JP2014512207A5 - - Google Patents

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JP2014512207A5
JP2014512207A5 JP2013557218A JP2013557218A JP2014512207A5 JP 2014512207 A5 JP2014512207 A5 JP 2014512207A5 JP 2013557218 A JP2013557218 A JP 2013557218A JP 2013557218 A JP2013557218 A JP 2013557218A JP 2014512207 A5 JP2014512207 A5 JP 2014512207A5
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手持ち式の蒸気送達デバイス向けの制御システムであって、
液体の所定の体積を完全に気化させるのに最小限必要な温度まで加熱要素を加熱するために過不足のない電力量を電源から提供し、一貫し且つ信頼性のある投与量を送達するために前記必要な温度で前記液体の所定の体積を完全に気化させるための前記過不足のない電力量を供給するように過不足のない持続時間を制御するように構成された回路を備える制御システム。 A control system for a handheld vapor delivery device comprising:
To provide a consistent and reliable dosage , providing a sufficient amount of power from the power source to heat the heating element to the minimum required temperature to fully vaporize a given volume of liquid A control system comprising a circuit configured to control a deficiency duration so as to supply the deficient amount of power to completely vaporize the predetermined volume of the liquid at the required temperature . 前記回路がワンショット回路を備える、請求項１に記載の制御システム。   The control system of claim 1, wherein the circuit comprises a one-shot circuit. 前記回路が、前記加熱要素の抵抗を監視し、前記必要な温度まで前記加熱要素を加熱するのに十分なレベルに前記電力量を調整するようにプログラムされた処理装置をさらに備える、請求項１に記載の制御システム。   The processing apparatus further comprises a processor programmed to monitor the resistance of the heating element and adjust the amount of power to a level sufficient to heat the heating element to the required temperature. The control system described in. 前記回路が、前記必要な温度まで前記加熱要素を加熱するのに十分な前記レベルに前記電力量を調整するように前記電源に動作可能に接続されたＤＣ／ＤＣ昇圧変換器およびスーパーキャパシタを備える、請求項１に記載の制御システム。   The circuit comprises a DC / DC boost converter and a supercapacitor operably connected to the power supply to adjust the amount of power to the level sufficient to heat the heating element to the required temperature. The control system according to claim 1. 前記回路が、前記電源を所定の回数だけ作動させるように構成される、請求項１に記載の制御システム。   The control system of claim 1, wherein the circuit is configured to activate the power source a predetermined number of times. ａ．第１の端部および第２の端部を有する筐体と、
ｂ．前記第１の端部に取り付けられたマウスピースと、
ｃ．流体送達システムと、
ｄ．前記マウスピースと前記流体送達システムとの間に加熱要素を備える気化システムと、
ｅ．前記液体の過不足のない体積を完全に気化させるのに必要な温度まで前記加熱要素を加熱するために過不足のない電力量を電源から提供し、前記必要な温度で前記液体の前記過不足のない体積を完全に気化させるための前記過不足のない電力量を供給するように過不足のない持続時間を制御するように構成された回路を備える電力制御システムと
を備える手持ち式の薬剤送達デバイス。 a. A housing having a first end and a second end;
b. A mouthpiece attached to the first end;
c. A fluid delivery system;
d. A vaporization system comprising a heating element between the mouthpiece and the fluid delivery system ;
e. Provide a sufficient amount of power from a power source to heat the heating element to a temperature required to completely vaporize the liquid excess and deficiency volume, and the liquid deficiency at the required temperature. A power control system comprising a circuit configured to control a deficiency duration so as to provide the deficient amount of power for complete vaporization of an empty volume; and a handheld drug delivery comprising: device. 前記制御システムがワンショット回路を備える、請求項６に記載の手持ち式の薬剤送達デバイス。   The handheld drug delivery device of claim 6, wherein the control system comprises a one-shot circuit. 前記回路が、前記加熱要素の抵抗を監視し、前記加熱要素が前記必要な温度に到達するまで前記電力を調整するようにプログラムされた処理装置を備える、請求項６に記載の手持ち式の薬剤送達デバイス。   The hand-held drug of claim 6, wherein the circuit comprises a processing device programmed to monitor the resistance of the heating element and adjust the power until the heating element reaches the required temperature. Delivery device. 前記制御システムが、スーパーキャパシタに動作可能に接続されたＤＣ／ＤＣ昇圧変換器を備える、請求項６に記載の手持ち式の薬剤送達デバイス。   The handheld drug delivery device of claim 6, wherein the control system comprises a DC / DC boost converter operably connected to a supercapacitor. 前記回路が、前記電源を所定の回数だけ作動させるようにプログラムされた処理装置を備える、請求項６に記載の手持ち式の薬剤送達デバイス。   The hand-held drug delivery device of claim 6, wherein the circuit comprises a processing device programmed to activate the power source a predetermined number of times. 前記電源がアルカリ電池である、請求項６に記載の手持ち式の薬剤送達デバイス。   The handheld drug delivery device of claim 6, wherein the power source is an alkaline battery. 前記流体送達システムが、
ａ．前記筐体の内側に位置し、第１の端部および第２の端部を有する流体リザーバと、
ｂ．前記流体リザーバの内側で前記第２の端部に位置決めされ、固定かつ個別の距離を開けて前記第１の端部の方へ徐々に前進し、前記流体リザーバからの液体の過不足のない体積を一貫して計測するように構成された圧力生成器とを備える、請求項６に記載の手持ち式の薬剤送達デバイス。 The fluid delivery system comprises:
a. A fluid reservoir located inside the housing and having a first end and a second end;
b. A volume that is positioned at the second end inside the fluid reservoir and is gradually advanced toward the first end at a fixed and discrete distance, so that there is no excess or deficiency of liquid from the fluid reservoir. 7. A handheld drug delivery device according to claim 6, comprising a pressure generator configured to consistently measure the pressure. 前記流体送達システムが、前記第１の端部で前記流体リザーバと流動的に連通しているキャップをさらに備え、前記キャップが、前記流体リザーバの反対側に出口を有し、前記流体リザーバに正の圧力が印加されると、前記流体リザーバの内側に貯蔵されている前記液体が前記出口から出て、前記出口に小滴を形成することができる、請求項１２に記載の手持ち式の薬剤送達デバイス。   The fluid delivery system further comprises a cap in fluid communication with the fluid reservoir at the first end, the cap having an outlet on the opposite side of the fluid reservoir, the positive end being in the fluid reservoir. 13. The handheld drug delivery of claim 12, wherein when the pressure is applied, the liquid stored inside the fluid reservoir can exit the outlet and form a droplet at the outlet. device. 前記小滴が前記出口上に位置しながら前記加熱要素に接触できるように、前記出口と前記加熱要素が、前記小滴より小さい距離だけ分離される、請求項１３に記載の手持ち式の薬剤送達デバイス。   14. Handheld drug delivery according to claim 13, wherein the outlet and the heating element are separated by a smaller distance than the droplet so that the droplet can contact the heating element while located on the outlet. device. 前記圧力生成器が、
ａ．前記流体リザーバの内側に収容され、前記キャップを通って前記液体を押し出すように構成されたピストンと、
ｂ．前記ピストンに動作可能に接続された流体排出作動装置とを備え、前記流体排出作動装置を作動させることで、前記ピストンが前記固定かつ個別の距離で前記第１の端部の方へ前進する、請求項１３に記載の手持ち式の薬剤送達デバイス。 The pressure generator is
a. A piston housed inside the fluid reservoir and configured to push the liquid through the cap;
b. A fluid discharge actuation device operably connected to the piston, and actuating the fluid discharge actuation device to advance the piston toward the first end at the fixed and discrete distance; The handheld drug delivery device according to claim 13. 前記マウスピースと前記加熱要素との間に位置決めされた透過性の膜をさらに備え、前記透過性の膜が、所定の寸法の蒸気の分子に対して透過性を有する、請求項１２に記載の手持ち式の薬剤送達デバイス。   13. The permeable membrane of claim 12, further comprising a permeable membrane positioned between the mouthpiece and the heating element, wherein the permeable membrane is permeable to vapor molecules of a predetermined size. Handheld drug delivery device. ａ．第１の端部および第２の端部を有する筐体と、
ｂ．前記第１の端部に取り付けられたマウスピースと、
ｃ．流体送達システムであって、
ｉ．前記筐体の内側に位置し、第１の端部および第２の端部を有する流体リザーバ、および
ｉｉ．前記流体リザーバの内側で前記第２の端部に位置決めされ、固定かつ個別の距離を開けて前記第１の端部の方へ徐々に前進し、前記流体リザーバからの液体の過不足のない体積を一貫して計測するように構成された圧力生成器を備える流体送達システムと、
ｄ．前記マウスピースと前記流体リザーバとの間に加熱要素を備える気化システムと、
ｅ．前記気化システムに電力を送達する制御システムと
を備える手持ち式の薬剤送達デバイス。 a. A housing having a first end and a second end;
b. A mouthpiece attached to the first end;
c. A fluid delivery system comprising:
i. A fluid reservoir located inside the housing and having a first end and a second end; and ii. A volume that is positioned at the second end inside the fluid reservoir and is gradually advanced toward the first end at a fixed and discrete distance, so that there is no excess or deficiency of liquid from the fluid reservoir. Fluid delivery system comprising a pressure generator configured to consistently measure
d. A vaporization system comprising a heating element between the mouthpiece and the fluid reservoir;
e. And a control system for delivering power to the vaporization system. 前記流体送達システムが、前記第１の端部で前記流体リザーバと流動的に連通しているキャップをさらに備え、前記キャップが、前記流体リザーバの反対側に出口を有し、前記流体リザーバに正の圧力が印加されると、前記流体リザーバの内側に貯蔵されている前記液体が前記出口から出て、前記出口に小滴を形成することができる、請求項１７に記載の手持ち式の薬剤送達デバイス。   The fluid delivery system further comprises a cap in fluid communication with the fluid reservoir at the first end, the cap having an outlet on the opposite side of the fluid reservoir, the positive end being in the fluid reservoir. 18. The hand-held drug delivery of claim 17, wherein when the pressure is applied, the liquid stored inside the fluid reservoir can exit the outlet and form a droplet at the outlet. device. 前記小滴が前記開口で前記出口上に位置しながら前記加熱要素に接触できるように、前記出口と前記加熱要素が、前記小滴より小さい距離だけ分離される、請求項１８に記載の手持ち式の薬剤送達デバイス。   19. The handheld of claim 18, wherein the outlet and the heating element are separated by a distance less than the droplet so that the droplet can contact the heating element while located on the outlet at the opening. Drug delivery device. 前記圧力生成器が、
ａ．前記流体リザーバの内側に収容され、前記キャップを通って前記液体を押し出すように構成されたピストンと、
ｂ．前記ピストンに動作可能に接続された流体排出作動装置とを備え、前記流体排出作動装置を作動させることで、前記ピストンが前記固定かつ個別の距離で前記第１の端部の方へ前進する、請求項１８に記載の手持ち式の薬剤送達デバイス。 The pressure generator is
a. A piston housed inside the fluid reservoir and configured to push the liquid through the cap;
b. A fluid discharge actuation device operably connected to the piston, and actuating the fluid discharge actuation device to advance the piston toward the first end at the fixed and discrete distance; 19. A handheld drug delivery device according to claim 18. 前記マウスピースと前記加熱要素との間に位置決めされた透過性の膜をさらに備え、前記透過性の膜が、所定の寸法の蒸気の分子に対して透過性を有する、請求項１７に記載の手持ち式の薬剤送達デバイス。   18. The permeable membrane of claim 17, further comprising a permeable membrane positioned between the mouthpiece and the heating element, wherein the permeable membrane is permeable to vapor molecules of a predetermined size. Handheld drug delivery device. 手持ち式のデバイスからの液体の薬剤の過不足のない量を効率的かつ一貫して気化させる方法であって、
ａ．加熱要素への液体の過不足のない体積を一貫して計測するステップと、
ｂ．過不足のない持続時間にわたって前記加熱要素を加熱するための過不足のない電力量を電源から供給するステップであって、前記過不足のない電力量と前記過不足のない持続時間の組合せによって、前記液体の前記過不足のない体積を完全に気化させるのに最小限必要な時間にわたって最小限必要な温度まで前記加熱要素を加熱する、供給するステップとを含む方法。 A method for efficiently and consistently evaporating an excess or deficiency of liquid medication from a handheld device,
a. Consistently measuring the volume of liquid in the heating element without excess or deficiency;
b. Supplying from a power source a power amount that is sufficient to heat the heating element over a time period that is free of excess or deficiency, wherein the combination of the power amount without excess and deficiency and the duration time without excess or deficiency, Heating the heating element to a minimum required temperature for a minimum time required to completely vaporize the excess-deficient volume of the liquid. 前記液体の過不足のない体積を計測するステップが、
ａ．前記液体を流体リザーバ内に貯蔵するステップと、
ｂ．前記流体リザーバの内側で正の圧力の過不足のない量を印加して、前記流体の過不足のない体積を前記流体リザーバから排出するステップとを含む、請求項２２に記載の方法。 Measuring the volume of the liquid without excess or deficiency;
a. Storing the liquid in a fluid reservoir;
b. 23. The method of claim 22, comprising applying a positive pressure deficiency amount inside the fluid reservoir to drain a deficient volume of fluid from the fluid reservoir. 前記正の圧力の過不足のない量が、前記流体リザーバ内でプランジャを所定の距離で徐々に前進させることによって印加される、請求項２３に記載の方法。 24. The method of claim 23, wherein a non-abundant amount of the positive pressure is applied by gradually advancing a plunger a predetermined distance within the fluid reservoir. 前記プランジャを前記所定の距離で前進させることが、駆動ナットを回して固定の回転運動をさせることによって実現される、請求項２４に記載の方法。   25. The method of claim 24, wherein advancing the plunger by the predetermined distance is accomplished by turning a drive nut to provide a fixed rotational motion. 前記駆動ナットを回すことが、ボタンを作動させることによって実現され、前記ボタンが、作動されるたびに前記駆動ナットを回して前記固定の回転運動をさせる、請求項２５に記載の方法。   26. The method of claim 25, wherein turning the drive nut is accomplished by actuating a button, and the button turns the drive nut to cause the fixed rotational motion each time it is actuated. 前記過不足のない電力量を供給するステップが、前記電源を所定の回数で作動させるように処理装置をプログラムすることによって実現される、請求項２２に記載の方法。   23. The method according to claim 22, wherein supplying the amount of power without excess or deficiency is realized by programming a processing device to operate the power supply a predetermined number of times. 前記過不足のない電力量を供給するステップが、
ａ．前記電力を供給しながら前記加熱要素の温度を監視するステップと、
ｂ．前記加熱要素の前記温度と所定の温度を比較するステップと、
ｃ．前記比較に基づいて前記過不足のない電力量が供給される前記過不足のない持続時間を調整するステップとを含む、請求項２２に記載の方法。 Supplying the electric energy without excess or deficiency,
a. Monitoring the temperature of the heating element while supplying the power;
b. Comparing the temperature of the heating element to a predetermined temperature;
c. 23. The method of claim 22, comprising adjusting the deficiency duration for which the deficient amount of power is supplied based on the comparison. 前記過不足のない電力量を供給するステップが、
ａ．前記電力を供給しながら前記加熱要素の温度を監視するステップと、
ｂ．前記加熱要素の前記温度と所定の温度を比較するステップと、
ｃ．前記比較に基づいて前記供給される電力量を調整するステップとを含む、請求項２２に記載の方法。 Supplying the electric energy without excess or deficiency,
a. Monitoring the temperature of the heating element while supplying the power;
b. Comparing the temperature of the heating element to a predetermined temperature;
c. 23. The method of claim 22, comprising adjusting the amount of power supplied based on the comparison. 前記加熱要素の前記温度を監視するステップが、前記加熱要素内の抵抗を測定することによって実現される、請求項２９に記載の方法。   30. The method of claim 29, wherein monitoring the temperature of the heating element is realized by measuring a resistance in the heating element. 前記供給される電力量を調整するように前記電源および前記処理装置に動作可能に接続されたスーパーキャパシタをさらに備える、請求項２９に記載の方法。   30. The method of claim 29, further comprising a supercapacitor operably connected to the power source and the processing device to regulate the amount of power supplied. 前記電源がアルカリ電池である、請求項３１に記載の方法。   32. The method of claim 31, wherein the power source is an alkaline battery. 前記電力を供給するステップが、前記手持ち式デバイスのマウスピースに空気流を生じさせることによって起動される、請求項２２に記載の方法。   23. The method of claim 22, wherein the step of supplying power is initiated by creating an air flow in a mouthpiece of the handheld device. 前記加熱要素と前記マウスピースとの間に透過性の膜を配置することによって、前記気化させる液体の蒸気の分子の寸法を制御するステップをさらに含み、前記透過性の膜が、所定の寸法の蒸気の分子のみに対して透過性を有する、請求項３３に記載の方法。   The method further comprises controlling the size of the vapor molecules of the vaporized liquid by disposing a permeable membrane between the heating element and the mouthpiece, the permeable membrane having a predetermined size. 34. A method according to claim 33, which is permeable only to vapor molecules. 手持ち式の蒸気送達デバイス向けの制御システムであって、
ａ．液体の所定の体積を完全に気化させるのに最小限必要な温度まで加熱要素を加熱するために過不足のない電力量を電源から提供する手段と、
ｂ．前記必要な温度で前記液体の所定の体積を完全に気化させるための前記過不足のない電力量を供給するように過不足のない持続時間を制御する手段とを備える、制御システム。 A control system for a handheld vapor delivery device comprising:
a. Means for providing a sufficient amount of power from a power source to heat the heating element to a minimum required temperature to fully vaporize a given volume of liquid;
b. A control system comprising: means for controlling a deficiency duration so as to supply the deficient amount of power for completely vaporizing the predetermined volume of the liquid at the required temperature.
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