JP2014530744A5 - - Google Patents

Info

Publication number

JP2014530744A5

JP2014530744A5 JP2014538902A JP2014538902A JP2014530744A5 JP 2014530744 A5 JP2014530744 A5 JP 2014530744A5 JP 2014538902 A JP2014538902 A JP 2014538902A JP 2014538902 A JP2014538902 A JP 2014538902A JP 2014530744 A5 JP2014530744 A5 JP 2014530744A5

Authority

JP

Japan

Prior art keywords

composition

particles

bioactive glass

der

carrier

Prior art date

2012-10-24

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000002245 particle Substances 0.000 claims description 36
• 239000005313 bioactive glass Substances 0.000 claims description 18
• 239000000463 material Substances 0.000 claims description 6
• 210000000988 bone and bone Anatomy 0.000 claims description 5
• 230000035876 healing Effects 0.000 claims description 2
• 239000000203 mixture Substances 0.000 claims 37
• 230000002745 absorbent Effects 0.000 claims 6
• 239000002250 absorbent Substances 0.000 claims 6
• WTJKGGKOPKCXLL-RRHRGVEJSA-N phosphatidylcholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCCC=CCCCCCCCC WTJKGGKOPKCXLL-RRHRGVEJSA-N 0.000 claims 6
• 230000002902 bimodal effect Effects 0.000 claims 5
• KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims 4
• 239000004568 cement Substances 0.000 claims 4
• 239000011248 coating agent Substances 0.000 claims 4
• 238000000576 coating method Methods 0.000 claims 4
• 229920002674 hyaluronan Polymers 0.000 claims 4
• 229960003160 hyaluronic acid Drugs 0.000 claims 4
• 150000001875 compounds Chemical class 0.000 claims 3
• 239000011521 glass Substances 0.000 claims 3
• 239000000017 hydrogel Substances 0.000 claims 3
• 229910052588 hydroxylapatite Inorganic materials 0.000 claims 3
• 239000007788 liquid Substances 0.000 claims 3
• XYJRXVWERLGGKC-UHFFFAOYSA-D pentacalcium;hydroxide;triphosphate Chemical compound [OH-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O XYJRXVWERLGGKC-UHFFFAOYSA-D 0.000 claims 3
• 150000003904 phospholipids Chemical class 0.000 claims 3
• 239000007787 solid Substances 0.000 claims 3
• 229920001661 Chitosan Polymers 0.000 claims 2
• 102000008186 Collagen Human genes 0.000 claims 2
• 108010035532 Collagen Proteins 0.000 claims 2
• 108010010803 Gelatin Proteins 0.000 claims 2
• 229920000615 alginic acid Polymers 0.000 claims 2
• 235000010443 alginic acid Nutrition 0.000 claims 2
• 229920001436 collagen Polymers 0.000 claims 2
• 229920000159 gelatin Polymers 0.000 claims 2
• 239000008273 gelatin Substances 0.000 claims 2
• 235000019322 gelatine Nutrition 0.000 claims 2
• 235000011852 gelatine desserts Nutrition 0.000 claims 2
• FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims 1
• 102000012422 Collagen Type I Human genes 0.000 claims 1
• 108010022452 Collagen Type I Proteins 0.000 claims 1
• 241000124008 Mammalia Species 0.000 claims 1
• CERQOIWHTDAKMF-UHFFFAOYSA-M Methacrylate Chemical compound CC(=C)C([O-])=O CERQOIWHTDAKMF-UHFFFAOYSA-M 0.000 claims 1
• 239000004721 Polyphenylene oxide Substances 0.000 claims 1
• 229940072056 alginate Drugs 0.000 claims 1
• 229960001126 alginic acid Drugs 0.000 claims 1
• 239000000783 alginic acid Substances 0.000 claims 1
• 150000004781 alginic acids Chemical class 0.000 claims 1
• 229910052586 apatite Inorganic materials 0.000 claims 1
• 229940045110 chitosan Drugs 0.000 claims 1
• 239000000499 gel Substances 0.000 claims 1
• 229940014259 gelatin Drugs 0.000 claims 1
• 239000003178 glass ionomer cement Substances 0.000 claims 1
• VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 claims 1
• 239000002985 plastic film Substances 0.000 claims 1
• 229920000570 polyether Polymers 0.000 claims 1
• 229920000642 polymer Polymers 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• 238000005457 optimization Methods 0.000 description 1