JP2015062622A - Manufacturing method for needle-like body - Google Patents

Abstract

PROBLEM TO BE SOLVED: To manufacture a needle-like body inexpensively by imparting a needle-like body duplication plate with durability.SOLUTION: A needle-like body original plate 101 is filled with a duplication plate material 300 in which additives such as a silica filler 302 are added to a silicone resin monomer 301. By peeling the duplication plate material 300 that has been solidified from a surface of the needle-like body original plate 101, a needle-like body duplication plate 201 made from the duplication plate material 300, is manufactured, in which recessed parts correspond to needle-like parts 503 are formed on a surface. A needle-like body material 510 is disposed on a surface having recessed parts 202, of the needle-like body duplication plate 201. The needle-like body material 510 is pressurized against the needle-like body duplication plate 201, and the needle-like body material 510 is heated and melted to be filled into the surface having the recessed parts 202 of the needle-like body duplication plate 201. In a state that the needle-like body material 510 is filled on the needle-like body duplication plate 201, cooling is performed. The needle-like body material 510 is completely peeled from the needle-like body duplication plate 201, to provide a needle-like body 501.

Description

  An object of the present invention is to provide a method for producing a needle-like body using a needle-like body duplication plate having durability that can be transferred a plurality of times during transfer processing and molding for producing the needle-like body. To do.

  As a method for easily delivering a delivery product without causing pain to the human body, there is a percutaneous absorption method in which a delivery product such as a drug is permeated through the skin and the delivery product is administered into the body. This is a method of puncturing the skin using a fine needle of the order of μm and administering a drug into the skin, and is called a microneedle. (See Patent Document 1).

  The shape of the fine needle-like body used at this time preferably has a sufficient fineness and tip angle for piercing the skin, and a sufficient length for allowing the drug solution to penetrate subcutaneously. Several μm to several hundred μm (specifically, for example, about 1 μm to 300 μm), and length is specifically several tens to several hundred μm (specifically, for example, about 10 μm to 1000 μm) Is desirable.

  In addition, the material constituting the needle-like body is desirably a material that does not adversely affect the human body even if the damaged needle-like body remains in the body. A compatible material has been proposed (see Patent Document 2).

  Further, as a method for producing the needle-like body, it has been proposed to prepare an original plate using cutting, form a duplicate plate from the original plate, and perform transfer processing molding using the duplicate plate (Patent Literature). 3).

  The transfer processing molding of the needle-shaped body includes thermal compression molding in which a heat-soluble material such as a resin is melted with heat and compressed and then cooled and cured. In many cases, a silicone rubber such as PDMS is used as a duplicate plate because of the ease of transfer from the original plate.

  On the other hand, rubber generally has a low mechanical strength, is easy to stretch compared to inorganic materials, and has a short life because it is easily cut. In order to overcome this, various additives are added to change the mechanical strength. For example, according to a report by Santawisuk et al., The mechanical properties are changed by adding silica particles to a silicone resin as a denture soft relief material (see Non-Patent Document 1).

JP 2009-273872 A JP 2009-201956 A JP 2009-240410 A JP 2009-61144 JP

W. Santawisuk et. Al., “Dynamic viscoelastic properties of experimental silicone soft lining materials” Dental Materials Journal 29 (2010) 4: 454-460

  However, in the heat compression step, depending on the resin, high melting point causes high heat to be applied to the duplicate plate, and the silicone rubber deteriorates.

  Accordingly, the present invention has been made to solve the above-described problems, and an object of the present invention is to provide a method for manufacturing a needle-like body that can be melted and compressed by high heat in transfer processing molding. . In particular, it is an object of the present invention to provide a method for producing a needle-like body at low cost by imparting durability to the needle-like body replica and allowing repeated use.

In order to solve the above-mentioned problem, the invention according to claim 1 is a method of manufacturing a needle-like body comprising a support substrate and a needle-like portion having a needle-like shape protruding from the surface of the support substrate. , A step of producing a needle-shaped body original plate comprising an original plate-side substrate and an original needle-side needle-shaped portion having the same shape as the needle-shaped portion protruding from the surface of the original plate-side substrate, and adding a filler to the silicone resin monomer Filling the cured replica plate material onto the surface of the needle-shaped body precursor and curing, and peeling the cured replica plate material from the surface of the needle-shaped body precursor to form the replicated plate material on the surface. A step of producing a needle-like body replica plate in which a concave portion corresponding to the needle-like portion is formed, a step of disposing a needle-like body material on a surface of the needle-like body replica plate including the concave portion, and the needle-like body material And pressurizing the acicular replica plate, and the acicular material And filling the surface including the concave portion of the acicular replica plate with heat, and cooling the acicular material and peeling it from the acicular replica plate to make the acicular material. And obtaining the needle-like body.
The invention according to claim 2 is the method for producing a needle-shaped body according to claim 1, wherein the linear expansion coefficient of the duplicate plate material is smaller than the linear expansion coefficient of the needle-shaped body material.
The invention according to claim 3 is the method for producing a needle-like body according to claim 1 or 2, wherein the filler has a particle size of 10 nm to 100 µm.
The invention according to claim 4 is the method for producing a needle-like body according to any one of claims 1 to 3, wherein the filler is any one of silica, titanium oxide, and zinc.

According to the present invention, a needle-shaped replica plate is produced using a replica plate material in which a filler is added to a silicone resin monomer, the needle-shaped material is pressurized against the needle-shaped replica plate, and the needle-shaped material is also used. So that the surface including the concave portion of the acicular replica is filled with heat, the acicular material is cooled and peeled off from the acicular replica to obtain a acicular body made of the acicular material. I made it.
Therefore, it is possible to obtain a needle-like body by compression-molding a needle-like body material melted at high heat using a needle-like body replication plate, and in particular, the needle-like body replication plate has durability and can be used repeatedly. Therefore, it is advantageous in manufacturing the needle-shaped body at low cost.

It is explanatory drawing of the acicular body original plate used for the manufacturing method of the acicular body of embodiment, (a) is a perspective view of an original plate, (b) is a top view of (a), (c) is (b). It is the II 'sectional view taken on the line. (A)-(f) is explanatory drawing which shows the process of the manufacturing method of the acicular body of embodiment. It is a figure which shows the durability test result of the acicular body replication plate produced in embodiment. It is a figure which shows the heat deterioration test of the acicular body replication plate produced in embodiment. It is a figure which shows the DT-TGA test result of the acicular body replication version produced in embodiment.

  Hereinafter, the manufacturing method of the acicular body and the acicular body replica of the present invention will be described.

  The method for producing a needle-like body of the present invention is a method for producing a needle-like body comprising a support substrate and a needle-like portion having a needle-like shape protruding from the surface of the support substrate, And a step of producing a needle-like body original plate having the same shape as the needle-like portion protruding from the surface of the original-side substrate, and a duplication plate material obtained by adding a filler to a silicone resin monomer Filling the surface of the acicular precursor and curing it, and peeling the cured duplicated plate material from the surface of the acicular precursor to form the replica plate material on the surface of the acicular portion. A step of producing a needle-like body replica plate in which a corresponding concave portion is formed; a step of disposing a needle-like body material on a surface of the needle-like body replica plate including the concave portion; While pressurizing the body replica plate, the needle-shaped body material is heated and melted before Filling the surface including the concave portion of the acicular body replica plate, and cooling the acicular body material and peeling the acicular body replica plate from the acicular body replica plate to obtain the acicular body material made of the acicular body material; And a process.

In general, deterioration of silicone resin during hot compression molding is as follows: (1) tearing due to adhesion when the molded product is peeled from the replica of the needle-like product, reduction in mechanical properties due to abrasion due to friction, (2) heat and oxidation, etc. It is caused by the destruction of the molecular structure due to the above.
In particular, in the case of peeling a needle-like body having a small size and a high aspect ratio from the needle-like duplicate plate, the needle-like body of the molded product can be easily formed due to a slight inclination or axial deviation at the time of peeling. Since the surface of the molded product is kept parallel to the surface of the needle-like body replica plate with high accuracy and a uniform force is not applied to the entire molded body during peeling, the concave portion of the molded body is particularly easily damaged. Therefore, there is a need for a transfer plate that is mechanically durable and heat resistant against axial misalignment in the peeling direction.

  The present invention is to prepare a material with heat resistance and mechanical properties added to this acicular replica, and apply a uniform force to the entire molded body against the high heat in the peeling direction. In particular, the effect is great when using a needle-like replica plate having fine recesses.

  In the present invention, it is preferable that the linear expansion coefficient of the material constituting the acicular body replica is smaller than the linear expansion coefficient of the acicular body material. Since the linear expansion coefficient of the material constituting the acicular body replica plate is smaller than the linear expansion coefficient of the acicular body material, the degree of cure shrinkage due to heat is relatively greater in the acicular body material, This is because the stress associated with the contraction of the needle-shaped body material is increased, and works favorably for peeling of the interface.

  Generally, a needle-like replica plate made of a resin material is superior in shape followability and inferior in durability to a needle-like replica plate made of a metal material. According to the present invention, since the peeling can be suitably performed, it is possible to reduce the load on the acicular replica plate during peeling, and it is possible to suppress the deterioration of the acicular replica plate made of a resin material. Therefore, the effect when the present invention is applied to a needle-like replica plate made of a resin material is great.

The needle-shaped body material is preferably formed of a material having biocompatibility. By using a material having biocompatibility, safety can be ensured when the needle-like body is applied to a living body.
Examples of the material having biocompatibility include polymers such as polylactic acid and polycarbonate.

  In the manufactured needle-like body, the needle-like portion and the support substrate that supports the needle-like portion may be made of the same material, or may be formed by filling different materials in combination. From the viewpoint of simplifying the process, it is preferable to integrally mold the needle-like portion and the support substrate.

Fig.1 (a) is a perspective view which shows an example of the acicular body original plate used for the manufacturing method of the acicular body of embodiment, (b) is a top view of (a), (c) is I of (b). FIG.
2A to 2F are schematic views showing a method for manufacturing the needle-shaped body of the embodiment. The acicular replica plate 201 used in the present invention has a concave pattern in which the shape of the concave portion of the acicular body is inverted. Moreover, as shown in the drawing, the surface of the needle-like body replica plate 201 and the inner peripheral surface of the recess 202 form a certain angle.

As shown in FIG. 2F, the needle-like body 501 includes a support substrate 502 and a needle-like portion 503 having a needle-like shape protruding from the surface of the support substrate 502.
The needle-like body 501 is manufactured by a transfer molding method using the needle-like body replica plate 201. Specifically, the needle-like portion 503 is formed in a shape obtained by reversing the shape of the concave-convex pattern formed on the surface of the needle-like replica plate 201. In other words, the concave portion 202 corresponding to the needle-like portion 503 is formed on the surface of the needle-like body replica plate 201.

  The shape of the needle-like portion 503 of the needle-like body 501 obtained by transfer molding may be freely designed depending on the application. For example, in the case of the purpose of promoting percutaneous absorption of a physiologically active substance or the purpose of taking a substance in a living body percutaneously out of the living body, the tip of the needle-like portion 503 is a sharp cone from the viewpoint of skin puncture performance. The shape may have a root width of several μm to several hundred μm, and a length of several tens μm to several hundred μm. In addition, a channel for reinforcing the ability to deliver a substance through the skin may be provided in the needle-like portion 503 or the support substrate 502. Further, the number and arrangement of the needle-like parts 503 may be freely designed as appropriate. For example, a plurality of needle-like portions 503 may be arranged in an array.

  The shape of the concave portion 202 of the needle-like body replica plate 201 is not particularly limited, and may be designed to an optimal shape as appropriate. For example, the shape of the recess 202 may be designed in a truncated cone shape such as a truncated cone, a quadrangular truncated pyramid, or a hexagonal truncated pyramid. When the shape of the concave portion 202 of the acicular body replica plate 201 is designed to be a frustum shape, the needle-like portion 503 obtained by transfer molding has a convex shape in which the concave portion 202 is inverted.

  Further, the depth of the concave portion 202 of the acicular body replica plate 201 is not particularly limited, and may be designed to an optimum depth as appropriate. However, the depth of the concave portion 202 is set to the height of the needle-shaped portion 503. The depth of the concave portion between the needle-like portions 503 in the needle-like body 501 becomes larger than the height of the needle-like portion 503, and a sufficient puncturing effect cannot be obtained when puncturing the needle-like body 501. There is. For this reason, it may be preferable that the depth of the concave portion 202 of the acicular body replica plate 201 is designed to be approximately the same as or lower than the height of the acicular portion 503.

  The angle θ formed by the surface of the needle-shaped replica plate 201 and the inner peripheral surface of the recess 202 may be in a range larger than 90 degrees and smaller than 180 degrees. In this case, an inclined portion is provided on the inner peripheral surface of the recess 202. When the angle θ formed by the surface of the needle-shaped replica plate 201 and the inner peripheral surface of the recess 202 is 90 degrees or less, the needle-shaped replica plate 201 and the needle-shaped body are contracted by the contraction of the needle-shaped body 501 that is a molded product. The fixation of 501 is stronger than when the angle θ is 90 degrees (when the inclined portion is not provided on the inner peripheral surface of the recess 202). Further, in the cooling process after forming the needle-like body 500, in order to enhance the peeling effect of the needle-like body 501 from the needle-like body replica plate 201, the angle θ is in the range of 100 degrees to 150 degrees. preferable.

Hereinafter, an embodiment of the method for producing a needle-shaped body of the present invention will be specifically described with reference to FIG. FIG. 2 is a schematic cross-sectional process drawing showing an example of a method for producing a needle-shaped body in the present invention.
The method for producing the acicular replica of the present invention is not particularly limited, and may be suitably produced using a known fine processing technique. Further, an original plate having a desired acicular shape may be produced using a fine processing technique, and an acicular duplicate plate may be produced by a transfer molding process from the original plate. Here, an original plate having a desired needle-like body shape is prepared using a microfabrication technique, a needle-like replica plate is produced by a transfer molding process from the master plate, and a transfer molding process using the needle-like replica plate is performed. A method for obtaining a needle-like body will be described as an example.

<Original plate making process>
First, an original plate material shown in FIG. 1 is prepared, and a needle-like body original plate 101 is produced using a fine processing technique.
The needle body original plate 101 includes an original plate side substrate 103, and an original plate side needle portion 105 having the same shape as the needle portion 503 projecting from the surface of the original plate side substrate 103.
There is no particular limitation on the method for producing the needle body original plate 101. As a method for manufacturing the needle-like body, a known method may be used, and fine processing used for machining or semiconductor manufacturing can be used. At this time, the material of the base material is not particularly limited, and it is desirable to select the material from the viewpoint of processability and the availability of the material. Examples thereof include metal materials such as SUS, aluminum, and titanium, ceramics such as alumina, aluminum nitride, and machinable ceramics, hard and brittle materials such as silicon and glass, and organic materials such as acrylic and polyacetal. A known production method may be used as appropriate according to the shape of the needle-shaped body to be produced. For example, you may produce the acicular body original plate 101 which has a desired pattern shape with a microfabrication technique. Here, as the fine processing technique, for example, a lithography method, a wet etching method, a dry etching method, a sand blast method, a laser processing method, a precision machining method, or the like may be used. There is no particular limitation on the original material 101, and a material suitable for the method used for microfabrication can be selected.

  From the above, the obtained acicular device can be used as the acicular original plate 101 for duplication described below.

<Needle replica production process>
Next, a method for producing a needle-like replica from the needle-like precursor shown in FIG. 2 will be described. As shown in FIGS. 2A, 2 </ b> B, and 2 </ b> C, the replica plate material 300 is filled into the needle-like body original plate 101. At this time, by adding an additive such as a silica filler 302 to the silicone resin monomer 301, the duplicate plate material 300 is configured, so that subsequent steps can be favorably advanced.
After the duplication plate material 300 is cured, as shown in FIG. 2D, the acicular body duplication plate 201 duplicated in a concave shape can be produced by peeling from the acicular body original plate 101. That is, the cured replica plate material 300 is peeled off from the surface of the acicular body original plate 101 to form the acicular body replica plate 201 that is made of the replica plate material 300 and has a concave portion 202 corresponding to the acicular portion 503 formed on the surface. Make it.
By producing the acicular body replica plate 201, a large amount of acicular bodies 501 can be manufactured from the same acicular body replica plate 201, so that the production cost can be suppressed and the productivity can be increased. .

As a general filler 302 to be added to the silicone resin 301, for example, Aerosil R 812 having the atomic group —O—Si (CH ₃ ) ₃ as the hydrophobic silica is selected, but it is not limited thereto. No. In addition, it is preferable that the particle size of the filler 302 exists in the range of 10 nm-100 micrometers. The particle size of the filler 302 is measured in accordance with JIS R1639-1 “Fine ceramics—Measuring method of particle characteristics—Part 1: Particle size distribution”.
When the particle size of the filler 302 is in the range of 10 nm to 100 μm, it is advantageous in terms of ensuring the quality of the acicular replica 201 while ensuring ease of manufacture.
When the particle size of the filler 302 is less than the above range, the dispersibility of the filler 302 (particles) is deteriorated, which is disadvantageous in that the filler 302 is hardly mixed with the silicone resin monomer 301.
When the particle size of the filler 302 exceeds the above range, the particle size of the filler 302 is equal to or larger than the size of the concave portion 202 corresponding to the needle-like portion 503, so that the quality of the needle-like replica plate 201 is ensured. Is disadvantageous.

  In order to improve the releasability of the acicular replica plate 201, the acicular precursor plate 101 used here may be subjected to surface shape processing and chemical surface modification before transfer. Specifically, polishing by machining, drilling, grooving, surface processing and surface modification using an etching process, or application of a release agent can be preferably used.

The duplication plate material 300 is not particularly limited, but a material is selected in consideration of the shape followability capable of satisfactorily transferring the needle body original plate 101, transferability in transfer molding described later, durability, and releasability. I can do it.
In addition, the replication plate material 300 and the method of filling the replication plate material 300 are not particularly limited, but the linear expansion coefficient of the replication plate material 300 (filling material) is smaller than the linear expansion coefficient of the needle-shaped body material 510. preferable.

<Transfer molding process>
Next, a transfer molding process using the needle-like body replica plate 201 will be described. As shown in FIG. 2 (e), the needle-like body replica plate 201 is filled with a needle-like body material 510 as a molding material.
That is, the step of disposing the needle-shaped body material 510 on the surface including the concave portion 202 of the needle-shaped body replica plate 201, pressurizing the needle-shaped body material 510 against the needle-shaped body replica plate 201, and the needle-shaped body material 510 Is heated and melted to fill the surface including the concave portion 202 of the acicular replica 201. In the present embodiment, the pressurization and heat melting of the needle-shaped body material 510 are performed using a hot press device 401.
The needle-like body material 510 is not particularly limited, but it is preferable to use polylactic acid, polycarbonate, polyglycolic acid, or the like, which is a biocompatible material, in the needle-like portion 503 serving as a puncture portion. If a biocompatible material is used, even if the needle-like portion 503 is folded and left in the body, it has an effect that it is harmless. The needle-shaped body material 510 and the transfer molding method are not particularly limited, and publicly known molding materials and transfer molding methods can be used as appropriate. The needle-shaped body material 510 is preferably a material having biocompatibility, In order to perform melt molding in the transfer molding process, a thermoplastic resin material can be suitably used. Although there is no restriction on the filling method of the needle-shaped body material 510 at this time, from the viewpoint of productivity, a known resin molding method such as an imprint method, a hot embossing method, an injection molding method, an extrusion molding method and a casting method is used. It may be used. In addition, although an example of polymer molding has been shown here as a method for producing a needle-like body, the method for producing a needle-like body according to the present invention is not limited to this, and the needle-like body is suitably produced using a known processing technique. Also good.

Next, cooling is performed in a state where the needle-like material 510 is filled on the needle-like replica plate 201. Cooling may be performed on at least the needle-shaped body material 510.
When a thermoplastic resin is used for the needle-shaped body material 510 and the transfer is performed by melting the needle-shaped body material 510 in the transfer molding step, the needle-shaped body material 510 and the needle-shaped body replica plate 201 are collectively collected after the transfer molding. And may be cooled to room temperature. When a thermoplastic resin is used as the needle-shaped body material 510 and a metal plate is used as the needle-shaped body replication plate 201, the amount of contraction of the needle-shaped body material 510 is greater than that of the needle-shaped body replication plate 201 due to the difference between the linear expansion coefficients of both. As shown in FIG. 2, the needle-like material 510 moves upward along the inclined portion of the inner peripheral surface of the concave portion 202 of the needle-like replica plate 201, and the needle-like replica plate 201. And the needle-shaped body material 510 are separated from each other. Subsequently, as shown in FIG. 2 (f), the acicular body material 510 is completely peeled from the acicular body replica plate 201 to obtain the acicular body 501 according to the present invention. At this time, since the molding material 501 is released from the acicular body replica plate 201 by cooling, the acicular body material 510 can be easily removed from the acicular body replica plate 201, and the acicular body accompanies peeling. Damage to the body 501 can be reduced.

  Moreover, when improving the peelability in the process of separating the needle-shaped body material 510 from the needle-shaped body replica plate 201, the mold is released on the surface of the needle-shaped body replica plate 201 in advance before performing the transfer molding process. A release layer may be deposited to increase the effect. As the release layer, for example, a well-known fluorine-based resin can be used. As a method for forming the release layer, a thin film forming method such as a CVD method, a spin coating method, or a dip coating method can be suitably used.

  From the above, the needle-shaped body and the needle-shaped body of the present invention can be manufactured. The needle-shaped body and the method for producing the needle-shaped body of the present invention are not limited to the above-described embodiments, and include other known methods that can be inferred in each step.

  Hereinafter, examples of the present invention will be described with specific examples. Naturally, the manufacturing method of the acicular body of the present invention is not limited to the following examples, and includes other manufacturing methods that can be inferred from known materials in each step.

<Example 1>
First, a single crystal silicon wafer having a thickness of 700 μm was prepared. Using a cutting apparatus having a diamond blade, 25 or more needle-like bodies arranged in an array of 5 rows and 5 rows on a silicon substrate were produced. The needle-like body obtained at this time was a quadrangular pyramid, the tip angle was 20 °, the height was about 500 μm, and the width of one side of the bottom surface was 200 μm.

  A fluorine-based mold release agent was applied to the obtained original plate to perform a mold release treatment.

  Next, as shown in FIG. 2, polydimethylsiloxane (PDMS) manufactured by Toray Dow Corning was prepared. Anatase type titanium dioxide (manufactured by Wako Pure Chemical Industries, Ltd.) was added at 15% by weight. After stirring with a plastic stir bar for 1 minute or longer, the mixture was allowed to stand for 15 minutes or longer at 0.08M Bar or lower with a decompressor, and then defoamed.

  The adjusted PDMS solution was dropped on the original plate, and a silicon substrate as a transfer base was placed thereon, and heated at 100 ° C. for 10 minutes to cure the PDMS solution. Thereafter, the acicular body original plate 101 was completely removed to peel off the transferred acicular body replica plate 201.

  From the above, a needle-like replica plate 201 made of PDMS was obtained.

  Next, as shown in FIG. 2, the polylactic acid that is the needle-shaped body material 510 is placed on the needle-shaped body replica plate 201, heated at 200 degrees to melt the material, and melted with a metal hot press machine. Polylactic acid was compressed.

Thereafter, the acicular body replica plate 201 and the acicular body material 510 were rapidly cooled to room temperature during the thermal compression to promote the release of the acicular body material 510 from the acicular body replica plate 201.
At this time, the needle-shaped body material 510 made of polylactic acid is easily peeled off from the needle-like body replica plate 201, and the end of the polylactic acid that is the needle-like body material 510 is picked with tweezers and peeled off from the needle-like body replica plate 201. I was able to do it.

  From the above, the needle-shaped body 501 was able to be manufactured. The obtained needle-like body 501 has the same shape as the needle-like needle-like body original plate 101 shown in FIG. 1, and a substantially conical needle-like portion 503 is formed at the center of the bottom surface of the inverted truncated cone-shaped recess. A total of 25 or more cells were arranged in a grid of 5 columns and 5 rows at intervals of 2 mm. Moreover, when the obtained acicular body 501 was observed with an optical microscope and a scanning electron microscope, no damage was observed in all the fine acicular portions 503.

<Example 2>
First, a single crystal silicon wafer having a thickness of 700 μm was prepared. Using a cutting device having a diamond blade, one needle-like body was produced on a silicon substrate.

  Next, as shown in FIG. 2, polydimethylsiloxane (PDMS) manufactured by Toray Dow Corning was prepared. In addition, a predetermined amount of PDMS (trade name MDX4-4210) (trimethylated silica, 15-40% (v / W)) containing silica filler 302 manufactured by Dow Corning Co., Ltd. is added, and a plastic stirring rod is used for 1 minute or more. After stirring, the mixture was allowed to stand for 15 minutes or longer at 0.08 M Bar or less with a decompressor to adjust the deaeration.

  The adjusted PDMS solution was dropped on the needle body original plate 101, and a silicon substrate as a base material to be transferred was placed thereon, and heated at 100 ° C. for 10 minutes to cure the PDMS solution. Thereafter, the acicular body original plate 101 was completely removed to peel off the transferred acicular body replica plate 201. From the above, a needle-like replica plate 201 made of PDMS was obtained.

  This molding operation is repeated by using polycarbonate, which is a material having a high melting point of 250 ° C., as the needle-like material 510, and the appearance of the needle-like replica 201 and the moldability of the needle-like body 501 are visually observed. Durability tests were performed until the appearance of the plate 201 and the molded product changed. Next, as shown in FIG. 2, the polycarbonate was placed on the acicular replica plate 201, heated at 280 ° C. to melt the material, and the molten polycarbonate was compressed by a metal hot press machine 401.

  Thereafter, the acicular body replica plate 201 and the polycarbonate were rapidly cooled to room temperature during the thermal compression to promote the release of the polycarbonate from the acicular body replica plate 201. At this time, the polycarbonate was easily peeled from the needle-like replica plate 201, and the end of the polycarbonate, which is the needle-like material 510, was picked with tweezers and could be easily peeled from the needle-like replica plate 201. When the same process was repeated to visually confirm the deterioration of the needle-like replica plate 201, cracks were found in the needle-like replica plate 201 after the molding was performed 35 times or more. On the other hand, in the acicular body replica plate 201 containing 50% PDMS, a large crack was observed 80 times. Further, in the acicular body replica plate 201 with 100% PDMS, a small crack was observed in the portion corresponding to the tip of the acicular body (needle portion 503) after the molding was performed 120 times or more. From these facts, it was confirmed that the durability of the acicular replica plate 201 was improved by adding the filler content.

  Furthermore, as shown in FIG. 3, the tensile strength and the compressive strength decrease depending on the content concentration of PDMS prepared by Silica Toray Dow Corning Co., Ltd., and the fracture strength tends to increase. It was. From this, as the PDMS concentration increased, the tensile strength and compressive strength increased, but the fracture strength tended to decrease. Therefore, the addition of the filler in the replica plate material was expected to improve the mechanical properties in consideration of the stress applied during the hot compression molding.

  Finally, as shown in FIG. 4, the temperature profile of the silica filler 302-containing silicone resin transfer needle replica 201 was observed. With respect to silicone resins having various filler content concentrations, the course of weight reduction was measured using a thermal analyzer. As a result, the weight loss decreased depending on the concentration of the filler content, and thermal decomposition was suppressed. The weight loss due to heating became smaller depending on the increase in filler content.

  As shown in FIG. 5, in the differential thermal-thermogravimetric simultaneous measurement, it was confirmed that weight loss due to heat can be suppressed by decreasing the PDMS concentration and increasing the filler concentration. From the above, it was confirmed that the needle-shaped duplicated plate 201 is useful for the heat resistance in the heat compression molding of the needle-shaped body.

  The method for producing a needle-like body of the present invention can be used not only for medical treatment but also in various fields that require a fine needle-like body. For example, MEMS devices, optical members, drug discovery, cosmetics, cosmetic applications, etc. It is also useful as a method for producing fine needles used in

DESCRIPTION OF SYMBOLS 101 ... Acicular body original plate 103 ... Original side substrate 105 ... Original side acicular part 201 ... Acicular body duplication plate 202 ... Concave 300 ... Duplication plate material 301 ... Silicone resin monomer / silicone resin 302 ... Silica filler 401 ... Hot press apparatus 501 ... Needle-like body 502 ... Support substrate 503 ... Needle-like part 510 ... Needle-like body material

Claims (4)

A method for producing a needle-like body comprising a support substrate and a needle-like portion having a needle-like shape protruding from the surface of the support substrate,
Producing a needle-like body original plate comprising an original plate-side substrate, and a master-side needle-like portion having the same shape as the needle-like portion protruding from the surface of the original plate-side substrate;
Filling and curing the surface of the acicular body original plate with a replication plate material obtained by adding a filler to a silicone resin monomer; and
A step of producing a needle-like replica plate made of the replica plate material and having a concave portion corresponding to the needle-like portion formed on the surface thereof by peeling the cured replica plate material from the surface of the needle-like master plate; ,
Disposing a needle-shaped body material on the surface including the concave portion of the needle-shaped body replication plate;
Pressurizing the needle-shaped body material against the needle-shaped body replication plate, and heating and melting the needle-shaped body material to fill the surface including the concave portion of the needle-shaped body replication plate;
Obtaining the needle-shaped body made of the needle-shaped body material by cooling the needle-shaped body material and peeling it from the needle-shaped body replication plate;
A method for producing a needle-like body comprising:   The method for manufacturing a needlelike object according to claim 1, wherein the linear expansion coefficient of the duplicate plate material is smaller than the linear expansion coefficient of the needlelike material.   The needle-shaped body manufacturing method according to claim 1, wherein the filler has a particle size of 10 nm to 100 μm.   The said filler is any one of a silica, a titanium oxide, and zinc, The manufacturing method of the acicular body in any one of Claims 1-3 characterized by the above-mentioned.

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