JP2014193838A5 - - Google Patents

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Publication number
JP2014193838A5
JP2014193838A5 JP2013229503A JP2013229503A JP2014193838A5 JP 2014193838 A5 JP2014193838 A5 JP 2014193838A5 JP 2013229503 A JP2013229503 A JP 2013229503A JP 2013229503 A JP2013229503 A JP 2013229503A JP 2014193838 A5 JP2014193838 A5 JP 2014193838A5
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JP
Japan
Prior art keywords
pyrroloquinoline
solution containing
quinones
solution
resin adsorbent
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JP2013229503A
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Japanese (ja)
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JP2014193838A (en
JP6217323B2 (en
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Priority to JP2013229503A priority Critical patent/JP6217323B2/en
Priority claimed from JP2013229503A external-priority patent/JP6217323B2/en
Publication of JP2014193838A publication Critical patent/JP2014193838A/en
Publication of JP2014193838A5 publication Critical patent/JP2014193838A5/ja
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Claims (10)

ピロロキノリンキノン類を含む溶液を樹脂吸着剤又は活性炭と接触させる工程を含む高純
度ピロロキノリンキノン類の製造方法。 A method for producing high-purity pyrroloquinoline quinones, comprising a step of bringing a solution containing pyrroloquinoline quinones into contact with a resin adsorbent or activated carbon. 樹脂吸着剤又は活性炭の比表面積が１００ｍ2／ｇ以上であることを特徴とする請
求項１記載の製造方法。 The production method according to claim 1, wherein the specific surface area of the resin adsorbent or the activated carbon is 100 m 2 / g or more. 樹脂吸着剤がスチレン系またはアクリル系の骨格を有すること特徴とする請求項１又は２
記載の製造方法。 The resin adsorbent has a styrene or acrylic skeleton.
The manufacturing method as described. ピロロキノリンキノン類が、式（１）の構造を有する酸化型ＰＱＱ、式（２）の構造を有
する還元型ＰＱＱ又はこれらの塩であることを特徴とする請求項１から３いずれか記載の
製造方法。
The pyrroloquinoline quinones are oxidized PQQ having the structure of the formula (1), reduced PQQ having the structure of the formula (2), or a salt thereof. Method.
ピロロキノリンキノン類を含む溶液がピロロキノリンキノン培養液であることを特徴とす
る請求項１から４いずれか記載の製造方法。 5. The production method according to claim 1, wherein the solution containing pyrroloquinoline quinones is a pyrroloquinoline quinone culture solution. ピロロキノリンキノン類を含む溶液がピロロキノリンキノン培養液をｐＨ２から８にして
析出物を除去した溶液であることを特徴とする請求項１から４いずれか記載の製造方法。 The method according to any one of claims 1 to 4, wherein the solution containing pyrroloquinoline quinones is a solution obtained by removing the precipitates by changing the pH of the pyrroloquinoline quinone culture solution from 2 to 8. ピロロキノリンキノン類を含む溶液がピロロキノリンキノン培養液をｐＨ２から８にして
析出物を除去した溶液を晶析し、得られた結晶を溶解させた溶液であることを特徴とする
請求項１から４いずれか記載の製造方法。 The solution containing pyrroloquinoline quinones is a solution in which the pyrroloquinoline quinone culture solution is adjusted to pH 2 to 8 to remove precipitates, and the resulting crystals are dissolved. 4. The production method according to any one of 4 above. ピロロキノリンキノン類を含む溶液を樹脂吸着剤または活性炭と接触させる工程の後、
更にピロロキノリンキノン類を含む溶液を再結晶もしくはカラムクロマトグラフィーで精
製する工程を含む請求項１から７いずれか記載のピロロキノリンキノンの製造方法。 After contacting the solution containing pyrroloquinoline quinones with a resin adsorbent or activated carbon,
Furthermore, the manufacturing method of the pyrroloquinoline quinone in any one of Claim 1 to 7 including the process of refine | purifying the solution containing pyrroloquinoline quinones by recrystallization or column chromatography. カラムクロマトグラフィーで精製する工程において、塩基性条件で該ピロロキノリンキノ
ンを脱離させることを特徴とする請求項８記載の製造方法。 9. The production method according to claim 8, wherein the pyrroloquinoline quinone is eliminated under basic conditions in the step of purification by column chromatography. 樹脂吸着剤又は活性炭と接触させることを特徴とする、ピロロキノリンキノン類と重金属
を含む混合溶液からの重金属除去方法。 A method for removing a heavy metal from a mixed solution containing a pyrroloquinoline quinone and a heavy metal, which is brought into contact with a resin adsorbent or activated carbon.
JP2013229503A 2013-02-27 2013-11-05 Method for producing pyrroloquinoline quinone Active JP6217323B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2013229503A JP6217323B2 (en) 2013-02-27 2013-11-05 Method for producing pyrroloquinoline quinone

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP2013037012 2013-02-27
JP2013037012 2013-02-27
JP2013229503A JP6217323B2 (en) 2013-02-27 2013-11-05 Method for producing pyrroloquinoline quinone

Publications (3)

Publication Number Publication Date
JP2014193838A JP2014193838A (en) 2014-10-09
JP2014193838A5 true JP2014193838A5 (en) 2016-10-20
JP6217323B2 JP6217323B2 (en) 2017-10-25

Family

ID=51839391

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013229503A Active JP6217323B2 (en) 2013-02-27 2013-11-05 Method for producing pyrroloquinoline quinone

Country Status (1)

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JP (1) JP6217323B2 (en)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101664608B1 (en) * 2014-12-05 2016-10-10 주식회사 성운바이오 Novel microorganism of hyphomicrobium sp. and method of producing pyrrolo-quinoline quinone using the same
CN105315278B (en) * 2015-11-02 2018-01-16 诸城市浩天药业有限公司 PQQ A crystal formations and preparation method thereof
WO2019244883A1 (en) 2018-06-19 2019-12-26 日産化学株式会社 Method for manufacturing salt-free polysiloxane
CN111635402B (en) * 2020-06-24 2021-04-30 北大方正集团有限公司 Separation and purification method of pyrroloquinoline quinone

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59113896A (en) * 1982-12-17 1984-06-30 Ube Ind Ltd Preparation of pyrroloquinolinequinone
JPS61283346A (en) * 1985-06-10 1986-12-13 Mitsubishi Chem Ind Ltd Preparation of protein adsorbent
JPH07113023B2 (en) * 1986-04-17 1995-12-06 三菱瓦斯化学株式会社 Method for purifying pyrroloquinoline quinone
JPS63267287A (en) * 1986-12-27 1988-11-04 Ube Ind Ltd Method for purifying pyrroloquinolinequinone

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