JP2014507147A5 - - Google Patents

Info

Publication number

JP2014507147A5

JP2014507147A5 JP2013553643A JP2013553643A JP2014507147A5 JP 2014507147 A5 JP2014507147 A5 JP 2014507147A5 JP 2013553643 A JP2013553643 A JP 2013553643A JP 2013553643 A JP2013553643 A JP 2013553643A JP 2014507147 A5 JP2014507147 A5 JP 2014507147A5

Authority

JP

Japan

Prior art keywords

aptamer

seq

tfpi

binds

pathway inhibitor

Prior art date

2012-02-13

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 108091023037 Aptamer Proteins 0.000 claims description 51
• 102100030951 Tissue factor pathway inhibitor Human genes 0.000 claims description 32
• 108010013555 lipoprotein-associated coagulation inhibitor Proteins 0.000 claims description 32
• 239000000126 substance Substances 0.000 claims description 18
• 238000006467 substitution reaction Methods 0.000 claims description 18
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 12
• 125000003729 nucleotide group Chemical group 0.000 claims description 10
• 108091028043 Nucleic acid sequence Proteins 0.000 claims description 9
• 150000007523 nucleic acids Chemical group 0.000 claims description 9
• 208000032843 Hemorrhage Diseases 0.000 claims description 8
• 208000034158 bleeding Diseases 0.000 claims description 8
• 230000000740 bleeding effect Effects 0.000 claims description 8
• 150000001875 compounds Chemical class 0.000 claims description 6
• 230000007812 deficiency Effects 0.000 claims description 6
• 238000010348 incorporation Methods 0.000 claims description 6
• 230000004048 modification Effects 0.000 claims description 6
• 238000012986 modification Methods 0.000 claims description 6
• 239000002773 nucleotide Substances 0.000 claims description 6
• 102100022641 Coagulation factor IX Human genes 0.000 claims description 4
• 102100026735 Coagulation factor VIII Human genes 0.000 claims description 4
• 206010053567 Coagulopathies Diseases 0.000 claims description 4
• 201000003542 Factor VIII deficiency Diseases 0.000 claims description 4
• 208000009292 Hemophilia A Diseases 0.000 claims description 4
• 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 claims description 4
• 239000002202 Polyethylene glycol Substances 0.000 claims description 4
• 230000037429 base substitution Effects 0.000 claims description 4
• 208000015294 blood coagulation disease Diseases 0.000 claims description 4
• 238000007385 chemical modification Methods 0.000 claims description 4
• 230000009852 coagulant defect Effects 0.000 claims description 4
• 208000009429 hemophilia B Diseases 0.000 claims description 4
• 208000031169 hemorrhagic disease Diseases 0.000 claims description 4
• 230000002163 immunogen Effects 0.000 claims description 4
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• 208000016988 Hemorrhagic Stroke Diseases 0.000 claims description 2
• 101000653189 Homo sapiens Tissue factor pathway inhibitor Proteins 0.000 claims description 2
• 208000034693 Laceration Diseases 0.000 claims description 2
• 241000124008 Mammalia Species 0.000 claims description 2
• 206010028980 Neoplasm Diseases 0.000 claims description 2
• 108700009202 Plasminogen Activator Inhibitor-1 Deficiency Proteins 0.000 claims description 2
• 208000027276 Von Willebrand disease Diseases 0.000 claims description 2
• 230000005856 abnormality Effects 0.000 claims description 2
• 208000016804 acquired coagulation factor deficiency Diseases 0.000 claims description 2
• 230000001154 acute effect Effects 0.000 claims description 2
• 239000003146 anticoagulant agent Substances 0.000 claims description 2
• 229940127219 anticoagulant drug Drugs 0.000 claims description 2
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• 208000009190 disseminated intravascular coagulation Diseases 0.000 claims description 2
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• 125000002467 phosphate group Chemical group [H]OP(=O)(O[H])O[*] 0.000 claims description 2
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• RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims description 2
• 206010043554 thrombocytopenia Diseases 0.000 claims description 2
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• 208000012137 von Willebrand disease (hereditary or acquired) Diseases 0.000 claims description 2
• 238000000034 method Methods 0.000 description 3