JP2014205708A5 - - Google Patents

Info

Publication number

JP2014205708A5

JP2014205708A5 JP2014139140A JP2014139140A JP2014205708A5 JP 2014205708 A5 JP2014205708 A5 JP 2014205708A5 JP 2014139140 A JP2014139140 A JP 2014139140A JP 2014139140 A JP2014139140 A JP 2014139140A JP 2014205708 A5 JP2014205708 A5 JP 2014205708A5

Authority

JP

Japan

Prior art keywords

obesity

compound

seq

ser

residue

Prior art date

2014-07-04

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
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• 150000001875 compounds Chemical class 0.000 claims 12
• 208000008589 Obesity Diseases 0.000 claims 10
• 235000020824 obesity Nutrition 0.000 claims 8
• 150000007523 nucleic acids Chemical class 0.000 claims 5
• 108020004707 nucleic acids Proteins 0.000 claims 5
• 102000039446 nucleic acids Human genes 0.000 claims 5
• 239000013604 expression vector Substances 0.000 claims 4
• 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 4
• 206010003210 Arteriosclerosis Diseases 0.000 claims 2
• 201000001320 Atherosclerosis Diseases 0.000 claims 2
• 208000032928 Dyslipidaemia Diseases 0.000 claims 2
• 208000002705 Glucose Intolerance Diseases 0.000 claims 2
• 206010020772 Hypertension Diseases 0.000 claims 2
• 206010061218 Inflammation Diseases 0.000 claims 2
• 206010022489 Insulin Resistance Diseases 0.000 claims 2
• 208000017170 Lipid metabolism disease Diseases 0.000 claims 2
• 208000011775 arteriosclerosis disease Diseases 0.000 claims 2
• 230000000923 atherogenic effect Effects 0.000 claims 2
• 208000012696 congenital leptin deficiency Diseases 0.000 claims 2
• 208000020694 gallbladder disease Diseases 0.000 claims 2
• 230000004054 inflammatory process Effects 0.000 claims 2
• 208000001022 morbid obesity Diseases 0.000 claims 2
• 239000008194 pharmaceutical composition Substances 0.000 claims 2
• 201000009104 prediabetes syndrome Diseases 0.000 claims 2
• 201000002859 sleep apnea Diseases 0.000 claims 2
• 230000004584 weight gain Effects 0.000 claims 2
• 235000019786 weight gain Nutrition 0.000 claims 2
• 230000004580 weight loss Effects 0.000 claims 2
• MTCFGRXMJLQNBG-UWTATZPHSA-N D-Serine Chemical compound OC[C@@H](N)C(O)=O MTCFGRXMJLQNBG-UWTATZPHSA-N 0.000 claims 1
• KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
• 206010033307 Overweight Diseases 0.000 claims 1
• 101710188315 Protein X Proteins 0.000 claims 1
• 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims 1
• 125000000217 alkyl group Chemical group 0.000 claims 1
• 150000001413 amino acids Chemical group 0.000 claims 1
• 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 1
• 208000029078 coronary artery disease Diseases 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 125000002485 formyl group Chemical group [H]C(*)=O 0.000 claims 1
• 208000019622 heart disease Diseases 0.000 claims 1
• 125000003588 lysine group Chemical group [H]N([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 229920000642 polymer Chemical group 0.000 claims 1
• 108090000765 processed proteins & peptides Proteins 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• 125000001424 substituent group Chemical group 0.000 claims 1
• 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 claims 1