JP2015029461A5 - - Google Patents
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- JP2015029461A5 JP2015029461A5 JP2013161165A JP2013161165A JP2015029461A5 JP 2015029461 A5 JP2015029461 A5 JP 2015029461A5 JP 2013161165 A JP2013161165 A JP 2013161165A JP 2013161165 A JP2013161165 A JP 2013161165A JP 2015029461 A5 JP2015029461 A5 JP 2015029461A5
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- JP
- Japan
- Prior art keywords
- imaging
- light source
- biological sample
- imaging device
- sample holding
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 238000003384 imaging method Methods 0.000 claims 17
- 239000012472 biological sample Substances 0.000 claims 6
- 239000000523 sample Substances 0.000 claims 6
- 230000003287 optical Effects 0.000 claims 2
Claims (6)
前記試料保持手段を照明する光源と、
前記試料保持手段を介して前記光源と対向して配置され、前記光源で照明された前記生体試料を3倍以下の倍率で撮像する撮像手段と、を備える、
撮像装置。 A sample holding means configured so that a biological sample is disposed inside and optical observation of the biological sample is possible from the outside;
A light source for illuminating the sample holding means;
An imaging unit that is arranged to face the light source via the sample holding unit and that images the biological sample illuminated by the light source at a magnification of 3 times or less,
Imaging device.
複数の前記光源が、前記複数の撮像手段のそれぞれに対応するように配置される、
請求項1に記載の撮像装置。 A plurality of the imaging means are disposed on the first surface;
The plurality of light sources are arranged to correspond to each of the plurality of imaging means.
The imaging device according to claim 1.
前記マイクロ流路の複数箇所が観察できる位置に、前記複数の前記撮像手段の全部又は一部が配置される、
請求項2に記載の撮像装置。 One or two or more sample holding means are formed with a microchannel configured as a flow cell through which the biological sample flows,
All or a part of the plurality of the imaging means is arranged at a position where a plurality of locations of the microchannel can be observed.
The imaging device according to claim 2 .
1つの前記撮像手段に対して前記光源である第1の光源及び第2の光源が設けられ、
前記第1の光源で照明した場合に前記1つの撮像手段が取得する像が、前記第2の光源で照明した場合に前記1つの撮像手段が取得する像に対して、前記1つの撮像手段の画素の略半分だけ位置が異なる、
請求項1乃至3のいずれか一項に記載の撮像装置。 The distance between the biological sample in the sample holding means and the imaging means is 1 mm or less,
A first light source and a second light source, which are the light sources, are provided for one imaging means;
The image acquired by the one imaging unit when illuminated by the first light source is compared with the image acquired by the one imaging unit when illuminated by the second light source. position by approximately half the pixels that Do different,
The imaging device according to any one of claims 1 to 3.
請求項1乃至4のいずれか一項に記載の撮像装置。 An optical system that is disposed between the sample holding unit and the imaging unit and forms an image of the biological sample on the imaging unit;
The imaging device according to any one of claims 1 to 4.
請求項1乃至5のいずれか一項に記載の撮像装置。 The imaging means is a CCD or CMOS image sensor.
The imaging device according to any one of claims 1 to 5.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2013161165A JP2015029461A (en) | 2013-08-02 | 2013-08-02 | Imaging device |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP2013161165A JP2015029461A (en) | 2013-08-02 | 2013-08-02 | Imaging device |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2015029461A JP2015029461A (en) | 2015-02-16 |
JP2015029461A5 true JP2015029461A5 (en) | 2016-09-23 |
Family
ID=52515339
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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JP2013161165A Pending JP2015029461A (en) | 2013-08-02 | 2013-08-02 | Imaging device |
Country Status (1)
Country | Link |
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JP (1) | JP2015029461A (en) |
Families Citing this family (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6416051B2 (en) * | 2015-07-24 | 2018-10-31 | Ckd株式会社 | CULTURE UNIT AND CULTURE DEVICE PROVIDED WITH IT |
JP6382875B2 (en) | 2016-03-15 | 2018-08-29 | 株式会社東芝 | Optical sensor, analysis apparatus, and analysis method |
JPWO2018207361A1 (en) | 2017-05-12 | 2020-03-12 | オリンパス株式会社 | Cell image acquisition device |
JP7273987B2 (en) * | 2019-10-25 | 2023-05-15 | 株式会社東芝 | Methods, kits and programs for characterizing tumor cell populations |
CN112266846A (en) * | 2020-11-19 | 2021-01-26 | 北京麦科伦科技有限公司 | Culture dish frame fixed bolster, incubator and biological sample form imaging device |
CN113801788A (en) * | 2021-08-30 | 2021-12-17 | 西安理工大学 | Cell culture device and method for monitoring cell growth state in real time |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2000261629A (en) * | 1999-03-10 | 2000-09-22 | Ricoh Co Ltd | Image reader |
JP4472166B2 (en) * | 2000-12-22 | 2010-06-02 | オリンパス株式会社 | 3D imaging equipment |
JP4889437B2 (en) * | 2006-10-16 | 2012-03-07 | オリンパス株式会社 | Weak light imaging device |
JP2008237064A (en) * | 2007-03-26 | 2008-10-09 | Tsuru Gakuen | Apparatus for observing cell and method for observing cell |
WO2011004568A1 (en) * | 2009-07-08 | 2011-01-13 | 株式会社ニコン | Image processing method for observation of fertilized eggs, image processing program, image processing device, and method for producing fertilized eggs |
JP5659158B2 (en) * | 2009-07-21 | 2015-01-28 | 国立大学法人京都大学 | Image processing apparatus, culture observation apparatus, and image processing method |
SG182625A1 (en) * | 2010-01-20 | 2012-08-30 | Emd Millipore Corp | Cell image capturing and remote monitoring systems |
JP5556444B2 (en) * | 2010-06-30 | 2014-07-23 | 株式会社ニコン | Microscope, culture observation equipment |
JP2012231764A (en) * | 2011-05-08 | 2012-11-29 | Kyokko Denki Kk | Apparatus and method for sorting and acquiring cell aggregate |
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2013
- 2013-08-02 JP JP2013161165A patent/JP2015029461A/en active Pending
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