JP2014185905A - Bar code display device - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a bar code display device that uses a versatile unit to easily determine whether or not a specimen includes a specific substance.SOLUTION: When a mosquito slapping piece 55 slaps a mosquito on a blood sampling hole 51, blood sucked by the mosquito drops in the blood sampling hole 51 and is supplied to a blood supply unit 20 through a blood supply path 24. The blood in the blood supply unit 20 (preferably blood plasma separated from the blood) is supplied to reaction chambers 11 to 13 respectively holding an antibody through blood supply paths 21 to 23. Various reagents such as a labelled antibody, a lavage fluid and others are supplied from reagent holding tanks 25 to 28 to the reaction chambers 11 to 13 through reagent supply paths 31 to 36, and an antigen-antibody reaction occurs. A two-dimensional bar code displayed on a bar code display unit 10 is read through a fluorescence analysis using a camera 72, and the presence or absence of an antigen in the blood is determined.

Description

  The present invention relates to a barcode display device that displays information corresponding to whether or not a specific substance is contained in a specimen using a barcode.

  2. Description of the Related Art Conventionally, a method for determining whether or not a specific substance is included in the specimen by using a substance that changes in optical characteristics by reacting with the specific substance contained in the specimen is used in various fields. That is, such a technique is utilized in a very wide range from a simple chemical measurement using a litmus paper to a fluorescent antibody method in which a fluorescent substance is bound to an antibody for measurement.

  In particular, measuring whether or not a predetermined antigen, antibody, or other specific substance is contained in a body fluid such as plasma is effective in determining the physical condition of the donor of the body fluid and the presence or absence of a disease. . Therefore, a technique for determining the presence or absence of a protein causing disease by using a business card-sized chip has also been proposed (see, for example, Patent Document 1).

Japanese Patent Application No. 2009-300433

  However, in the technique described in Patent Document 1, a specimen or a reagent is moved in the chip by applying a centrifugal force to the chip. Therefore, it is necessary to detect the fluorescence at a predetermined timing each time the chip is rotated or stopped many times, and the fluorescence state must be read many times with a special device. Therefore, the present invention has been made with the object of providing a barcode display device that displays information corresponding to whether or not a specific substance is contained in a specimen by using a barcode that can be read by a more versatile device. .

  The barcode display device of the present invention made to achieve the above object is a barcode display unit that displays information as a one-dimensional or two-dimensional barcode, and is optically reacted with a specific substance contained in a specimen. A bar code display unit having a changing part whose characteristics change and in which information corresponding to the bar code changes according to a change in optical characteristics of the changing part is provided.

  In the barcode display device of the present invention configured as described above, the changing portion of the barcode display portion reacts with a specific substance contained in the specimen and changes its optical characteristics. The information corresponding to the barcode displayed on the barcode display unit is changed by the change in the optical characteristics of the changing unit. For this reason, if the barcode displayed on the barcode display part is read and the information corresponding to it is acquired, it can be judged whether a specific substance is contained in the sample.

  Since the barcode can be easily read by a highly versatile device, the barcode display device of the present invention makes it very easy to determine whether or not a sample contains a specific substance by using a highly versatile device. can do.

  In the present invention, the bar code display section may include a plurality of the changing sections that change optical characteristics by reacting with different specific substances. In that case, depending on which of each specific substance is included in the sample and which is not included, the barcode displayed on the barcode display section changes in at least four ways, and by reading the barcode, It is possible to determine which of each specific substance is included and which is not included. Therefore, in this case, even when there are a plurality of types of specific substances to be examined, it can be very easily determined whether or not each specific substance is included in the specimen.

  In the present invention, the specimen may be a human body fluid. In this case, as described above, the physical condition of the donor of the body fluid and the presence or absence of a disease can be determined based on the presence or absence of the specific substance in the body fluid, which is extremely useful. The bodily fluid in the present invention is blood, serum, plasma, saliva, cerebrospinal fluid, sweat, semen, vaginal fluid, tears, sputum, mucus, lymph, cytosol, ascites, pleural effusion, amniotic fluid, bladder wash, It is a concept including various liquids related to the human body such as bronchoalveolar lavage fluid, feces, urine and the like.

It is the side view and top view showing the structure of the barcode display apparatus of 1st Embodiment. It is a perspective view which fractures | ruptures and represents the structure of the reaction chamber vicinity of the barcode display apparatus. It is a block diagram showing the structure of the control system of the barcode display apparatus. It is a flowchart showing the process performed with the control system. It is explanatory drawing showing an example of the effect of 1st Embodiment. It is explanatory drawing showing the modification of the barcode display part of 1st Embodiment. It is a front view showing the structure of the barcode display apparatus of 2nd Embodiment. It is a front view showing the structure of the barcode display apparatus of 3rd Embodiment. It is a rear view showing the structure of the barcode display apparatus of 4th Embodiment. It is a front view showing the structure of the barcode display apparatus of 5th Embodiment. It is a front view showing the structure of the barcode display device of 6th Embodiment. It is a front view showing the structure of the barcode display apparatus of 7th Embodiment. It is a front view showing the structure of the barcode display device of 8th Embodiment. It is explanatory drawing showing the modification of the barcode display apparatus of 8th Embodiment. It is explanatory drawing showing the structure of the barcode display apparatus of 9th Embodiment. It is a flowchart showing the process of the control system of the barcode display apparatus. It is explanatory drawing showing an example of a general two-dimensional barcode (QR code).

[Configuration of First Embodiment]
Next, embodiments of the present invention will be described with reference to the drawings. FIG. 1A is a side view showing the configuration of the barcode display device 1 of the first embodiment to which the present invention is applied. The barcode display device 1 of the present embodiment uses a blood collected through a mosquito when the subject is bitten as a specimen, and determines whether the blood contains a predetermined antigen. It is.

  As shown in FIG. 1A, the bar code display device 1 includes a substrate 7 that is disposed on a plane so that one end side (hereinafter, also referred to as a front side) is placed on a table 3. . The substrate 7 can be made of various materials as long as they are chemically stable and easy to process, such as glass and resin. FIG. 1B is a plan view of the barcode display device 1 as viewed from the surface direction of the substrate 7 (the direction of arrow A in FIG. 1A). FIG. 2 is a perspective view showing a configuration in the vicinity of a reaction chamber 13 which will be described later.

  As shown in FIGS. 1A and 1B, the substrate 7 is configured to be separable into three parts: a barcode display unit 10, a mosquito removing unit 50, and a processing unit 70. Three reaction chambers 11, 12, 13 having a square shape in plan view are formed on the surface of the bar code display unit 10 by cutting the surface of the substrate 7, and a specific format is formed on the surface of the surrounding substrate 7. The three characteristic marks 15 indicating that the two-dimensional bar code is a fluorescent paint is printed. In addition to the characteristic mark 15, a plurality of square marks 16 similar to the reaction chambers 11, 12, and 13 are printed on the surface of the substrate 7 with a fluorescent paint. The mark 16 may indicate the serial number of the barcode display device 1 or may indicate the subject's ID. In FIG. 1B, the portion where fluorescence is emitted is shown in black, and a QR code (registered trademark) as an example of a two-dimensional barcode is displayed on the surface of the substrate 7 in the barcode display unit 10. The bar code with positive and negative reversed is displayed by fluorescence.

  Inside the reaction chambers 11, 12, and 13, a carrier to which an antigen and / or an antibody is bound is uniformly accommodated at least over the entire bottom surface. As the shape of the carrier, in addition to microbeads such as spherical and elliptical spheres, so-called microrods such as cylinders and polygonal columns, plate-like microplates, and the like can be used. In FIGS. 1 and 2, the microbeads filled in the reaction chamber 13 are not shown.

  On the lower surface of the substrate 7 in the barcode display unit 10, blood collected through the blood collection hole 51 as described later is supplied to the reaction chambers 11, 12, and 13 through the blood supply paths 21, 22, and 23. A blood supply unit 20 is provided. Here, when a mosquito is beaten on the blood collection hole 51 as will be described later, the blood sucked by the mosquito is supplied to the blood supply unit 20 via the blood supply path 24. It is desirable to supply only the reaction chambers 11, 12, 13. For this reason, the blood supply unit 20 may have a built-in filter for separating plasma, or may separate plasma using centrifugal force as in Patent Document 1. In the former case, a pump for smoothly passing the filter may be incorporated.

  The blood (preferably plasma) inside the blood supply unit 20 is supplied to the reaction chambers 11, 12, and 13 through the blood supply paths 21, 22, and 23 due to the inclination of the substrate 7 due to the inclination of the substrate 7 (see FIG. 2). A very small amount of blood is collected from one mosquito. Therefore, in this embodiment, blood supply valves 21A to 23A (see FIG. 3) configured to close blood supply paths 21 to 23 when energized using piezoelectric elements are connected to upstream ends of blood supply paths 21 to 23. The blood is uniformly supplied to each of the reaction chambers 11 to 13.

  In addition, a plurality of reagent holding tanks 25, 26, 27, and 28 holding various reagents are provided at the front end of the surface of the substrate 7 in the barcode display unit 10. The reagent holding tank 25 is connected to the reaction chamber 11 via a reagent supply path 31, and the reagent holding tank 26 is connected to the reaction chambers 11 and 12 via reagent supply paths 32 and 33, respectively. The reagent holding tank 27 is connected to the reaction chambers 12 and 13 via reagent supply paths 34 and 35, respectively, and the reagent holding tank 28 is connected to the reaction chamber 13 via a reagent supply path 36 (FIG. 2). reference). Each of the reagent supply paths 31 to 36 is formed on the surface of the substrate 7 as a narrow groove to the extent that capillary action occurs.

  In the present embodiment, the reagent can be appropriately selected from various reagents such as a labeled antibody, a washing solution, a substrate, a hydrogen peroxide solution, and a diluent. Note that the number of reagent holding tanks may be further increased, and the number of reagent supply paths connected to one reaction chamber may be further increased. The reagent held in the reagent holding tanks 25 to 28 is supplied to the reaction chambers 11, 12, and 13 through the reagent supply paths 31 to 36 due to the inclination of the substrate 7 by its own weight. At the upstream end, reagent supply valves 31A to 36A (see FIG. 3) similar to the blood supply valve 21A and the like are provided.

  In addition, a waste liquid tank 40 is provided by cutting the surface of the substrate 7 at the rear end of the surface of the substrate 7 in the barcode display unit 10, and the waste liquid tank 40 is disposed via waste liquid discharge paths 41, 42, 43. Are connected to the reaction chambers 11, 12, 13 (see FIG. 2). The liquid after the reaction in the reaction chambers 11, 12, and 13 is discharged to the waste liquid tank 40 through the waste liquid discharge paths 41 to 43 by its own weight due to the inclination of the substrate 7, but upstream of each of the waste liquid discharge paths 41 to 43. Waste liquid discharge valves 41A to 43A (see FIG. 3) similar to the blood supply valve 21A and the like are provided at the end.

  For this reason, the following reactions can be performed in the reaction chambers 11, 12, and 13 by controlling the valves 21A to 43A. That is, the reaction chambers 11, 12, and 13 carry antibodies that bind to the antigens A, B, and C, respectively. A labeled antibody that binds to the antigens A, B, and C and is labeled with a fluorescent substance and plasma that is to be examined for the presence of the antigens A, B, and C are supplied to the reaction chambers 11, 12, and 13, respectively. For example, a labeled antibody binds to a reaction chamber corresponding to an antigen present in plasma among A to C. Thereafter, if the labeled antibody that has not been bound by the washing solution is washed away to the waste liquid tank 40, the fluorescent substance remains only in the reaction chamber corresponding to the existing antigen, and the reaction chamber is in a state corresponding to the black of the two-dimensional barcode. Become.

  Such a reaction is an extremely simple reaction even in an antigen-antibody reaction. However, in the barcode display unit 10, as described above, by increasing the number of reagent holding tanks and reagent supply channels, the labeled antibody is indirectly applied to the antigen. More complicated reactions can be carried out using antibodies or diluents to be bound to.

  Next, the substrate 7 in the mosquito removing part 50 is provided with a blood collection hole 51 that penetrates the front and back surfaces and opens in a mortar shape on the front side, and is further rotated by a motor 52 via a shaft 53 to collect the blood collection hole. A mosquito hitting piece 55 for hitting a mosquito flying over 51 is provided. The mosquito hitting piece 55 is made of a material having a certain degree of elasticity. When the mosquito is hit on the blood collection hole 51, the mosquito is crushed while being pushed into the blood collection hole 51 by elastic deformation, and the mosquito sucks. The blood that has been dropped is dropped into the blood collection hole 51. The lower end of the blood collection hole 51 communicates with the blood supply unit 20 via the blood supply path 24 described above, and the blood is supplied to the blood supply unit 20 by its own weight. The blood supply path 24 can be divided between the lower part of the mosquito collecting part 50 and the lower part of the barcode display part 10. When the mosquito removing part 50 and the barcode display part 10 are connected, they are connected in a liquid-tight manner. The

  In addition, a plurality (for example, three) of attraction liquid holding tanks 56 for holding the attraction liquid L for attracting mosquitoes are provided on the surface of the substrate 7 around the blood collection hole 51. Each of the attracting liquid holding tanks 56 is formed in a cylindrical shape having an open upper surface, and the attracting liquid L is supplied from the attracting liquid supply unit 58 through the attracting liquid supply path 57. The attracting liquid L is controlled so as to rise and be held on the upper surface of the attracting liquid holding tank 56 as will be described later. For this reason, in addition to the tank (not shown) that holds the attracting liquid L, the attracting liquid supply unit 58 includes a hydraulic pressure sensor 58A that individually detects the liquid pressure inside each attracting liquid supply path 57, and each attracting liquid. A pump 58B for individually pumping the attracting liquid L to the attracting liquid holding tank 56 via the supply path 57 is incorporated (see FIG. 3).

  A camera 72 is held above the surface of the substrate 7 in the processing unit 70 via a support shaft 71. In addition, a control unit 75 is connected to the camera 72 via a signal line 73. The control unit 75 is configured mainly with a microcomputer including a CPU, a ROM, and a RAM, and also includes a communication unit 75A (see FIG. 3) that communicates with the outside via an antenna 76. The camera 72 includes a laser irradiation unit 72A that emits fluorescence by irradiating the surface of the substrate 7 in the barcode display unit 10 with laser light, the fluorescence, and the blood collection hole 51 in a state where no fluorescence is generated. And an imaging unit 72B capable of imaging the upper side (see FIG. 3).

[Control of First Embodiment]
As shown in FIG. 3, the control unit 75 includes the motor 52, the attracting liquid supply unit 58, the camera 72, the blood supply valves 21A to 23A, the reagent supply valves 31A to 36A, and the waste liquid discharge valves 41A to 43A. Are connected to enable input / output. Then, the CPU of the control unit 75 executes the following processing based on a program stored in the ROM when the barcode display device 1 is powered on.

  That is, as shown in FIG. 4, when the process is started, first, in S10 (S represents a step: the same applies hereinafter), it is determined whether or not there is a mosquito above the blood collection hole 51. The determination is made based on the video imaged through 72B. If there is no mosquito (S10: N), the process proceeds to S11, and the fluid pressure corresponds to the state in which the liquid level of the attracting liquid L is raised based on the fluid pressure detected by each fluid pressure sensor 58A. It is determined whether or not the specified value is to be determined. If each fluid pressure detected by each fluid pressure sensor 58A is a specified value (S11: Y), the process proceeds to S10 as described above, and if there is an attracting fluid supply path 57 where the fluid pressure is not a specified value. (S11: N), the attracting liquid L is pumped by the pump 58B corresponding to the attracting liquid supply path 57, and the process proceeds to S10 described above.

  By the above process, the loop process of S10 to S12 is repeatedly executed until the mosquito passes above the blood collection hole 51 while holding the attracting liquid L so that the liquid level rises from the upper surface of the attracting liquid holding tank 56.

  Then, when the mosquito passes over the blood collection hole 51 (S10: Y), the mosquito is hit through the mosquito hitting piece 55 by driving the motor 52 in S15. Then, as described above, since blood is supplied to the blood supply path 24, in the subsequent S16, the blood supply valves 21A to 23A and the reagent supply valves 31A to 36A are driven in an appropriate order, and the reaction chambers 11 to 13 are driven. Blood and reagents are supplied in a predetermined order. In the subsequent S17, the labeled antibodies and the like that have not been combined are discharged as waste liquid by driving the waste liquid discharge valves 41A to 43A, and in S18, fluorescence emitted from the surface of the barcode display unit 10 in response to laser irradiation. Is imaged.

  Then, since the fluorescence emitted from the surface of the barcode display unit 10 presents an image in which the positive and negative of the two-dimensional barcode including the reaction chambers 11 to 13 are also included in the configuration, in the subsequent S19, the communication unit 75A Accesses the website corresponding to the two-dimensional barcode. Here, a general two-dimensional barcode (QR code) is configured by two-dimensionally arranging a large number of white or black cells as exemplified in FIG. 17, for example. 1B may display a simplified two-dimensional barcode as shown in the barcode display unit 10 in FIG. 1B, and the marks 16 are actually printed more and more finely than in FIG. The reaction chambers 11 to 13 may actually be configured to be smaller than that in FIG. 1B, so that a two-dimensional barcode similar to that shown in FIG. 17 may be displayed.

  FIG. 5 is an explanatory diagram showing changes in the barcode display unit 10 when a two-dimensional barcode similar to that shown in FIG. 17 is displayed. As shown in FIG. 5 (A), when some of the sections of the mark 16 configured in the same manner as a general two-dimensional bar code are reaction chambers 11, 12, and 13, when all of them become black, FIG. A two-dimensional barcode as shown in FIG. 5B is displayed. When all of the barcode becomes white, a two-dimensional barcode as shown in FIG. 5C is displayed. These correspond to different websites corresponding to different test results (or different pages within the same website). In S19, the website or page corresponding to the inspection result is thus accessed.

  Returning to FIG. 4, in S20 following S19, information regarding the presence or absence of illness, etc. is acquired from the website, and the information is transmitted to the subject's mobile phone (may be a multi-function mobile phone) for processing. Ends. Here, the e-mail address of the subject's mobile phone or the like may be acquired as information represented by the above-described mark 16 or the like, or may be stored in advance in the ROM. That is, like the former, the two-dimensional barcode displayed on the barcode display unit 10 is a set of a portion corresponding to the antigen detection result and a portion corresponding to information for specifying an individual. May be. For example, in the example of FIG. 5A, areas A and C are assigned to a part corresponding to information for specifying personal information such as an e-mail address, and area B is assigned to a part corresponding to an antigen detection result. Also good. Moreover, after completion | finish of the said process, the barcode display part 10 is replaced | exchanged for a new thing by the test subject.

  Note that the processing of S18 to S20 may be executed by an application downloaded to a multi-function mobile phone (so-called smart phone) having a fluorescence imaging function provided with a laser light source, an X-ray lamp, and the like. The camera 72 and the like on the code display device 1 side can be omitted.

  Further, as personal information written as information in the areas A and C, various information such as name, age, address, face photograph, hospital room, etc. can be considered in addition to the e-mail address. Furthermore, the barcode display device 1 may be arranged in a private room of a hospital, and the barcode display unit 10 may be replaced every morning and collected at a nurse station or the like. In that case, if the personal information can be acquired from the mark 16 as described above, it is not necessary to describe each patient name on each barcode display unit 10 with a felt pen or the like. Therefore, even if the barcode display unit 10 touches the eyes of a third party, it cannot be easily determined which patient has been examined, and the privacy of the patient can be well protected. Further, the marks 16 corresponding directly to the personal information or the like do not have to be printed in the areas A and C. The mark 16 corresponding to the serial number of the barcode display unit 10 is printed, and the personal information and the personal information are stored in a database such as a hospital. It may be associated.

  Thus, in the barcode display device 1 of the present embodiment, the reaction chambers 11 to 13 of the barcode display unit 10 change so as to react with a specific antigen contained in blood (plasma) to generate fluorescence. . Due to this change, the two-dimensional bar code displayed on the bar code display unit 10 changes, and the corresponding information also changes. In addition, the bar code display unit 10 includes a plurality of reaction chambers 11 to 13, and can detect the presence or absence of a different antigen in each of the reaction chambers 11 to 13. Therefore, in this embodiment, a highly versatile apparatus such as a two-dimensional bar code reader can easily determine which of a plurality of antigens is contained in plasma and which is not contained by one reading. it can. Therefore, early detection for a plurality of diseases is possible. In the embodiment, the two-dimensional barcode corresponds to the barcode, the reaction chambers 11 to 13 correspond to the change part, and the specific antigen corresponds to the specific substance.

  In this embodiment, the attracting liquid L may be mixed with an anesthetic, and in that case, the anesthetic is injected into the subject's skin together with the mosquito's saliva. There is little to feel. In addition, the attractant L may be mixed with an influenza vaccine. In that case, the subject can be taken with preventive measures against influenza by being bitten by a mosquito. Further, the mark 16 on the barcode display unit 10 does not necessarily have to be divided into areas A, B, and C, and may not have a portion corresponding to personal information. Conversely, as shown in FIG. A small two-dimensional barcode 16A corresponding to the personal information may be provided. In the latter case, the amount of information related to personal information can be increased.

[Second Embodiment]
Next, FIG. 7 is a front view illustrating the configuration of the barcode display device 101 according to the second embodiment. In this barcode display device 101, a barcode display unit 10A having a configuration similar to that of the barcode display unit 10 described above is attached to a toothbrush 120 configured as follows. The bar code display unit 10A is a bar code display unit in that a transparent film (not shown) is attached to the surface of the substrate 7 so that liquid inside the reaction chamber 11 and the like does not leak even when the top and bottom are inverted. Unlike 10, the others are similarly configured.

  The bristle 121 and the handle 122 constituting the toothbrush 120 are formed with hollow portions 121A and 122A communicating with each other, and the base end of the hollow portion 122A is connected to the blood supply path 24. For this reason, when bleeding from a gum or the like during brushing, the blood can be sent to the blood supply unit 20. In order to carry out such blood transport more reliably, it is desirable that the hollow portion 121A has an inner diameter that causes capillary action. Then, after the tooth brushing is finished, if the handle 122 is placed on the table 3 similar to that of the first embodiment and the barcode display unit 10A is connected to the processing unit 70 in the same manner as the barcode display unit 10, the above-described S16 to S20. The processing is executed by the processing unit 70 to detect the antigen. The toothbrush 120 may be replaced with an interdental brush.

  In addition, when the present invention is applied to the toothbrush 120 or the interdental brush as described above, it is possible to detect the presence or absence of dental caries or periodontal disease of the subject. For example, at least one of the reaction chambers 11 to 13 is loaded with an antibody that causes an antigen-antibody reaction with caries fungus or periodontal disease bacteria, and binds to the caries fungus or periodontal fungus in the reaction chamber. A labeled antibody may be supplied. In that case, when caries bacteria or periodontal disease bacteria are mixed in saliva or blood sent through the hollow part 121A of the hair 121, the antigen-antibody reaction occurs, and the reaction chamber emits fluorescence. . In addition, since caries progress with an acid generated by caries fungi, any one of reaction chambers 11 to 13 may carry or introduce a reagent that changes color according to PH.

[Third Embodiment]
FIG. 8 is a front view illustrating the configuration of the barcode display device 201 according to the third embodiment. This barcode display device 201 is configured by mounting a syringe-like hollow needle 224 that can be inserted into the earlobe E in the blood supply path 24 of the barcode display unit 10A similar to the second embodiment. Further, the barcode display device 201 includes a fixing portion 230 for fixing the end of the barcode display portion 10A on the blood supply path 24 side to the earlobe E. The fixing part 230 is a well-known fixing part used in general piercing. Further, the barcode display device 201 includes a control unit (not shown) on the back surface of the barcode display unit 10A (the surface opposite to the side on which the marks 15 and 16 are printed and the back surface in FIG. 8). A control part performs control (S16, S17 of Drawing 4) to the above-mentioned valves 21A-43A.

  In the barcode display device 201 configured as described above, since the state of the barcode display unit 10A can be confirmed from around the subject, if the security cameras arranged in various places in the city have the function of the processing unit 70, The presence or absence of the antigen can be determined via the security camera.

  Further, if the control for the valves 21A to 43A is changed and the reaction chambers 11 to 13 are sequentially used every predetermined time (for example, every hour), for example, the determination of the presence or absence of a single antigen is performed. It is also possible to perform control such that the subject's plasma state is continuously monitored and any abnormality is reported. Note that, as described in JP-A-2004-132820, if a configuration in which bead-shaped carriers are supplied to the reaction chambers 11 to 13 and replaced is adopted, the presence or absence of the antibody is repeatedly determined while the carriers are replaced. Then, the result can be notified.

  Furthermore, a nanoparticle that changes color by reacting with glucose has been developed by Professor Jin Zhang of the University of Western Ontario, etc., and a contact lens that changes color when the blood glucose level increases is proposed. If the subject's blood glucose level is repeatedly determined using the bead-shaped carrier carrying such nanoparticles, the diabetic subject can be instructed when to inject insulin. In addition, the detection of the blood glucose level using such nanoparticles may be performed via a barcode provided on the contact lens as in a ninth embodiment described later.

  Further, since the barcode display device 201 collects blood as a sample through the needle 224, if the liquid is collected by piercing the needle 224 into the food, whether or not allergen is present in the food. It can also be judged. The determination of the presence or absence of allergens related to the liquid content of food can be performed in the same manner even when the liquid content is dropped into the blood collection hole 51 of the barcode display device 1 of the first embodiment. Furthermore, blood, serum, plasma, saliva, cerebrospinal fluid, sweat, semen, vaginal fluid, tears, sputum, mucus, lymph, cytosol, ascites, pleural effusion, amniotic fluid, bladder wash, bronchoalveolar lavage, stool Alternatively, a body fluid such as urine, or a solution in which hair, nails, earwax or the like is dissolved may be dropped into the blood collection hole 51 to determine the presence or absence of an antigen. Furthermore, those body fluids and the like may be derived from animals other than humans (such as pets). In addition, the presence or absence of allergens such as pollen, house dust, and mites in the atmosphere can be determined by introducing bubbling liquid by directly introducing outside air into the water tank. In addition, such bubbling and dripping of the liquid after bubbling may be automatically performed by a device provided on the rooftop of the building.

[Fourth Embodiment]
FIG. 9 is a front view illustrating the configuration of the barcode display device 301 according to the fourth embodiment. In this bar code display device 301, a bar code display unit 10B having substantially the same configuration as the bar code display unit 10A described above is attached to a napkin 320 configured as follows. The bar code display unit 10B has a structure in which the substrate 7 is made of a relatively soft material having flexibility, and a minute hole is provided on the back surface of the substrate 7 so that blood can flow from the back surface side of the substrate 7 to the reaction chambers 11 to 11. 13 is different from the bar code display unit 10A in that the penetrable portion 13 and the blood supply unit 20 and the blood supply paths 21 to 24 are omitted. Further, on the surface of the bar code display unit 10B, a control unit 75B that performs control (S16, S17 in FIG. 4) on the above-described valves 31A to 43A is provided.

  The napkin 320 is provided with an absorbent body 323 between a back sheet 321 attached to the underwear via an adhesive layer (not shown) and a top sheet 322 that contacts the skin and has water permeability. The back surface of the substrate 7 is attached to the front surface of 321. In addition, a minute hole (not shown) is formed in the back sheet 321 at a portion facing the reaction chambers 11 to 13.

  For this reason, a part of the blood once absorbed by the absorber 323 penetrates into the reaction chambers 11 to 13. Therefore, by executing control on the valves 31A to 43A by the control unit 75B, a two-dimensional barcode corresponding to the presence or absence of the antigen is displayed on the surface of the barcode display unit 10B. It is possible to easily determine whether or not the antigen is contained in blood by imaging the two-dimensional barcode with a multi-function mobile phone or the like having a fluorescence imaging function as described above.

  The hole formed in the back surface of the substrate 7 or the back sheet 321 may function as a filter for separating plasma, and in that case, only plasma in blood can be targeted for the antigen-antibody reaction. .

[Fifth Embodiment]
FIG. 10 is a front view illustrating a configuration of a barcode display device 401 according to the fifth embodiment. In this barcode display device 401, a barcode display unit 10B and a control unit 75B similar to those in the fourth embodiment are attached to the front body 411 of the T-shirt 410 from the back side of the substrate 7. In this bar code display device 401, it is possible to determine whether or not the antigen is contained in sweat permeating from the surface of the T-shirt 410 into the reaction chambers 11 to 13 in the same manner as in the fourth embodiment. it can.

  Further, the bar code display unit 10B and the control unit 75B described above can similarly determine whether or not the antigen is contained in sweat even when the bar code display unit 10B and the control unit 75B are attached to socks or a headband. For example, if the passenger of an aircraft is obliged to wear a headband with the bar code display unit 10B and the control unit 75B attached, and if the image is taken via a camera having a fluorescence imaging function in the arrival lobby of the airport, the infectious disease It can also be determined whether or not.

  Furthermore, if such a barcode display unit 10B and the control unit 75B are floated on the river with the surface side facing up and fluorescent imaging is performed by an aircraft, an artificial satellite, or the like, the pollution state of the river can be detected. . For example, as disclosed in Japanese Patent No. 4212749 etc., various antibodies that act on dioxins are known, and if the antigen-antibody reaction is carried out using such an antibody, the concentration of dioxin in water or the like can be increased. It can be known via a two-dimensional barcode. Furthermore, since it is known that cigarette smoke contains dioxin, if such bar code display unit 10B and control unit 75B are hung from the ceiling or attached to a wall, It is possible to know how much smoke is in a place via a two-dimensional barcode.

[Sixth Embodiment]
Depending on the environment in which the barcode display unit is handled, a reagent holding tank and the like can be omitted as in the barcode display device 501 of the sixth embodiment shown in FIG. The bar code display device 501 includes a bar code display unit 10C having substantially the same configuration as the bar code display unit 10B described above on the front body 511 of the T-shirt 510 worn by the runner at the marathon event, as in the fifth embodiment. Attached. The bar code display unit 10C has openings 11A to 13A above the reaction chambers 11 to 13, and the reagent holding tanks 25 to 28, the reagent supply paths 31 to 36, the valves 21A to 43A, and the waste liquid tank 40 are omitted. Unlike the bar code display unit 10B, the rest is configured in the same manner. Moreover, in this embodiment, since the valves 21A to 43A are omitted, the controller 75B can also be omitted.

  In this embodiment, when the runner runs on a predetermined marathon course, water containing the labeled antibody, the washing solution, etc. is applied to the runner as a mist in a predetermined order. Then, a part of the mist enters the reaction chambers 11 to 13 through the openings 11A to 13A, and the antigen-antibody reaction occurs when the sweat contains a predetermined antigen. Therefore, whether or not the sweat contains the antigen can be easily determined in the same manner as in each of the embodiments.

[Seventh, eighth and ninth embodiments and other embodiments]
In addition, this invention is not limited to each said embodiment at all, It can implement with a various form in the range which does not deviate from the summary of this invention. For example, the changing portions (reaction chambers 11 to 13) of the present invention are not limited to those in which optical properties relating to fluorescence change, and other optical properties may change. For example, in the reaction chambers 11 to 13 described above, when a labeled antibody is attached, the light transmittance changes (in many cases, decreases). Therefore, the transparency of the marks 15 and 16 may be set lower than that of other portions of the substrate 7, and the two-dimensional barcode may be read with the transmitted light.

  Further, it is not always necessary to use the antigen-antibody reaction, and the optical characteristics of the changed portion may be changed by a completely different method such as discoloration of litmus paper. For example, like the barcode display device 601 of the seventh embodiment shown in FIG. 12, monochrome liquid crystal displays 611 to 613 are attached to the reaction chambers 11 to 13 of the T-shirt 510 of the sixth embodiment, and T You may energize through the electricity supply circuit (illustration omitted) which makes a part of shirt 510 an electricity supply path | route. In that case, the resistance value of the T-shirt 510 changes depending on the amount of sweat contained in the T-shirt 510 and the amount of mineral contained in the sweat, and the brightness of the liquid crystal display also changes. The degree of change in brightness can be made different between the liquid crystal displays 611, 612, and 613 depending on circuit design. In this embodiment, the marks 15 and 16 are directly printed on the T-shirt 510 with black ink.

  Therefore, in that case, if the two-dimensional barcode constituted by the liquid crystal displays 611 to 613 and the marks 15 and 16 is read by a general barcode reader, the amount of sweat of the runner wearing the T-shirt 510 and the amount of sweat It can be judged whether or not it contains a mineral content. Therefore, if such a decision is made at a water supply station, it is possible to accurately determine whether the runner should recommend water, mineral water, or even salt water, and the runner becomes heat ill. Can be suppressed more satisfactorily.

  Various other methods for detecting moisture and mineral content of sweat are conceivable. For example, it may be applied that the water-absorbing porous material pre-impregnated with the dye is discolored by water absorption, or the porous material pre-impregnated with the silver nitrate aqueous solution reacts with NaCl and becomes cloudy. May be.

  Further, even if the analysis chip described in Patent Document 1 is arranged so that the reaction chambers are arranged in a matrix on the same plane, a two-dimensional barcode corresponding to the presence or absence of the antigen can be formed. However, in that case, it is desirable that the arrangement of the analysis chips arranged as described above is further simplified by making them necessary and sufficient for the detection of one antigen individually. Furthermore, the presence or absence of allergens may be detected in each of the reaction chambers 11 to 13 by enclosing skin cells collected from a person with an allergic constitution and cultivating them with an IPS technique and a culture solution. In that case, if the skin cells react with the allergen and generate heat, the optical characteristics of the reaction chambers 11 to 13 related to infrared rays will change.

  Further, the barcode display device of the present invention may require some manual work. For example, the barcode display device 701 of the eighth embodiment shown in FIG. 13 prints the same mark 16 as shown in FIG. 5A on the barcode display unit 710 on the surface of the substrate 707 with a fluorescent paint. In some of the compartments 711, 712, and 713, antibodies are supported. Such a bar code display device 701 changes the bar code displayed on its surface as shown in FIGS. 5B and 5C by sequentially immersing the substrate 707 in plasma, labeled antibody, washing solution, or the like. Can be made. In this case, the barcode display device 701 can have a very simple configuration.

  Also in the present embodiment, as described with reference to FIG. 5A, the areas A and C shown in FIG. 13 in the barcode display unit 710 are used to specify personal information such as an email address. The region B may be assigned to a part corresponding to the detection result of the antigen. In that case, even when a large number of barcode display devices 701 are prepared in a hospital or the like and examination is performed on a plurality of patients, the names of individual patients are described on the barcode display device 701 with felt pens or the like. There is no need. Therefore, even if the barcode display device 701 touches the eyes of a third party, it cannot be easily determined which patient has been examined, and the privacy of the patient can be well protected. In the case of the example of FIG. 13, the marks 16 corresponding directly to the personal information or the like may not be printed in the areas A and C, and the marks 16 corresponding to the serial number of the barcode display device 701 are printed. In a database such as a hospital, it may be associated with personal information.

  Further, in such a barcode display device 701, if the urine test reagents are carried in the sections 711, 712, and 713, the region B displays information corresponding to the urinalysis results by applying urine. . In that case, even if the barcode display devices 701 of a plurality of patients are arranged and collected in a toilet or the like, the patient's privacy can be well protected as described above. Further, the mark 16 of the bar code display unit 710 does not necessarily have to be divided into areas A, B, and C, and may not have a portion corresponding to personal information. Conversely, as shown in FIG. A small two-dimensional barcode 16A corresponding to the personal information may be provided. In the latter case, the amount of information related to personal information can be increased.

  Next, FIG. 15 is an explanatory diagram illustrating a configuration of a barcode display device 801 according to the ninth embodiment. As shown in FIG. 15, the barcode display device 801 includes a barcode display unit 810 printed on the surface of the contact lens 802. Some of the sections 811, 812, and 813 constituting the bar code display unit 810 are configured using the above-described nanoparticles that change color by reacting with glucose in tear fluid. In the present embodiment, only information corresponding to the subject's katakana name and the mobile phone number is printed in the areas A and C of the mark 16 so as not to obstruct the subject's field of view through the contact lens 802. There has been a lot of blank space.

  In the barcode display device 801 configured in this way, the subject is imaged by the security display camera 822 arranged in various places in the city or building and connected to the control unit 820 as follows. Can be taught when to inject insulin.

  FIG. 16 is a flowchart showing processing executed by the control unit 820. As shown in FIG. 16, in this process, first, in S31, it is determined whether or not a human pupil is detected via the security camera 822. Since the technology for detecting the human pupil has been put into practical use in the control of various cameras, this step applies this technology.

  If no pupil is detected (S31: N), the process stands by in S31. If a pupil is detected (S31: Y), the process proceeds to S32. In S32, it is determined whether or not the movement of the pupil is unstable, for example, blinks are abnormally high, the pupil position is not stable, and is abnormally blurred. This determination is made, for example, based on whether or not the pupil is stably detected at a certain position or on a certain trajectory. When the movement of the pupil is unstable (S32: Y), it is suspicious and detection of the bar code display unit 810 described below is impossible. A notification that there is a suspicious person is made, and the process proceeds to S31 described above.

  If the movement of the pupil is not unstable (S32: N), the process proceeds to S34, and it is determined whether or not a two-dimensional barcode is detected in the pupil. When the pupil of a general person who does not wear the barcode display device 801 is detected in S31 or the like, since the barcode is not detected (S34: N), the process proceeds to S31 described above, and the next human pupil is detected. The process waits until is detected.

  When a two-dimensional barcode is detected in the pupil (S34: Y), the blood glucose level of the subject is read by reading the two-dimensional barcode, that is, the two-dimensional barcode displayed on the barcode display unit 810, in S35. Is determined. In subsequent S37, it is determined whether or not the blood glucose level determined in S35 is in a state that requires notification, such as requiring insulin injection, or requiring insulin injection within a few minutes. If notification is not required (S37: N), the process proceeds to S31 as it is, and if notification is required (S37: Y), the notification is transmitted to the subject's mobile phone as a short message at S38. Then, the process proceeds to S31. In this embodiment, such a process can teach the subject when to inject insulin.

  As a method for preventing the barcode display unit 810 from obstructing the field of view of the subject, various methods other than increasing the blank portion of the mark 16 as in the present embodiment are conceivable. For example, in the processes of S34 and S35, zooming in by the security camera 822 may be performed, and the barcode display unit 810 may be downsized to a limit size that can be read by zooming up. You may comprise by the color which is hard to become.

  In the present invention, the barcode is not limited to the two-dimensional barcode, and may be another type of two-dimensional barcode, one-dimensional barcode, or another barcode. It may be a code.

DESCRIPTION OF SYMBOLS 1,101,201,301,401,501,601,701,801 ... Barcode display device 7,707 ... Substrate 10,10A, 10B, 10C, 710,810 ... Barcode display part 11,12,13 ... Reaction Chamber 15, 16 ... Mark 20 ... Blood supply unit 25, 26, 27, 28 ... Reagent holding tank 40 ... Waste liquid tank 72 ... Camera 75, 75B, 820 ... Control unit 75A ... Communication unit 611, 612, 613 ... Liquid crystal display 711 , 712,713,811,812,813 ... division

Claims (3)

A bar code display unit that displays information as a one-dimensional or two-dimensional bar code, and has a change part that changes in optical characteristics in response to a specific substance contained in a specimen, and the optical characteristic of the change part A bar code display section in which information corresponding to the bar code changes due to a change in
A bar code display device comprising:   The bar code display device according to claim 1, wherein the bar code display unit includes a plurality of the change units whose optical characteristics change in response to different specific substances.   The bar code display device according to claim 1, wherein the specimen is a human body fluid.