JP2014503589A - 組合せ - Google Patents
組合せ Download PDFInfo
- Publication number
- JP2014503589A JP2014503589A JP2013551318A JP2013551318A JP2014503589A JP 2014503589 A JP2014503589 A JP 2014503589A JP 2013551318 A JP2013551318 A JP 2013551318A JP 2013551318 A JP2013551318 A JP 2013551318A JP 2014503589 A JP2014503589 A JP 2014503589A
- Authority
- JP
- Japan
- Prior art keywords
- amino
- compound
- pharmaceutically acceptable
- combination
- acceptable salt
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 150000003839 salts Chemical class 0.000 claims abstract 30
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract 21
- 238000000034 method Methods 0.000 claims abstract 17
- CUIHSIWYWATEQL-UHFFFAOYSA-N pazopanib Chemical compound C1=CC2=C(C)N(C)N=C2C=C1N(C)C(N=1)=CC=NC=1NC1=CC=C(C)C(S(N)(=O)=O)=C1 CUIHSIWYWATEQL-UHFFFAOYSA-N 0.000 claims abstract 17
- ZWLPBLYKEWSWPD-UHFFFAOYSA-N o-toluic acid Chemical compound CC1=CC=CC=C1C(O)=O ZWLPBLYKEWSWPD-UHFFFAOYSA-N 0.000 claims abstract 11
- BVAHPPKGOOJSPU-UHFFFAOYSA-N 2-[[5-chloro-2-[(5-methyl-2-propan-2-ylpyrazol-3-yl)amino]pyridin-4-yl]amino]-n-methoxybenzamide Chemical compound CONC(=O)C1=CC=CC=C1NC1=CC(NC=2N(N=C(C)C=2)C(C)C)=NC=C1Cl BVAHPPKGOOJSPU-UHFFFAOYSA-N 0.000 claims abstract 10
- 206010033128 Ovarian cancer Diseases 0.000 claims abstract 7
- 206010061535 Ovarian neoplasm Diseases 0.000 claims abstract 7
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 claims abstract 6
- 150000001875 compounds Chemical class 0.000 claims 8
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical class Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 7
- -1 2,3-Dimethyl-2H-indazol-6-yl Chemical group 0.000 claims 4
- 125000004744 butyloxycarbonyl group Chemical group 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 3
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 3
- 125000000250 methylamino group Chemical group [H]N(*)C([H])([H])[H] 0.000 claims 3
- YCMLQMDWSXFTIF-UHFFFAOYSA-N 2-methylbenzenesulfonimidic acid Chemical compound CC1=CC=CC=C1S(N)(=O)=O YCMLQMDWSXFTIF-UHFFFAOYSA-N 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 150000001408 amides Chemical class 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
- A61K31/416—1,2-Diazoles condensed with carbocyclic ring systems, e.g. indazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161436435P | 2011-01-26 | 2011-01-26 | |
| US61/436,435 | 2011-01-26 | ||
| PCT/US2012/022638 WO2012103276A1 (en) | 2011-01-26 | 2012-01-26 | Combinations |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2014503589A true JP2014503589A (ja) | 2014-02-13 |
| JP2014503589A5 JP2014503589A5 (enrdf_load_stackoverflow) | 2015-03-19 |
Family
ID=46581159
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013551318A Pending JP2014503589A (ja) | 2011-01-26 | 2012-01-26 | 組合せ |
Country Status (13)
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HK1204998A1 (en) * | 2012-02-17 | 2015-12-11 | 药品循环有限责任公司 | Combinations of histone deacetylase inhibitor and pazopanib and uses thereof |
| US20160263116A1 (en) * | 2012-10-12 | 2016-09-15 | Glaxosmithkline Llc | Combinations |
| KR20150073989A (ko) * | 2012-10-22 | 2015-07-01 | 글락소스미스클라인 엘엘씨 | 조합물 |
| US20150306099A1 (en) * | 2012-11-27 | 2015-10-29 | Glaxosmithkline Llc | Combination |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010062578A1 (en) * | 2008-10-27 | 2010-06-03 | Glaxosmithkline Llc | Pyrazolylaminopyridines as inhibitors of fak |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8034860B2 (en) * | 2006-07-21 | 2011-10-11 | Eastman Specialties Holdings Corporation | Organosol plastisol compositions |
| CA2681015C (en) * | 2007-03-16 | 2016-06-21 | The Scripps Research Institute | Inhibitors of focal adhesion kinase |
| KR101695501B1 (ko) * | 2008-06-17 | 2017-01-11 | 아스트라제네카 아베 | 피리딘 화합물 |
| US20110301113A1 (en) * | 2008-09-26 | 2011-12-08 | Concert Pharmaceuticals Inc. | Pyridineamine derivatives |
-
2012
- 2012-01-26 SG SG2013053178A patent/SG191926A1/en unknown
- 2012-01-26 US US13/979,002 patent/US20130296356A1/en not_active Abandoned
- 2012-01-26 KR KR1020137022325A patent/KR20140011322A/ko not_active Withdrawn
- 2012-01-26 CN CN201280013896.6A patent/CN103476413B/zh not_active Expired - Fee Related
- 2012-01-26 EP EP12739192.8A patent/EP2667871A4/en not_active Withdrawn
- 2012-01-26 BR BR112013018565A patent/BR112013018565A2/pt not_active IP Right Cessation
- 2012-01-26 MX MX2013008654A patent/MX2013008654A/es not_active Application Discontinuation
- 2012-01-26 WO PCT/US2012/022638 patent/WO2012103276A1/en active Application Filing
- 2012-01-26 EA EA201391076A patent/EA201391076A1/ru unknown
- 2012-01-26 AU AU2012209100A patent/AU2012209100A1/en not_active Abandoned
- 2012-01-26 JP JP2013551318A patent/JP2014503589A/ja active Pending
- 2012-01-26 CA CA2825790A patent/CA2825790A1/en not_active Abandoned
-
2013
- 2013-07-08 IL IL227377A patent/IL227377A0/en unknown
-
2015
- 2015-11-19 US US14/945,818 patent/US20160067248A1/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010062578A1 (en) * | 2008-10-27 | 2010-06-03 | Glaxosmithkline Llc | Pyrazolylaminopyridines as inhibitors of fak |
Also Published As
| Publication number | Publication date |
|---|---|
| US20160067248A1 (en) | 2016-03-10 |
| EP2667871A1 (en) | 2013-12-04 |
| CN103476413B (zh) | 2016-03-16 |
| CN103476413A (zh) | 2013-12-25 |
| EA201391076A1 (ru) | 2014-07-30 |
| EP2667871A4 (en) | 2014-07-09 |
| CA2825790A1 (en) | 2012-08-02 |
| SG191926A1 (en) | 2013-08-30 |
| WO2012103276A1 (en) | 2012-08-02 |
| IL227377A0 (en) | 2013-09-30 |
| US20130296356A1 (en) | 2013-11-07 |
| KR20140011322A (ko) | 2014-01-28 |
| MX2013008654A (es) | 2013-09-02 |
| AU2012209100A1 (en) | 2013-08-01 |
| BR112013018565A2 (pt) | 2016-09-27 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| A521 | Request for written amendment filed |
Free format text: JAPANESE INTERMEDIATE CODE: A523 Effective date: 20150126 |
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| A621 | Written request for application examination |
Free format text: JAPANESE INTERMEDIATE CODE: A621 Effective date: 20150126 |
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| A131 | Notification of reasons for refusal |
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| A977 | Report on retrieval |
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| A02 | Decision of refusal |
Free format text: JAPANESE INTERMEDIATE CODE: A02 Effective date: 20160513 |