JP2014528450A5 - - Google Patents
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- Publication number
- JP2014528450A5 JP2014528450A5 JP2014534680A JP2014534680A JP2014528450A5 JP 2014528450 A5 JP2014528450 A5 JP 2014528450A5 JP 2014534680 A JP2014534680 A JP 2014534680A JP 2014534680 A JP2014534680 A JP 2014534680A JP 2014528450 A5 JP2014528450 A5 JP 2014528450A5
- Authority
- JP
- Japan
- Prior art keywords
- pyridin
- pyrimidin
- thiazol
- amine
- ylamino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 150000001875 compounds Chemical class 0.000 claims 14
- 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims 12
- -1 4-(((2,4-Diaminopteridin-6-yl) methyl) (methyl) amino) benzamido Chemical group 0.000 claims 12
- 239000008194 pharmaceutical composition Substances 0.000 claims 12
- 229910052739 hydrogen Inorganic materials 0.000 claims 8
- 239000001257 hydrogen Substances 0.000 claims 8
- 125000004435 hydrogen atoms Chemical class [H]* 0.000 claims 8
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 8
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 7
- 239000011780 sodium chloride Substances 0.000 claims 7
- 241000700605 Viruses Species 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 5
- HXWIHKLVPKVLFO-UHFFFAOYSA-N 2-[(4-pyridin-2-yl-1,3-thiazol-2-yl)-pyrimidin-2-ylamino]ethanol Chemical compound N=1C=CC=NC=1N(CCO)C(SC=1)=NC=1C1=CC=CC=N1 HXWIHKLVPKVLFO-UHFFFAOYSA-N 0.000 claims 4
- QERRMNCBNQADTC-UHFFFAOYSA-N 4-(3,5-dimethylpyridin-2-yl)-N-pyrimidin-2-yl-1,3-thiazol-2-amine Chemical compound CC1=CC(C)=CN=C1C1=CSC(NC=2N=CC=CN=2)=N1 QERRMNCBNQADTC-UHFFFAOYSA-N 0.000 claims 4
- QZPXTNVERNDKCO-UHFFFAOYSA-N 4-(4-methylpyridin-2-yl)-N-pyrimidin-2-yl-1,3-thiazol-2-amine Chemical compound CC1=CC=NC(C=2N=C(NC=3N=CC=CN=3)SC=2)=C1 QZPXTNVERNDKCO-UHFFFAOYSA-N 0.000 claims 4
- IZLGVISZPCTBOM-UHFFFAOYSA-N 4-(6-bromopyridin-2-yl)-N-pyrimidin-2-yl-1,3-thiazol-2-amine Chemical compound BrC1=CC=CC(C=2N=C(NC=3N=CC=CN=3)SC=2)=N1 IZLGVISZPCTBOM-UHFFFAOYSA-N 0.000 claims 4
- LJDMFGGAHQJRIW-UHFFFAOYSA-N 4-pyridin-2-yl-2-(pyrimidin-2-ylamino)-1,3-thiazole-5-carbonitrile Chemical compound N=1C(C=2N=CC=CC=2)=C(C#N)SC=1NC1=NC=CC=N1 LJDMFGGAHQJRIW-UHFFFAOYSA-N 0.000 claims 4
- JOWNSKXJCUZVAR-UHFFFAOYSA-N 4-pyridin-2-yl-2-(pyrimidin-2-ylamino)-1,3-thiazole-5-carboxylic acid Chemical compound N=1C(C=2N=CC=CC=2)=C(C(=O)O)SC=1NC1=NC=CC=N1 JOWNSKXJCUZVAR-UHFFFAOYSA-N 0.000 claims 4
- HFABGDPBRCVHKI-UHFFFAOYSA-N 4-pyridin-2-yl-N-[4-(trifluoromethyl)pyrimidin-2-yl]-1,3-thiazol-2-amine Chemical compound FC(F)(F)C1=CC=NC(NC=2SC=C(N=2)C=2N=CC=CC=2)=N1 HFABGDPBRCVHKI-UHFFFAOYSA-N 0.000 claims 4
- NKZCXGIZJHEBIX-UHFFFAOYSA-N 4-pyridin-2-yl-N-pyrimidin-4-yl-1,3-thiazol-2-amine Chemical compound C=1C=NC=NC=1NC(SC=1)=NC=1C1=CC=CC=N1 NKZCXGIZJHEBIX-UHFFFAOYSA-N 0.000 claims 4
- BKGZDPJCXISOJV-UHFFFAOYSA-N 5-bromo-4-pyridin-2-yl-N-pyrimidin-2-yl-1,3-thiazol-2-amine Chemical compound N=1C(C=2N=CC=CC=2)=C(Br)SC=1NC1=NC=CC=N1 BKGZDPJCXISOJV-UHFFFAOYSA-N 0.000 claims 4
- FFCNHBKDZGXAEB-UHFFFAOYSA-N 5-cyclohexyl-4-pyridin-2-yl-N-pyrimidin-2-yl-1,3-thiazol-2-amine Chemical compound C1CCCCC1C1=C(C=2N=CC=CC=2)N=C(NC=2N=CC=CN=2)S1 FFCNHBKDZGXAEB-UHFFFAOYSA-N 0.000 claims 4
- SWTCIZZQJZZPHQ-UHFFFAOYSA-N 5-ethyl-4-pyridin-2-yl-N-pyrimidin-2-yl-1,3-thiazol-2-amine Chemical compound N=1C(C=2N=CC=CC=2)=C(CC)SC=1NC1=NC=CC=N1 SWTCIZZQJZZPHQ-UHFFFAOYSA-N 0.000 claims 4
- BBRGRJOZVHSCPX-UHFFFAOYSA-N 5-methyl-4-pyridin-2-yl-N-pyrimidin-2-yl-1,3-thiazol-2-amine Chemical compound N=1C(C=2N=CC=CC=2)=C(C)SC=1NC1=NC=CC=N1 BBRGRJOZVHSCPX-UHFFFAOYSA-N 0.000 claims 4
- JLKXZQUQIBQRJX-UHFFFAOYSA-N 5-nonyl-4-pyridin-2-yl-N-pyrimidin-2-yl-1,3-thiazol-2-amine Chemical compound N=1C(C=2N=CC=CC=2)=C(CCCCCCCCC)SC=1NC1=NC=CC=N1 JLKXZQUQIBQRJX-UHFFFAOYSA-N 0.000 claims 4
- XLWUIVIANDMKLA-UHFFFAOYSA-N 5-pentyl-4-pyridin-2-yl-N-pyrimidin-2-yl-1,3-thiazol-2-amine Chemical compound N=1C(C=2N=CC=CC=2)=C(CCCCC)SC=1NC1=NC=CC=N1 XLWUIVIANDMKLA-UHFFFAOYSA-N 0.000 claims 4
- WMWWFLUMIMEMLP-UHFFFAOYSA-N 5-propan-2-yl-4-pyridin-2-yl-N-pyrimidin-2-yl-1,3-thiazol-2-amine Chemical compound N=1C(C=2N=CC=CC=2)=C(C(C)C)SC=1NC1=NC=CC=N1 WMWWFLUMIMEMLP-UHFFFAOYSA-N 0.000 claims 4
- SHDLBBBNPZBTDJ-UHFFFAOYSA-N 6-[2-(pyrimidin-2-ylamino)-1,3-thiazol-4-yl]-1H-pyridin-2-one Chemical compound OC1=CC=CC(C=2N=C(NC=3N=CC=CN=3)SC=2)=N1 SHDLBBBNPZBTDJ-UHFFFAOYSA-N 0.000 claims 4
- IENJOXRGJKIPRK-UHFFFAOYSA-N 6-methyl-N-(4-pyridin-2-yl-1,3-thiazol-2-yl)-1,3-benzothiazol-2-amine Chemical compound S1C2=CC(C)=CC=C2N=C1NC(SC=1)=NC=1C1=CC=CC=N1 IENJOXRGJKIPRK-UHFFFAOYSA-N 0.000 claims 4
- 208000006454 Hepatitis Diseases 0.000 claims 4
- WZDDCNUYYXWDSE-UHFFFAOYSA-N N-(4-methylpyrimidin-2-yl)-4-pyridin-2-yl-1,3-thiazol-2-amine Chemical compound CC1=CC=NC(NC=2SC=C(N=2)C=2N=CC=CC=2)=N1 WZDDCNUYYXWDSE-UHFFFAOYSA-N 0.000 claims 4
- YVEBSOQNIVRDRH-UHFFFAOYSA-N N-(5-bromopyrimidin-2-yl)-4-pyridin-2-yl-1,3-thiazol-2-amine Chemical compound N1=CC(Br)=CN=C1NC1=NC(C=2N=CC=CC=2)=CS1 YVEBSOQNIVRDRH-UHFFFAOYSA-N 0.000 claims 4
- NIBXGRDCQVHBHE-UHFFFAOYSA-N N-(5-chloropyrimidin-2-yl)-4-pyridin-2-yl-1,3-thiazol-2-amine Chemical compound N1=CC(Cl)=CN=C1NC1=NC(C=2N=CC=CC=2)=CS1 NIBXGRDCQVHBHE-UHFFFAOYSA-N 0.000 claims 4
- YOGMJDLDADTOPF-UHFFFAOYSA-N N-benzyl-4-pyridin-2-yl-2-(pyrimidin-2-ylamino)-1,3-thiazole-5-carboxamide Chemical compound S1C(NC=2N=CC=CN=2)=NC(C=2N=CC=CC=2)=C1C(=O)NCC1=CC=CC=C1 YOGMJDLDADTOPF-UHFFFAOYSA-N 0.000 claims 4
- PMGMBUWSZZUMTO-UHFFFAOYSA-N N-benzyl-4-pyridin-2-yl-N-pyrimidin-2-yl-1,3-thiazol-2-amine Chemical compound C=1C=CC=CC=1CN(C=1N=CC=CN=1)C(SC=1)=NC=1C1=CC=CC=N1 PMGMBUWSZZUMTO-UHFFFAOYSA-N 0.000 claims 4
- XOTDCNMYRMZMQI-UHFFFAOYSA-N N-methyl-4-pyridin-2-yl-N-pyrimidin-2-yl-1,3-thiazol-2-amine Chemical compound N=1C=CC=NC=1N(C)C(SC=1)=NC=1C1=CC=CC=N1 XOTDCNMYRMZMQI-UHFFFAOYSA-N 0.000 claims 4
- DYPIPKBSINXYKJ-UHFFFAOYSA-N N-propan-2-yl-4-pyridin-2-yl-N-pyrimidin-2-yl-1,3-thiazol-2-amine Chemical compound N=1C=CC=NC=1N(C(C)C)C(SC=1)=NC=1C1=CC=CC=N1 DYPIPKBSINXYKJ-UHFFFAOYSA-N 0.000 claims 4
- UKGBKXNZHVJTOF-UHFFFAOYSA-N N-pyrimidin-2-yl-4-quinolin-2-yl-1,3-thiazol-2-amine Chemical compound N=1C(C=2N=C3C=CC=CC3=CC=2)=CSC=1NC1=NC=CC=N1 UKGBKXNZHVJTOF-UHFFFAOYSA-N 0.000 claims 4
- RXLFKSFMSCGFBD-UHFFFAOYSA-N [4-pyridin-2-yl-2-(pyrimidin-2-ylamino)-1,3-thiazol-5-yl]methanol Chemical compound N=1C(C=2N=CC=CC=2)=C(CO)SC=1NC1=NC=CC=N1 RXLFKSFMSCGFBD-UHFFFAOYSA-N 0.000 claims 4
- MADRSCSVNCWXAW-UHFFFAOYSA-N [4-pyridin-2-yl-2-(pyrimidin-2-ylamino)-1,3-thiazol-5-yl]methyl acetate Chemical compound N=1C(C=2N=CC=CC=2)=C(COC(=O)C)SC=1NC1=NC=CC=N1 MADRSCSVNCWXAW-UHFFFAOYSA-N 0.000 claims 4
- RGZMYQPBLDEPQB-UHFFFAOYSA-N [4-pyridin-2-yl-2-(pyrimidin-2-ylamino)-1,3-thiazol-5-yl]methyl butanoate Chemical compound N=1C(C=2N=CC=CC=2)=C(COC(=O)CCC)SC=1NC1=NC=CC=N1 RGZMYQPBLDEPQB-UHFFFAOYSA-N 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 4
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 4
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims 4
- WKBOTKDWSSQWDR-UHFFFAOYSA-N bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims 4
- 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 4
- KMRVCRSSXCJYOF-UHFFFAOYSA-N ethyl 2-[(4-methylpyrimidin-2-yl)amino]-4-pyridin-2-yl-1,3-thiazole-5-carboxylate Chemical compound N=1C(C=2N=CC=CC=2)=C(C(=O)OCC)SC=1NC1=NC=CC(C)=N1 KMRVCRSSXCJYOF-UHFFFAOYSA-N 0.000 claims 4
- UOZGFTNEUUUFGL-UHFFFAOYSA-N ethyl 4-(4-methylpyridin-2-yl)-2-(pyrimidin-2-ylamino)-1,3-thiazole-5-carboxylate Chemical compound N=1C(C=2N=CC=C(C)C=2)=C(C(=O)OCC)SC=1NC1=NC=CC=N1 UOZGFTNEUUUFGL-UHFFFAOYSA-N 0.000 claims 4
- YOTCDUGBYAOKIV-UHFFFAOYSA-N ethyl 4-(6-methylpyridin-2-yl)-2-(pyrimidin-2-ylamino)-1,3-thiazole-5-carboxylate Chemical compound N=1C(C=2N=C(C)C=CC=2)=C(C(=O)OCC)SC=1NC1=NC=CC=N1 YOTCDUGBYAOKIV-UHFFFAOYSA-N 0.000 claims 4
- PWVAPGWIKKAAMS-UHFFFAOYSA-N ethyl 4-pyridin-2-yl-2-(pyrimidin-2-ylamino)-1,3-thiazole-5-carboxylate Chemical compound N=1C(C=2N=CC=CC=2)=C(C(=O)OCC)SC=1NC1=NC=CC=N1 PWVAPGWIKKAAMS-UHFFFAOYSA-N 0.000 claims 4
- 231100000283 hepatitis Toxicity 0.000 claims 4
- 125000002140 imidazol-4-yl group Chemical group [H]N1C([H])=NC([*])=C1[H] 0.000 claims 4
- JLBSDCDXDAOFJE-UHFFFAOYSA-N methyl 4-pyridin-2-yl-2-(pyrimidin-2-ylamino)-1,3-thiazole-5-carboxylate Chemical compound N=1C(C=2N=CC=CC=2)=C(C(=O)OC)SC=1NC1=NC=CC=N1 JLBSDCDXDAOFJE-UHFFFAOYSA-N 0.000 claims 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 4
- IJEVNRAIXXCJEN-UHFFFAOYSA-N tert-butyl 2-[tert-butyl(pyrimidin-2-yl)amino]-4-pyridin-2-yl-1,3-thiazole-5-carboxylate Chemical compound CC(C)(C)OC(=O)C=1SC(N(C=2N=CC=CN=2)C(C)(C)C)=NC=1C1=CC=CC=N1 IJEVNRAIXXCJEN-UHFFFAOYSA-N 0.000 claims 4
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 4
- 239000000651 prodrug Substances 0.000 claims 3
- 229940002612 prodrugs Drugs 0.000 claims 3
- 239000012453 solvate Substances 0.000 claims 3
- AGQNMYLPVLOPBV-UHFFFAOYSA-N 3-[(4-phenyl-1,3-thiazol-2-yl)amino]phenol Chemical compound OC1=CC=CC(NC=2SC=C(N=2)C=2C=CC=CC=2)=C1 AGQNMYLPVLOPBV-UHFFFAOYSA-N 0.000 claims 2
- FMLLSOIFCVZTFJ-UHFFFAOYSA-N 4-phenyl-N-pyrimidin-2-yl-1,3-thiazol-2-amine Chemical compound N=1C=CC=NC=1NC(SC=1)=NC=1C1=CC=CC=C1 FMLLSOIFCVZTFJ-UHFFFAOYSA-N 0.000 claims 2
- QAINFPRHEISSOY-UHFFFAOYSA-N 4-pyridin-2-yl-N-pyrimidin-2-yl-1,3-thiazol-2-amine Chemical compound N=1C=CC=NC=1NC(SC=1)=NC=1C1=CC=CC=N1 QAINFPRHEISSOY-UHFFFAOYSA-N 0.000 claims 2
- VSKCWIXMOBTHAR-UHFFFAOYSA-N 4-pyridin-3-yl-N-pyrimidin-2-yl-1,3-thiazol-2-amine Chemical compound N=1C=CC=NC=1NC(SC=1)=NC=1C1=CC=CN=C1 VSKCWIXMOBTHAR-UHFFFAOYSA-N 0.000 claims 2
- NYGKCRRUCANIBJ-UHFFFAOYSA-N 4-pyridin-4-yl-N-pyrimidin-2-yl-1,3-thiazol-2-amine Chemical compound N=1C=CC=NC=1NC(SC=1)=NC=1C1=CC=NC=C1 NYGKCRRUCANIBJ-UHFFFAOYSA-N 0.000 claims 2
- FAXWKQAPUYLLPC-UHFFFAOYSA-N N,4-diphenyl-1,3-thiazol-2-amine Chemical compound C=1C=CC=CC=1NC(SC=1)=NC=1C1=CC=CC=C1 FAXWKQAPUYLLPC-UHFFFAOYSA-N 0.000 claims 2
- RYCUBTFYRLAMFA-UHFFFAOYSA-N N,4-dipyridin-2-yl-1,3-thiazol-2-amine Chemical compound C=1C=CC=NC=1NC(SC=1)=NC=1C1=CC=CC=N1 RYCUBTFYRLAMFA-UHFFFAOYSA-N 0.000 claims 2
- FXXYURIGCUUXRW-UHFFFAOYSA-N N-(3-chloro-2-methylphenyl)-4-pyridin-2-yl-1,3-thiazol-2-amine Chemical compound CC1=C(Cl)C=CC=C1NC1=NC(C=2N=CC=CC=2)=CS1 FXXYURIGCUUXRW-UHFFFAOYSA-N 0.000 claims 2
- VZHGZKUEVAANEJ-UHFFFAOYSA-N N-phenyl-4-pyridin-2-yl-1,3-thiazol-2-amine Chemical compound C=1C=CC=CC=1NC(SC=1)=NC=1C1=CC=CC=N1 VZHGZKUEVAANEJ-UHFFFAOYSA-N 0.000 claims 2
- FZGLXJIEPKFFOC-UHFFFAOYSA-N N-pyrazin-2-yl-4-pyridin-2-yl-1,3-thiazol-2-amine Chemical compound C=1N=CC=NC=1NC(SC=1)=NC=1C1=CC=CC=N1 FZGLXJIEPKFFOC-UHFFFAOYSA-N 0.000 claims 2
- 230000010261 cell growth Effects 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000006990 Cholangiocarcinoma Diseases 0.000 claims 1
- 241000724675 Hepatitis E virus Species 0.000 claims 1
- 241000724709 Hepatitis delta virus Species 0.000 claims 1
- 208000006359 Hepatoblastoma Diseases 0.000 claims 1
- 206010073071 Hepatocellular carcinoma Diseases 0.000 claims 1
- 206010024324 Leukaemias Diseases 0.000 claims 1
- 210000004185 Liver Anatomy 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010061289 Metastatic neoplasm Diseases 0.000 claims 1
- 206010033128 Ovarian cancer Diseases 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 201000009910 diseases by infectious agent Diseases 0.000 claims 1
- 231100000844 hepatocellular carcinoma Toxicity 0.000 claims 1
- 201000007270 liver cancer Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 0 C*N(C(S1C2*(C)C2)=*C(C)=C1I*)[Al]* Chemical compound C*N(C(S1C2*(C)C2)=*C(C)=C1I*)[Al]* 0.000 description 1
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161542907P | 2011-10-04 | 2011-10-04 | |
US61/542,907 | 2011-10-04 | ||
PCT/US2012/058674 WO2013052613A1 (en) | 2011-10-04 | 2012-10-04 | Substituted aminothiazoles as inhibitors of cancers, including hepatocellular carcinoma, and as inhibitors of hepatitis virus replication |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2017079817A Division JP2017149753A (ja) | 2011-10-04 | 2017-04-13 | 肝細胞癌を含む癌の阻害剤、および肝炎ウイルス複製の阻害剤としての置換アミノチアゾール |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2014528450A JP2014528450A (ja) | 2014-10-27 |
JP2014528450A5 true JP2014528450A5 (US07476746-20090113-C00133.png) | 2015-11-26 |
JP6240078B2 JP6240078B2 (ja) | 2017-11-29 |
Family
ID=48044139
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2014534680A Expired - Fee Related JP6240078B2 (ja) | 2011-10-04 | 2012-10-04 | 肝細胞癌を含む癌の阻害剤、および肝炎ウイルス複製の阻害剤としての置換アミノチアゾール |
JP2017079817A Withdrawn JP2017149753A (ja) | 2011-10-04 | 2017-04-13 | 肝細胞癌を含む癌の阻害剤、および肝炎ウイルス複製の阻害剤としての置換アミノチアゾール |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2017079817A Withdrawn JP2017149753A (ja) | 2011-10-04 | 2017-04-13 | 肝細胞癌を含む癌の阻害剤、および肝炎ウイルス複製の阻害剤としての置換アミノチアゾール |
Country Status (12)
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US9582896B2 (en) * | 2011-09-02 | 2017-02-28 | Qualcomm Incorporated | Line tracking with automatic model initialization by graph matching and cycle detection |
ES2672701T3 (es) * | 2012-11-07 | 2018-06-15 | Karus Therapeutics Limited | Nuevos inhibidores de histona deacetilasa y su uso en terapia |
US20160031874A1 (en) * | 2013-03-13 | 2016-02-04 | The Broad Institute, Inc. | Substituted aminothiazoles for the treatment of tuberculosis |
WO2014181137A1 (en) | 2013-05-10 | 2014-11-13 | Karus Therapeutics Ltd | Novel histone deacetylase inhibitors |
WO2016046759A2 (en) | 2014-09-22 | 2016-03-31 | Fratagene Therapeutics Ltd. | Compositions and methods for treating friedreich's ataxia |
US10442779B2 (en) | 2014-09-22 | 2019-10-15 | Fratagene Therapeutics S.R.L. | Compositions and methods for treating Friedreich's ataxia |
GB201419264D0 (en) | 2014-10-29 | 2014-12-10 | Karus Therapeutics Ltd | Compounds |
GB201419228D0 (en) | 2014-10-29 | 2014-12-10 | Karus Therapeutics Ltd | Compounds |
CA2984252A1 (en) * | 2015-04-29 | 2016-11-03 | Foresight Biotherapeutics, Inc. | Therapeutic combinations of antiviral and anti-inflammatory therapies |
CN105524056A (zh) * | 2016-01-05 | 2016-04-27 | 中山大学肿瘤防治中心 | 一种氨基噻唑化合物及其制备方法和应用 |
US10913734B2 (en) * | 2016-07-11 | 2021-02-09 | Baruch S. Blumberg Institute | Substituted aminothiazoles |
ES2959860T3 (es) * | 2017-06-22 | 2024-02-28 | Celgene Corp | Tratamiento del carcinoma hepatocelular caracterizado por la infección por el virus de la hepatitis B |
US10426775B2 (en) | 2017-09-11 | 2019-10-01 | Fratagene Therapeutics Srl | Methods for treating Friedreich's ataxia with etravirine |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2317889T3 (es) * | 2000-03-01 | 2009-05-01 | Janssen Pharmaceutica Nv | Derivados de tiazolilo 2,4-disustituido. |
ES2407807T3 (es) * | 2001-08-13 | 2013-06-14 | Janssen Pharmaceutica N.V. | Derivados de tiazolilo 2-amino-4,5-trisustituidos y su uso frente a enfermedades autoinmunitarias |
WO2005097767A1 (en) * | 2004-03-30 | 2005-10-20 | Merck & Co., Inc. | 2-aminothiazole compounds useful as aspartyl protease inhibitors |
AU2005232753A1 (en) * | 2004-04-13 | 2005-10-27 | Astellas Pharma Inc. | Polycylic thiazoles as potassium ion channel modulators |
US8088806B2 (en) | 2005-05-09 | 2012-01-03 | Achillion Pharmaceuticals, Inc. | Thiazole compounds and methods of use |
CA2645072A1 (en) * | 2006-03-08 | 2007-09-13 | Achillion Pharmaceuticals, Inc. | Substituted aminothiazole derivatives with anti-hcv activity |
US9034574B2 (en) * | 2006-12-27 | 2015-05-19 | The Johns Hopkins University | Agents for reversing epigenetic silencing of genes |
US20110105436A1 (en) * | 2008-03-10 | 2011-05-05 | Auckland Uniservices Limited | Heteroaryl compounds, compositions, and methods of use in cancer treatment |
EP2411526A4 (en) * | 2009-03-27 | 2012-09-19 | Zacharon Pharmaceuticals Inc | MODULATORS OF GANGLIOSID BIOSYNTHESIS |
-
2012
- 2012-10-04 BR BR112014007963A patent/BR112014007963A2/pt not_active IP Right Cessation
- 2012-10-04 JP JP2014534680A patent/JP6240078B2/ja not_active Expired - Fee Related
- 2012-10-04 KR KR1020147011691A patent/KR20140071472A/ko not_active Application Discontinuation
- 2012-10-04 SG SG11201401207XA patent/SG11201401207XA/en unknown
- 2012-10-04 CA CA2850779A patent/CA2850779A1/en not_active Abandoned
- 2012-10-04 AU AU2012318670A patent/AU2012318670B2/en not_active Ceased
- 2012-10-04 US US14/349,014 patent/US20140249154A1/en not_active Abandoned
- 2012-10-04 EP EP12838333.8A patent/EP2763674A4/en not_active Withdrawn
- 2012-10-04 WO PCT/US2012/058674 patent/WO2013052613A1/en active Application Filing
- 2012-10-04 CN CN201280059490.1A patent/CN103957908A/zh active Pending
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2014
- 2014-04-03 IL IL231923A patent/IL231923A0/en unknown
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2015
- 2015-01-30 HK HK15101053.5A patent/HK1200361A1/xx unknown
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2016
- 2016-09-07 US US15/258,393 patent/US10087173B2/en not_active Expired - Fee Related
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2017
- 2017-04-13 JP JP2017079817A patent/JP2017149753A/ja not_active Withdrawn