JP2014510152A5 - - Google Patents
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- Publication number
- JP2014510152A5 JP2014510152A5 JP2014504014A JP2014504014A JP2014510152A5 JP 2014510152 A5 JP2014510152 A5 JP 2014510152A5 JP 2014504014 A JP2014504014 A JP 2014504014A JP 2014504014 A JP2014504014 A JP 2014504014A JP 2014510152 A5 JP2014510152 A5 JP 2014510152A5
- Authority
- JP
- Japan
- Prior art keywords
- formulation
- viscosity
- acetate
- reduced
- less
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000009472 formulation Methods 0.000 claims 56
- 239000000203 mixture Substances 0.000 claims 56
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 12
- QTBSBXVTEAMEQO-UHFFFAOYSA-M acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 12
- DHMQDGOQFOQNFH-UHFFFAOYSA-N glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 12
- 102000004169 proteins and genes Human genes 0.000 claims 10
- 108090000623 proteins and genes Proteins 0.000 claims 10
- 230000001225 therapeutic Effects 0.000 claims 9
- 239000004475 Arginine Substances 0.000 claims 6
- QIVBCDIJIAJPQS-SECBINFHSA-N D-tryptophane Chemical compound C1=CC=C2C(C[C@@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-SECBINFHSA-N 0.000 claims 6
- 239000004471 Glycine Substances 0.000 claims 6
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims 6
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 6
- 229960005190 Phenylalanine Drugs 0.000 claims 6
- 239000000427 antigen Substances 0.000 claims 5
- 102000038129 antigens Human genes 0.000 claims 5
- 108091007172 antigens Proteins 0.000 claims 5
- 229920001184 polypeptide Polymers 0.000 claims 5
- 102000004965 antibodies Human genes 0.000 claims 3
- 108090001123 antibodies Proteins 0.000 claims 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N D-sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 2
- 102000000743 Interleukin-5 Human genes 0.000 claims 2
- 108010002616 Interleukin-5 Proteins 0.000 claims 2
- 229940100602 Interleukin-5 Drugs 0.000 claims 2
- CZMRCDWAGMRECN-GDQSFJPYSA-N Sucrose Natural products O([C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](CO)O1)[C@@]1(CO)[C@H](O)[C@@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-GDQSFJPYSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000005720 sucrose Substances 0.000 claims 2
- 102000018358 Immunoglobulins Human genes 0.000 claims 1
- 108060003951 Immunoglobulins Proteins 0.000 claims 1
- 229940068968 Polysorbate 80 Drugs 0.000 claims 1
- 159000000021 acetate salts Chemical class 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- 238000007911 parenteral administration Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 1
- 229920000053 polysorbate 80 Polymers 0.000 claims 1
Claims (37)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201161473123P | 2011-04-07 | 2011-04-07 | |
US61/473,123 | 2011-04-07 | ||
PCT/US2012/032464 WO2012141978A2 (en) | 2011-04-07 | 2012-04-06 | Formulations with reduced viscosity |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2014510152A JP2014510152A (en) | 2014-04-24 |
JP2014510152A5 true JP2014510152A5 (en) | 2015-05-21 |
Family
ID=47009919
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2014504014A Pending JP2014510152A (en) | 2011-04-07 | 2012-04-06 | Formulation with reduced viscosity |
Country Status (12)
Country | Link |
---|---|
US (1) | US20140044727A1 (en) |
EP (1) | EP2694708A4 (en) |
JP (1) | JP2014510152A (en) |
KR (1) | KR20140066124A (en) |
CN (1) | CN103582724A (en) |
AU (1) | AU2012243126A1 (en) |
BR (1) | BR112013025845A2 (en) |
CA (1) | CA2832560A1 (en) |
EA (1) | EA201391489A1 (en) |
IL (1) | IL228626A0 (en) |
SG (1) | SG193964A1 (en) |
WO (1) | WO2012141978A2 (en) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5743234B2 (en) * | 2010-01-15 | 2015-07-01 | キリン−アムジェン・インコーポレーテッド | Antibody formulations and treatment regimens |
US20140023655A1 (en) * | 2011-04-07 | 2014-01-23 | Glaxosmithkline Llc | Formulations with reduced viscosity |
MA37777B1 (en) * | 2012-06-21 | 2017-07-31 | Ucb Pharma Sa | Pharmaceutical preparation |
FR2994390B1 (en) | 2012-08-10 | 2014-08-15 | Adocia | METHOD FOR LOWERING THE VISCOSITY OF HIGH CONCENTRATION PROTEIN SOLUTIONS |
CA2923859C (en) | 2013-09-11 | 2021-11-23 | Arsia Therapeutics, Inc. | Liquid protein formulations containing viscosity-lowering agents |
US11471479B2 (en) | 2014-10-01 | 2022-10-18 | Eagle Biologics, Inc. | Polysaccharide and nucleic acid formulations containing viscosity-lowering agents |
CA2996088A1 (en) | 2015-08-24 | 2017-03-02 | Glaxosmithkline Intellectual Property (No. 2) Limited | Biopharmaceutical compositions |
CN105733250B (en) * | 2016-05-04 | 2017-12-26 | 山东省药学科学院 | One kind crosslinking polyglutamic acid suspension and preparation method and application |
JP7177777B2 (en) * | 2017-01-11 | 2022-11-24 | セルトリオン, インク. | Stable liquid formulation |
JOP20190255A1 (en) * | 2017-04-28 | 2019-10-27 | Amgen Inc | Formulations of human anti-rankl antibodies, and methods of using the same |
WO2018204374A1 (en) | 2017-05-02 | 2018-11-08 | Merck Sharp & Dohme Corp. | Formulations of anti-lag3 antibodies and co-formulations of anti-lag3 antibodies and anti-pd-1 antibodies |
JOP20190260A1 (en) | 2017-05-02 | 2019-10-31 | Merck Sharp & Dohme | Stable formulations of programmed death receptor 1 (pd-1) antibodies and methods of use thereof |
SG11202003754YA (en) | 2017-05-16 | 2020-05-28 | Bhamis Research Laboratory Pvt Ltd | High concentration protein formulations with reduced viscosity |
EP3634467A4 (en) * | 2017-06-06 | 2021-07-28 | GlaxoSmithKline LLC | Biopharmaceutical compositions and methods for pediatric patients |
KR102594028B1 (en) * | 2018-03-07 | 2023-10-24 | 화이자 인코포레이티드 | Anti-PD-1 antibody composition |
EP3958840A1 (en) * | 2019-04-23 | 2022-03-02 | Amgen Inc. | The use of low molecular weight polyvinylpyrrolidone (pvp) to reduce viscosity of high concentration protein formulations |
GB202102258D0 (en) * | 2021-02-17 | 2021-03-31 | Arecor Ltd | Novel composition |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP2116265B1 (en) * | 2000-10-12 | 2020-12-23 | Genentech, Inc. | Reduced-viscosity concentrated protein formulations |
US20050164929A1 (en) * | 2000-11-06 | 2005-07-28 | Lupine Logic, Inc. | Methods of preventing and treating inflammatory bowel disease |
MY145693A (en) * | 2002-11-01 | 2012-03-30 | Glaxosmithkline Biolog Sa | A method of drying without freezing or bubbling |
US20050053666A1 (en) * | 2002-12-31 | 2005-03-10 | Stelios Tzannis | Antibody-containing particles and compositions |
CA2623429C (en) * | 2005-09-30 | 2015-01-13 | Medimmune Limited | Interleukin-13 antibody composition |
US7390786B2 (en) * | 2005-12-21 | 2008-06-24 | Wyeth | Protein formulations with reduced viscosity and uses thereof |
US9084777B2 (en) * | 2005-12-28 | 2015-07-21 | Chugai Seiyaku Kabushiki Kaisha | Stabilized antibody-containing formulations |
UA107557C2 (en) * | 2007-07-06 | 2015-01-26 | OFATUMUMAB ANTIBODY COMPOSITION | |
JP2010532790A (en) * | 2007-07-06 | 2010-10-14 | グラクソスミスクライン・リミテッド・ライアビリティ・カンパニー | Antibody prescription |
AU2008304111B2 (en) * | 2007-09-27 | 2014-04-24 | Amgen Inc. | Pharmaceutical formulations |
PE20091174A1 (en) * | 2007-12-27 | 2009-08-03 | Chugai Pharmaceutical Co Ltd | LIQUID FORMULATION WITH HIGH CONCENTRATION OF ANTIBODY CONTENT |
CN107095846A (en) * | 2009-12-21 | 2017-08-29 | 霍夫曼-拉罗奇有限公司 | Antibody formulations |
JP2013525484A (en) * | 2010-05-03 | 2013-06-20 | ジェネンテック, インコーポレイテッド | Compositions and methods useful for reducing the viscosity of protein-containing formulations |
-
2012
- 2012-04-06 AU AU2012243126A patent/AU2012243126A1/en not_active Abandoned
- 2012-04-06 KR KR1020137029164A patent/KR20140066124A/en not_active Application Discontinuation
- 2012-04-06 BR BR112013025845A patent/BR112013025845A2/en not_active IP Right Cessation
- 2012-04-06 EA EA201391489A patent/EA201391489A1/en unknown
- 2012-04-06 CA CA2832560A patent/CA2832560A1/en not_active Abandoned
- 2012-04-06 US US14/110,252 patent/US20140044727A1/en not_active Abandoned
- 2012-04-06 CN CN201280025770.0A patent/CN103582724A/en active Pending
- 2012-04-06 WO PCT/US2012/032464 patent/WO2012141978A2/en active Application Filing
- 2012-04-06 JP JP2014504014A patent/JP2014510152A/en active Pending
- 2012-04-06 SG SG2013072434A patent/SG193964A1/en unknown
- 2012-04-06 EP EP12771966.4A patent/EP2694708A4/en not_active Withdrawn
-
2013
- 2013-09-29 IL IL228626A patent/IL228626A0/en unknown
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