JP2015062518A - Manufacturing method for needle-like body - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a manufacturing method for a needle-like body by which tip ends of needle-like parts of the needle-like body are stable in shape.SOLUTION: A needle-like body 1 includes: needle-like parts having a needle-like shape; and a support substrate for supporting base ends of the needle-like parts. A concave plate 10 is prepared which includes recess parts 1004 corresponding to the needle-like parts on a surface 1002. The concave plate 10 that is manufactured is exposed to a solvent vapor 12 of a needle-like body formation liquid. Thus, a sticking step is made in which a solvent 16 for dissolving a needle-like body formation material that forms the needle-like body 1 is made to stick to the surface 1002 that has the recess parts 1004. A filling step is performed in which the needle-like body formation liquid 18 containing the solvent 16 and the needle-like body formation material is filled into the surface 1002 having the recess parts 1004, of the concave plate 10. A needle-like body formation step is performed in which the needle-like body 1 is formed by drying and solidifying the needle-like body formation liquid. A peeling step is performed in which the needle-like body 1 is peeled from the concave plate 10, to provide the needle-like body 1.

Description

  The present invention relates to a method for manufacturing a needle-shaped body.

  The percutaneous absorption method, which is a method of injecting a delivery product such as a drug from the skin and administering the delivery product into the body, is used as a method capable of easily administering the delivery product without causing pain to the human body. .

  In the field of transdermal administration, a method has been proposed in which a skin is perforated using a needle-like body having a needle-like shape having a needle shape on the order of μm, and a drug or the like is administered into the skin (Patent Literature). 1).

  Further, as a method for producing a needle-like body, it has been proposed to prepare an original plate using machining, form a transfer plate from the original plate, and perform transfer processing molding using the transfer plate (Patent Document 2). reference).

  Further, as a method for producing a needle-like body, it has been proposed to prepare an original plate using an etching method, form a transfer plate from the original plate, and perform transfer processing molding using the transfer plate (Patent Document 3). reference).

  In addition, the material constituting the needle-shaped body is desirably a material that does not adversely affect the human body even if the damaged needle-shaped portion remains in the body, and such materials include chitin and chitosan. Biocompatible materials have been proposed (see Patent Document 4).

  In the case of producing a needle-shaped body using such a biocompatible material, it is generally produced by filling the transfer plate with a solution of the material and then removing the solvent by a method such as drying.

JP-A-48-93192 International Publication No. 2008/013282 Pamphlet International Publication No. 2008/004597 Pamphlet International Publication No. 2008/020632 Pamphlet

  However, if the material solution is simply poured into the transfer plate, the material solution is not filled to every corner of the transfer plate having fine concave portions, and it is difficult to obtain a needle-like body having a stable shape at the tip of the needle-like portion. Therefore, an object of the present invention is to provide a method for manufacturing a needle-shaped body for solving the problem.

In order to solve the above-mentioned problem, the invention according to claim 1 is a method of manufacturing a needle-like body comprising a needle-like portion having a needle-like shape and a support substrate that supports a base end of the needle-like portion. An adhesion step of preparing an intaglio plate having a concave portion corresponding to the needle-like portion on the surface, and attaching a solvent for dissolving the needle-like body forming material forming the needle-like body to the surface including the concave portion; And a filling step of filling the surface including the concave portion with a needle-like body forming liquid containing the needle-like body forming material, and a needle-like shape forming the needle-like body by drying and solidifying the needle-like body forming liquid A body forming step, and a peeling step of peeling the needle-like body from the intaglio.
The invention according to claim 2 is characterized in that the attaching step is performed by exposing the intaglio to an atmosphere in the range of 70% to 100% of the saturated vapor pressure of the solvent. It is a manufacturing method of the acicular body of description.
The invention according to claim 3 is characterized in that the attaching step is performed in a temperature range of 50 ° C. or higher and 100 ° C. or lower, and the solvent is water. It is.

  According to the method for manufacturing a needle-shaped body of the present invention, before filling the intaglio with the needle-shaped body forming liquid solution, the attaching step of attaching a solvent for dissolving the needle-shaped body forming material that forms the needle-shaped body to the intaglio is performed. By providing, it is advantageous in obtaining a needle-like body having a stable shape at the tip of the needle-like portion.

It is a perspective view of the needlelike object manufactured by the manufacturing method of the needlelike object of an embodiment. (A) is a top view from the acicular part side of the acicular body manufactured by the manufacturing method of the acicular body of embodiment, (b) is the cross section in the II 'surface of the acicular body in (a). FIG. (A), (b) is explanatory drawing of an adhesion process, (c) is explanatory drawing of a filling process, (d) is explanatory drawing of the acicular body obtained by the peeling process.

  The method for producing a needle-like body of the present invention is a method for producing a needle-like body comprising a needle-like portion having a needle-like shape and a support substrate that supports the proximal end of the needle-like portion, Preparing an intaglio plate with a concave portion corresponding to the needle-shaped portion, and attaching a solvent that dissolves the needle-shaped body forming material that forms the needle-shaped body to the surface including the concave portion; and the solvent and the needle shape A filling step of filling the surface including the concave portion with a needle-like body forming liquid containing a body-forming material; and a needle-like body forming step of forming the needle-like body by drying and solidifying the needle-like body forming liquid. And a peeling step of peeling the needle-like body from the intaglio. By using the manufacturing method of the needle-like body of this configuration, the needle-like body tip obtained can be a stable needle-like body.

  Furthermore, it is preferable that the adhesion step is performed by exposing the intaglio to an atmosphere within a range of 70% to 100% of the saturated vapor pressure of the solvent. By setting the vapor pressure within the range, the solvent can be adhered to the details of the intaglio.

  Furthermore, it is preferable that the adhesion step is performed in a temperature range of 50 ° C. or higher and 100 ° C. or lower, and the solvent is water. By setting this temperature range, the solvent can be adhered to the details of the intaglio.

  Embodiments of the present invention will be described in detail with reference to the drawings. First, the structure and material of the needle-shaped body of the present invention will be described, and then the method for producing the needle-shaped body will be described.

FIG. 1 shows a perspective view of the needle-shaped body of the present invention. FIG. 2 shows a schematic diagram of the needle-shaped body of the present invention.
The needle-like body 1 of the present invention refers to a molded body composed of a support substrate 32 and a needle-like portion 34. In other words, the needle-like body 1 includes a needle-like portion 34 having a needle-like shape and a support substrate 32 that supports the proximal end of the needle-like portion 34.
The shape of the needle-shaped portion 34 may be any shape as long as it is suitable for puncturing the skin, and may be designed as appropriate. Specifically, the shape of the needle-like portion 34 may be a cone, a pyramid, a cylinder, a prism, a pencil shape (a body portion is a column shape, and a tip portion is a cone shape), and the like. Further, either (1) the shape of the needle-shaped portion 34 on the support substrate 32 or (2) the shape of the plurality of needle-shaped portions 34 standing on the support substrate 32 may be used.

  In addition, when a plurality of needle-like portions 34 are erected on the support substrate 32, the needle-like portions 34 are preferably arranged in an array. Here, “array shape” indicates a state in which the unit needle-like bodies are arranged, and includes, for example, patterns such as a lattice arrangement, a close-packed arrangement, a concentric arrangement, and a random arrangement. Shall be.

FIG. 2A is a top view from the needle-like part side of the needle-like body, and FIG. 2B is a cross-sectional view of the needle-like body taken along the line II ′ in FIG.
In the needle-like body 1 of the present invention, it is preferable that the size of the needle-like needle-like portion 34 has a thinness and length suitable for forming a puncture hole in the skin. Specifically, the height H of the needle-like portion 34 shown in FIG. 2B is preferably in the range of 10 μm or more and 1000 μm or less. The height H of the needle-like part 34 is the distance from the support substrate 32 to the tip of the needle-like part 34.
The height H of the needle-shaped part 34 is preferably determined in consideration of how deep the puncture hole formed when the needle-shaped part 34 is punctured within the above range is formed in the skin.
In particular, when the puncture hole formed when the needle-like portion 34 is punctured is held “in the stratum corneum”, the height H of the needle-like portion 34 of the needle-like body 1 is, for example, 10 μm to 300 μm, more preferably 30 μm. It is desirable to set it within the range of 200 μm or less.
When the puncture hole formed when the needle-like portion 34 is punctured is kept at a “length that penetrates the stratum corneum and does not reach the nerve layer”, the height H of the needle-like portion 34 of the needle-like body 1 Is preferably in the range of 200 μm to 700 μm, more preferably 200 μm to 500 μm, and still more preferably 200 μm to 300 μm.
Further, when the puncture hole formed when puncturing the needle-like portion 34 is “the length that the puncture hole reaches the dermis”, the height H of the needle-like portion 34 of the needle-like body 1 is 200 μm or more and 500 μm or less. It is preferable to be within the range. When the puncture hole formed when puncturing the needle-like portion 34 is “the length that the puncture hole reaches the epidermis”, the height H of the needle-like portion 34 of the needle-like body 1 is 200 μm or more and 300 μm or less. It is preferable to be within the range.

The width D of the acicular portion 34 is preferably in the range of 1 μm to 300 μm. The width D of the needle-shaped part 34 is preferably determined in consideration of the depth of the puncture hole formed when the needle-shaped part 34 is punctured within the above range.
The width D of the needle-like portion 34 is set so that the needle-like portion 34 is projected on the substrate surface (surface) of the support substrate 32 perpendicularly to the substrate surface in the outline of the needle-like portion 34 projected onto the substrate surface. This is the largest dimension in the dimension along the direction.
For example, when the needle-shaped part 34 is conical, the width D is a diameter of a circle formed by an intersecting line where the outer peripheral surface of the needle-shaped part 34 intersects the surface of the support substrate 32. When the needle-like portion 34 is a regular quadrangular pyramid, a square diagonal line formed by an intersecting line where the outer peripheral surface of the needle-like portion 34 and the surface of the support substrate 32 intersect has a width D. Further, when the needle-like portion 34 is a cylinder, the width D is a diameter of a circle formed by an intersecting line where the outer peripheral surface of the needle-like portion 34 and the surface of the support substrate 32 intersect. When the acicular portion 34 is a regular quadrangular prism, a square diagonal line formed by an intersecting line where the outer peripheral surface of the acicular portion 34 and the surface of the support substrate 32 intersect has a width D.

The aspect ratio is preferably in the range of 1 to 10. The aspect ratio A is defined by A = H / D using the length H and the width D of the needle-like portion 34.
In the needle-like body 1 according to the embodiment, when the needle-like portion 34 has a tip angle like a cone shape and penetrates the stratum corneum, the tip angle θ of the needle-like portion 34 is 5 ° or more and 30 ° or less. Preferably, it is within a range of 10 ° to 20 °. The tip angle θ indicates the maximum angle (vertical angle) when the needle-like portion 34 is projected in parallel with the substrate surface of the support substrate 32.

  The material constituting the needles in the present invention is preferably a biodegradable polysaccharide, such as dextran, dextrin, pectin, pullulan, chondroitin sulfate, alginate, chitosan, carboxymethylcellulose, hydroxymethylcellulose, hydroxyethylcellulose, hydroxypropyl. There are cellulose, methylcellulose, ethylcellulose and the like. Moreover, the mixture of these biodegradable polysaccharides may be sufficient. By using a biodegradable polysaccharide, the needle-like part 34 can be dissolved in the skin after the needle-like part 34 is punctured into the skin. Therefore, when the medicinal component is contained in the needle-like body 1, the delivery product can be quickly introduced into the skin.

  The needle-shaped body of the present invention can include a delivery product for delivery into the skin. Delivery products may include pharmacologically active substances and cosmetic delivery products. At this time, when a material having a fragrance is used as a delivery product, an odor can be imparted during use, which is preferable for use as a cosmetic product.

  The pharmacologically active substance may be appropriately selected depending on the application. For example, it may be a vaccine such as influenza, an anti-pain drug for cancer patients, insulin, a biologic, a gene therapy drug, an injection, an oral preparation, a preparation for skin application, and the like. Since the needle-shaped body of the present invention punctures the skin, it can be applied to pharmacologically active substances that require subcutaneous injection in addition to pharmacologically active substances that are conventionally used for transdermal administration. In particular, vaccines that are injections are suitable for application to children because there is no pain in administration when needles are used. In addition, it is difficult for children to take an oral agent by conventional oral administration, but when a needle-shaped body is used, it is not necessary to drink a drug at the time of administration, so it is suitable for application to children.

  In the dissolution type needle-like body in which the punctured needle is eluted into the skin and the delivery product is delivered into the body, the delivery product is contained inside the needle-like body. However, there is a problem that the drug that does not elute into the skin and remains on the support substrate of the needle-like body is wasted. By containing the delivery product only in the needle-like portion side layer, waste of the drug can be solved.

  The cosmetic composition is a composition used as a cosmetic product and a cosmetic product. For example, moisturizers, colorants, fragrances, and physiologically active substances that exhibit cosmetic effects (improvement effect on wrinkles, acne, pregnancy lines, improvement effect on hair loss, etc.), and the like.

  In particular, when the depth of the puncture hole is kept “in the stratum corneum”, the delivery product can be retained in the stratum corneum. Since the stratum corneum is constantly generated by metabolism, the deliverables in the stratum corneum are discharged out of the body with time. For this reason, a delivery thing can be excluded by washing | cleaning skin, peeling skin, etc.

  In addition, when the “puncture hole passes through the stratum corneum and does not reach the nerve layer”, the delivery product can be delivered deeper than the stratum corneum. Since the puncture hole formed in the stratum corneum is closed over time, the delivery delivered under the stratum corneum is held in the living body while being blocked by the stratum corneum from the outside. For this reason, the delivered product can be reduced for exfoliation due to metabolism of the stratum corneum and washing such as skin care, and can be held for a long time.

  For this reason, since it can maintain a long-term makeup state when used for cosmetic purposes, it is particularly at sites where long-term color retention is required, such as the eyebrows, around the eyes, around the lips, etc. It can be suitably used for the delivery of cosmetic compositions.

  Further, it can be suitably used as a prescription (makeup, treatment, etc.) corresponding to skin abnormalities (spot-like spots, etc.) caused by sites below the stratum corneum.

  On the other hand, when the delivery product is administered with a needle-like body, the delivery product may be applied onto the target skin before or after the needle-like body is punctured into the skin. At this time, the delivery material may be placed on the needle-like body, and the delivery material may be applied to the target skin surface.

  In addition, the needle-like body of the present invention may have a delivery product on the surface of the needle-like portion 34.

  In the needle-like body of the present invention, the support substrate 32 may have flexibility. By using the support substrate 32 having flexibility, it is possible to suitably puncture a flexible object such as a curved surface or biological skin. Moreover, when it has flexibility, the roller which the needle-shaped part 34 stood can be formed by making it roll shape.

  In the prescription using the needle-shaped body of the present invention, an applicator for fixing the insertion position and direction may be used.

  Next, the manufacturing method of the said acicular body is demonstrated.

  FIG. 3 is an explanatory view of the method for producing the needle-shaped body of the present invention.

<Process for producing intaglio>
Next, an intaglio 10 having a needle-like pattern is prepared.
In other words, as shown in FIG. 3A, an intaglio 10 having a concave portion 1004 corresponding to the needle-like portion 34 on the surface 1002 is prepared.
As a manufacturing method of the original plate for determining the shape of the needle-like body 1, a known manufacturing method may be appropriately used according to the shape of the needle-like body 1. At this time, the original plate may be formed using a fine processing technique. For example, a lithography method, a wet etching method, a dry etching method, a sand blasting method, a laser processing method, or a precision machining method may be used as the fine processing technology. good. As a method of forming the intaglio 10 from the original plate, a known shape transfer method may be used as appropriate. For example, (1) Ni intaglio is formed by Ni electroforming, and (2) transfer molding using a molten resin.

<Step of attaching the solvent to the intaglio>
Next, the manufactured intaglio 10 is exposed to the solvent vapor 12 of the needle-like body forming liquid (FIG. 3A). Thereby, the solvent 16 can adhere to the surface of the recess 1004 of the intaglio 10.
That is, an attaching step is performed in which the solvent 16 that dissolves the needle-like body forming material that forms the needle-like body 1 is attached to the surface 1002 including the concave portion 1004.
As a method for attaching the solvent 16 to the surface of the concave portion 1004 of the intaglio 10, a method in which the intaglio 10 is exposed in an atmosphere of 70% to 100% of the saturated vapor pressure of the solvent 16 of the needle-like body forming liquid is suitably employed. be able to.
In addition, as a method of attaching the solvent 16 to the surface of the recess 1004 of the intaglio 10, a method of spraying the solvent 16 on the intaglio 10 by spraying or spraying, a method of immersing the intaglio 10 in the solvent 16, A method of dropping the solvent 16 into the recess 1004 can be employed. However, in the case of the method of spraying the solvent 16 by spraying or spraying, or the method of immersing the intaglio 10 in the solvent 16, the solvent 16 does not sufficiently enter the recess 1004 of the intaglio 10, and the solvent 16 enters the surface of the recess 1004 of the intaglio 10. May not be able to adhere. Moreover, in the case of the method of dripping the solvent 16 in the recessed part 1004 by the inkjet method, there exists a possibility that manufacturing cost may become high.
In the method in which the intaglio 10 is exposed in an atmosphere of 70% to 100% of the saturated vapor pressure of the solvent 16 of the acicular body forming liquid, the width of the acicular portion 34 is 1 μm to 300 μm, and the aspect ratio is 1 When the acicular body 1 within the range of 10 or less is produced, the solvent 16 can be attached to the surface of the concave portion 1004 of the intaglio 10 most efficiently.
The solvent vapor 12 of the acicular body forming liquid is 70% or more and 100% or less of the saturated vapor pressure of the solvent 16 of the acicular body forming liquid, so that the solvent 16 is attached over the details of the intaglio 10 (the entire area of the concave portion 1004). This is preferable.
If the solvent vapor 12 is less than 70% of the saturated vapor pressure of the solvent 16 of the needle-like body forming liquid, the amount of vapor is insufficient, which is disadvantageous in that the solvent 16 may not adhere sufficiently to the surface of the recess 1004.
If the solvent vapor 12 exceeds 100% of the saturated vapor pressure of the solvent 16 of the needle-like body forming liquid, the solvent 16 cannot exist as vapor and aggregates as a liquid, so that the solvent is uniformly distributed on the surface of the recess 1004. This is disadvantageous in that it may not adhere.
The solvent 16 for the acicular body forming liquid may be any solvent that dissolves the acicular body forming material, and water is used. In addition to water, other solvent components such as alcohol may be added. When the solvent 16 is water, the temperature is preferably set to 50 ° C. or more and 100 ° C. or less in order to adhere the solvent 16 over the details of the intaglio 10 (entire region of the recess 1004).
When the temperature is less than 50 ° C., the solvent 16 may not be sufficiently adhered to the recess 1004 of the intaglio 10.
When the temperature exceeds 100 ° C., it is disadvantageous in that the attached solvent 16 evaporates immediately.
The time for exposing the intaglio 10 to the solvent vapor 16 of the needle-like body forming liquid is preferably 5 minutes or more. Thereafter, when the intaglio 10 is taken out, the concave portion 1004 is filled with the solvent 16 of the needle-like body forming liquid (FIG. 3B).

<Step of filling the needle-shaped body forming liquid>
Next, as shown in FIG. 3C, the needle-like body forming liquid 18 is supplied to the intaglio 10.
In other words, a filling step of filling the surface 1004 including the concave portion 1002 of the intaglio 10 with the needle-like body forming liquid 18 containing the solvent 16 and the needle-like body forming material is performed.
About the supply method of the acicular body formation liquid 18, you may select a well-known method suitably according to the shape and dimension of the intaglio 10. For example, as a method for supplying the needle-like body forming liquid 18, a spin coating method, an ink jet method, a method using a dispenser, a casting method, or the like may be used. Further, when filling, the environment around the intaglio 10 may be under reduced pressure or under vacuum.

<Step of drying the needle-shaped body forming liquid>
Next, a needle-like body forming step for forming the needle-like body 1 by drying and solidifying the needle-like body forming liquid 18 is performed.
The drying method may be appropriately selected according to the environment such as natural drying, bottom surface heating using a hot plate, and drying by hot air drying. However, it is necessary to perform the drying temperature at a temperature at which the aqueous solution (needle forming liquid) does not boil. The drying temperature is preferably at least 110 ° C. or lower.

<Step of peeling the needle-like body from the intaglio>
After the drying is completed, a peeling step for peeling the needle-like body 1 from the intaglio 10 is performed, so that the needle-like body 1 can be obtained (FIG. 3D).

  EXAMPLES Hereinafter, although this invention is demonstrated in detail using an Example and a comparative example, this invention is not limited to this form.

[Example 1]
A needle-like body was produced by the following method.
(1) First, acicular body original plates were formed on a silicon substrate by using precision machining, with 36 square pyramids (bottom surface 38 μm × 38 μm, height 120 μm) arranged in a grid of 6 rows and 6 rows at 1 mm intervals. . Next, a nickel film having a thickness of 500 μm is formed on the acicular body original plate formed of the silicon substrate by plating, and the silicon substrate is heated with a 30% by weight potassium hydroxide aqueous solution heated to 90 ° C. The intaglio plate made of nickel was prepared by wet etching.
(2) A 10% by weight aqueous solution of pullulan (Tokyo Chemical Industry Co., Ltd.) was prepared.
(3) The intaglio was placed in a thermo-hygrostat set to 80 ° C./80% RH for 30 minutes.
(4) The intaglio was removed from the thermo-hygrostat, and the pullulan aqueous solution prepared in (2) was poured using a dispenser method.
(5) An intaglio filled with an aqueous pullulan solution was placed on a hot plate set at 90 ° C., and dried for 30 minutes to evaporate water.
(6) The acicular body was peeled from the intaglio.

[Comparative Example 1]
A needle-like body was produced by the following method.
(1) First, the same intaglio plate made of nickel as in Example 1 was prepared.
(2) A 10% by weight aqueous solution of pullulan (Tokyo Chemical Industry Co., Ltd.) was prepared.
(3) The pullulan aqueous solution prepared in (2) was poured into the intaglio using the dispenser method.
(4) An intaglio plate filled with an aqueous pullulan solution was placed on a hot plate set at 90 ° C. and dried for 30 minutes to evaporate water.
(5) The acicular body was peeled from the intaglio.

(result)
When the needle-like bodies of Example 1 and Comparative Example 1 were observed with an optical microscope, it was confirmed that the needle-like body of Example 1 was formed up to the needle tip with all 36 needles (needle-like portions). However, in the needle-like body of Comparative Example 1, the material was not filled up to the tip of any needle.

[Example 2]
A needle-like body was produced by the following method.
(1) First, acicular body original plates were formed on a silicon substrate by using precision machining, with 36 square pyramids (bottom surface 38 μm × 38 μm, height 120 μm) arranged in a grid of 6 rows and 6 rows at 1 mm intervals. . Next, a thermosetting silicone resin was applied to the acicular body original plate formed of the silicon substrate, and then heated and cured. Thereafter, the original needle plate was peeled off to produce an intaglio plate made of silicone resin.
(2) A 2% by weight aqueous solution of carboxymethylcellulose (Tokyo Chemical Industry Co., Ltd.) was prepared.
(3) The intaglio was placed in a thermo-hygrostat set to 80 ° C./80% RH for 30 minutes.
(4) The intaglio was removed from the thermo-hygrostat, and the carboxymethyl cellulose aqueous solution prepared in (2) was poured using a dispenser method.
(5) An intaglio filled with an aqueous carboxymethyl cellulose solution was placed on a hot plate set at 90 ° C., and dried for 30 minutes to evaporate water.
(6) The acicular body was peeled from the intaglio.

[Comparative Example 2]
A needle-like body was produced by the following method.
(1) First, an intaglio plate made of the same silicone resin as in Example 2 was produced.
(2) A 2% by weight aqueous solution of carboxymethylcellulose (Tokyo Chemical Industry Co., Ltd.) was prepared.
(3) The carboxymethylcellulose aqueous solution prepared in (2) was poured into the intaglio using a dispenser method.
(4) An intaglio plate filled with an aqueous carboxymethyl cellulose solution was placed on a hot plate set at 90 ° C., and dried for 30 minutes to evaporate water.
(5) The acicular body was peeled from the intaglio.

(result)
When the needle-like bodies of Example 2 and Comparative Example 2 were observed with an optical microscope, it was confirmed that the needle-like body of Example 2 was formed up to the needle tip with all 36 needles (needle-like portions). However, in the needle-like body of Comparative Example 2, the material was not filled up to the tip of any needle.

  The acicular body of the present invention can be used in various fields that require fine acicular bodies. For example, it can be expected to be applied as a needle-like body used for MEMS devices, optical members, sample jigs, drug discovery, medical use, cosmetics, cosmetic use, and the like.

DESCRIPTION OF SYMBOLS 1 ... Needle-like body 10 ... Intaglio 1002 ... Surface 1004 ... Concavity 12 ... Solvent vapor 16 of needle-like body forming liquid ... Solvent 18 of needle-like body forming liquid ... Needle Shaped body forming liquid 34 ... acicular part 32 ... support substrate

Claims (3)

A method of manufacturing a needle-like body comprising a needle-like portion having a needle-like shape and a support substrate that supports a base end of the needle-like portion,
Prepare an intaglio plate with a concave portion corresponding to the needle-like portion on the surface,
An attaching step of attaching a solvent that dissolves the needle-like body forming material that forms the needle-like body to the surface including the concave portion;
A filling step of filling the surface containing the concave portion with a needle-like body forming liquid containing the solvent and the needle-like body forming material;
A needle-like body forming step of forming the needle-like body by drying and solidifying the needle-like body forming liquid;
A peeling step of peeling the needle-like body from the intaglio,
A method for producing a needle-like body comprising: The attaching step is performed by exposing the intaglio plate to an atmosphere in the range of 70% to 100% of the saturated vapor pressure of the solvent.
The method for producing a needle-like body according to claim 1. The attaching step is performed in a temperature range of 50 ° C. or more and 100 ° C. or less, and the solvent is water;
The method for producing a needle-shaped body according to claim 1 or 2, wherein

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