquid circuit is formed. Also good.

(Liquid circuit)
The liquid circuit 2 is basically a closed-type liquid flow path that is cut off from the outside air, and includes a storage bag 4 for the liquid L containing the liquid whose quality has been controlled by low-temperature storage, and a liquid-feeding line 10 that transfers the liquid L. And a puncture needle connecting portion 5 that is provided at the end of the liquid supply line 10 and discharges the liquid L, and a drip chamber 7 provided on the liquid supply line 10. The storage bag 4 is an example of a liquid storage part, and the puncture needle connection part 5 is an example of a liquid discharge part.

  The liquid feeding line 10 is a liquid flow path that connects the storage bag 4 and the puncture needle connecting portion 5, and is formed using, for example, a flexible tube made of vinyl chloride. A drip chamber 7 is attached on the liquid feed line 10, that is, in the middle of the liquid feed line 10. The upstream side across the drip chamber 7 is an upstream line 11, and the downstream side is a downstream line 12. is there.

  The drip chamber 7 is a cylindrical container having a width wider than the inner diameter of the tube forming the flow path, and bubbles are separated and captured from the liquid L flowing into the drip chamber 7. The drip chamber 7 is installed in the driving and heating device 3 so that the longitudinal direction thereof is directed upward and downward. A bubble discharge port 7a is provided at the upper part, preferably the upper end part serving as the ceiling, and the liquid discharge port 7b is provided at the lower end part. Is provided. A liquid receiving port 7 c is provided on the side wall of the drip chamber 7. The liquid receiving port 7c is preferably provided at the same position as or lower than the bubble discharging port 7a. With this configuration, it is possible to suppress the liquid L flowing into the drip chamber 7 from the liquid receiving port 7c from directly flowing out from the bubble discharge port 7a (short circuit from the liquid receiving port 7c to the bubble discharge port 7a).

  A plate-like heated portion 13 made of vinyl chloride is provided in the middle of the upstream line 11, and a meandering liquid flow path 13 a is formed in the heated portion 13. The heated portion 13 is disposed so as to be in contact with the heater 31 of the drive warming device 3, and the liquid L passing through the heated portion 13 is heated by the heater 31. Further, tubes are connected to the inlet 13b and the outlet 13c of the liquid flow path 13a, respectively. The tube on the inlet 13b side is connected to the storage bag 4 to form an introduction channel (introduction section) 11a, and the tube on the outlet 13c side is connected to the liquid inlet 7c of the drip chamber 7 to detect a bubble detection channel (bubble detection). Part) 11b.

  One end (upstream end) of the tube forming the downstream line 12 is connected to the liquid discharge port 7b of the drip chamber 7, and the other end (downstream end) is connected to the puncture needle connection portion 5. Is provided.

  The liquid circuit 2 communicates with the bubble discharge port 7 a of the drip chamber 7 and the storage bag 4, and branches from the bubble return line 15 through which bubbles trapped in the drip chamber 7 pass and the downstream line 12. And an additional bubble return line 17 that communicates the downstream line 12 and the storage bag 4. The bubble return line 15 and the additional bubble return line 17 are formed of a flexible tube in the same manner as the liquid feed line 10.

(Drive warming device)
The drive warming device 3 includes a holder and a hook that hold the liquid circuit 2 in a predetermined position. And the drive warming device 3 is the state with the liquid circuit 2 installed in the predetermined position, the empty detector 30a arrange | positioned in order from the storage bag 4 side (upstream side) of the upstream line 11, and liquid feeding pump P1. The heater 31 and the upstream detector 30b are provided. Further, the drive warming device 3 includes a first downstream detector 30c, a second downstream detector 30d, and a main clamp C1 that are arranged in order from the drip chamber 7 side (upstream side) of the downstream line 12. ing. The drive warming device 3 includes a liquid level adjustment pump P <b> 2 corresponding to the bubble return line 15, and a sub clamp C <b> 2 corresponding to the additional bubble return line 17.

  The empty detector 30a, the upstream detector 30b, the first downstream detector 30c, and the second downstream detector 30d are, for example, ultrasonic sensors, and bubbles that pass through the liquid supply line 10 together with the liquid L. Is detected. In addition, each detector 30a to 30d may be capable of detecting not only the presence / absence of bubbles contained in the liquid L but also the volume of the bubbles.

  The sky detector 30a is disposed close to (along) the introduction flow path 11a of the upstream line 11, and detects bubbles contained in the liquid L passing through the introduction flow path 11a. Further, the upstream detector 30 b is disposed close to (along) the bubble detection flow path 11 b between the heated portion 13 heated by the heater 31 and the drip chamber 7.

  The first downstream detector (downstream detector) 30c is close to (along) the flow path between the drip chamber 7 and the connecting portion 12a branched to the additional bubble return line 17 in the downstream line 12. The air bubbles contained in the liquid L passing through the flow path are detected. Further, the second downstream detector (downstream detector) 30d is arranged in the vicinity of (along) the flow path between the connecting portion 12a and the puncture needle connecting portion 5 in the downstream line 12. , Bubbles contained in the liquid L passing through the flow path are detected.

  The liquid feed pump P1 is a roller pump that squeezes the introduction flow path 11a of the upstream line 11 with a rotating claw and, as a result, pressure-feeds the liquid L passing through the upstream line 11. Similarly, the liquid level adjustment pump P2 is a roller pump that pumps the fluid passing through the bubble return line 15, specifically, the liquid L and the bubbles. In this embodiment, since the liquid feed line 10 and the bubble return line 15 are formed by flexible tubes, it is meaningful to use the liquid feed pump P1 and the liquid level adjustment pump P2 as roller pumps. This is effective in maintaining a closed system in the upstream line 11 and the bubble return line 15. However, the liquid feed pump P1 is not limited to the roller pump. For example, when the liquid feed line 10 and the bubble return line 15 are made of a hard material, another liquid feed pump may be used. Further, a liquid level adjustment clamp may be arranged in place of the liquid level adjustment pump P2, and the liquid level adjustment clamp and the main clamp C1 may be opened and closed to replace the liquid level adjustment pump. The liquid level adjusting clamp will be described later.

  The heater (heating unit) 31 is provided at a position that contacts or faces the heated portion 13 of the upstream line 11, and heats the liquid that passes through the liquid flow path 13 a of the heated portion 13.

  The main clamp C1 opens and closes the downstream line 12. The main clamp C1 is provided corresponding to the position on the puncture needle connecting part 5 side (downstream side) with respect to the connecting part 12a between the downstream line 12 and the additional bubble return line 17. The sub-clamp C2 is provided corresponding to the position of the additional bubble return line 17 and opens and closes the additional bubble return line 17. The main clamp C1 and the sub clamp C2 only need to be able to close and open the flow path in the downstream line 12 and the additional bubble return line 17, and a clamp or a roller clamp capable of adjusting the flow path diameter can be used.

  The drive warming device 3 controls the liquid feed pump P1, the liquid level adjustment pump P2, the main clamp C1, and the sub clamp C2 based on the values detected by the detectors 30a to 30d. 50. The control unit 50 includes a control board on which a CPU, a RAM, a ROM, and the like are mounted, a memory, a communication module that transmits and receives various control signals, and the control board performs operation processing according to a predetermined program. A function (for example, a flow rate adjusting function) may be realized.

  The control unit 50 is connected to the detectors 30a to 30d by wire or wirelessly, and the bubbles in the liquid L passing through the liquid feeding line 10 based on the values detected by the detectors 30a to 30d. Monitor for presence.

  The control unit 50 is connected to the liquid feeding pump P1 and the liquid level adjusting pump P2 by wire or wirelessly. The control unit 50 controls the liquid feeding flow rate that is the flow rate of the liquid L that passes through the upstream line 11 by controlling the liquid feeding pump P1. Moreover, the control part 50 controls the return flow rate which is a flow volume of at least one of the liquid L and the bubble which pass the bubble return line 15 by controlling the liquid level adjustment pump P2.

  The control unit 50 controls the liquid flow rate and the return flow rate so that the liquid level in the drip chamber 7 does not fall below a predetermined height. The return flow rate is controlled to be smaller.

  For example, the control unit 50 monitors the detection value of the empty detector 30a, and when air bubbles are detected by the empty detector 30a, the liquid supply flow rate is decreased or stopped so as to stop. Controls the pump P1. Further, the control unit 50 calculates the volume of the bubbles by integrating the values detected per unit time by the empty detector 30a, and if the calculated value exceeds a predetermined value, the inside of the storage bag 4 is You may make it judge that it became empty and stop the drive of the liquid feeding pump P1.

  Moreover, the control part 50 is monitoring the detection value in the upstream detector 30b, and when a bubble is detected by the upstream detector 30b, it sets liquid feeding pump P1 so that a liquid feeding flow volume may be decreased. In addition, in order to suppress a drop in the liquid level in the drip chamber 7, the liquid level adjustment pump P2 is controlled to increase the return flow rate. Further, the return flow rate of the liquid level adjustment pump P2 may be increased without changing the flow rate of the liquid feed pump P1.

  In addition, the control unit 50 calculates the volume of the bubble by integrating the values detected per unit time by the upstream detector 30b, and if the calculated value exceeds a predetermined value, the liquid supply flow rate is set. The liquid feed pump P1 and the liquid level adjustment pump P2 can be controlled so as to decrease and increase the return flow rate. Further, the return flow rate of the liquid level adjustment pump P2 may be increased without changing the flow rate of the liquid feed pump P1.

  The liquid level adjustment pump P2 may be replaced with a clamp. When the clamp is called a liquid level adjustment clamp, the following control is performed.

  Moreover, the control part 50 is monitoring the detection value in the upstream detector 30b, and when a bubble is detected by the upstream detector 30b, it sets liquid feeding pump P1 so that a liquid feeding flow volume may be decreased. In addition, the main clamp C1 is closed and the liquid level adjustment clamp is opened to return the liquid to the storage bag 4 and the liquid level of the drip chamber 7 is raised for a certain period of time in order to suppress the liquid level drop in the drip chamber 7 Let Further, the main clamp C1 may be closed and the liquid level adjustment clamp may be opened without changing the liquid supply flow rate of the liquid supply pump P1.

  In addition, the control unit 50 calculates the volume of the bubble by integrating the values detected per unit time by the upstream detector 30b, and if the calculated value exceeds a predetermined value, the liquid supply flow rate is set. To reduce the liquid level in the drip chamber 7 and reduce the liquid level in the drip chamber 7, the main clamp C1 is closed and the liquid level adjustment clamp is opened to return the liquid to the storage bag and raise the liquid level in the drip chamber 7. You can also. Further, the main clamp C1 may be closed and the liquid level adjustment clamp may be opened without decreasing the liquid feed flow rate of the liquid feed pump P1.

  Further, the control unit 50 controls the main clamp C1 based on the detection values of the first downstream detector 30c and the second downstream detector 30d to open and close the downstream line 12, and also opens the sub clamp C2. The additional bubble return line 17 is controlled to open and close.

  For example, when air bubbles are detected by the first downstream detector 30c, the control unit 50 controls the main clamp C1 to close the downstream line 12. On the other hand, the control unit 50 controls the sub clamp C <b> 2 to open the additional bubble return line 17 and return the liquid L to the storage bag 4. As a result, discharge of the liquid L containing bubbles from the puncture needle connecting portion 5 can be effectively suppressed without stopping the liquid L transfer operation. The control unit 50 calculates the volume of the bubble by integrating the values detected per unit time by the first downstream detector 30c, and if the calculated value exceeds a predetermined value, the downstream side It can also be controlled to close the line 12 while opening the additional bubble return line 17.

  Further, the control unit 50 controls the main clamp C1 to control the downstream line 12 when bubbles are detected by the second downstream detector 30d even if bubbles are not detected by the first downstream detector 30c. On the other hand, the additional bubble return line 17 is opened by controlling the secondary clamp C2. As a result, even if the first downstream detector 30c is damaged, the bubbles in the liquid L can be detected by the second downstream detector 30d, and thus the liquid L containing the bubbles is discharged from the puncture needle connecting portion 5. Can be further reduced. The control unit 50 calculates the volume of the bubble by integrating the values detected per unit time by the second downstream side detector 30d, and if the calculated value exceeds a predetermined value, the downstream side It can also be controlled to close the line 12 while opening the additional bubble return line 17.

  According to the liquid transfer device 1 according to the present embodiment, even if bubbles are included in the liquid L that has passed through the heater 31, the bubbles can be captured by the drip chamber 7. Furthermore, the position of the liquid level in the drip chamber 7 can be adjusted by pumping the trapped bubbles to the storage bag 4 by the liquid level adjustment pump P2. As a result, it is possible to effectively prevent the bubbles trapped in the drip chamber 7 from dropping without stopping the operation. Even if bubbles are not detected in the bubble detection flow path, the liquid level adjustment pump P2 is periodically operated for a certain period of time to fill the liquid in the drip chamber 7 to prevent bubbles from flowing out of the drip chamber 7. Can also be prevented. Further, a liquid level adjustment clamp may be arranged instead of the liquid level adjustment pump, and the liquid level adjustment clamp and the main clamp C1 may be opened and closed to replace the liquid level adjustment pump.

  In addition, since the liquid transfer apparatus 1 includes the detectors 30a to 30d that detect bubbles in the liquid L that passes through the liquid supply line 10, the presence or absence of bubbles in the liquid that passes through the liquid supply line 10 is monitored. can do.

  In particular, since the liquid transfer apparatus 1 has the upstream detector 30b that detects bubbles in the liquid L passing through the upstream line 11, the liquid transfer device 1 can monitor the inflow of bubbles into the drip chamber 7, and the liquid in the drip chamber 7 can be monitored. This is effective in preventing the outflow of bubbles due to surface degradation. Further, the upstream detector 30b is arranged along the bubble detection flow path 11b and can detect bubbles contained in the liquid L heated by the heater 31, so that bubbles in the liquid L that are likely to be generated by heating are detected. Appropriate detection is possible, and bubbles flowing into the drip chamber 7 can be effectively monitored.

  Further, since the liquid transfer apparatus 1 includes the first downstream detector 30c and the second downstream detector 30d that detect bubbles in the liquid passing through the downstream line 12, the bubbles are discharged from the drip chamber 7. Can be monitored effectively.

  In addition, the liquid feed pump P <b> 1 of the liquid transfer device 1 is provided on the introduction flow path 11 a side that is upstream of the heated portion 13. The liquid feed pump P <b> 1 can also be disposed on the downstream side of the heated portion 13. However, since the heated portion 13 according to the present embodiment is made of a flexible resin, if the liquid feed pump P1 is arranged downstream of the heated portion 13, the heated portion 13 is sucked by the liquid feed pump P1. There is a possibility that a negative pressure acts on the heating unit 13 and the liquid flow path 13a is partially narrowed to reduce the flow rate. However, in this embodiment, since the liquid feed pump P1 is provided on the upstream side of the heated portion 13, the heated portion 13 acts so that a positive pressure is applied and the flow path is expanded. Therefore, the liquid L can be transferred efficiently.

  Further, since the liquid transfer device 1 can detect bubbles in the liquid passing through the introduction flow path 11 a of the upstream line 11, the presence or absence of the liquid stored in the storage bag 4 can be monitored.

  Further, the liquid transfer apparatus 1 includes a main clamp C1 that opens and closes the downstream line 12 and a sub clamp C2 that opens and closes the additional bubble return line 17. As a result, even when air bubbles are contained in the liquid L that has passed through the drip chamber 7, the liquid L containing air bubbles is prevented from being discharged from the puncture needle connecting portion 5 by closing the main clamp C1. it can. Further, when the downstream line 12 is opened by the main clamp C1, the additional bubble return line 17 is closed by the sub clamp C2, and when the downstream line 12 is closed, the additional bubble return line 17 is opened. It is not necessary to substantially stop the transfer operation of the liquid L.

  Moreover, the liquid transfer apparatus 1 has the 1st downstream detector 30c, and when the bubble is detected by the 1st downstream detector 30c, the downstream line 12 is closed and the additional bubble return line 17 is opened. Thus, the discharge of the liquid L containing bubbles from the puncture needle connecting portion 5 can be effectively suppressed without stopping the transfer operation of the liquid L.

  Moreover, the liquid transfer apparatus 1 includes a second downstream detector 30d in addition to the first downstream detector 30c. Therefore, even if the first downstream detector 30c is damaged, if there is a bubble in the liquid L, it can be detected by the second downstream detector 30d, so that the bubble is included from the puncture needle connecting portion 5. The possibility that the liquid L is discharged can be further reduced.

  Moreover, each detector 30a-30d can also enable it to detect the volume of the bubble contained in the liquid L which passes the liquid feeding line 10. FIG. In this case, by detecting the volume of the bubble, the bubble can be monitored based on a quantitative value, and the liquid L containing the bubble is discharged from the puncture needle connecting portion 5 without stopping the transfer operation of the liquid L. This is effective in preventing this.

  Further, the liquid transfer device 1 includes a control unit 50 that controls a liquid supply flow rate for transferring the liquid L by the liquid supply pump P1 and a return flow rate for transferring at least one of bubbles and liquid by the liquid level adjustment pump P2. The control unit 50 controls the driving of the liquid feeding pump P1 and the driving of the liquid level adjusting pump P2 so that the return flow rate becomes smaller than the liquid feeding flow rate, so that the liquid level in the drip chamber 7 decreases more than necessary. Can be effectively prevented. As a result, it is possible to effectively prevent the bubbles trapped in the drip chamber 7 from dropping without stopping the operation.

  Further, the control unit 50 controls the driving of the liquid level adjustment pump P2 based on the detection value of the upstream detector 30b that detects bubbles in the liquid L transferred to the drip chamber 7. Therefore, it is possible to effectively prevent the liquid level in the drip chamber 7 from being lowered more than necessary.

  Moreover, the control part 50 controls opening and closing of the downstream line 12 by the main clamp C1, and opening and closing of the additional bubble return line 17 by the sub clamp C2. Further, when air bubbles are not detected by the first downstream detector 30c and the second downstream detector 30d, the control unit 50 controls the main clamp C1 to open the downstream line 12 to detect the first downstream side. When bubbles are detected by the detector 30c and the second downstream detector 30d, the main clamp C1 is controlled to close the downstream line 12, and the auxiliary clamp C2 is controlled to open the additional bubble return line 17. As a result, the liquid L containing bubbles can be effectively prevented from being discharged from the puncture needle connecting portion 5 without stopping the liquid L transfer operation.

  As described above, the present invention has been specifically described based on the above embodiment, but the present invention is not limited to the above embodiment. For example, the liquid supply line, the drip chamber, the bubble return line, and the additional bubble return line. It may be a liquid transfer device in which a member corresponding to the above or a flow path is incorporated. Moreover, in said embodiment, although each detector 30a-30d which detects the bubble in the liquid L which passes each of the upstream line 11 and the downstream line 12 was provided, it passes any one line. It may be a liquid transfer device provided with a detector for detecting bubbles. Moreover, the control part may be comprised by the some control unit from which a control object differs.

  DESCRIPTION OF SYMBOLS 1 ... Liquid transfer apparatus, 4 ... Storage bag (liquid storage part), 5 ... Puncture needle connection part (liquid discharge part), 7 ... Drip chamber, 7a ... Bubble discharge part provided in the upper part of a drip chamber, 10 ... Delivery Liquid line, 11 ... upstream line, 11a ... introduction flow path (introduction part), 11b ... bubble detection flow path (bubble detection part), 12 ... downstream line, 13 ... heated portion, 15 ... bubble return line, 17 ... Additional bubble return line, 30a ... Empty detector, 30b ... Upstream detector, 30c ... First downstream detector, 30d ... Second downstream detector, 31 ... Heater (heating unit), 50 ... Control Part, C1 ... main clamp, C2 ... sub clamp, L ... liquid, P1 ... liquid feed pump, P2 ... liquid level adjustment pump.

Claims (14)

A liquid reservoir for storing a liquid containing blood components;
A liquid discharger for discharging the liquid;
A liquid feed line for connecting the liquid storage part and the liquid discharge part;
A heating unit for heating the liquid passing through the liquid feeding line;
A liquid feed pump for pumping the liquid passing through the liquid feed line;
A drip chamber provided on the liquid feeding line and capturing bubbles contained in the liquid that has passed through the heating unit;
A bubble return line that communicates between the upper part of the drip chamber and the liquid reservoir and through which bubbles trapped in the drip chamber pass;
A liquid level adjustment pump that is trapped in the drip chamber and pumps fluid passing through the bubble return line, and
The liquid feeding device includes an upstream line that communicates the liquid reservoir and the drip chamber, and a downstream line that communicates the drip chamber and the liquid discharge unit.   The liquid transfer apparatus according to claim 1, further comprising an upstream detector that detects bubbles in the liquid passing through the upstream line. The upstream line includes a heated portion heated by the heated portion, an introduction portion that connects the heated portion and the liquid storage portion, the heated portion, and the drip chamber. An air bubble detection unit to communicate with,
The liquid transfer device according to claim 2, wherein the upstream detector is disposed along the bubble detection unit.   The liquid transfer apparatus according to claim 1, further comprising a downstream detector that detects bubbles in the liquid passing through the downstream line. An additional bubble return line connecting the downstream line and the liquid reservoir;
A main clamp that opens and closes the downstream line disposed on the liquid discharge unit side, which is downstream of the connecting portion between the downstream line and the additional bubble return line;
The liquid transfer device according to claim 4, further comprising a sub clamp that opens and closes the additional bubble return line.   The liquid transfer device according to claim 5, wherein the downstream detector includes a first downstream detector disposed between the drip chamber and the communication portion of the downstream line.   The liquid transfer device according to claim 5 or 6, wherein the downstream detector has a second downstream detector disposed between the connecting portion of the downstream line and the main clamp. A control unit for controlling a liquid feed flow rate for transferring the liquid by the liquid feed pump and a return flow rate for transferring the fluid passing through the bubble return line by the liquid level adjustment pump;
The said control part controls the drive of the said liquid feed pump, and the drive of the said liquid level adjustment pump so that the said return flow volume may become smaller than the said liquid feed flow rate. Liquid transfer device. A control unit for controlling a return flow rate for transferring the fluid passing through the bubble return line by the liquid level adjustment pump;
The liquid transfer device according to claim 2, wherein the control unit controls driving of the liquid level adjustment pump based on a value detected by the upstream detector. A control unit for controlling the opening and closing of the downstream line by the main clamp and the opening and closing of the additional bubble return line by the sub clamp;
When the air bubble is not detected by the first downstream detector, the control unit controls the main clamp to open the downstream line, and when the air bubble is detected by the first downstream detector. 7. The liquid transfer device according to claim 6, wherein the main clamp is controlled to close the downstream line, and the secondary clamp is controlled to open the additional bubble return line.   The liquid transfer device according to claim 3, wherein the liquid feed pump is provided on the introduction portion side that is upstream of the heated portion.   The liquid transfer device according to claim 3, further comprising an empty detector that detects bubbles in the liquid passing through the introduction unit.   The liquid transfer device according to claim 2, wherein the upstream detector detects a volume of bubbles contained in the liquid passing through the upstream line.   11. The liquid transfer device according to claim 4, wherein the downstream detector detects a volume of bubbles contained in the liquid passing through the downstream line.

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