JP2014506796A5 - - Google Patents
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- Publication number
- JP2014506796A5 JP2014506796A5 JP2013554526A JP2013554526A JP2014506796A5 JP 2014506796 A5 JP2014506796 A5 JP 2014506796A5 JP 2013554526 A JP2013554526 A JP 2013554526A JP 2013554526 A JP2013554526 A JP 2013554526A JP 2014506796 A5 JP2014506796 A5 JP 2014506796A5
- Authority
- JP
- Japan
- Prior art keywords
- stationary phase
- solid stationary
- pressure
- bar
- analyte
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000005526 G1 to G0 transition Effects 0.000 claims 18
- 239000007787 solid Substances 0.000 claims 18
- 239000012491 analyte Substances 0.000 claims 9
- 238000000034 method Methods 0.000 claims 8
- 102000004190 Enzymes Human genes 0.000 claims 6
- 108090000790 Enzymes Proteins 0.000 claims 6
- 239000002245 particle Substances 0.000 claims 6
- 229920000642 polymer Polymers 0.000 claims 6
- 239000011148 porous material Substances 0.000 claims 6
- 239000007788 liquid Substances 0.000 claims 5
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims 4
- 239000012530 fluid Substances 0.000 claims 2
- 239000000377 silicon dioxide Substances 0.000 claims 2
- AUNDWZCDAOTGDQ-UHFFFAOYSA-N 4-triethoxysilylbutanal Chemical compound CCO[Si](OCC)(OCC)CCCC=O AUNDWZCDAOTGDQ-UHFFFAOYSA-N 0.000 claims 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 claims 1
- 239000005977 Ethylene Substances 0.000 claims 1
- 239000000919 ceramic Substances 0.000 claims 1
- 238000004587 chromatography analysis Methods 0.000 claims 1
- 239000000463 material Substances 0.000 claims 1
- 229910044991 metal oxide Inorganic materials 0.000 claims 1
- 150000004706 metal oxides Chemical class 0.000 claims 1
- 229910000077 silane Inorganic materials 0.000 claims 1
- -1 surface hybrid Inorganic materials 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161443380P | 2011-02-16 | 2011-02-16 | |
| US61/443,380 | 2011-02-16 | ||
| US201161474155P | 2011-04-11 | 2011-04-11 | |
| US61/474,155 | 2011-04-11 | ||
| PCT/US2012/024869 WO2012112448A1 (en) | 2011-02-16 | 2012-02-13 | Immobilized enzymatic reactor |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017149718A Division JP6630317B2 (ja) | 2011-02-16 | 2017-08-02 | 固定化酵素反応器 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2014506796A JP2014506796A (ja) | 2014-03-20 |
| JP2014506796A5 true JP2014506796A5 (https=) | 2015-04-02 |
| JP6189752B2 JP6189752B2 (ja) | 2017-08-30 |
Family
ID=46672898
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013554526A Expired - Fee Related JP6189752B2 (ja) | 2011-02-16 | 2012-02-13 | 固定化酵素反応器 |
| JP2017149718A Expired - Fee Related JP6630317B2 (ja) | 2011-02-16 | 2017-08-02 | 固定化酵素反応器 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017149718A Expired - Fee Related JP6630317B2 (ja) | 2011-02-16 | 2017-08-02 | 固定化酵素反応器 |
Country Status (4)
| Country | Link |
|---|---|
| US (4) | US9890411B2 (https=) |
| EP (2) | EP3421586B1 (https=) |
| JP (2) | JP6189752B2 (https=) |
| WO (1) | WO2012112448A1 (https=) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104198631B (zh) * | 2014-08-11 | 2017-01-18 | 贾明宏 | 一种提高蛋白质在氘代试剂中氢氘原子交换效率的方法 |
| EP3302509B1 (en) | 2015-05-29 | 2024-01-24 | Lifenet Health | Placenta-derived matrix and methods of preparing and use thereof |
| CN108348818B (zh) | 2015-08-13 | 2021-05-28 | 沃特世科技公司 | 镍-钴合金材料装置和部件 |
| EP3491374B1 (en) | 2016-07-28 | 2024-10-09 | Waters Technologies Corporation | Encapsulated pre-analytic workflow reagents for flow-through devices, liquid chromatography and mass spectrometric analysis |
| WO2020261221A1 (en) * | 2019-06-26 | 2020-12-30 | Waters Technologies Corporation | Coatings with immobilized affinity ligands and enzymes and use thereof in liquid chromatography assays |
| WO2025262605A1 (en) * | 2024-06-18 | 2025-12-26 | Waters Technologies Corporation | Enzyme-immobilized particles for on-line protein digestion |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2357184A1 (de) | 1973-11-16 | 1975-05-22 | Merck Patent Gmbh | Verfahren zur herstellung von organisch modifizierten siliciumdioxiden |
| US4994373A (en) | 1983-01-27 | 1991-02-19 | Enzo Biochem, Inc. | Method and structures employing chemically-labelled polynucleotide probes |
| IL78678A0 (en) * | 1986-05-04 | 1986-08-31 | Yeda Res & Dev | Substituted silica |
| JPH04269656A (ja) | 1991-02-26 | 1992-09-25 | Toray Dow Corning Silicone Co Ltd | 液体クロマトグラフィー用充填剤 |
| US6686035B2 (en) | 1999-02-05 | 2004-02-03 | Waters Investments Limited | Porous inorganic/organic hybrid particles for chromatographic separations and process for their preparation |
| US6528167B2 (en) | 2001-01-31 | 2003-03-04 | Waters Investments Limited | Porous hybrid particles with organic groups removed from the surface |
| US7201844B1 (en) | 2001-03-14 | 2007-04-10 | Hammen Corporation | Composite matrices with interstital polymer networks |
| US7097882B2 (en) | 2001-08-21 | 2006-08-29 | Samsung Sdi Co., Ltd. | Substrate for immobilizing physiological material, and method of fabricating same |
| US20050095690A1 (en) | 2003-10-31 | 2005-05-05 | Naik Rajesh R. | Entrapment of biomolecules and inorganic nanoparticles by biosilicification |
| US8715982B2 (en) | 2005-03-08 | 2014-05-06 | Agency For Science, Technology And Research | Immobilised enzymes |
| US20090256068A1 (en) * | 2008-04-10 | 2009-10-15 | Konstantinos Petritis | Solution fragmentation systems and processes for proteomics analysis |
| US20090203068A1 (en) | 2008-02-07 | 2009-08-13 | Battelle Memorial Institute | High Pressure Enzymatic Digestion System For Protein Characterization |
| EP2350275A4 (en) * | 2008-11-17 | 2013-07-17 | Agency Science Tech & Res | HYDROPHOBIC MAGNETIC PARTICLES |
| JP6151021B2 (ja) * | 2009-06-01 | 2017-06-21 | ウオーターズ・テクノロジーズ・コーポレイシヨン | クロマトグラフ分離用ハイブリッド材料 |
| JP2011027429A (ja) * | 2009-07-21 | 2011-02-10 | Kirin Holdings Co Ltd | 液体クロマトグラフィーを用いたグリコアルカロイド類の精製および分析法 |
| EP2460002A4 (en) | 2009-07-31 | 2013-11-27 | Waters Technologies Corp | METHOD AND DEVICE FOR CARRYING OUT MASS SPECTROSCOPIES |
-
2012
- 2012-02-13 JP JP2013554526A patent/JP6189752B2/ja not_active Expired - Fee Related
- 2012-02-13 WO PCT/US2012/024869 patent/WO2012112448A1/en not_active Ceased
- 2012-02-13 US US13/985,900 patent/US9890411B2/en active Active
- 2012-02-13 EP EP18186325.9A patent/EP3421586B1/en active Active
- 2012-02-13 EP EP12747041.7A patent/EP2675889B1/en active Active
-
2017
- 2017-08-02 JP JP2017149718A patent/JP6630317B2/ja not_active Expired - Fee Related
-
2018
- 2018-01-31 US US15/884,902 patent/US10533209B2/en active Active
-
2019
- 2019-12-16 US US16/715,764 patent/US11434517B2/en active Active
-
2022
- 2022-08-04 US US17/881,175 patent/US11905548B2/en active Active
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