JP2015013834A - Attachment sheet with a support frame - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an attachment sheet with a support frame which can attach to an attached subject without damaging the attached subject an attachment sheet which can be stably stuck even to a mobility uneven surface without using an adhesive compound.SOLUTION: Provided is an attachment sheet with a support frame comprising an attachment sheet having a gel membrane which is a hydrogel film or a dry gel film obtained by gelating bubble films; and a support frame having an aperture and supporting the above attachment sheet arranged to block the above aperture, the component of the above support frame having a porous structure.

Description

  The present invention is a sticker with a support frame that can be applied to an object to be attached without damaging the object to be attached, by using an adhesive sheet that can stably adhere to a moving uneven surface without using an adhesive component. It is related to the sheet.

As a patch sheet to be affixed to the surface of the skin, a cosmetic pack sheet for beauty and a medical haptic agent are known.
As such a sticking sheet, for example, a sheet-shaped pack cosmetic based on a self-crosslinking alkylcellulose derivative hydrogel obtained by irradiation of an alkylcellulose derivative is disclosed (for example, Patent Document 1).

  Patent Document 2 discloses a method for producing a polymer self-supporting film by drying a foam film of an aqueous solution of a surface active polymer stretched on a frame. According to such a method, a polymer self-supporting film having a thickness of nanometer order can be manufactured.

  Patent Document 3 discloses that a thin film polymer structure (nanosheet) having a functional substance on both sides is stuck on the surface of the skin. In this document, the thin film polymer structure is applied to the skin while being supported on the surface of a soluble support membrane, and the soluble support membrane is dissolved after application to leave the thin film polymer structure on the skin. The technique of, is disclosed.

Japanese Patent No. 4596774 JP 2011-143332 A WO2008 / 050913

However, these adhesive sheets can be stably adhered to a living body surface or the like, in particular, a moving uneven surface unless there is a complicated operation such as using an adhesive or dissolving a soluble support film. There is a problem that it is difficult.
Further, the method for producing a thin film disclosed in Patent Document 2 in which a foam film of an aqueous solution of a surface active polymer compound such as gelatin is dried at room temperature is used when the concentration of the polymer compound in the foam film is low. There is a problem that the foam film is broken and a thin film cannot be formed.
Furthermore, there is a problem in that when the sticking sheet is stuck to the sticking object while being supported by the support frame, the sticking object may be damaged by the support frame.

  The present invention has been made in view of the above circumstances, and without using an adhesive component, an adhesive sheet that can stably adhere to a moving uneven surface without damaging an object to be applied. The main object is to provide a sheet for sticking with a support frame that can be stuck on an object to be stuck.

  In order to achieve the above object, the present invention has an adhesive sheet having a gel film which is a hydrogel film or a dry gel film in which a foam film is gelled, an opening, and is arranged so as to close the opening And a support frame for supporting the sticking sheet, and a constituent material of the support frame has a porous structure.

  The present invention supports an adhesive sheet having a gel film that is a hydrogel film or a dry gel film obtained by gelling a foam film, and the adhesive sheet that has an opening and is arranged so as to close the opening. A support frame with a support frame, wherein the support frame has a convex portion arranged on the non-stick surface side of the sticking sheet.

  The present invention supports an adhesive sheet having a gel film that is a hydrogel film or a dry gel film obtained by gelling a foam film, and the adhesive sheet that has an opening and is arranged so as to close the opening. A support frame attached sheet, wherein the Young's modulus of the constituent material of the support frame is equal to or lower than the Young's modulus of the object to be pasted.

According to the present invention, since the adhesive sheet has a gel film, it can be adhered to a living body or a biological material with sufficient strength without using an adhesive component, and has a movement. Even when affixed to an uneven surface, it can be made difficult to peel off.
Moreover, by having the said support frame, the sheet | seat for a sticking | pasting can be stuck on a to-be-adhered thing, without damaging to-be-attached object.

  In the present invention, with a support frame that can be applied to an object to be attached without damaging the object to be attached, the adhesive sheet that can stably adhere to a moving uneven surface without using an adhesive component There exists an effect that the sheet | seat for sticking can be provided.

It is a schematic plan view which shows an example of the sheet | seat for sticking with a support frame of this aspect. It is an example of the sectional view on the AA line of FIG. It is another example of the sectional view on the AA line of FIG. It is a schematic diagram which shows an example of the usage method of the sheet | seat for sticking in this aspect. It is a schematic diagram which shows the other example of the usage method of the sheet | seat for sticking in this aspect. It is a schematic process drawing which shows an example of the formation method of the gel film used for this aspect. It is a schematic process drawing which shows the other example of the formation method of the gel film used for this aspect. It is a schematic sectional drawing which shows the other example of the sheet | seat for sticking with a support frame of this aspect. It is a schematic sectional drawing which shows the other example of the sheet | seat for sticking with a support frame of this aspect. It is a schematic plan view which shows the other example of the sheet | seat for sticking with a support frame of this aspect. It is the BB sectional view taken on the line of FIG.

Hereinafter, the sticking sheet with a support frame of the present invention will be described.
The sticking sheet with a support frame of the present invention includes a sticking sheet having a gel film which is a hydrogel film or a dry gel film in which a foam film is gelled, and an opening, and is arranged so as to close the opening. A support frame with a support frame that supports the above-mentioned sticking sheet, wherein the constituent material of the support frame has a porous structure (first embodiment), the support frame, An aspect (second embodiment) having a convex portion arranged on the non-sticking surface side of the sticking sheet, an aspect in which the Young's modulus of the constituent material of the support frame is less than or equal to the Young's modulus of the article to be stuck (third It can be roughly divided into three embodiments).
Hereinafter, the sheet for sticking with a support frame of the present invention will be described separately for each embodiment.

A. 1st embodiment First, the 1st embodiment of the sheet | seat for sticking with a support frame of this invention is demonstrated. The sheet for sticking with a support frame according to this aspect is the sheet for sticking with a support frame described above, and the constituent material of the support frame has a porous structure.

Such a sticking sheet with a support frame according to this aspect will be described with reference to the drawings. FIG. 1 is a schematic plan view showing an example of a sticking sheet with a support frame of the present invention. 2 is an example of a cross-sectional view taken along line AA in FIG. 1, and FIG. 3 is another example of a cross-sectional view taken along line AA in FIG. As illustrated in FIG. 1 to FIG. 3, the sticking sheet 10 with a support frame of the present embodiment includes a sticking sheet 4 having a gel film 2 that is a hydrogel film or a dry gel film obtained by gelling a foam film, And a support frame 1 that supports the sticking sheet 4 disposed so as to close the opening 11, and the constituent material of the support frame has a porous structure.
In this example, the support frame 1 shows an example having only the frame portion 1a. FIG. 2 shows an example in which the sticking sheet 4 has only the gel film 2, and FIG. 3 shows an example in which the sticking sheet 4 has the gel film 2 and the functional layer 3.

  According to this aspect, as illustrated in FIG. 4, the support frame having the flexible support frame 1 and the sticking sheet 4 having the gel film 2 stretched so as to close the opening 11 of the support frame 1. The attached sheet 10 (FIG. 4A) can be deformed along the surface shape of the article 40 whose surface is not flat, and the attached sheet 4 is fixed to the support frame 1. The surface of the gel film 2 can be adhered and adhered sufficiently to the surface of the object 40 such as skin moistened with water by surface tension (FIG. 4B). The peripheral edge of the sticking sheet 4 (gel film 2) and the support frame 1 (1a) are formed by adhering the support frame 1 (1a) after the surface of the sticking sheet 4 (gel film 2) and the surface of the object 40 are adhered. By making it couple | bonded so weakly as to isolate | separate when peeling, the sheet | seat 4 for a sticking (gel film 2) can be left on the to-be-sticked object 40 surface (FIG.4 (c)).

Moreover, according to this aspect, the gel film contained in the sticking sheet has high adhesion to the surface of a living body or a biomaterial such as skin, and has high flexibility. For this reason, the sticking sheet having the gel film is hardly peeled off even when it is stuck on a fine uneven surface that moves like skin.
FIGS. 5A to 5B are schematic views showing an example of a state in which a patch sheet 4 having a single layer structure of the gel film 2 is stuck to the skin. First, in a state where the finger is bent (FIG. 5A), the surface of the gel film 2 of the application sheet 4 is adhered and adhered to the skin surface of the joint portion of the finger moistened with water by surface tension. In this case, even if the finger is stretched after the application and wrinkles are formed on the skin surface, the application sheet 4 (gel film 2) can also be deformed following the shape of the wrinkles (FIG. 5 (b)). Further, the sticking sheet 4 is hardly peeled off even if the finger is repeatedly bent and stretched. That is, the sticking sheet in this aspect has excellent unevenness followability and is difficult to peel even when attached to a fine uneven surface that moves like skin.

Here, since the gel film (hydrogel film or dry gel film) contained in the patch sheet has a network structure of a polymer compound, it can be used as a pharmaceutical effective ingredient or a cosmetic effective ingredient. It is possible to hold or transmit a desired component to be supplied to the object to be pasted.
For this reason, it becomes possible to supply the said component to a to-be-adhered object by hold | maintaining the said desired component in other layers, such as a functional layer laminated | stacked on the gel film or the gel film.
For this reason, it can be useful for the purpose of protecting the surface of a living body or a biomaterial, or for cosmetic use or medical use.

Moreover, according to this aspect, since the constituent material of the support frame has a porous structure, the support frame can be excellent in flexibility. For this reason, it is possible to prevent the adherend from being damaged even when the support frame comes into contact with the adherend when the sticking sheet is attached to the adherend using the sticking sheet with the support frame of this aspect. it can.
In addition, when the support frame in this embodiment is used as a foam film-forming support frame used for forming a gel film contained in the adhesive sheet, it is easy to increase the contact area with the adhesive sheet. Yes, it can be excellent in bonding strength with the sheet for sticking and excellent in supportability.
Furthermore, the porous structure having a large number of pores can facilitate water absorption. Further, by absorbing water, the support frame can be attached to the object to be attached. Thereby, it is not necessary to fix the sticking sheet with a support frame of this aspect by other means until the sticking of the sticking sheet to the article to be pasted, and the sticking property is excellent. be able to.
Here, “patchability” refers to the stickability to the surface of a living body or a biological material such as skin.

The sheet for sticking with a support frame of this aspect has at least a sheet for sticking and a support frame.
Hereinafter, each structure of the sheet for sticking with a support frame of this aspect will be described in detail.

1. Sheet for pasting The thin film sheet for pasting in this embodiment has at least a gel film.

(1) Gel film The gel film in this embodiment is obtained by gelling a foam film, and is a hydrogel film or a dry gel film. Hereinafter, the hydrogel film and the dry gel film will be described separately.

(A) Hydrogel film The hydrogel film in this embodiment is obtained by gelling a foam film.
Here, the “hydrogel” refers to a gel in which a large amount of water is held in a network structure formed by combining polymers.
The hydrogel film is preferably prepared by gelling an aqueous foam film containing a gel raw material in a state containing water.

  The gel raw material is not particularly limited as long as it is water-soluble and exhibits surface activity and can form a foam film. Moreover, as a gel raw material, it is preferable that safety | security with respect to a biological body is high, for example, protein and polysaccharide can be mentioned. Specific examples include gelatin, collagen, agarose, hyaluronic acid, and cellulose. Water-soluble polymers such as polyethylene glycol and polyacrylamide can also be used. Of these, gelatin, collagen, and agarose are preferably used. Since gelatin, collagen, and agarose all have surface activity, it is thought that the molecules of these compounds are placed on both the front and back surfaces of the foam membrane so that the hydrophobic part is on the outside and the hydrophilic part is on the inside. It is done. Since the foam film has a homogeneous structure on the front and back, the gel film prepared from the foam film is homogeneous on the front and back and can be used without distinction between the front and back.

Although the origin of gelatin is not particularly limited, gelatin derived from porcine epidermis, porcine bone, bovine skin, bovine bone, fish and the like can be used.
The origin of collagen is not particularly limited, but collagen derived from pig skin, pig bone, cow skin, cow bone, fish and the like can be used.
The origin of agarose is not particularly limited, but agarose derived from seaweed or the like can be used.

  Moreover, the hydrogel film may contain a surfactant, an emulsification aid, a wetting agent and the like as appropriate. The surfactant, the emulsification aid, and the wetting agent are used for the purpose of stabilizing the foam film when forming the gel film.

  As the surfactant, surfactants with high safety to living bodies such as sucrose fatty acid esters are preferable.

  As the emulsification aid, emulsification aids with high safety to the living body such as methylcellulose, glycerin, polyethylene glycol, polyvinyl alcohol, sucrose, and polyglycerin are preferable. Volatilization of water from the foam film before gelation causes rupture of the foam film. The emulsification auxiliary agent has an action of suppressing volatilization of water from the foam film, that is, an action as a wetting agent for the foam film, and therefore can be added for the purpose of suppressing foam film rupture. In addition to the action as a wetting agent, an emulsification aid such as polyethylene glycol enters between the polymers constituting the gel film, and suppresses the formation of cross-links between the polymers to increase the flexibility of the film. Also have. For this reason, the gel film prepared from the aqueous solution containing the emulsification aid has an advantageous effect that it has high flexibility and high adhesion to the surface of a living body such as skin.

Furthermore, the hydrogel film may contain a desired component to be supplied to a living body such as skin, such as a component effective as a medicine or a component effective as a cosmetic. These components can be incorporated and retained in the polymer network in the gel film.
In addition, since the hydrogel film has a network structure of a polymer compound, it can permeate a desired component to be supplied to a living body such as skin, such as a component effective as a medicine or a component effective as a cosmetic. Is possible.

The thickness of the hydrogel film is not particularly limited, but is preferably in the range of 100 nm to 200 μm, more preferably in the range of 1 μm to 200 μm, and still more preferably in the range of 1 μm to 100 μm. When the thickness of the hydrogel film is within the above range, the flexibility of the film is very high, so that the adhesion to a surface having fine irregularities such as skin is high, and the thin film is not easily peeled off after being applied.
Here, the thickness of the hydrogel film is a value measured by measuring the position of the film-air interface by focusing with an optical microscope. As an optical microscope, Olympus Nano Search Microscope OLS3500 can be used.

(B) Dry gel film The dry gel film in this embodiment is obtained by gelling a foam film. The dry gel film is preferably prepared by gelling and drying an aqueous foam film containing a gel raw material in a state containing water.
In addition, since it is the same as that of the said hydrogel film | membrane about a gel raw material, description here is abbreviate | omitted.

  Moreover, the dry gel film may contain a surfactant, an emulsification aid, a wetting agent, and the like as appropriate. Since the surfactant, the emulsification aid, and the wet are the same as those of the hydrogel film, the description thereof is omitted here.

Furthermore, the dry gel film may contain a desired component to be supplied to a living body such as skin, such as a pharmaceutical effective component or a cosmetic effective component. These components can be incorporated and retained in the polymer network in the gel film.
In addition, since the dry gel film has a network structure of polymer compounds, it penetrates desired components to be supplied to a living body such as skin, such as components effective as pharmaceuticals and components effective as cosmetics. Is possible.

The thickness of the dried gel film is not particularly limited, but is preferably in the range of 100 nm to 10 μm, and more preferably in the range of 200 nm to 1 μm. When the thickness of the dry gel film is within the above range, the film is very flexible, and thus has an excellent adhesion to a surface having fine irregularities such as skin, and the thin film is difficult to peel off after being applied. . In addition, when the thickness of the dried gel film is equal to or greater than the above lower limit value, the structural color due to light interference can be visually observed, so that the dried gel film can be visually observed without being colored by a coloring agent despite being extremely thin. Can be identified.
Here, when measuring the thickness of the dried gel film, the surface of the cover glass is wetted with water, the dried gel film is adhered to the glass surface with surface tension, vacuum-dried for 1 hour, and the water is completely volatilized. The level difference between the film-air interface and the glass surface was measured to determine the thickness of the dried gel film. As an optical microscope, Olympus Nano Search Microscope OLS3500 can be used.

(C) Formation method of gel film The formation method of the gel film in this aspect should just be a method which can form the hydrogel film which gelatinized the foam film, or the dry gel film. A hydrogel film forming method includes a foam film forming step of forming a foam film of a foam film forming aqueous solution containing a gel raw material in an opening of a foam film forming support frame, and the foam film is gelled in a state containing water. And a gelling step of forming a hydrogel film. The method for forming a dry gel film includes a foam film forming step of forming a foam film of a foam film forming aqueous solution containing a gel raw material at an opening of a foam film forming support frame, and the foam film containing water. It is preferable to have a gelling step of gelling to form a hydrogel film and a drying step of drying the hydrogel film.

  6 (a) to 6 (c) and FIGS. 7 (a) to 7 (e) are process diagrams showing an example of a method for forming a gel film in this embodiment. First, as shown in FIGS. 6A and 7A, a foam film forming support frame 20 having at least one opening 21 is prepared. Next, as shown in FIG. 7B, the foam film-forming support frame 20 is dipped in the foam film-forming aqueous solution 30 and pulled up so as to close the opening 21 as shown in FIG. 7C. The foam film 22 of the aqueous solution 30 for forming a foam film is formed. Next, as shown in FIGS. 6B and 7D, the hydrogel film 2a (gel film 2) is formed by gelling the foam film 22 in a state containing water. Subsequently, as shown in FIGS. 6C and 7E, the hydrogel film 2a (gel film 2) is further dried to form a dry gel film 2b (gel film 2).

  In the method of forming a foam film from an aqueous solution containing a gel raw material and gelling the foam film in a state containing water to obtain a hydrogel film, unlike the method described in Patent Document 2 in which the foam film is directly dried, Even when the gel raw material in the aqueous solution for forming a foam film has a low concentration, the hydrogel film can be formed without breaking the foam film. Further, even when the obtained hydrogel film is dried, the film is not broken. Furthermore, the hydrogel film and the dried gel film obtained by such a method have sufficient adhesion on the skin surface and are difficult to peel off even when applied to a moving uneven surface.

  Hereinafter, each step in the foam film forming support frame and the gel film forming method used for forming the gel film will be described.

(I) Foam film forming support frame The material of the foam film forming support frame for forming the foam film is not particularly limited as long as the foam film of the foam film forming aqueous solution containing the gel raw material can be formed. For example, resin, glass, metal, etc. can be mentioned. Also, the foam film forming support frame may or may not have flexibility. Especially, it is preferable that the support frame for foam film formation is a flexible film-like member.

What is necessary is just to select suitably the dimension and shape of the support frame for foam film formation. Area of the opening formed in the foam film forming support frame may as long as capable of forming a foam film, but is preferably in the range of 100mm ² ~40000mm ^2, within the range of 300mm ² ~2000mm ² More preferably. The shape of the opening is not particularly limited, and may be any shape such as a circle, a triangle, a polygon such as a quadrangle, etc., depending on the purpose. Among them, the shape of the opening is preferably a circle or a polygon with rounded corners. In the case of these shapes, since the stress applied to the periphery of the foam film can be reduced, the ease of handling of the foam film can be improved.

(Ii) Foam film forming process In the foam film forming process, the foam film of the foam film forming aqueous solution containing the gel raw material is formed in the opening of the foam film forming support frame.

  Since the gel raw material has been described above, the description thereof is omitted here.

  When the gel raw material is gelatin, an aqueous gelatin solution is used as an aqueous solution for forming a foam film. The gelatin concentration in the gelatin aqueous solution is not particularly limited, but is preferably a low concentration, specifically, in the range of 0.1% by mass to 2.9% by mass, preferably 0.1% by mass to 2.5%. It is within the range of mass%, more preferably within the range of 1.0 mass% to 2.0 mass%. When the gelatin concentration is low, the foam film is thinner than when the gelatin concentration is high, and the produced hydrogel film and dry gel film are sufficiently flexible and difficult to peel off even on uneven surfaces. Therefore, it is preferable. Formation of a thin film from a low-concentration gelatin aqueous solution cannot be achieved by the method described in Patent Document 2.

  The gelatin aqueous solution contains the gelatin having the above-mentioned concentration in a non-gelled sol state at the stage of the foam film formation process. In order to maintain the sol state, the temperature is preferably in the range of 20 ° C to 40 ° C. The pH of the aqueous gelatin solution (measured at 23 ° C.) can be in the range of 6.0 to 8.0.

The thickness of the foam film prepared from the gelatin aqueous solution can be adjusted by adjusting the pulling rate of the foam film-forming support frame from the gelatin aqueous solution. In addition, after forming the foam film on the foam film forming support frame, the thickness of the gelatin film can be reduced by removing the gelatin aqueous solution from the foam film using a pipette or the like, or by adding the gelatin aqueous solution to the foam film. It is also possible. Typically, the thickness of the foam film formed by the aqueous gelatin solution is in the range of 1 μm to 200 μm, more preferably in the range of 10 μm to 100 μm.
The method for measuring the thickness of the foam film is the same as the method for measuring the thickness of the gel film.

  When the gel raw material is agarose, an agarose aqueous solution is used as the aqueous solution for forming a foam film. The agarose concentration in the agarose aqueous solution is not particularly limited, but is preferably a low concentration, specifically within the range of 0.1% by mass to 5.0% by mass, preferably 0.1% by mass to 2.0%. It is in the range of mass%, more preferably in the range of 0.5 mass% to 1.0 mass%. When the agarose concentration is low, the foam film is thinner than when the agarose concentration is high, and the produced hydrogel film and dried gel film are sufficiently flexible and difficult to peel off even on uneven surfaces. preferable. Formation of a thin film from a low-concentration agarose aqueous solution cannot be achieved by the method described in Patent Document 2.

  The agarose aqueous solution contains the agarose having the above-mentioned concentration in a sol state that is not gelled at the stage of the foam film formation process. In order to maintain the sol state, the temperature is preferably in the range of 20 ° C to 60 ° C. The pH of the agarose aqueous solution (measured value at 23 ° C.) can be in the range of 6.0 to 8.0.

The thickness of the foam film prepared from the agarose aqueous solution can be adjusted in the same manner as the gelatin aqueous solution. Typically, the thickness of the foam film formed by the agarose aqueous solution having the above-mentioned concentration is 1 μm to 200 μm, and more preferably 10 μm to 100 μm.
The method for measuring the thickness of the foam film is the same as the method for measuring the thickness of the gel film.

  When the gel raw material is collagen, an aqueous collagen solution is used as the aqueous solution for forming a foam film. The collagen concentration in the collagen aqueous solution is not particularly limited, but it is preferably a low concentration, specifically within the range of 0.1% by mass to 5.0% by mass, preferably 0.5% by mass to 5.0%. It is in the range of mass%, more preferably in the range of 1.0 mass% to 3.0 mass%. When the collagen concentration is low, the foam membrane is thinner than when the collagen concentration is high, and the produced hydrogel membrane and dry gel membrane are sufficiently flexible and difficult to peel off even on uneven surfaces. Therefore, it is preferable. Formation of a thin film from a low concentration collagen aqueous solution cannot be achieved by the method described in Patent Document 2.

The thickness of the foam film prepared from the collagen aqueous solution can be adjusted in the same manner as the gelatin aqueous solution. Typically, the thickness of the foam film formed by the collagen aqueous solution having the above-mentioned concentration is in the range of 1 μm to 200 μm, more preferably in the range of 10 μm to 100 μm.
The method for measuring the thickness of the foam film is the same as the method for measuring the thickness of the gel film.

  The collagen aqueous solution contains the above-mentioned concentration of collagen in a sol state that is not gelled at the stage of the foam film formation step. Unlike the gelatin aqueous solution and the agarose aqueous solution, the collagen aqueous solution is characterized in that it is in a sol state at a low temperature and a pH condition around pH 3.0, and is in a gel state at a high temperature and a pH condition around pH 7.0. In order to maintain the sol state, the temperature is preferably in the range of 4 ° C to 23 ° C. The pH of the aqueous collagen solution (measured value at 23 ° C.) is preferably in the range of 2.0 to 4.0 when the aqueous solution is prepared. The collagen aqueous solution is preferably adjusted to have a pH (measured value at 23 ° C.) in the range of 6.0 to 8.0 before forming the foam film. The pH can be adjusted by adding an alkali component such as sodium hydroxide.

The foam film-forming aqueous solution may contain other components as appropriate in addition to the gel raw material. Specifically, the aqueous solution for forming a foam film may contain a surfactant, an emulsification aid, a wetting agent, etc. for the purpose of stabilizing the foam film. Since the surfactant, the emulsification aid, and the wetting agent have been described above, the description thereof is omitted here.
The concentration of the surfactant in the aqueous solution for forming a foam film is not particularly limited, but can typically be in the range of 0.01% by mass to 1% by mass.
The concentration of the emulsification aid in the aqueous solution for forming a foam film is not particularly limited, but can typically be in the range of 0.01% by mass to 10% by mass.

  In the aqueous solution for forming a foam film, it is also possible to mix desired components to be supplied to a living body such as skin, such as a component effective as a pharmaceutical and a component effective as a cosmetic. The components contained in the foam film-forming aqueous solution can be incorporated and retained in the polymer network structure in the hydrogel film and the dry gel film.

(Iii) Gelation process In a gelation process, a foam film is gelatinized in the state containing water, and a hydrogel film is formed. The gel film forming method in this embodiment is different from the method described in Patent Document 2 in which the foam film is directly dried, and the foam film is broken even when the gel raw material in the aqueous solution for forming the foam film has a low concentration. It is possible to form a hydrogel film without drying, and it is also possible to dry the formed hydrogel film.

  In the gelation step, before the foam film dries, it gels in a state containing water to form a hydrogel. It is not essential that the gelling conditions are such that the moisture in the foam film is completely maintained, and any conditions may be used as long as a hydrogel film containing water is formed.

  When the gelatin aqueous solution having the above-mentioned concentration is used as the foam film-forming aqueous solution, gelation can be performed by cooling the foam film. Specifically, a gelatin hydrogel can be formed by cooling the foam film at a temperature of 1 ° C. to 19 ° C. for a short time, preferably 1 minute to 10 minutes.

  When an agarose aqueous solution having the above concentration is used as the foam film forming aqueous solution, gelation can be performed by cooling the foam film. Specifically, a hydrogel of agarose can be formed by cooling the foam film at a temperature of 1 ° C. to 19 ° C. for a short time, preferably 1 minute to 10 minutes.

  When the collagen aqueous solution having the above-mentioned concentration is used as the foam film-forming aqueous solution, the gelation can be performed by heating the foam film of the collagen aqueous solution adjusted to a pH condition near neutrality. Specifically, by heating a foam membrane formed from a collagen aqueous solution adjusted to pH 6.0 to 8.0 at a temperature of 32 ° C. to 37 ° C. for a short time, preferably 1 minute to 30 minutes, Collagen hydrogels can be formed.

  In order to suppress the volatilization of moisture in the gelation step, it is preferable to perform the gelation in a closed container adjusted to saturated humidity.

(Iv) Drying step In the drying step, the hydrogel film is dried. The dried gel film can be prepared by further drying the hydrogel film.

  The gelling step and the drying step do not need to be performed as separate steps, and the hydrogel membrane is processed from the foam membrane under the condition that the hydrogel membrane is subsequently dried, and the hydrogel membrane is processed as an intermediate product. It is also possible to obtain a dry gel film without obtaining

  Although the conditions for drying are not specifically limited, Preferably it is made to dry at 19 degrees C or less for 2 hours or more. The moisture in the dried gel film is not particularly limited, but is preferably dried until the moisture content is 10% by mass or less.

(V) Other Steps As a method for retaining a drug-effective component or a component effective as a cosmetic in a gel film, for example, a hydrogel film obtained by further adding the above-described components to an aqueous solution for forming a foam film Or the method of forming a dry gel film | membrane, and the method of making the said component contact the obtained hydrogel film | membrane or dry gel film | membrane are mentioned. In the latter method, the contact of the above components is performed by an arbitrary method such as immersion of a hydrogel thin or dry gel film in a liquid containing the above components or application of a liquid containing the above components to a hydrogel film or a dry gel film. It can be carried out.

(2) Sheet for pasting The sheet for pasting in this embodiment has the gel film, and if necessary, has another layer such as a functional layer formed on the gel film. Also good.
In addition, as a sticking sheet | seat which has such a functional layer, it can be specifically shown in FIG. 3 already demonstrated.

  The functional layer includes, for example, desired components to be supplied to the object to be pasted through the gel film, such as components effective as pharmaceuticals and components effective as cosmetics. it can.

  Examples of a method for containing a component effective as a pharmaceutical or a component effective as a cosmetic in the functional layer include, for example, a method of forming a functional layer using the functional layer forming composition further added with the above components, And the method of making the said component contact the obtained functional layer is mentioned. In the latter method, the contact of the component can be performed by any method such as immersion of the functional layer in a liquid containing the component, or application of a liquid containing the component to the functional layer.

  Moreover, it can have a printing layer which forms a character and a pattern on a gel film as said functional layer. The printed layer may be formed on the entire surface of the gel film or may be formed in a pattern.

  As the sticking surface of the sticking sheet in this embodiment, the surface of the gel film of the sticking sheet may be the sticking surface, and the surface of the functional layer may be the sticking surface. Especially, it is preferable to make the surface of a gel film into a sticking surface. This is because the adhesiveness of the sticking sheet to the adherend is excellent. On the other hand, when the surface of the functional layer is used as the pasting surface, for example, by increasing the area ratio of the portion where the functional layer is not formed on the gel film, the adhesiveness of the pasting sheet to the object to be pasted is increased. Can be secured.

  The use of the sheet for sticking in this aspect is not limited as long as it is used for sticking to a sticking object, and can be used, for example, for the purpose of protecting the surface of a living body or a biomaterial as the sticking object. is there.

  The adhesive sheet in this embodiment is useful for cosmetic use or medical use. Specifically, makeup cosmetics such as concealers for unevenness correction and color correction, cosmetic pack materials, wound dressings for protecting wounds on the skin surface, and procedures for applying a drug transcutaneously. A skin-absorbing preparation, affixed to the surface of an organ or tissue in a living body, can be used for applications such as a protective sheet that protects the surface of an organ or tissue or prevents adhesion to other organs or tissues. The sticking sheet in this embodiment can also be used as a decorative seal such as a nail seal or a tattoo seal.

2. Support frame The support frame in this aspect has an opening part and supports the said sticking sheet arrange | positioned so that the said opening part may be plugged up. Further, the constituent material of the support frame has a porous structure.
Here, supporting the sticking sheet arranged so as to close the opening portion is combined with the periphery of the sticking sheet arranged so as to close the opening portion, thereby supporting the sticking sheet. That's what it means.

The structure of the constituent material of the support frame is not particularly limited as long as it is a porous structure having a large number of pores inside. As a constituent material of such a porous structure, for example, a nonwoven fabric formed by laminating fibrous materials, a foam formed by adding a foaming agent to a constituent material and foaming, or a powder of the constituent material is sintered. And a powder sintered body formed as described above.
In the present invention, it is particularly preferable to use a nonwoven fabric. This is because processing and the like are easy.

  Moreover, as content of the constituent material of the said porous structure, what is necessary is just to be used for a part of constituent material of the said support frame, but it is 10 mass% or more of all the constituent materials of the said support frame. In particular, the content is preferably 50% by mass or more, particularly 100% by mass, that is, it is preferable that the support frame is formed only of a constituent material having a porous structure. This is because, when the content is within the above-described range, the effect of preventing damage to the object to be stuck can be obtained. Further, because of the porous structure, the contact area between the gel film and the support frame is increased, and the gel film can be supported more strongly.

The type of the constituent material of the support frame is not particularly limited as long as the support frame can be molded into a desired shape, and various organic materials and inorganic materials can be used.
Examples of the organic material include polypropylene, polymethylpentene, polypropylene copolymer, polyethylene, fluororesin such as Teflon (registered trademark) and ethylene-tetrafluoroethylene copolymer, polycarbonate, acetal resin, polysulfone, polyvinyl chloride, Examples thereof include natural or synthetic resin materials such as polystyrene, styrene-acrylonitrile copolymer, acrylic resins such as polymethyl methacrylate, polyurethane, polyester, polyimide, polyglycolic acid, polylactic acid, collagen, elastin, and cellulose.
Examples of the inorganic material include glass, silicone rubber, and various metals.
Among these, urethane rubber and silicone rubber are preferable in this embodiment. This is because the molding is easy, and even when the adherend is a living body, there is little influence on the living body.
In this embodiment, these materials may be used alone, or a plurality of materials may be used in combination.

The degree of hydrophilicity of the constituent material is not particularly limited as long as it can stably support the sticking sheet, but is preferably excellent in hydrophilicity. This is because the support frame can easily be in a water-absorbing state by being able to be excellent in hydrophilicity, and thus the support frame can be easily attached to the article to be pasted. .
In this embodiment, specifically, the water contact angle of the constituent material is preferably less than 50 °.
The water contact angle refers to a contact angle with water or a liquid having an equivalent contact angle, and a drop (pure amount) of pure water is dropped on the film surface made of the above constituent materials for a fixed time. After the lapse of time, the shape of the water droplet can be observed using a microscope or a CCD camera, and the measurement can be performed using a method for physically obtaining the contact angle.
More specifically, using a contact angle measuring device (CA-Z type manufactured by Kyowa Interface Science Co., Ltd.) (measured 30 seconds after dropping a drop of pure water from a microsyringe), from the result, or The result can be obtained as a graph.

  The Young's modulus of the constituent material of the support frame is not particularly limited as long as it can stably support the sticking sheet. For example, the Young's modulus is described in “C. Third Embodiment” described later. It can be the same as the contents of.

The shape of the support frame may be any shape as long as it has an opening in at least a portion of the sticking sheet to be pasted on the adherend.
The shape and area of such an opening can be appropriately set according to the use of the adhesive sheet, for example, the same as the support frame for foam film formation in “1. Adhesive sheet” above. Can do.
In addition, the support may or may not have flexibility. Especially, it is preferable that a support body is a flexible film-like member. When the support is a flexible film-like member, even when the surface of the object to be pasted is not flat, the sheet for pasting can be sufficiently adhered to the surface of the object to be pasted. Because.

  The film thickness of the support frame is not particularly limited as long as it can stably support the sticking sheet, and varies depending on the film thickness and size of the sticking sheet. When the gel film contained in the sheet and the support frame are directly bonded, it is preferably thicker than the film thickness of the gel film, and specifically can be in the range of 10 μm to 5 mm. When the film thickness is within the above range, it is easy to make the support frame excellent in flexibility, and the sticking sheet with the support frame of this aspect is deformed according to the surface shape of the object to be stuck. It is because it can be made excellent in pasting property, such as being able to do.

The width of the support frame in plan view is not particularly limited as long as it can stably support the sticking sheet, and varies depending on the film thickness, size, etc. of the sticking sheet. For example, it can be 1 mm or more. It is because the support property of the sticking sheet can be excellent when the width is in the above range. In addition, the upper limit is not particularly limited, and is appropriately set according to the application of the support frame-attached sheet of the present invention.
The width refers to the shortest distance in plan view between the outer periphery of the support frame and the opening end, and is specifically the distance indicated by a in FIG. .

  The support frame supports the sticking sheet, and may be composed only of a frame portion that is bonded to the sticking sheet, but if necessary, on the non-sticking side of the sticking sheet. It is preferable that it has a convex part. As such a convex part, it can be set as the content as described in the term of the "B. 2nd embodiment" mentioned later, for example.

  As a method for forming the support frame, a general molding method such as injection molding or press molding can be used. Further, the support frame may be formed integrally or may be a combination of a plurality of parts.

  As the binding force between the support frame and the sticking sheet, when the sticking sheet is stuck to the sticking object using the sticking sheet with the support frame, the sticking sheet is left on the sticking object, What is necessary is just to be able to remove a support frame, and it is preferable that it is smaller than the coupling | bonding force of a to-be-attached thing and the thin film for sticking.

  The method for joining the support frame to the sticking sheet is not particularly limited as long as it can be joined to the sticking sheet with a desired binding force. However, it is preferable that the gel film contained in the support frame and the sticking sheet is directly bonded without using other members. Since the support frame and the gel film are directly bonded, for example, the support frame can be easily combined with each other by using the support frame as a foam film forming support frame used at the time of foam film formation. Because it can.

It is preferable that the said support frame is used also as a support frame for foam film formation used at the time of foam film formation. As shown in FIG. 7 already described, the foam film forming support frame used in forming the foam film can be used as a support frame without being separated from the gel film even after the gel film is formed. In FIG. 7, the periphery of the hydrogel film 2 a or the dried gel film 2 b is bonded to the foam film forming support frame 20.
For this reason, it is because it can be made easy to combine with the thin film for pasting by being used as a support frame for foam film formation.

(3) Sheet for sticking with a support frame The sheet for sticking with a support frame of this aspect has the support frame and the sheet for sticking, but may have other members as necessary. .
Examples of such other members include a protective sheet that protects the sticking surface of the sticking sheet.

The method for producing the sheet with a support frame of this embodiment is not particularly limited as long as it can be a method in which the support frame and the sheet for application are combined. For example, the support frame according to this embodiment 1 may be used as the foam film-forming support frame 20 in FIG.
Further, the gel film may be separated from the foam film forming support frame used at the time of forming the gel film, and fixed to the support frame so as to close the opening. good. Even in this case, at any stage, if necessary, the gel film can be subjected to processing such as cutting to an appropriate size, addition of a desired component, formation of a functional layer, and the like.

As a use of the sheet for sticking with a support frame of this aspect, any sheet may be used as long as it can be used for sticking the sheet for sticking to an object to be stuck.
In this aspect, among them, it is preferably used for sticking to a sticking object whose surface is easily damaged, and particularly preferably used for sticking to the surface of a living body or a biomaterial as the sticking object. . It is because the effect that it can stick without scratching the adherend of the sheet for sticking with a support frame of this embodiment can be more effectively exhibited.

B. Second Embodiment Next, a second embodiment of the sticking sheet with a support frame of the present invention will be described. The sheet for sticking with a support frame according to this aspect is the sheet for sticking with a support frame described above, wherein the support frame has a convex portion arranged on the non-sticking surface side of the sheet for sticking. Is.

Such a sticking sheet with a support frame according to this aspect will be described with reference to the drawings. FIG. 8 is a schematic cross-sectional view showing an example of the sticking sheet with a support frame of this embodiment. As illustrated in FIG. 8, the support frame-attached sheet 10 of the present embodiment includes an adhesive sheet 4 having a gel film 2 that is a hydrogel film or a dry gel film obtained by gelling a foam film, and an opening 11. And a support frame 1 that supports the sticking sheet 4 disposed so as to close the opening 11, and the support frame 1 is disposed on the non-sticking surface side of the sticking sheet 4. It has the convex part 1b.
In addition, in this example, the said convex part 1b is a flat convex part (cylindrical convex part) arrange | positioned in the perimeter of the outer edge part of a circular support frame (frame part 1a).

According to this aspect, by having the convex portion, it is possible to grip the sticking sheet with the support frame, or to hold the convex portion and press it against the pasting object when sticking to the pasting subject. For example, the sticking property of the sticking sheet can be improved.
Moreover, from such a thing, when affixing a sticking sheet on a sticking object using the sticking sheet with a support frame of this aspect, it is possible to prevent the sticking object from being damaged.

The shape of such a convex portion is not particularly limited as long as it can have a desired sticking property and an ability to prevent damage to an object to be pasted, but is not limited to a support frame (frame portion). A flat plate disposed at the outer edge or a columnar column spaced apart can be exemplified. It is because it can be made easy to hold | grip by being the said shape.
8 and 9 which have already been described are schematic cross-sectional views showing an example in which the shape of the convex portion is a flat convex portion arranged on the entire periphery of the outer edge portion of the circular support frame (frame portion). Each of the flat projections is arranged so as to have a vertical cross-sectional view and a tapered cross-sectional view with respect to the application surface of the sticking sheet. 10 and 11 show a case where the convex portions are four columnar convex portions spaced apart formed on the outer edge portion of a circular support frame (frame portion), and FIG. It is a schematic plan view which shows an example of the to-be-bonded surface side of the sheet for sticking with a support frame, and FIG. 11 is sectional drawing on the BB line of FIG.
Moreover, when the said convex part is a separated columnar thing, it is preferable that the number of convex parts is 2 or more. It is because it can be excellent in sticking property.

The height of the convex portion is not particularly limited as long as it facilitates the gripping of the sheet for sticking with a support frame of the present invention, and can be, for example, in the range of 1 mm to 50 mm. This is because gripping can be facilitated by the height.
In addition, the height of the said convex part means the height from the non-sticking side surface of the sheet for sticking. Moreover, when the sheet | seat for sticking has a functional layer in the non-sticking surface side of a gel film, it means the height from the surface of a functional layer.

  As a method of forming the convex portion, a method of adhering a member processed into the shape of the convex portion to the frame portion using an adhesive or the like, or a part of the support frame (frame portion) to which the sheet for pasting is applied A method in which a bent portion is used as a convex portion can be mentioned.

The sheet for sticking with a support frame of this embodiment has at least a sheet for sticking and a support frame.
In addition, since it can be made to be the same as that of the content of the said "A. 1st embodiment" also about the content of the sheet | seat for sticking in this aspect, the support frame other than a convex part, and the sheet | seat for sticking with a support frame. The description here is omitted.

C. Third Embodiment Next, a third embodiment of the sticking sheet with a support frame of the present invention will be described. The sheet for sticking with a support frame of this aspect is the sheet for sticking with a support frame described above, wherein the Young's modulus of the constituent material of the support frame is equal to or lower than the Young's modulus of the object to be stuck. .

  Such a sticking sheet with a support frame of this aspect can be the same as that described in FIGS. 1 and 2, for example.

According to this aspect, when the Young's modulus of the constituent material of the support frame is equal to or less than the Young's modulus of the object to be pasted, the support frame can be excellent in flexibility. For this reason, even if a support frame contacts a to-be-pasted object when the sheet for affixing is affixed to a to-be-pasted object using the sheet | seat for a pasting with a support frame of this invention, it prevents that a to-be-abraded object is damaged. be able to.
Moreover, according to the surface shape of a to-be-attached material, the sticking sheet with a support frame of this aspect can be easily deformed, for example, it can be made excellent in sticking property.

The Young's modulus of the constituent material of the support frame is not particularly limited as long as it is equal to or lower than the Young's modulus of the object to be pasted and can stably support the sticking sheet.
Specifically, in the case where the object to be stuck is a nail or skin of a living body, it may be less than the Young's modulus of the nail or skin of the living body.
In the present invention, it is preferable that the Young's modulus of the object to be pasted is smaller than that.
In addition, the comparison of the Young's modulus of a constituent material and an adherend is normally performed using the same measuring method.

The Young's modulus of such a constituent material varies depending on the type and location of the object to be pasted. For example, when the object to be pasted is a human body, it is preferably less than 2 GPa. It is preferably within the range of 0.1 MPa to 100 MPa, and particularly preferably within the range of 0.1 MPa to 10 MPa. When the Young's modulus is within the above-mentioned range, it is easy to make the support frame excellent in flexibility. It is because it can be made excellent in pastability such as being easily deformed. In addition, the Young's modulus of a human nail known as a relatively hard material to be stuck on the surface of a living body is 2 GPa, and the Young's modulus of the skin is about several MPa. For this reason, by making the Young's modulus of the above-mentioned constituent materials below the Young's modulus of the human body's nails and skin as described above, it is possible to stably prevent damage to the adherend even when the human body is to be attached. It is because it can be made. Furthermore, when the lower limit of the Young's modulus is in the above range, the sticking sheet can be stably supported.
The method for measuring the Young's modulus is not particularly limited as long as it can be measured with high accuracy. For example, a test piece of 1 cm in length and 5 mm in width is used as a tensile tester Tensilon (STA-1150). Can be used to calculate the Young's modulus from the slope of the curve when the specimen is stretched by 1% in the obtained stress-strain curve at 23 ° C. at a speed of 50 mm / min.

As a method for adjusting the Young's modulus of the constituent material, it varies depending on the type of the constituent material, but when the constituent material is an organic or inorganic resin material, adjustment of the addition ratio of the curing agent, curing time, etc. A method for adjusting the Young's modulus by adjusting the curing conditions is described.
Moreover, as a constituent material of such Young's modulus, it differs according to a to-be-adhered thing, and it can be used by adjusting the organic material and inorganic material which were mentioned above, However, Young's modulus is the structure of less than 2 GPa Specifically, the material is preferably polypropylene, polyethylene, Teflon (registered trademark), polyurethane (urethane rubber), silicone rubber or the like. This is because the Young's modulus can be easily adjusted.
More specifically, in the case of silicone rubber, the ratio of the main material and the curing agent (main material: curing agent) is adjusted to 10: 1, and cured at 75 ° C. for 90 minutes, so that the Young's modulus is 1 MPa. Silicone rubber can be obtained.

The sheet for sticking with a support frame of this embodiment has at least a sheet for sticking and a support frame.
The contents of the sheet for sticking in this aspect, the supporting frame other than the Young's modulus of the constituent material, and the sheet for sticking with a supporting frame shall be the same as those described in the above section “A. First embodiment”. The description here is omitted.

  The present invention is not limited to the above embodiment. The above-described embodiment is an exemplification, and the present invention has substantially the same configuration as the technical idea described in the claims of the present invention, and any device that exhibits the same function and effect is the present invention. It is included in the technical scope of the invention.

  The present invention will be described more specifically with reference to the following examples.

[Reference example]
1. Preparation of support frame A polystyrene film of 4 cm × 4 cm and a thickness of 250 μm manufactured by SUNDIC was cut out so that a true circular opening having a diameter of 3.2 cm was formed at the center, thereby preparing a support frame having an opening.

2. Preparation of aqueous solution (1) Aqueous solution 1-a, 1-b
Aqueous solutions prepared by dissolving Sigma-Aldrich gelatin in pure water to a concentration of 2% by mass or 6% by mass were referred to as “aqueous solution 1-a” and “aqueous solution 1-b”, respectively.
(2) Aqueous solution 2-a, 2-b
Aqueous solutions prepared by dissolving Sigma Aldrich Agarose in pure water to a concentration of 2% by mass or 6% by mass were designated as “Aqueous Solution 2-a” [Aqueous Solution 2-b], respectively.
(3) Aqueous solution 3-a, 3-b
An aqueous solution prepared by adjusting the concentration of collagen Cellmatrix Type I-A manufactured by Nitta Gelatin Co. to 2% by mass (pH = 3) or 6% by mass (pH = 3) was obtained as “Aqueous solution 3-a” [Aqueous solution 3]. -B].

3. Formation of Gelatin Hydrogel Film and Dry Gel Film The support frame is immersed in the aqueous solution 1-a in a sol state at 37 ° C. for 1 second, and then the support frame is removed from the aqueous solution so that the support frame is parallel to the vertical direction. It was lifted up so that a foam film of an aqueous solution was formed in the opening. Immediately after lifting, the support was exposed to a temperature condition of 4 ° C. for 10 minutes to gel the foam film of the aqueous solution, thereby preparing a hydrogel film 1-a having a thickness of about 10 μm.
Next, the hydrogel film was dried at 4 ° C. for 120 minutes to obtain a dried gel film 1-a having a thickness of about 400 nm.

  Further, the aqueous solution 1-b is also gelled after forming a foam film with the aqueous solution by the same method to produce a hydrogel film 1-b having a thickness of about 10 μm, and dried to a dried gel film 1 having a thickness of 1.2 μm. -B was produced.

4). Formation of hydrogel film and dry gel film of agarose The support frame is immersed in an aqueous solution 2-a in a sol state at 50 ° C. for 1 second, and then the support frame is removed from the aqueous solution so that the support frame is parallel to the vertical direction. It was lifted up so that a foam film of an aqueous solution was formed in the opening. Immediately after the lifting, the support was exposed to a temperature condition of 4 ° C. for 10 minutes to gel the foam film of the aqueous solution, thereby preparing a hydrogel film 2-a having a thickness of about 10 μm.
Next, the hydrogel film was dried at 4 ° C. for 120 minutes to obtain a dried gel film 2-a having a thickness of about 400 nm.

  Also for the aqueous solution 2-b, a foam film was formed with an aqueous solution and gelled by the same method to produce a hydrogel film 2-b having a thickness of about 10 μm, and dried to a dried gel film 2-b having a thickness of 1.2 μm. Was made.

5. Formation of collagen hydrogel membrane and dry gel membrane At 4 ° C., the aqueous solution 3-a was adjusted to pH = 7 with sodium hydroxide and immersed in an aqueous solution in a sol state at 4 ° C. for 1 second. The support frame was lifted from the aqueous solution so as to be parallel to the base plate so that a foam film of the aqueous solution was formed in the opening of the support frame. Immediately after the lifting, the support was exposed to a temperature condition of 37 ° C. for 30 minutes to gel the foam film of the aqueous solution, thereby producing a hydrogel film 3-a having a thickness of about 10 μm.
Next, the hydrogel film was dried at 23 ° C. for 120 minutes to obtain a dried gel film 3-a having a thickness of about 400 nm.

  Also for the aqueous solution 3-b, a foam film is formed with an aqueous solution and gelled by the same method to produce a hydrogel film 3-b having a thickness of about 10 μm, and dried to a dried gel film 3-b having a thickness of 1.2 μm. Was made.

[Comparative Example 1]
1. Formation of Gelatin Hydrogel Film and Dry Gel Film Aqueous solution 1-a was subjected to a drying treatment at a temperature of 23 ° C. without gelation after forming a foam film with an aqueous solution by the same method as in Example 1. The foam film was broken.

2. Formation of Agarose Hydrogel Film and Dry Gel Film Aqueous solution 2-a was subjected to a drying treatment at a temperature of 23 ° C. without gelation after forming a foam film with an aqueous solution by the same method as in Example 1. The foam film was broken.

3. Formation of collagen hydrogel membrane and dry gel membrane For aqueous solution 3-a, the aqueous solution 3-a was adjusted to pH = 7 at 4 ° C. by the same method as in Example 1 to form a foam film and gelled. When the drying process was performed at a temperature of 23 ° C., the foam film was broken.

[Evaluation]
1. Evaluation of Hydrogel Film Adhesion to Human Skin For each of the hydrogel films 1-a, 2-a, and 3-a prepared above, the support frame portion of the support frame on which the hydrogel film was formed was grasped and wetted with water. When the hydrogel film was brought into contact with the human skin, the hydrogel film adhered to the skin due to surface tension, and when the support frame part was moved away from the skin, the hydrogel film separated from the support frame part, and only the hydrogel film could be applied to the skin. . In addition, since the hydrogel film is very thin, it can be applied to curved or refracted parts, and all of the hydrogel film follows the curved shape when it is brought into contact with a finger joint moistened with water with the finger bent. The film was in close contact with the skin due to surface tension, and the hydrogel film did not peel off while sticking to the skin even during refraction of the finger after application, and the appearance after application was hardly noticeable.

  The hydrogel membranes 1-b, 2-b, and 3-b could also be attached by bringing the finger joints into close contact with a finger joint moistened with water with surface tension. However, compared with the hydrogel films 1-a, 2-a, and 3-a, the adhesion to the skin is weak, and the hydrogel film tends to be displaced from the skin during finger refraction. In addition, the appearance after sticking tends to be noticeable.

2. Evaluation of application of dry gel film to human skin For each of the dry gel films 1-a, 2-a, and 3-a prepared above, the support frame portion of the support frame on which the dry gel film is formed is grasped, When the dried gel film is brought into contact with the human skin wetted with, the dried gel film is very thin, so it is flexible and adheres to the skin with surface tension so as to follow the fine shape of the skin, and the support frame is moved away from the skin. The dried gel film peeled off from the support frame, and only the dried gel film could be applied to the skin. In addition, since the dry gel film is very thin, it can be applied to curved or refracted parts. When the finger is bent and touched with a finger joint moistened with water, the dry gel film follows the curved shape. All of these adhered to the skin by surface tension, and even when the finger was refracted after application, the dried gel film did not peel off while being adhered to the skin, and the appearance after application was hardly noticeable.

  The dried gel films 1-b, 2-b, and 3-b could also be attached by bringing them into close contact with a finger joint moistened with water with surface tension while the fingers were bent. However, the adhesiveness to the skin is weak compared with the adhesive sheet having the dry gel films 1-a, 2-a, and 3-a, and the dry gel film tends to be displaced from the skin during finger refraction. . In addition, the appearance after sticking tends to be noticeable.

3. Effect of film flexibility by addition of polyethylene glycol 1 ml each of a solution containing 2% by weight of gelatin and 0%, 1%, 2% or 6% by weight of polyethylene glycol on a 3 cm × 3 cm bare glass The solution is made into a sol state at 37 ° C., uniformly coated, exposed to a temperature condition of 4 ° C. for 10 minutes to gel the solution, and dried at 4 ° C. for 24 hours to be applied onto the raw glass. A dry film was formed. Then, when the hardness of the dry film | membrane was measured using Picodenter HM500 by Fischer Instruments, the value of the Martens hardness of the film | membrane became low and the flexibility increased with the increase in the amount of polyethylene glycol. The results are shown in the table below.

[Example 1]
1. Preparation of Support Frame As a constituent material of the support frame, a 4 cm × 4 cm polyethylene resin non-woven fabric (Asahi DuPont Flashspun Products (Tyvek, 1073B)) with a film thickness of 178 μm is prepared. Cut out so as to form a 2 cm perfect circular opening, and using an aqueous solution containing 1.5% by weight of gelatin and 1.0% by weight of polyethylene glycol, otherwise the hydrogel film or A sheet for sticking with a support frame having a sheet for sticking having a dry gel film and a support frame was produced.

[Example 2]
A 5 cm x 5 cm polyethylene resin non-woven fabric (Asahi DuPont Flashspun Products (Tyvek, 1073B)) was prepared as the support frame material, and a 3.2 cm diameter circular shape was formed at the center of the non-woven fabric. It cut out so that the opening part could be formed. Next, except that a support frame having a plate-like convex part formed so as to surround the support frame (frame part) having a height of 0.5 cm and bending the four sides of the support frame 90 degrees toward the non-stick surface side is prepared. Produced a sticking sheet with a support frame in the same manner as in Example 1.

[Example 3]
Except that the support frame was prepared in the same manner as in Example 1 except that the type of the constituent material of the support frame was changed to silicone rubber having a Young's modulus of 1 MPa (manufactured by Dow Corning Toray), the same procedure as in Example 1 was performed. A sticking sheet with a support frame was prepared.
The Young's modulus was measured by a method using a tensile tester Tensilon (STA-1150) for the above-mentioned test piece of 1 cm in length × 5 mm in width.

[Comparative Example 1]
As a constituent material of the support frame, a polystyrene film (manufactured by SUNDIC) having a thickness of 4 cm × 4 cm, a thickness of 250 μm, and a Young's modulus of 3 GPa is prepared, and a true circular opening having a diameter of 3.2 cm is formed at the center of the film. A sticking sheet with a support frame was produced in the same manner as in Example 1 except that a support frame having a cutout and an opening was prepared.
The Young's modulus was measured in the same manner as in Example 3.

[Evaluation]
Occurrence of scratches on the surface of the adherend during the above-mentioned evaluations described in the reference examples, “1. Evaluation of application of hydrogel film to human skin” and “2. Evaluation of application of dry gel film to human skin” The presence or absence of was evaluated visually.
In addition, the Young's modulus of the surface of the human skin to be evaluated was 1 MPa to 2000 MPa. In addition, the Young's modulus of the skin surface was measured by a method using a tensile tester Tensilon (STA1150) for the above-mentioned test piece of 1 cm in length × 5 mm in width.

As a result, in Examples 1 to 3, there was no scratch on the object to be stuck when the sticking sheet using the sticking sheet with a support frame was stuck.
On the other hand, in Comparative Example 1, the side surface of the support frame touched the adherend in the sticking sheet with the support frame, which sometimes caused cuts.

DESCRIPTION OF SYMBOLS 1 ... Support frame 1a ... Frame part 1b ... Convex part 2 ... Gel film 2a ... Hydrogel film 2b ... Dry gel film 3 ... Functional layer 4 ... Sheet for sticking 10 ... Sheet for sticking with support frame 20 ... Support frame for foam film formation

Claims (3)

A patch sheet having a gel film that is a hydrogel film or a dry gel film obtained by gelling a foam film;
A support frame that has an opening and supports the sticking sheet arranged to close the opening;
Have
The support frame-attaching sheet, wherein the constituent material of the support frame has a porous structure. A patch sheet having a gel film that is a hydrogel film or a dry gel film obtained by gelling a foam film;
A support frame that has an opening and supports the sticking sheet arranged to close the opening;
Have
The sheet for sticking with a support frame, wherein the support frame has a convex portion arranged on the non-sticking surface side of the sheet for sticking. A patch sheet having a gel film that is a hydrogel film or a dry gel film obtained by gelling a foam film;
A support frame that has an opening and supports the sticking sheet arranged to close the opening;
Have
A sheet for sticking with a support frame, wherein a Young's modulus of a constituent material of the support frame is equal to or less than a Young's modulus of an object to be pasted.

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