JP2014521564A - Buffer lining for shipping containers - Google Patents

Abstract

  The present invention relates to a shock absorber lining (10) for a transport container (40), the lining being arranged along the lateral wall (38) of the container (40) and in advance from its lower edge (11). A carrier (42) adapted to support at least one cushioning element (20, 22, 24, 26) extending laterally inwardly from the carrier (42) at a defined distance (30).

Description

  The present invention relates to a buffer lining for a transport container which is particularly adapted for the transport of vitreous items, in particular vitreous items for cartridges filled with liquid medicaments.

  Certain pharmaceuticals, such as liquid drugs, require packaging with packaging that is inert to the drug. In order to deal with pre-determined hygiene standards, for example, a vitreous body made of glass is commonly used for packaging liquid medicaments. Before or during drug bottling of such a vitreous body, generally the body in tubular form needs to be transported in a reliable, safe and harmless manner. In particular, for mass production processes, cracks and collapse of such glassy packaging units need to be prevented.

  Otherwise, the entire stack of vitreous or filled cartridges can be contaminated by one damaged or cracked vitreous or cartridge.

  Patent document 1 has already disclosed a plastic shipping container having an inner lining at the bottom and its side walls. There, the lining consists of a liquid absorbent foam.

  In particular, in the vitreous body 32 illustrated in the schematic diagram of FIG. 1, bodies or cartridges 32 arranged in an upright orientation on the bottom wall 28 of the transport container 40 are arranged on each other, in particular on the proximal end of the vitreous body 32. The problem may be that the bulging portions 36 that are located are adjacent to each other. When closely packed, the items or bodies 32 are in direct contact with each other by their bulging portions 36. Further, the bulging portion 36 of the item 32 located near the rigid side wall 38 of the shipping container 40 approaches or directly contacts the side wall portion 38.

  In particular, if the container 40 is subject to side impact impacts 9 that cannot be avoided, the mechanical impact can spread across the placement of the item 32. Due to the tightly packed arrangement and due to the contact structure of the proximal bulge portion 36, the externally applied impact 9 can spread and propagate greatly across the arrangement of the vitreous items 32. As a result, a single or several items 32 may be susceptible to crushing or cracking in response to such external impacts 9 induced or transmitted through the lateral side wall 38.

German patent DE 103 39 830A1

  Accordingly, it is an object of the present invention to provide an improved mass transport container that is specifically designed for the transport of vitreous and has improved buffer properties. There is a need to greatly reduce the likelihood and extent of crushing and damage of the items arranged there by an improved transport structure. Furthermore, improved defenses against externally applied mechanical impacts need to be achieved for the items contained therein. Despite improved defenses, the container further needs to provide a high packing density of items contained therein.

  The present invention provides a buffer lining for a shipping container. The lining includes a carrier disposed along the lateral sidewall of the container and adapted to support at least one cushioning element that extends laterally inwardly from the carrier at a predefined distance from its lower edge. The carrier is applied and designed to lie on the inner surface of the side wall of the container. The at least one cushioning element is designed to project inwardly from the preferred flat shaped carrier and thus away from the side wall of the container and towards the lateral side wall of the item contained therein. The predefined distance between the at least one buffer element and the lower edge of the carrier is greater than zero. The non-zero distance of the cushioning element from the lower edge of the carrier allows a side receptacle to be formed and provided near the bottom of the container.

  In this way, the bottom edge of the carrier, when attached thereto, is generally supported by the bottom of the shipping container so that the side receptacle or recess is the bottom of the container and the buffer lining that covers the side wall of the container. In between.

  The cushioning element is particularly adapted for transmitting mechanical shocks between the side wall of the container and the side wall of the items transported in the container. Since the at least one buffering element is located at a predefined distance from the lower edge of the carrier and the carrier is positioned at the lower edge on the bottom wall of the container, the side gap or recess is at least one buffering element. , Formed between the carrier and the bottom wall of the container.

  The side recess is designed and adapted to receive a vitreous item, such as a laterally or radially outward or bulging portion of the cartridge. In practice, the vitreous item stays in a substantial lateral and / or vertical gap between the lateral wall of the carrier or container and the bulging portion of the vitreous body due to the at least one laterally-extending cushioning element. It can be positioned in the transport container in such a way. By virtue of the at least one cushioning element, the vitreous items can only be accommodated in a transport container structured such that these ridges and thus their lower or proximal edges no longer make impact-propagating contact with the lateral wall of the transport container.

  As a result, inevitable mechanical collisions or individual impact events of the shipping container are transmitted only by the cushioning elements on the side walls of the items arranged here. The at least one cushioning element eliminates the direct contact structure between the laterally extending bulging portion of the vitreous item and the fairly rigid side wall of the container, and is quite fragile on the side wall of the container and the glass item. Or, direct impact propagation between the bulging parts that are prone to cracking no longer occurs.

  According to a preferred embodiment, the distance between the bottom cushioning element and the lower edge of the carrier is at least 5 mm.

  Preferably, the distance between the bottom cushioning element and the lower edge of the carrier is chosen to accommodate the bulging portion of the transport item arranged and arranged in the transport container, preferably in a tightly packed structure Is done. The bulging portion of the transport item occurs in the glassy item manufacturing process. Accordingly, the bulging portion generally includes a vitreous melted and radially thickened edge.

  The lateral thickness as well as the vertical position of the bottom cushioning element is positioned at the bottom wall, the bottom gap formed between the bottom cushioning element and the carrier, where the vitreous melt or bulge edge is located. Designed to be able to.

  According to another preferred embodiment, the at least one cushioning element comprises a corrugated structure extending substantially parallel to the at least one corrugation or the lower edge of the carrier. By means of the undulations, the longitudinal position of the contact point between the buffer element and the adjacently arranged transport item can change. In this way, mechanical shocks or collisions that are accidents on the side walls of the shipping container can be distributed or dissipated to a plurality of adjacently placed shipping items at different longitudinal positions. Accordingly, the support or adjacent positions of transport items arranged adjacent to each other can change in a direction at least perpendicular to the direction of propagation of the undulations.

  Furthermore, the waved cushioning element can also enhance the mechanical stability of the buffer lining itself. A corrugated structure that corrugates and projects laterally inwardly can advantageously increase the rigidity of the relatively thin carrier of the buffer lining, thereby facilitating and improving the general handling of the lining.

  In a further preferred embodiment, the carrier includes a plurality of substantially parallel oriented buffer undulations that co-extend or propagate along the carrier at various distances from the lower edge of the carrier. Instead of adding a parallel orientation of the buffer corrugations to each other and / or to the extension of the lower edge of the carrier, it is also conceivable that the buffer corrugations extend at a predefined angle with respect to the lower edge of the carrier. .

  The amplitude of the at least one corrugation preferably extends substantially perpendicular to the direction of propagation. Thus, the profile of the at least one undulation may be similar to a sinusoidal waveform or waveform. Preferably, the outermost corrugations are separated from the lower edge of the carrier by a distance that is substantially the same or greater than the distance between the corrugations that are located adjacent and / or propagate together.

  According to another preferred embodiment, the at least one cushioning element comprises a rubber material protruding from the carrier and having a thickness between 1 mm and 4 mm, preferably between 2 mm and 3 mm. The shock-absorbing element is preferably made of an elastically deformable rubber material, and mechanical shocks that impinge on the lateral side walls of the transport container from the outside are effectively absorbed or at least attenuated. In addition to or as an alternative to the rubber material, and plastic materials such as elastomers or thermoplastic materials can be used to provide at least one cushioning element.

  According to a further preferred embodiment, the carrier is made of or comprises a plastic material. For example, the carrier comprises a thermoplastic or elastomeric material and may comprise a flat and uniformly shaped carrier structure for at least one cushioning element attached thereto. The carrier may include a shape that substantially corresponds to the size and shape of the sidewall segments around the shipping container.

  Furthermore, the entire buffer lining can be designed as an insert that is removably arranged in the shipping container. The cushion lining can serve as a protective or cushioning structure that is disposed between the relatively rigid side wall segments of the shipping container and the laterally disposed vitreous item.

  In still other embodiments, the carrier and at least one cushioning element are integrally molded. Thus, the carrier and cushioning element can comprise the same material and can be manufactured as a plastic or elastomeric member. It is further conceivable that the cushioning element is produced as an injection molded structure of two or more components comprising, for example, a plastic carrier and an elastomer or rubber-based cushioning element firmly bonded thereto.

  At least one cushioning element made of an elastic material may comprise a solid and uniform structure.

  In further embodiments, the at least one cushioning element comprises cardboard-like structures of various flute sizes in a single and / or double arrangement. Thus, the buffer element may include one or several layers with a corrugated flute in the middle. In general, a wide variety of flute sizes such as “A”, “B”, “C”, “E” and “F” or microflutes are generally considered as corrugated flutes. Furthermore, the corrugated cardboard-like internal structure of the cushioning element can be of a single wall and thus a double wall type similar to single and / or double arrangement. The cushioning element can be made of a paper-based material, but can also include a correspondingly molded plastic or elastomeric material.

  In yet another preferred embodiment, the buffer lining includes at least two segments corresponding in size and shape to at least two adjacent lateral walls of the shipping container. Preferably, the buffer lining includes as many as three or four segments disposed on and / or along the inner side wall of the rectangular shipping container.

  It is further beneficial if the buffer lining includes one or several crease lines or crease lines to separate or separate the corresponding side walls of the shipping container and the corresponding various segments. The cushion lining may generally include an elongated stripe or strip having four or more adjacently disposed segments separated by a crease line or crease line that extends substantially perpendicular to the lower edge of the lining carrier. When properly folded, the cushion lining can correspond and match the inner sidewall structure of the shipping container. This can then serve as an inner cover for the fairly rigid side walls of the shipping container.

  Many lining segments can vary depending on the structure of the shipping container. In general, it is conceivable that the container, in particular its peripheral sidewall structure, is triangular, pentagonal, hexagonal or other polygonal. In this case, the lining includes a corresponding shape and shape.

  According to another independent aspect, the present invention also includes a substantially rectangular bottom having a substantially flat shape to support many transport items such as a vitreous or a cartridge filled or filled with a liquid medicament. It relates to a shaped transport container. The shipping container further has at least four lateral sidewalls forming a bottom peripheral framework. In addition, the shipping container is equipped with at least one buffer lining as indicated above. The buffer lining is disposed at least on the inner surface of the lateral side wall.

  Here, this is further beneficial if the buffer lining is not secured inside the shipping container or is placed loosely. In this way, release and disassembly of the buffer lining and the shipping container can be facilitated. In particular, when empty shipping containers are stacked on top of each other, the buffer lining is removed and stored or moved elsewhere so that the empty shipping containers are not damaged when stacked it can.

  According to another embodiment, the shipping container has a plurality of cartridges arranged therein, wherein each cartridge has a vitreous body and is at least partially filled with a drug administered, for example, by injection. Has been.

As used herein, the term “drug” or “drug” preferably means a pharmaceutical formulation comprising at least one pharmaceutically active compound,
Here, in one embodiment, the pharmaceutically active compound has a molecular weight of up to 1500 Da and / or a peptide, protein, polysaccharide, vaccine, DNA, RNA, antibody, enzyme, antibody, hormone, Or an oligonucleotide, or a mixture of the above pharmaceutically active compounds,
In a further embodiment herein, the pharmaceutically active compound is diabetes or a diabetes-related complication such as diabetic retinopathy, thromboembolism such as deep vein or pulmonary thromboembolism, acute coronary syndrome (ACS) Useful for the treatment and / or prevention of angina pectoris, myocardial infarction, cancer, macular degeneration, inflammation, hay fever, atherosclerosis, and / or rheumatoid arthritis,
In a further embodiment herein, the pharmaceutically active compound comprises at least one peptide for the treatment and / or prevention of diabetes or complications associated with diabetes such as diabetic retinopathy,
In a further embodiment herein, the pharmaceutically active compound is at least one human insulin, or a human insulin analog or derivative, glucagon-like peptide (GLP-1), or an analog or derivative thereof, or exendin-3 Or exendin-4 or an analog or derivative of exendin-3 or exendin-4.

  Insulin analogues include, for example, Gly (A21), Arg (B31), Arg (B32) human insulin; Lys (B3), Glu (B29) human insulin; Lys (B28), Pro (B29) human insulin; B28) Human insulin; human insulin, wherein proline at position B28 is replaced with Asp, Lys, Leu, Val or Ala, and at position B29, Lys may be replaced with Pro; Ala (B26) human insulin; Des (B28-B30) human insulin; Des (B27) human insulin, and Des (B30) human insulin.

  Insulin derivatives include, for example, B29-N-myristoyl-des (B30) human insulin; B29-N-palmitoyl-des (B30) human insulin; B29-N-myristoyl human insulin; B29-N-palmitoyl human insulin; B28- N-myristoyl LysB28ProB29 human insulin; B28-N-palmitoyl-LysB28ProB29 human insulin; B30-N-myristoyl-ThrB29LysB30 human insulin; B30-N-palmitoyl-ThrB29LysB30 human insulin; B29-N- (N-palmitoyl) -Des (B30) human insulin; B29-N- (N-ritocryl-γ-glutamyl) -des (B30) human insulin; B29-N- (ω-ca Ruboxyheptadecanoyl) -des (B30) human insulin and B29-N- (ω-carboxyheptadecanoyl) human insulin.

  Exendin-4 is, for example, exendin-4 (1-39), H-His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp-Leu-Ser-Lys-Gln-Met-Glu-Glu- Peptide of Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Lys-Asn-Gly-Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser-NH2 sequence Means.

Exendin-4 derivatives include, for example, the following compound list:
H- (Lys) 4-desPro36, desPro37 exendin-4 (1-39) -NH2,
H- (Lys) 5-desPro36, desPro37 exendin-4 (1-39) -NH2,
desPro36 [Asp28] exendin-4 (1-39),
desPro36 [IsoAsp28] exendin-4 (1-39),
desPro36 [Met (O) 14, Asp28] exendin-4 (1-39),
desPro36 [Met (O) 14, IsoAsp28] Exendin-4 (1-39),
desPro36 [Trp (O2) 25, Asp28] exendin-4 (1-39),
desPro36 [Trp (O2) 25, IsoAsp28] exendin-4 (1-39),
desPro36 [Met (O) 14Trp (O2) 25, Asp28] exendin-4 (1-39),
desPro36 [Met (O) 14Trp (O2) 25, IsoAsp28] Exendin-4 (1-39); or desPro36 [Asp28] Exendin-4 (1-39),
desPro36 [IsoAsp28] exendin-4 (1-39),
desPro36 [Met (O) 14, Asp28] exendin-4 (1-39),
desPro36 [Met (O) 14, IsoAsp28] Exendin- (1-39),
desPro36 [Trp (O2) 25, Asp28] exendin-4 (1-39),
desPro36 [Trp (O2) 25, IsoAsp28] exendin-4 (1-39),
desPro36 [Met (O) 14, Trp (O2) 25, Asp28] exendin-4 (1-39),
desPro36 [Met (O) 14, Trp (O 2) 25, IsoAsp 28] Exendin-4 (1-39),
Wherein the group -Lys6-NH2 may be linked to the C-terminus of the exendin-4 derivative;

Or an exendin-4 derivative H- (Lys) 6-desPro36 [Asp28] exendin-4 (1-39) -Lys6-NH2, having the following sequence:
desAsp28Pro36, Pro37, Pro38 exendin-4 (1-39) -NH2,
H- (Lys) 6-desPro36, Pro38 [Asp28] Exendin-4 (1-39) -NH2,
H-Asn- (Glu) 5desPro36, Pro37, Pro38 [Asp28] Exendin-4 (1-39) -NH2,
desPro36, Pro37, Pro38 [Asp28] Exendin-4 (1-39)-(Lys) 6-NH2,
H- (Lys) 6-desPro36, Pro37, Pro38 [Asp28] Exendin-4 (1-39)-(Lys) 6-NH2,
H-Asn- (Glu) 5-desPro36, Pro37, Pro38 [Asp28] Exendin-4 (1-39)-(Lys) 6-NH2,
H- (Lys) 6-desPro36 [Trp (O2) 25, Asp28] exendin-4 (1-39) -Lys6-NH2,
H-desAsp28 Pro36, Pro37, Pro38 [Trp (O2) 25] exendin-4 (1-39) -NH2,
H- (Lys) 6-desPro36, Pro37, Pro38 [Trp (O2) 25, Asp28] exendin-4 (1-39) -NH2,
H-Asn- (Glu) 5-desPro36, Pro37, Pro38 [Trp (O2) 25, Asp28] exendin-4 (1-39) -NH2,
desPro36, Pro37, Pro38 [Trp (O2) 25, Asp28] exendin-4 (1-39)-(Lys) 6-NH2,
H- (Lys) 6-desPro36, Pro37, Pro38 [Trp (O2) 25, Asp28] exendin-4 (1-39)-(Lys) 6-NH2,
H-Asn- (Glu) 5-desPro36, Pro37, Pro38 [Trp (O2) 25, Asp28] exendin-4 (1-39)-(Lys) 6-NH2,
H- (Lys) 6-desPro36 [Met (O) 14, Asp28] exendin-4 (1-39) -Lys6-NH2,
desMet (O) 14, Asp28Pro36, Pro37, Pro38 Exendin-4 (1-39) -NH2,
H- (Lys) 6-desPro36, Pro37, Pro38 [Met (O) 14, Asp28] exendin-4 (1-39) -NH2,
H-Asn- (Glu) 5-desPro36, Pro37, Pro38 [Met (O) 14, Asp28] exendin-4 (1-39) -NH2,
desPro36, Pro37, Pro38 [Met (O) 14, Asp28] Exendin-4 (1-39)-(Lys) 6-NH2,
H- (Lys) 6-desPro36, Pro37, Pro38 [Met (O) 14, Asp28] exendin-4 (1-39)-(Lys) 6-NH2,
H-Asn- (Glu) 5, desPro36, Pro37, Pro38 [Met (O) 14, Asp28] exendin-4 (1-39)-(Lys) 6-NH2,
H-Lys6-desPro36 [Met (O) 14, Trp (O2) 25, Asp28] Exendin-4 (1-39) -Lys6-NH2,
H-desAsp28, Pro36, Pro37, Pro38 [Met (O) 14, Trp (O2) 25] exendin-4 (1-39) -NH2,
H- (Lys) 6-desPro36, Pro37, Pro38 [Met (O) 14, Asp28] exendin-4 (1-39) -NH2,
H-Asn- (Glu) 5-desPro36, Pro37, Pro38 [Met (O) 14, Trp (O2) 25, Asp28] Exendin-4 (1-39) -NH2,
desPro36, Pro37, Pro38 [Met (O) 14, Trp (O2) 25, Asp28] Exendin-4 (1-39)-(Lys) 6-NH2,
H- (Lys) 6-desPro36, Pro37, Pro38 [Met (O) 14, Trp (O2) 25, Asp28] Exendin-4 (S1-39)-(Lys) 6-NH2,
H-Asn- (Glu) 5-desPro36, Pro37, Pro38 [Met (O) 14, Trp (O2) 25, Asp28] Exendin-4 (1-39)-(Lys) 6-NH2;
Or a pharmaceutically acceptable salt or solvate of any of the exendin-4 derivatives described above;
Selected from.

  Hormones are, for example, Rote Liste, 2008 edition of 50, such as gonadotropin (holitropin, lutropin, corion gonadotropin, menotropin), somatropin (somatropin), desmopressin, telluripressin, gonadorelin, triptorelin, leuprorelin, buserelin, nafarelin, goserelin. Pituitary hormones or hypothalamic hormones or regulatory active peptides and their antagonists.

  Examples of polysaccharides include, for example, glucosaminoglycan, hyaluronic acid, heparin, low molecular weight heparin, or ultra low molecular weight heparin or derivatives thereof, or sulfated, for example, polysulfated forms of the above polysaccharides, and / or Pharmaceutically acceptable salts thereof. An example of a pharmaceutically acceptable salt of polysulfated low molecular weight heparin is enoxaparin sodium salt.

  Antibodies are also globular plasma proteins (~ 150 kDa) known as immunoglobulins that share the basic structure. Since these have sugar chains attached to amino acid residues, they are glycoproteins. The basic functional unit of each antibody is an immunoglobulin (Ig) monomer (contains only 1 lg units), ie the secreted antibody is also a dimer comprising two Ig units such as IgA, teleost IgM Can be a tetramer with 4 Ig units, or a pentamer with 5 Ig units, such as mammalian IgM.

  An Ig monomer is a “Y” -shaped molecule consisting of four polypeptide chains, two identical single chains, and two identical light chains joined by a disulfide bond between cysteine residues. Each heavy chain is about 440 amino acids long and each light chain is about 220 amino acids long. Each heavy and light chain contains intrachain disulfide bonds that stabilize these folds. Each chain is composed of structural domains called Ig domains. These domains contain about 70-110 amino acids and are classified into various categories (eg variable or V and constant or C) according to their size and function. They have a unique immunoglobulin fold that creates a “sandwich” shape in which the two β-sheets are held together by interactions between conserved cysteines and other charged amino acids.

  There are five types of mammalian Ig heavy chains denoted α, δ, ε, γ and μ. The type of heavy chain present defines the isotype of the antibody, and these chains are found in IgA, IgD, IgE, IgG and IgM, respectively.

  Different heavy chains differ in size and composition, with α and γ about 450 amino acids. And δ contains about 500 amino acids, while μ and ε have about 550 amino acids. Each heavy chain has two regions, a constant region (CH) and a variable region (VH). In one species, the constant regions are essentially the same in antibodies of the same isotype, but are different in antibodies of different isotypes. Heavy chains γ, α and δ have a constant region consisting of three tandem Ig domains and a hinge region to add flexibility, and heavy chains μ and ε are constant regions consisting of four immunoglobulin domains. Have. The variable region of the heavy chain is different for antibodies produced by different B cells, but is the same for all antibodies produced by a single B cell or B cell clone. The variable region of each heavy chain is approximately 110 amino acids long and consists of a single Ig domain.

  In mammals, there are two types of immunoglobulin light chains, denoted λ and κ. The light chain has two series of domains: one constant region (CL) and one variable region (VL). . The approximate length of the light chain is 211 to 217 amino acids. Each antibody contains two light chains that are always identical, ie only one type of light chain κ or λ is present for each mammalian antibody.

  Although the general structure of all antibodies is very similar, the specific nature of a given antibody is determined by the variable (V) region, as detailed above. More specifically, three of the variable loop, each of the three light chains (VL) and heavy chain (VH) are involved in binding to the antigen, ie its antigen specificity. These loops are referred to as complementarity determining regions (CDRs). Since CDRs from both the VH and VL regions contribute to the antigen binding site, it is the combination of heavy and light chains that determines the final antigen specificity, not each of them alone.

  “Antibody fragment”. It contains at least one antigen bound to a fragment as defined above and exhibits essentially the same function and specificity as a complete antibody from which the fragment is derived. Restricted proteolytic digestion with papain cleaves the Ig prototype into three fragments. Two identical amino-terminal fragments, each containing one full light chain and about half the heavy chain, are antigen-binding fragments (Fabs). The third fragment is a crystal-forming fragment (Fc) that is the same size but half of both heavy chains with these interchain disulfide bonds contain the carboxyl terminus. Fc contains carbohydrates, complement binding and FcR binding sites. Restriction pepsin digestion results in a single F (ab ') 2 fragment containing H-H interchain disulfide bonds and containing both the Fab fragment and the hinge region. F (ab ′) 2 is divalent for antigen binding. The disulfide bond of F (ab ′) 2 can be cleaved to obtain Fab ′. Furthermore, the heavy and light chain variable regions can be fused together to form a single chain variable fragment (scFv).

  Pharmaceutically acceptable salts include, for example, acid addition salts and basic salts. Examples of acid addition salts include HCl or HBr salts. The basic salt has, for example, a cation selected from alkali or alkaline earth metals, such as Na +, K +, or Ca2 +, or ammonium ions N + (R1) (R2) (R3) (R4). A salt, wherein R1-R4 are, independently of one another, hydrogen; optionally substituted C1-C6 alkyl group, optionally substituted C2-C6 alkenyl group, optionally substituted C6-C10 aryl group, Or an optionally substituted C6-C10 heteroaryl group. Further examples of pharmaceutically acceptable salts are described in “Remington's Pharmaceutical Sciences”, 17th edition, Alfonso R. Gennaro (edited), Mark Publishing, Easton, Pa., USA, 1985 and Encyclopedia of Pharmaceutical Technology. Yes.

  Examples of pharmaceutically acceptable solvates include hydrates.

  It will be further apparent to those skilled in the art that various changes and modifications may be made in the present invention without departing from the spirit and scope of the invention. Furthermore, it is noted that any reference signs used in the appended claims shall not be construed as limiting the scope of the invention.

  Preferred embodiments of the invention are described in detail below with reference to the drawings:

1 schematically shows a transport structure according to the prior art. 2 is an illustration of a shipping container equipped with a buffer lining. FIG. 4 shows a single perspective view of a buffer lining before insertion into a shipping container. FIG. 3 is an illustration of a cross-section of a buffer lining along AA according to FIG. 2. Various samples of cardboard-like structures implemented as buffer elements are shown.

DETAILED DESCRIPTION The shipping container 40 includes a substantially flat shaped bottom wall 28 and sidewalls 38 that extend substantially perpendicular to the orientation of the bottom wall 28, as shown in FIGS. 1 and 2 further show an item 32 that is transported and contained in such a shipping container 40. The item 32 includes, by way of example, a vitreous body, such as clear glass, and further has a bead cap 34 at the upper distal end. Opposite the upper end, the vitreous body 32 includes an outwardly extending bulging edge 36. This bulging portion 36 is the remainder of the manufacturing process of the glass cylinder 32 formed by a suitable melting process.

  As further shown in FIG. 2, the cushion lining 10 includes a flat, uniformly shaped carrier 42 that is almost all adjacent to the interior surface of the sidewall 38 of the shipping container 40. The buffer lining 10 further includes or supports a number of buffer elements 20, 22, 24, 26 that extend and protrude inwardly from the carrier 42.

  Any one of the buffer elements 20, 22, 24, 26 includes a wavy portion that extends and propagates in the horizontal direction, eg, substantially parallel to the lower edge 11 of the carrier 42. With this lower edge 11, the carrier 42 and the entire buffer lining 10 can be supported by the bottom wall 28 of the transport container 40. Accordingly, the cushion lining 10 is positioned vertically oriented on the bottom wall 28 of the container 40 and stands on its lower side edge 11.

  The undulations 20, 22, 24, 26 are preferably securely attached to the carrier 42, so that there is a prior connection between the undulation 26 and the lower edge 11, and therefore between the undulation 26 and the bottom wall 28. A defined gap 30 can be provided. By maintaining a predefined distance 30 between the bottom wall and the bottom wavy portion 26, each lateral recess for the bulging portion 36 of the vitreous item 32 is formed in the lateral side wall 38. Can bring.

  As illustrated in FIG. 2, such a receptacle for the laterally outwardly extending bulge portion 36 is formed by the bottom corrugated portion 26, the carrier 42 and the bottom wall 28 of the shipping container 40. Thus, the vitreous item 32 can be attached to the container 40 by establishing a side adjoining with a number of cushioning elements 20, 22, 24, 26, while its laterally bulging portion 36 does not cause contact with the side wall 38 or the carrier 42 of the cushion lining 10.

  A mechanical collision or mechanical impact 9 that impinges on the side wall 38 of the transport container 40 can propagate transversely to the vitreous body 22 across many buffer elements 20, 22, 24, 26. In this way, very large point loads acting on the laterally extending bulge portion 36 can be effectively avoided, and the unavoidable mechanical loads are axially and thus substantially cylindrical in the vitreous body 32. Can be distributed smoothly and uniformly in the vertical direction of the sketch of FIG.

  FIG. 3 shows a perspective view of the buffer lining 10 arranged like a frame. Here, a rectangular or substantially secondary lining 10 includes four segments 12, 14, 16, 18 where segments 12, 16 and segments 14, 18 include substantially the same shape. The cushion lining 10, which is not folded and not clearly shown, includes three creases or crease lines 13 that extend substantially perpendicular to the lower edges 11 of the various lining segments 12, 14, 16, 18.

  The crease or crease line 13 may be designed as an embossed, perforated or otherwise structurally weakened line to easily and / or define the respective fold in the form as shown in FIG. . The four segments 12, 14, 16, 18 of the cushion lining 10 are separated by three creases or crease lines 13, while the segments 12, 14 remain unconnected at the open end 15. In this way, the cushion lining 10 can be placed flexibly inside the correspondingly shaped shipping container 40 and can easily offset the final production or shape tolerances of such a container 40. The described and open structure of the lining 10 is also beneficial for receiving and transporting such a lining 10 separately, independent of the shipping container 40.

  By providing an open framework rather than closure for the cushion lining, a relatively wide range of adjacent portions over the entire surface of the buffer segments 12, 14, 16, 18 and the respective lateral sidewalls 38 of the shipping container 40 are effectively obtained. Can be provided. The buffer undulations 20, 22, 24, 26 generally extend along the full width or extension of the various lining segments 12, 14, 16, 18 between adjacent fold lines 13 or free ends 15.

  The corrugations of the buffer elements 20, 22, 24, 26 propagate and extend parallel to or along the lower edge of the carrier 42. The amplitude of the undulations of the buffer element varies in the vertical direction and thus substantially perpendicular to the lower edge 11, while the undulations 20, 22, 24, 26 in the direction normal to the plane of the carrier 42. The thickness of is substantially constant.

  As shown in section AA according to FIG. 4, the thickness of the corrugations or buffer elements 20, 22, 24, 26 is approximately twice the thickness of the carrier 42. However, the geometry, number and spacing between the corrugations of the buffer elements 20, 22, 24, 26 can vary depending on the size and type of the vitreous item 32 transported in the transport container 40.

  The highly fragile item 32 is intended to be provided with a cushion lining with a significant degree of cushioning. Pretty sturdy items 32 can be transported with linings optimized to provide maximum packing density.

  It is further noted that the illustrated cushion lining provides excellent cushioning and uniform distribution of mechanical impact on items packed or packed in a shipping container. Also, the buffer lining is fairly thin and thus has little effect on the available storage space provided by the shipping container.

  FIG. 5 is a final illustration of a variety of different cardboard-like structures of different flutes sizes in the dual arrangements 52, 54, 56 as well as various single arrangements 44, 46, 48, 50. For example, corrugated structure 44 corresponds to an F-flute, structure 46 represents an E-flute, structure 48 represents a B-flute, and corrugated structure 50 refers to a C-flute.

  Dual structure 52 is similar to FE-flute, structure 54 is an illustration of EB-flute, and structure 56 schematically illustrates BC-flute. When designed as a cardboard-like structure, the corrugations of the cushioning elements 20, 22, 24, 26 can include paper-based fiberboard or corrugated structures 44, 46, 48, 50, 52, as shown in FIG. It may include a plastic material similar to at least one of 54, 56, or a combination thereof, or at least included in the part.

DESCRIPTION OF SYMBOLS 9: Mechanical impact 10: Lining assembly 11: Lower edge 12: Lining segment 13: Crease line 14: Lining segment 15: Open end 16: Lining segment 18: Lining segment 20: Buffer element 22: Buffer element 24 : Buffer element 26: buffer element 28: bottom wall 30: gap 32: cartridge 34: bead cap 36: bulging edge 38: side wall 40: transport container 42: carrier 44: cardboard-like structure 46: cardboard-like structure 48: cardboard-like Structure 50: Cardboard-like structure 52: Cardboard-like structure 54: Cardboard-like structure 56: Cardboard-like structure

Claims (14)

Buffer lining for shipping containers, which:
A carrier (42) arranged along the lateral wall (38) of the container (40) and laterally from the carrier (42) at a predefined distance (30) from its lower edge (11) The carrier (42) adapted to support at least one buffer element (20, 22, 24, 26) extending therein;
Comprising the above-mentioned buffer lining.   Buffer lining according to claim 1, wherein the distance (30) between the lowermost buffer element (26) and the lower edge (11) of the carrier (42) is at least 5 mm.   The distance (30) between the bottom cushioning element (26) and the lower edge (11) is intended to accommodate the bulging portion (36) of the transport item (32) arranged in the transport container (40). The buffer lining according to claim 1 or 2, which is selected as follows.   4. The shock absorber element (20, 22, 24, 26) according to claim 1, comprising at least one undulation extending substantially parallel to the lower edge (11) of the carrier (42). Buffer lining.   A plurality of substantially parallel-oriented buffered corrugations (20, 22, 24, 26) in which the carrier (42) extends together along the carrier (42) at different distances from the lower edge (11) of the carrier (42). The buffer lining of claim 4 comprising:   6. The at least one buffer element (20, 22, 24, 26) protrudes from the carrier (42) and comprises a rubber material having a thickness of 1 mm to 4 mm, preferably 2 mm to 3 mm. The buffer lining according to claim 1.   7. A buffer lining according to any one of the preceding claims, wherein the carrier (42) is made of a plastic material.   8. The shock absorber lining according to claim 1, wherein the carrier (42) and the at least one shock absorber element (20, 22, 24, 26) are integrally molded.   Buffer according to any one of the preceding claims, wherein the at least one buffer element (20, 22, 24, 26) comprises cardboard-like structures of various flutes sizes in a single and / or double arrangement. Lining.   10. The method as claimed in claim 1, comprising at least two adjacently disposed side walls (38) of the transport container (40) and at least two segments (12, 14, 16, 18) corresponding in size and shape. Buffer lining according to item.   Buffer lining according to claim 10, wherein the segments (12, 14, 16, 18) are separated by crease lines or crease lines (13).   Claims disposed on the inner surface of the substantially flat shaped bottom (28), at least four lateral sidewalls (12, 14, 16, 18), and at least one lateral sidewall (12, 14, 16, 18). Item 12. A shipping container having a substantially rectangular shape, comprising at least one buffer lining (10) according to any one of items 1-11.   13. Transport container according to claim 12, wherein the buffer lining (10) is arranged without being fixed inside the transport container.   14. A transport container according to claim 12 or 13, comprising a plurality of cartridges (32) arranged therein, said cartridges (32) having a vitreous body and at least partially filled with a drug. The above shipping container.

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