JP2014507147A5 - - Google Patents
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- Publication number
- JP2014507147A5 JP2014507147A5 JP2013553643A JP2013553643A JP2014507147A5 JP 2014507147 A5 JP2014507147 A5 JP 2014507147A5 JP 2013553643 A JP2013553643 A JP 2013553643A JP 2013553643 A JP2013553643 A JP 2013553643A JP 2014507147 A5 JP2014507147 A5 JP 2014507147A5
- Authority
- JP
- Japan
- Prior art keywords
- aptamer
- seq
- tfpi
- binds
- pathway inhibitor
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920002395 Aptamer Polymers 0.000 claims description 51
- 102100008880 TFPI Human genes 0.000 claims description 34
- 101710034269 TFPI Proteins 0.000 claims description 34
- 238000006467 substitution reaction Methods 0.000 claims description 22
- 239000000126 substance Substances 0.000 claims description 18
- 229920001850 Nucleic acid sequence Polymers 0.000 claims description 13
- 206010018987 Haemorrhage Diseases 0.000 claims description 12
- 230000000740 bleeding Effects 0.000 claims description 12
- 231100000319 bleeding Toxicity 0.000 claims description 12
- 150000007523 nucleic acids Chemical group 0.000 claims description 9
- 150000001875 compounds Chemical class 0.000 claims description 6
- 238000010348 incorporation Methods 0.000 claims description 6
- 230000004048 modification Effects 0.000 claims description 6
- 238000006011 modification reaction Methods 0.000 claims description 6
- 125000003729 nucleotide group Chemical group 0.000 claims description 6
- 206010009802 Coagulopathy Diseases 0.000 claims description 4
- 102100000368 F8 Human genes 0.000 claims description 4
- 101700070229 F8 Proteins 0.000 claims description 4
- 102100006624 F9 Human genes 0.000 claims description 4
- 101700074227 F9 Proteins 0.000 claims description 4
- 208000009292 Hemophilia A Diseases 0.000 claims description 4
- 208000009429 Hemophilia B Diseases 0.000 claims description 4
- 239000002202 Polyethylene glycol Substances 0.000 claims description 4
- 208000008425 Protein Deficiency Diseases 0.000 claims description 4
- 238000007385 chemical modification Methods 0.000 claims description 4
- 201000007368 coagulation protein disease Diseases 0.000 claims description 4
- 201000010099 disease Diseases 0.000 claims description 4
- 201000003542 factor VIII deficiency Diseases 0.000 claims description 4
- 230000002163 immunogen Effects 0.000 claims description 4
- 230000002401 inhibitory effect Effects 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 229920001223 polyethylene glycol Polymers 0.000 claims description 4
- 206010067787 Coagulation factor deficiency Diseases 0.000 claims description 2
- 206010010356 Congenital anomaly Diseases 0.000 claims description 2
- 208000009190 Disseminated Intravascular Coagulation Diseases 0.000 claims description 2
- 206010019016 Haemorrhagic stroke Diseases 0.000 claims description 2
- 208000002085 Hemarthrosis Diseases 0.000 claims description 2
- 206010022114 Injury Diseases 0.000 claims description 2
- 208000002473 Lacerations Diseases 0.000 claims description 2
- 241000124008 Mammalia Species 0.000 claims description 2
- 208000007106 Menorrhagia Diseases 0.000 claims description 2
- 229940012957 Plasmin Drugs 0.000 claims description 2
- 208000006106 Plasminogen Activator Inhibitor-1 Deficiency Diseases 0.000 claims description 2
- 206010043554 Thrombocytopenia Diseases 0.000 claims description 2
- 206010047715 Von Willebrand's disease Diseases 0.000 claims description 2
- 230000001154 acute Effects 0.000 claims description 2
- 230000002730 additional Effects 0.000 claims description 2
- 230000002429 anti-coagulation Effects 0.000 claims description 2
- 239000003146 anticoagulant agent Substances 0.000 claims description 2
- 201000011510 cancer Diseases 0.000 claims description 2
- NAGJZTKCGNOGPW-UHFFFAOYSA-L dithiophosphate(2-) Chemical compound OP([O-])([S-])=S NAGJZTKCGNOGPW-UHFFFAOYSA-L 0.000 claims description 2
- 201000007219 factor XI deficiency Diseases 0.000 claims description 2
- 230000003993 interaction Effects 0.000 claims description 2
- 238000007917 intracranial administration Methods 0.000 claims description 2
- 150000002634 lipophilic molecules Chemical class 0.000 claims description 2
- 201000009673 liver disease Diseases 0.000 claims description 2
- 230000001404 mediated Effects 0.000 claims description 2
- 230000035772 mutation Effects 0.000 claims description 2
- 239000002773 nucleotide Substances 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims description 2
- 230000000896 plasminic Effects 0.000 claims description 2
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims description 2
- 230000000472 traumatic Effects 0.000 claims description 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13/026,165 | 2011-02-11 | ||
| US13/026,165 US8598327B2 (en) | 2009-08-18 | 2011-02-11 | Aptamers to tissue factor pathway inhibitor and their use as bleeding disorder therapeutics |
| PCT/US2012/024916 WO2012109675A1 (en) | 2011-02-11 | 2012-02-13 | Aptamers to tissue factor pathway inhibitor and their use as bleeding disorder therapeutics |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014507147A JP2014507147A (ja) | 2014-03-27 |
| JP2014507147A5 true JP2014507147A5 (pt) | 2015-04-09 |
| JP6002691B2 JP6002691B2 (ja) | 2016-10-05 |
Family
ID=45771912
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013553643A Active JP6002691B2 (ja) | 2011-02-11 | 2012-02-13 | 組織因子経路阻害剤に対するアプタマーおよび出血障害治療薬としてのそれらの使用 |
Country Status (5)
| Country | Link |
|---|---|
| EP (1) | EP2673364A1 (pt) |
| JP (1) | JP6002691B2 (pt) |
| AU (1) | AU2012214148A1 (pt) |
| CA (1) | CA2827160A1 (pt) |
| WO (1) | WO2012109675A1 (pt) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2562114C2 (ru) | 2008-12-22 | 2015-09-10 | Ново Нордиск А/С | Антитела против ингибитора метаболического пути тканевого фактора |
| WO2011109452A1 (en) | 2010-03-01 | 2011-09-09 | Bayer Healthcare Llc | Optimized Monoclonal Antibodies against Tissue Factor Pathway Inhibitor (TFPI) |
| WO2013142153A2 (en) * | 2012-03-22 | 2013-09-26 | Baxter International Inc. | Aptamers to tissue factor pathway inhibitor and their use as bleeding disorder therapeutics |
| KR101969402B1 (ko) * | 2016-10-27 | 2019-04-16 | 대한민국 | 물사출 분쇄기의 거치장치 |
| CN111411164B (zh) * | 2020-05-26 | 2022-11-01 | 中国检验检疫科学研究院 | 利用数字pcr检测番茄溃疡病菌的方法及其使用的成套试剂 |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6011020A (en) | 1990-06-11 | 2000-01-04 | Nexstar Pharmaceuticals, Inc. | Nucleic acid ligand complexes |
| US5262564A (en) | 1992-10-30 | 1993-11-16 | Octamer, Inc. | Sulfinic acid adducts of organo nitroso compounds useful as retroviral inactivating agents anti-retroviral agents and anti-tumor agents |
| US6207646B1 (en) | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US6429199B1 (en) | 1994-07-15 | 2002-08-06 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules for activating dendritic cells |
| US6239116B1 (en) | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| JP2001513776A (ja) | 1997-02-28 | 2001-09-04 | ユニバーシティ オブ アイオワ リサーチ ファウンデーション | ＬＰＳ関連障害の処置における非メチル化ＣｐＧジヌクレオチドを含む核酸の使用 |
| US6426334B1 (en) | 1997-04-30 | 2002-07-30 | Hybridon, Inc. | Oligonucleotide mediated specific cytokine induction and reduction of tumor growth in a mammal |
| DK1009413T3 (da) | 1997-09-05 | 2007-06-11 | Univ California | Anvendelse af immunstimulerende oligonukleotider til forebyggelse eller behandling af astma |
| US6514948B1 (en) | 1999-07-02 | 2003-02-04 | The Regents Of The University Of California | Method for enhancing an immune response |
| US20080161425A1 (en) * | 2005-07-29 | 2008-07-03 | Universiteit Van Maastricht | Regulation of Tissue Factor Activity by Protein S and Tissue Factor Pathway Inhibitor |
| BR122021014783B1 (pt) * | 2008-12-19 | 2023-03-14 | Baxalta GmbH | Peptídeo que se liga a tfpi, uso do peptídeo, composição farmacêutica e método para purificação de tfpi |
| FR2942232B1 (fr) * | 2009-02-19 | 2015-03-13 | Lfb Biotechnologies | Moyens pour la purification d'une proteine de la coagulation et procedes pour sa mise en oeuvre |
| US8252913B2 (en) * | 2009-08-18 | 2012-08-28 | Baxter International Inc. | Aptamers to tissue factor pathway inhibitor and their use as bleeding disorder therapeutics |
-
2012
- 2012-02-13 CA CA2827160A patent/CA2827160A1/en not_active Abandoned
- 2012-02-13 JP JP2013553643A patent/JP6002691B2/ja active Active
- 2012-02-13 AU AU2012214148A patent/AU2012214148A1/en not_active Abandoned
- 2012-02-13 EP EP12706378.2A patent/EP2673364A1/en not_active Withdrawn
- 2012-02-13 WO PCT/US2012/024916 patent/WO2012109675A1/en active Application Filing
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