JP2014125456A - Sanitary insect pest expellent - Google Patents
Sanitary insect pest expellent Download PDFInfo
- Publication number
- JP2014125456A JP2014125456A JP2012284133A JP2012284133A JP2014125456A JP 2014125456 A JP2014125456 A JP 2014125456A JP 2012284133 A JP2012284133 A JP 2012284133A JP 2012284133 A JP2012284133 A JP 2012284133A JP 2014125456 A JP2014125456 A JP 2014125456A
- Authority
- JP
- Japan
- Prior art keywords
- anionic surfactant
- amphoteric surfactant
- surfactant
- type
- sodium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000607479 Yersinia pestis Species 0.000 title claims abstract description 40
- 241000238631 Hexapoda Species 0.000 title abstract description 7
- 239000003945 anionic surfactant Substances 0.000 claims abstract description 54
- 239000002280 amphoteric surfactant Substances 0.000 claims abstract description 53
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 31
- KWIUHFFTVRNATP-UHFFFAOYSA-O N,N,N-trimethylglycinium Chemical compound C[N+](C)(C)CC(O)=O KWIUHFFTVRNATP-UHFFFAOYSA-O 0.000 claims abstract description 15
- KWIUHFFTVRNATP-UHFFFAOYSA-N Betaine Natural products C[N+](C)(C)CC([O-])=O KWIUHFFTVRNATP-UHFFFAOYSA-N 0.000 claims abstract description 14
- 229960003237 betaine Drugs 0.000 claims abstract description 14
- 238000002156 mixing Methods 0.000 claims abstract description 11
- 150000001412 amines Chemical class 0.000 claims abstract description 10
- 150000001732 carboxylic acid derivatives Chemical class 0.000 claims abstract description 7
- LSNNMFCWUKXFEE-UHFFFAOYSA-M Bisulfite Chemical compound OS([O-])=O LSNNMFCWUKXFEE-UHFFFAOYSA-M 0.000 claims abstract description 6
- 229910019142 PO4 Inorganic materials 0.000 claims abstract description 6
- 239000010452 phosphate Substances 0.000 claims abstract description 6
- -1 sulfate ester Chemical class 0.000 claims description 28
- 241001674048 Phthiraptera Species 0.000 claims description 24
- 239000003795 chemical substances by application Substances 0.000 claims description 17
- 241000258242 Siphonaptera Species 0.000 claims description 10
- 241000238876 Acari Species 0.000 claims description 9
- 238000002360 preparation method Methods 0.000 abstract description 17
- 230000000694 effects Effects 0.000 abstract description 16
- 150000001875 compounds Chemical class 0.000 abstract description 12
- 239000002728 pyrethroid Substances 0.000 abstract description 8
- SBNFWQZLDJGRLK-RTWAWAEBSA-N (1R)-trans-phenothrin Chemical compound CC1(C)[C@H](C=C(C)C)[C@H]1C(=O)OCC1=CC=CC(OC=2C=CC=CC=2)=C1 SBNFWQZLDJGRLK-RTWAWAEBSA-N 0.000 abstract description 7
- 229960003536 phenothrin Drugs 0.000 abstract description 7
- 241001465754 Metazoa Species 0.000 abstract description 6
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 abstract description 5
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 description 28
- 208000028454 lice infestation Diseases 0.000 description 13
- 229910052708 sodium Inorganic materials 0.000 description 12
- 239000011734 sodium Substances 0.000 description 12
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 11
- 235000014113 dietary fatty acids Nutrition 0.000 description 10
- 229930195729 fatty acid Natural products 0.000 description 10
- 239000000194 fatty acid Substances 0.000 description 10
- 241000517324 Pediculidae Species 0.000 description 9
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 8
- 241000517307 Pediculus humanus Species 0.000 description 7
- 150000004665 fatty acids Chemical class 0.000 description 7
- 230000002195 synergetic effect Effects 0.000 description 7
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 6
- 239000008213 purified water Substances 0.000 description 6
- 235000019333 sodium laurylsulphate Nutrition 0.000 description 6
- 125000000217 alkyl group Chemical group 0.000 description 5
- YVIGPQSYEAOLAD-UHFFFAOYSA-L disodium;dodecyl phosphate Chemical compound [Na+].[Na+].CCCCCCCCCCCCOP([O-])([O-])=O YVIGPQSYEAOLAD-UHFFFAOYSA-L 0.000 description 5
- ONLRKTIYOMZEJM-UHFFFAOYSA-N n-methylmethanamine oxide Chemical compound C[NH+](C)[O-] ONLRKTIYOMZEJM-UHFFFAOYSA-N 0.000 description 5
- BTURAGWYSMTVOW-UHFFFAOYSA-M sodium dodecanoate Chemical compound [Na+].CCCCCCCCCCCC([O-])=O BTURAGWYSMTVOW-UHFFFAOYSA-M 0.000 description 5
- 229940082004 sodium laurate Drugs 0.000 description 5
- GGHPAKFFUZUEKL-UHFFFAOYSA-M sodium;hexadecyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCCCOS([O-])(=O)=O GGHPAKFFUZUEKL-UHFFFAOYSA-M 0.000 description 5
- XPALGXXLALUMLE-UHFFFAOYSA-N 2-(dimethylamino)tetradecanoic acid Chemical compound CCCCCCCCCCCCC(N(C)C)C(O)=O XPALGXXLALUMLE-UHFFFAOYSA-N 0.000 description 4
- DDGPBVIAYDDWDH-UHFFFAOYSA-N 3-[dodecyl(dimethyl)azaniumyl]-2-hydroxypropane-1-sulfonate Chemical compound CCCCCCCCCCCC[N+](C)(C)CC(O)CS([O-])(=O)=O DDGPBVIAYDDWDH-UHFFFAOYSA-N 0.000 description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 4
- 241000282320 Panthera leo Species 0.000 description 4
- 239000004480 active ingredient Substances 0.000 description 4
- 125000004432 carbon atom Chemical group C* 0.000 description 4
- 235000019864 coconut oil Nutrition 0.000 description 4
- 239000003240 coconut oil Substances 0.000 description 4
- 229940075560 sodium lauryl sulfoacetate Drugs 0.000 description 4
- UAJTZZNRJCKXJN-UHFFFAOYSA-M sodium;2-dodecoxy-2-oxoethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O UAJTZZNRJCKXJN-UHFFFAOYSA-M 0.000 description 4
- JIFGDHWVYVXWCX-UHFFFAOYSA-N 2-[dodecyl(hydroxy)amino]ethane-1,1-diol Chemical compound CCCCCCCCCCCCN(O)CC(O)O JIFGDHWVYVXWCX-UHFFFAOYSA-N 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
- 241000282412 Homo Species 0.000 description 3
- 229910052799 carbon Inorganic materials 0.000 description 3
- 150000002148 esters Chemical class 0.000 description 3
- DVEKCXOJTLDBFE-UHFFFAOYSA-N n-dodecyl-n,n-dimethylglycinate Chemical compound CCCCCCCCCCCC[N+](C)(C)CC([O-])=O DVEKCXOJTLDBFE-UHFFFAOYSA-N 0.000 description 3
- FSYKKLYZXJSNPZ-UHFFFAOYSA-N sarcosine Chemical compound C[NH2+]CC([O-])=O FSYKKLYZXJSNPZ-UHFFFAOYSA-N 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 2
- UQOXSYQRUXKNQH-UHFFFAOYSA-N 1-hexadecoxyhexadecane;phosphoric acid Chemical compound OP(O)(O)=O.CCCCCCCCCCCCCCCCOCCCCCCCCCCCCCCCC UQOXSYQRUXKNQH-UHFFFAOYSA-N 0.000 description 2
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 2
- SPSPIUSUWPLVKD-UHFFFAOYSA-N 2,3-dibutyl-6-methylphenol Chemical compound CCCCC1=CC=C(C)C(O)=C1CCCC SPSPIUSUWPLVKD-UHFFFAOYSA-N 0.000 description 2
- OUNZARDETXBPIX-UHFFFAOYSA-N 2-(2-dodecoxyethoxy)acetic acid Chemical compound CCCCCCCCCCCCOCCOCC(O)=O OUNZARDETXBPIX-UHFFFAOYSA-N 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- 241000517306 Pediculus humanus corporis Species 0.000 description 2
- QVFOGJXHRGAFSH-UHFFFAOYSA-N acetic acid;1-dodecoxydodecane Chemical compound CC(O)=O.CCCCCCCCCCCCOCCCCCCCCCCCC QVFOGJXHRGAFSH-UHFFFAOYSA-N 0.000 description 2
- BTBJBAZGXNKLQC-UHFFFAOYSA-N ammonium lauryl sulfate Chemical compound [NH4+].CCCCCCCCCCCCOS([O-])(=O)=O BTBJBAZGXNKLQC-UHFFFAOYSA-N 0.000 description 2
- 229940063953 ammonium lauryl sulfate Drugs 0.000 description 2
- 125000000129 anionic group Chemical group 0.000 description 2
- CZBZUDVBLSSABA-UHFFFAOYSA-N butylated hydroxyanisole Chemical compound COC1=CC=C(O)C(C(C)(C)C)=C1.COC1=CC=C(O)C=C1C(C)(C)C CZBZUDVBLSSABA-UHFFFAOYSA-N 0.000 description 2
- 235000010354 butylated hydroxytoluene Nutrition 0.000 description 2
- 230000000052 comparative effect Effects 0.000 description 2
- ZRKZFNZPJKEWPC-UHFFFAOYSA-N decylamine-N,N-dimethyl-N-oxide Chemical compound CCCCCCCCCC[N+](C)(C)[O-] ZRKZFNZPJKEWPC-UHFFFAOYSA-N 0.000 description 2
- SMVRDGHCVNAOIN-UHFFFAOYSA-L disodium;1-dodecoxydodecane;sulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=O.CCCCCCCCCCCCOCCCCCCCCCCCC SMVRDGHCVNAOIN-UHFFFAOYSA-L 0.000 description 2
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 description 2
- SYELZBGXAIXKHU-UHFFFAOYSA-N dodecyldimethylamine N-oxide Chemical compound CCCCCCCCCCCC[N+](C)(C)[O-] SYELZBGXAIXKHU-UHFFFAOYSA-N 0.000 description 2
- SFNALCNOMXIBKG-UHFFFAOYSA-N ethylene glycol monododecyl ether Chemical compound CCCCCCCCCCCCOCCO SFNALCNOMXIBKG-UHFFFAOYSA-N 0.000 description 2
- NYPJDWWKZLNGGM-UHFFFAOYSA-N fenvalerate Chemical compound C=1C=C(Cl)C=CC=1C(C(C)C)C(=O)OC(C#N)C(C=1)=CC=CC=1OC1=CC=CC=C1 NYPJDWWKZLNGGM-UHFFFAOYSA-N 0.000 description 2
- 238000009472 formulation Methods 0.000 description 2
- 239000003205 fragrance Substances 0.000 description 2
- 238000010438 heat treatment Methods 0.000 description 2
- 239000002917 insecticide Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 239000000203 mixture Substances 0.000 description 2
- BEVGWNKCJKXLQC-UHFFFAOYSA-N n-methylmethanamine;hydrate Chemical compound [OH-].C[NH2+]C BEVGWNKCJKXLQC-UHFFFAOYSA-N 0.000 description 2
- 239000002736 nonionic surfactant Substances 0.000 description 2
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 2
- 229940080236 sodium cetyl sulfate Drugs 0.000 description 2
- 229940057950 sodium laureth sulfate Drugs 0.000 description 2
- 229950005425 sodium myristyl sulfate Drugs 0.000 description 2
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 2
- GEHJYWRUCIMESM-UHFFFAOYSA-L sodium sulfite Chemical compound [Na+].[Na+].[O-]S([O-])=O GEHJYWRUCIMESM-UHFFFAOYSA-L 0.000 description 2
- SXHLENDCVBIJFO-UHFFFAOYSA-M sodium;2-[2-(2-dodecoxyethoxy)ethoxy]ethyl sulfate Chemical compound [Na+].CCCCCCCCCCCCOCCOCCOCCOS([O-])(=O)=O SXHLENDCVBIJFO-UHFFFAOYSA-M 0.000 description 2
- UPUIQOIQVMNQAP-UHFFFAOYSA-M sodium;tetradecyl sulfate Chemical compound [Na+].CCCCCCCCCCCCCCOS([O-])(=O)=O UPUIQOIQVMNQAP-UHFFFAOYSA-M 0.000 description 2
- 239000007787 solid Substances 0.000 description 2
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 2
- 239000004094 surface-active agent Substances 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- 238000000108 ultra-filtration Methods 0.000 description 2
- 235000020681 well water Nutrition 0.000 description 2
- 239000002349 well water Substances 0.000 description 2
- GVJHHUAWPYXKBD-IEOSBIPESA-N α-tocopherol Chemical compound OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-IEOSBIPESA-N 0.000 description 2
- ZCVAOQKBXKSDMS-AQYZNVCMSA-N (+)-trans-allethrin Chemical compound CC1(C)[C@H](C=C(C)C)[C@H]1C(=O)OC1C(C)=C(CC=C)C(=O)C1 ZCVAOQKBXKSDMS-AQYZNVCMSA-N 0.000 description 1
- NOOLISFMXDJSKH-KXUCPTDWSA-N (-)-Menthol Chemical compound CC(C)[C@@H]1CC[C@@H](C)C[C@H]1O NOOLISFMXDJSKH-KXUCPTDWSA-N 0.000 description 1
- CXBMCYHAMVGWJQ-CABCVRRESA-N (1,3-dioxo-4,5,6,7-tetrahydroisoindol-2-yl)methyl (1r,3r)-2,2-dimethyl-3-(2-methylprop-1-enyl)cyclopropane-1-carboxylate Chemical compound CC1(C)[C@H](C=C(C)C)[C@H]1C(=O)OCN1C(=O)C(CCCC2)=C2C1=O CXBMCYHAMVGWJQ-CABCVRRESA-N 0.000 description 1
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 1
- LPMBTLLQQJBUOO-KTKRTIGZSA-N (z)-n,n-bis(2-hydroxyethyl)octadec-9-enamide Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)N(CCO)CCO LPMBTLLQQJBUOO-KTKRTIGZSA-N 0.000 description 1
- QCTZUSWOKFCWNB-QXMHVHEDSA-N (z)-n,n-dimethyloctadec-9-en-1-amine oxide Chemical compound CCCCCCCC\C=C/CCCCCCCC[N+](C)(C)[O-] QCTZUSWOKFCWNB-QXMHVHEDSA-N 0.000 description 1
- ARIWANIATODDMH-AWEZNQCLSA-N 1-lauroyl-sn-glycerol Chemical compound CCCCCCCCCCCC(=O)OC[C@@H](O)CO ARIWANIATODDMH-AWEZNQCLSA-N 0.000 description 1
- FMTFEIJHMMQUJI-NJAFHUGGSA-N 102130-98-3 Natural products CC=CCC1=C(C)[C@H](CC1=O)OC(=O)[C@@H]1[C@@H](C=C(C)C)C1(C)C FMTFEIJHMMQUJI-NJAFHUGGSA-N 0.000 description 1
- CHHHXKFHOYLYRE-UHFFFAOYSA-M 2,4-Hexadienoic acid, potassium salt (1:1), (2E,4E)- Chemical compound [K+].CC=CC=CC([O-])=O CHHHXKFHOYLYRE-UHFFFAOYSA-M 0.000 description 1
- BKUWWVKLLKXDJK-UHFFFAOYSA-N 2-(dimethylamino)icosanoic acid Chemical compound CCCCCCCCCCCCCCCCCCC(N(C)C)C(O)=O BKUWWVKLLKXDJK-UHFFFAOYSA-N 0.000 description 1
- GWEBEJYKXBMRJL-UHFFFAOYSA-N 2-[bis(2-hydroxyethyl)amino]ethanol;1-dodecoxydodecane;sulfuric acid Chemical compound OS(O)(=O)=O.OCCN(CCO)CCO.CCCCCCCCCCCCOCCCCCCCCCCCC GWEBEJYKXBMRJL-UHFFFAOYSA-N 0.000 description 1
- RZRILSWMGXWSJY-UHFFFAOYSA-N 2-[bis(2-hydroxyethyl)amino]ethanol;sulfuric acid Chemical compound OS(O)(=O)=O.OCCN(CCO)CCO RZRILSWMGXWSJY-UHFFFAOYSA-N 0.000 description 1
- ZSLUVFAKFWKJRC-IGMARMGPSA-N 232Th Chemical compound [232Th] ZSLUVFAKFWKJRC-IGMARMGPSA-N 0.000 description 1
- LIFHMKCDDVTICL-UHFFFAOYSA-N 6-(chloromethyl)phenanthridine Chemical compound C1=CC=C2C(CCl)=NC3=CC=CC=C3C2=C1 LIFHMKCDDVTICL-UHFFFAOYSA-N 0.000 description 1
- XZIIFPSPUDAGJM-UHFFFAOYSA-N 6-chloro-2-n,2-n-diethylpyrimidine-2,4-diamine Chemical compound CCN(CC)C1=NC(N)=CC(Cl)=N1 XZIIFPSPUDAGJM-UHFFFAOYSA-N 0.000 description 1
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 1
- 241000282472 Canis lupus familiaris Species 0.000 description 1
- 235000013162 Cocos nucifera Nutrition 0.000 description 1
- 244000060011 Cocos nucifera Species 0.000 description 1
- 239000005946 Cypermethrin Substances 0.000 description 1
- JDRSMPFHFNXQRB-CMTNHCDUSA-N Decyl beta-D-threo-hexopyranoside Chemical compound CCCCCCCCCCO[C@@H]1O[C@H](CO)C(O)[C@H](O)C1O JDRSMPFHFNXQRB-CMTNHCDUSA-N 0.000 description 1
- 239000005892 Deltamethrin Substances 0.000 description 1
- 239000005896 Etofenprox Substances 0.000 description 1
- 241000282326 Felis catus Species 0.000 description 1
- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical compound [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 description 1
- 239000005639 Lauric acid Substances 0.000 description 1
- ARIWANIATODDMH-UHFFFAOYSA-N Lauric acid monoglyceride Natural products CCCCCCCCCCCC(=O)OCC(O)CO ARIWANIATODDMH-UHFFFAOYSA-N 0.000 description 1
- AOMUHOFOVNGZAN-UHFFFAOYSA-N N,N-bis(2-hydroxyethyl)dodecanamide Chemical compound CCCCCCCCCCCC(=O)N(CCO)CCO AOMUHOFOVNGZAN-UHFFFAOYSA-N 0.000 description 1
- 241000283973 Oryctolagus cuniculus Species 0.000 description 1
- 241000286209 Phasianidae Species 0.000 description 1
- 229920001214 Polysorbate 60 Polymers 0.000 description 1
- 108010077895 Sarcosine Proteins 0.000 description 1
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 1
- 229910052776 Thorium Inorganic materials 0.000 description 1
- GSEJCLTVZPLZKY-UHFFFAOYSA-N Triethanolamine Chemical compound OCCN(CCO)CCO GSEJCLTVZPLZKY-UHFFFAOYSA-N 0.000 description 1
- 229930003427 Vitamin E Natural products 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 229940024113 allethrin Drugs 0.000 description 1
- 229940087168 alpha tocopherol Drugs 0.000 description 1
- 230000003110 anti-inflammatory effect Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 125000002091 cationic group Chemical group 0.000 description 1
- 229960000541 cetyl alcohol Drugs 0.000 description 1
- 238000013329 compounding Methods 0.000 description 1
- 230000007797 corrosion Effects 0.000 description 1
- 238000005260 corrosion Methods 0.000 description 1
- NSFKBZXCXCJZDQ-UHFFFAOYSA-N cumene;sodium Chemical compound [Na].CC(C)C1=CC=CC=C1 NSFKBZXCXCJZDQ-UHFFFAOYSA-N 0.000 description 1
- 229960001591 cyfluthrin Drugs 0.000 description 1
- QQODLKZGRKWIFG-QSFXBCCZSA-N cyfluthrin Chemical compound CC1(C)[C@@H](C=C(Cl)Cl)[C@H]1C(=O)O[C@@H](C#N)C1=CC=C(F)C(OC=2C=CC=CC=2)=C1 QQODLKZGRKWIFG-QSFXBCCZSA-N 0.000 description 1
- 229960005424 cypermethrin Drugs 0.000 description 1
- KAATUXNTWXVJKI-UHFFFAOYSA-N cypermethrin Chemical compound CC1(C)C(C=C(Cl)Cl)C1C(=O)OC(C#N)C1=CC=CC(OC=2C=CC=CC=2)=C1 KAATUXNTWXVJKI-UHFFFAOYSA-N 0.000 description 1
- 229960002483 decamethrin Drugs 0.000 description 1
- CTTKODQWVMTOPW-UHFFFAOYSA-N decanoic acid;sodium Chemical compound [Na].CCCCCCCCCC(O)=O CTTKODQWVMTOPW-UHFFFAOYSA-N 0.000 description 1
- 229940073499 decyl glucoside Drugs 0.000 description 1
- OWZREIFADZCYQD-NSHGMRRFSA-N deltamethrin Chemical compound CC1(C)[C@@H](C=C(Br)Br)[C@H]1C(=O)O[C@H](C#N)C1=CC=CC(OC=2C=CC=CC=2)=C1 OWZREIFADZCYQD-NSHGMRRFSA-N 0.000 description 1
- 239000003599 detergent Substances 0.000 description 1
- 230000006866 deterioration Effects 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 229940101029 dipotassium glycyrrhizinate Drugs 0.000 description 1
- GWTCIAGIKURVBJ-UHFFFAOYSA-L dipotassium;dodecyl phosphate Chemical compound [K+].[K+].CCCCCCCCCCCCOP([O-])([O-])=O GWTCIAGIKURVBJ-UHFFFAOYSA-L 0.000 description 1
- PTEWEFISOFMTTD-UHFFFAOYSA-L disodium;naphthalene-1,2-disulfonate Chemical compound [Na+].[Na+].C1=CC=CC2=C(S([O-])(=O)=O)C(S(=O)(=O)[O-])=CC=C21 PTEWEFISOFMTTD-UHFFFAOYSA-L 0.000 description 1
- 238000004821 distillation Methods 0.000 description 1
- TVACALAUIQMRDF-UHFFFAOYSA-N dodecyl dihydrogen phosphate Chemical compound CCCCCCCCCCCCOP(O)(O)=O TVACALAUIQMRDF-UHFFFAOYSA-N 0.000 description 1
- 125000003438 dodecyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
- JZKFHQMONDVVNF-UHFFFAOYSA-N dodecyl sulfate;tris(2-hydroxyethyl)azanium Chemical compound OCCN(CCO)CCO.CCCCCCCCCCCCOS(O)(=O)=O JZKFHQMONDVVNF-UHFFFAOYSA-N 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
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- 125000000400 lauroyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- PYIDGJJWBIBVIA-UYTYNIKBSA-N lauryl glucoside Chemical compound CCCCCCCCCCCCO[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O PYIDGJJWBIBVIA-UYTYNIKBSA-N 0.000 description 1
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- XGZOMURMPLSSKQ-UHFFFAOYSA-N n,n-bis(2-hydroxyethyl)octadecanamide Chemical compound CCCCCCCCCCCCCCCCCC(=O)N(CCO)CCO XGZOMURMPLSSKQ-UHFFFAOYSA-N 0.000 description 1
- SFBHPFQSSDCYSL-UHFFFAOYSA-N n,n-dimethyltetradecan-1-amine Chemical compound CCCCCCCCCCCCCCN(C)C SFBHPFQSSDCYSL-UHFFFAOYSA-N 0.000 description 1
- GOQYKNQRPGWPLP-UHFFFAOYSA-N n-heptadecyl alcohol Natural products CCCCCCCCCCCCCCCCCO GOQYKNQRPGWPLP-UHFFFAOYSA-N 0.000 description 1
- 210000002569 neuron Anatomy 0.000 description 1
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- 229960000490 permethrin Drugs 0.000 description 1
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- 239000008055 phosphate buffer solution Substances 0.000 description 1
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- 229940033623 potassium lauryl phosphate Drugs 0.000 description 1
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- 239000001632 sodium acetate Substances 0.000 description 1
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- BYKRNSHANADUFY-UHFFFAOYSA-M sodium octanoate Chemical compound [Na+].CCCCCCCC([O-])=O BYKRNSHANADUFY-UHFFFAOYSA-M 0.000 description 1
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- KVCGISUBCHHTDD-UHFFFAOYSA-M sodium;4-methylbenzenesulfonate Chemical compound [Na+].CC1=CC=C(S([O-])(=O)=O)C=C1 KVCGISUBCHHTDD-UHFFFAOYSA-M 0.000 description 1
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- DAJSVUQLFFJUSX-UHFFFAOYSA-M sodium;dodecane-1-sulfonate Chemical compound [Na+].CCCCCCCCCCCCS([O-])(=O)=O DAJSVUQLFFJUSX-UHFFFAOYSA-M 0.000 description 1
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- HIEHAIZHJZLEPQ-UHFFFAOYSA-M sodium;naphthalene-1-sulfonate Chemical compound [Na+].C1=CC=C2C(S(=O)(=O)[O-])=CC=CC2=C1 HIEHAIZHJZLEPQ-UHFFFAOYSA-M 0.000 description 1
- HRQDCDQDOPSGBR-UHFFFAOYSA-M sodium;octane-1-sulfonate Chemical compound [Na+].CCCCCCCCS([O-])(=O)=O HRQDCDQDOPSGBR-UHFFFAOYSA-M 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
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- 230000001954 sterilising effect Effects 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
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- YWSCPYYRJXKUDB-KAKFPZCNSA-N tralomethrin Chemical compound CC1(C)[C@@H](C(Br)C(Br)(Br)Br)[C@H]1C(=O)O[C@H](C#N)C1=CC=CC(OC=2C=CC=CC=2)=C1 YWSCPYYRJXKUDB-KAKFPZCNSA-N 0.000 description 1
- RHZZVWTVJHZKAH-UHFFFAOYSA-K trisodium;naphthalene-1,2,3-trisulfonate Chemical compound [Na+].[Na+].[Na+].C1=CC=C2C(S([O-])(=O)=O)=C(S([O-])(=O)=O)C(S(=O)(=O)[O-])=CC2=C1 RHZZVWTVJHZKAH-UHFFFAOYSA-K 0.000 description 1
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- 239000004711 α-olefin Substances 0.000 description 1
- 235000004835 α-tocopherol Nutrition 0.000 description 1
- 239000002076 α-tocopherol Substances 0.000 description 1
Landscapes
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
Description
本発明は、安全性及び実用性に優れ、シラミ、ダニ、ノミなどの衛生害虫の駆除について効果を有する衛生害虫駆除剤に関する。 The present invention relates to a sanitary pest control agent which is excellent in safety and practicality and has an effect on controlling sanitary pests such as lice, mites and fleas.
従来、シラミ、ダニ、ノミなどの衛生害虫からの被害を防ぐために、また、被害の拡散を防ぐために、人や動物に塗布して使用する衛生害虫駆除剤が知られている。一般的に、シラミは保育園児、幼稚園児、小学校低学年の児童などに寄生し、ダニ及びノミは犬、猫、ウサギなどのペットなどに寄生することが多いため、人や動物に使用できる薬剤として、確かな安全性を有するピレスロイド系殺虫剤のフェノトリンが知られているが、近年、それら神経細胞に働きかける薬剤に対しては抵抗性を有する衛生害虫の存在も報告されているため、ピレスロイド系の作用機序とは異なり、また、現在使用されているフェノトリン製剤と同程度以上の安全性を有する製剤が求められている。 Conventionally, sanitary pest control agents that are applied to humans and animals to prevent damage from sanitary pests such as lice, mites, and fleas and to prevent the spread of the damage are known. In general, lice are parasitic on preschoolers, kindergarteners, elementary school children, etc., and ticks and fleas are often parasitized on pets such as dogs, cats, and rabbits. As a pyrethroid insecticide, phenothrin, which has a certain safety, is known, but in recent years, the presence of sanitary pests that have resistance to drugs that act on these nerve cells has also been reported, In addition, there is a need for a preparation having a safety comparable to or higher than that of the currently used phenothrin preparation.
例えば、特許文献1には、炭素数が9〜24である高級アルコール又は炭素数が1〜22である脂肪酸の少なくともいずれか一方を含有するシラミ駆除剤が開示されている。 For example, Patent Document 1 discloses a lice control agent containing at least one of a higher alcohol having 9 to 24 carbon atoms or a fatty acid having 1 to 22 carbon atoms.
しかしながら、特許文献1に記載の製剤は親水性が乏しいために、水で洗い流すときのすすぎ性が悪く、例えば、アタマジラミ(学名:Pediculus humanus humanus)を駆除するために頭髪に使用した後に、又は、ケジラミ(学名:Phthiruspubis)を駆除するために陰毛に使用した後に、有効成分である高級アルコール又は脂肪酸を水で洗い流すために時間がかかり、また、多くの水を要する。 However, since the preparation described in Patent Document 1 has poor hydrophilicity, it is poorly rinsed when washed with water, for example, after being used on the hair to control head lice (scientific name: Pediculus humanus humanus), or After use on the pubic hair to control pheasants (scientific name: Phthirpus pubis), it takes time to wash away the higher alcohol or fatty acid, which is an active ingredient, with water, and requires a lot of water.
また、シラミ、ダニ、ノミなどの衛生害虫が感染するのは園児、児童、ペットなどが多いことにより、それら有効成分を水で洗い流している途中でそれら感染した者がぐずるなどして、それら有効成分を十分に洗い流すことができないおそれがあった。 In addition, sanitary pests such as lice, mites, and fleas are infected by many children, children, pets, etc., and those infected persons sway while washing these active ingredients with water. There was a risk that the components could not be washed away sufficiently.
また、衣類に付着するコロモジラミ(学名:Pediculus humanus corporis)に対して使用した場合でも、親水性が乏しい有効成分である高級アルコール又は脂肪酸を、再度洗剤を用いて洗う必要があり、時間と、多くの水を要する。 Even when used against body lice (scientific name: Pediculus humanus corporis) adhering to clothing, it is necessary to wash the higher alcohol or fatty acid, which is an active ingredient with poor hydrophilicity, again with a detergent. Of water.
そこで、本発明では、人、動物、衣類に使用することができ、フェノトリンなどのピレスロイド系化合物を使用しない場合においても、水溶性で、水によるすすぎが良好で、シラミ、ダニ、ノミなどの衛生害虫を駆除する効果が高い製剤を提供することを目的とする。 Therefore, in the present invention, it can be used for humans, animals, clothing, and even when pyrethroid compounds such as phenothrin are not used, it is water-soluble, is well rinsed with water, and is hygienic such as lice, mites, fleas, etc. An object is to provide a preparation having a high effect of controlling pests.
(1)すなわち、本発明に係る衛生害虫駆除剤は、アニオン界面活性剤と、両性界面活性剤と、水とを含有し、前記アニオン界面活性剤及び前記両性界面活性剤の配合比率が、前記アニオン界面活性剤/前記両性界面活性剤=12/1〜1/33であることを特徴とする衛生害虫駆除剤である。 (1) That is, the sanitary pest control agent according to the present invention contains an anionic surfactant, an amphoteric surfactant, and water, and the blending ratio of the anionic surfactant and the amphoteric surfactant is the above. An anionic surfactant / the amphoteric surfactant = 12/1 to 1/33.
(2)そして、前記アニオン界面活性剤が、カルボン酸型、スルホン酸型、硫酸エステル型、リン酸エステル型から選ばれる少なくとも1種であり、前記両性界面活性剤が、アミンオキサイド型、ベタイン型から選ばれる少なくとも1種であることを特徴とする前記(1)に記載の衛生害虫駆除剤である。 (2) The anionic surfactant is at least one selected from a carboxylic acid type, a sulfonic acid type, a sulfate ester type, and a phosphate ester type, and the amphoteric surfactant is an amine oxide type or a betaine type. It is at least 1 sort (s) chosen from these, The hygiene pest control agent as described in said (1) characterized by the above-mentioned.
(3)そして、前記アニオン界面活性剤及び前記両性界面活性剤の総量が0.5〜95重量%であることを特徴とする前記(1)又は前記(2)に記載の衛生害虫駆除剤である。 (3) The sanitary pest control agent according to (1) or (2), wherein the total amount of the anionic surfactant and the amphoteric surfactant is 0.5 to 95% by weight. is there.
(4)そして、前記アニオン界面活性剤及び前記両性界面活性剤が駆除成分であることを特徴とする前記(1)から前記(3)のいずれかに記載の衛生害虫駆除剤である。 (4) The sanitary pest control agent according to any one of (1) to (3), wherein the anionic surfactant and the amphoteric surfactant are control components.
(5)そして、前記衛生害虫がシラミ、ダニ、ノミであることを特徴とする前記(1)から前記(4)のいずれかに記載の衛生害虫駆除剤。 (5) The sanitary pest control agent according to any one of (1) to (4), wherein the sanitary pest is lice, mites, or fleas.
このように構成すれば、人、動物、衣類に使用することができ、フェノトリンなどのピレスロイド系化合物を使用しない場合においても、水溶性で、水によるすすぎが良好で、シラミ、ダニ、ノミなどの衛生害虫を駆除する効果が高い製剤が得られる。 If constituted in this way, it can be used for humans, animals, clothing, and even when pyrethroid compounds such as phenothrin are not used, it is water-soluble and is well rinsed with water, such as lice, mites, fleas, etc. A preparation with a high effect of controlling sanitary pests can be obtained.
以下、本発明の衛生害虫駆除剤に関する実施形態について詳しく説明する。なお、説明中における範囲を示す表記のある場合は、上限と下限を含有するものである。 Hereinafter, embodiments of the sanitary pest control agent of the present invention will be described in detail. In addition, when there exists a description which shows the range in description, an upper limit and a lower limit are contained.
本発明は、シラミなどの衛生害虫を駆除するための有効成分であるアニオン界面活性剤と両性界面活性剤とを所定の配合比率で含有し、さらに水を含有する水溶性の製剤である。 The present invention is a water-soluble preparation containing an anionic surfactant and an amphoteric surfactant, which are active ingredients for controlling sanitary pests such as lice, in a predetermined blending ratio, and further containing water.
本発明において使用されるアニオン界面活性剤は、両性界面活性剤との相乗効果によりシラミなどの衛生害虫を駆除するための駆除成分であり、陰イオン性の親水基を有する界面活性剤であり、その中でもカルボン酸型、スルホン酸型、硫酸エステル型、リン酸エステル型から選ばれる少なくとも1種が好ましく、液状、又は固形である100%純分の化合物だけでなく、それらを所定量の水で希釈した水溶液であってもよい。 The anionic surfactant used in the present invention is a controlling component for controlling sanitary pests such as lice by a synergistic effect with an amphoteric surfactant, and is a surfactant having an anionic hydrophilic group, Among them, at least one selected from a carboxylic acid type, a sulfonic acid type, a sulfate ester type, and a phosphate ester type is preferable, and not only a 100% pure compound that is liquid or solid but also a predetermined amount of water. It may be a diluted aqueous solution.
カルボン酸型のアニオン界面活性剤としては、ラウリン酸ナトリウム、ステアリン酸ナトリウム、ラウレス−6カルボン酸ナトリウム(ポリオキシエチレン(4.5)ラウリルエーテル酢酸ナトリウム)、ラウロイルサルコシンナトリウム、オクタン酸ナトリウム、デカン酸ナトリウム、ミリスチリン酸ナトリウム、パルミチン酸ナトリウム、ヤシ油脂肪酸(C8〜18)サルコンシンナトリウムなどが好ましい。 Carboxylic acid type anionic surfactants include sodium laurate, sodium stearate, sodium laureth-6 carboxylate (sodium polyoxyethylene (4.5) lauryl ether acetate), sodium lauroyl sarcosine, sodium octanoate, decanoic acid Sodium, sodium myristylate, sodium palmitate, coconut oil fatty acid (C8-18) sarcosine sodium and the like are preferable.
スルホン酸型のアニオン界面活性剤としては、ラウリルスルホ酢酸ナトリウム、1−ヘキサンスルホン酸ナトリウム、1−オクタンスルホン酸ナトリウム、1−デカンスルホン酸ナトリウム、1−ドデカンスルホン酸ナトリウム、トルエンスルホン酸ナトリウム、クメンスルホン酸ナトリウム、ナフタレンスルホン酸ナトリウム、ナフタレンジスルホン酸二ナトリウム、ナフタレントリスルホン酸三ナトリウム、アルファオレフィンスルホン酸ナトリウムなどが好ましい。 Examples of the sulfonic acid type anionic surfactant include sodium lauryl sulfoacetate, sodium 1-hexanesulfonate, sodium 1-octanesulfonate, sodium 1-decanesulfonate, sodium 1-dodecanesulfonate, sodium toluenesulfonate, cumene Sodium sulfonate, sodium naphthalene sulfonate, disodium naphthalene disulfonate, trisodium naphthalene trisulfonate, sodium alpha olefin sulfonate and the like are preferable.
硫酸エステル型のアニオン界面活性剤としては、ラウリル硫酸ナトリウム、ミリスチル硫酸ナトリウム、ラウレス硫酸ナトリウム(ポリオキシエチレン(3)ラウリルエーテル硫酸ナトリウム)、セチル硫酸ナトリウム、ココグリセリル硫酸ナトリウム(硬化ヤシ油脂肪酸グリセリル硫酸ナトリウム)、ラウリル硫酸トリエタノールアミン、ラウリル硫酸アンモニウム、ラウレス硫酸トリエタノールアミンなどが好ましい。 Sulfate-type anionic surfactants include sodium lauryl sulfate, sodium myristyl sulfate, sodium laureth sulfate (polyoxyethylene (3) sodium lauryl ether sulfate), sodium cetyl sulfate, sodium cocoglyceryl sulfate (hardened coconut oil fatty acid glyceryl sulfate) Sodium), triethanolamine lauryl sulfate, ammonium lauryl sulfate, triethanolamine laureth sulfate and the like are preferable.
リン酸エステル型のアニオン界面活性剤としては、ラウリルリン酸ナトリウム、ポリオキシエチレンセチルエーテルリン酸ナトリウム(ポリオキシエチレン(5)セチルエーテルリン酸ナトリウム)、ラウリルリン酸、ラウリルリン酸カリウムなどが好ましい。 As the phosphoric acid ester type anionic surfactant, sodium lauryl phosphate, sodium polyoxyethylene cetyl ether phosphate (polyoxyethylene (5) sodium cetyl ether phosphate), lauryl phosphate, potassium lauryl phosphate and the like are preferable. .
前記アニオン界面活性剤の配合量は、0.3〜55重量%であることが好ましく、0.5〜50重量%であることがさらに好ましく、0.6〜40重量%であることが最も好ましい。この範囲にあると、水溶性でシラミなどの衛生害虫を駆除する効果が高い製剤を得ることができる。なお、前記アニオン界面活性剤は1種類のみ、又は2種類以上組み合わせて用いることができる。 The amount of the anionic surfactant is preferably 0.3 to 55% by weight, more preferably 0.5 to 50% by weight, and most preferably 0.6 to 40% by weight. . When the amount is within this range, a preparation that is water-soluble and highly effective in combating sanitary pests such as lice can be obtained. The anionic surfactant can be used alone or in combination of two or more.
本発明において使用される両性界面活性剤は、アニオン界面活性剤との相乗効果によりシラミなどの衛生害虫を駆除するための駆除成分であり、陰イオン性及び陽イオン性の親水基を両有する界面活性剤であり、その中でもアミンオキサイド型、ベタイン型から選ばれる少なくとも1種が好ましく、液状、又は固形である100%純分の化合物だけでなく、それらを所定量の水で希釈した水溶液であってもよい。 The amphoteric surfactant used in the present invention is a controlling component for controlling sanitary pests such as lice by a synergistic effect with an anionic surfactant, and an interface having both anionic and cationic hydrophilic groups. Among them, at least one selected from amine oxide type and betaine type is preferable, and it is not only a 100% pure compound that is liquid or solid, but also an aqueous solution obtained by diluting them with a predetermined amount of water. May be.
アミンオキサイド型の両性界面活性剤としては、ラウリルジメチルアミンオキサイド、アルキルジメチルアミンオキサイド(N,N−ジメチルアルキル(C8〜18)アミンオキサイド)、ヤシアルキルジメチルアミンオキサイド、デシルジメチルアミンオキサイド、ミリスチルジメチルアミンオキサイド、ジヒドロキシエチルラウリルアミンオキサイド、オレイルジメチルアミンオキサイドなどが好ましい。 Amine oxide type amphoteric surfactants include lauryl dimethylamine oxide, alkyldimethylamine oxide (N, N-dimethylalkyl (C8-18) amine oxide), coconut alkyldimethylamine oxide, decyldimethylamine oxide, myristyldimethylamine. Oxide, dihydroxyethyl lauryl amine oxide, oleyl dimethyl amine oxide and the like are preferable.
ベタイン型の両性界面活性剤としては、ラウリルジメチルアミノ酢酸ベタイン、ラウリルヒドロキシスルホベタイン、ステアリルジメチルアミノ酢酸ベタイン、ドデシルアミノメチルジメチルスルホプロピルベタイン、ヤシ油脂肪酸(C8〜18)アミドプロピルベタイン、2−アルキル−N−カルボキシメチル−N−ヒドロキシエチルイミダゾリニウムベタイン、ラウリン酸アミドプロピルベタインなどが好ましい。 Examples of betaine-type amphoteric surfactants include lauryldimethylaminoacetic acid betaine, laurylhydroxysulfobetaine, stearyldimethylaminoacetic acid betaine, dodecylaminomethyldimethylsulfopropylbetaine, coconut oil fatty acid (C8-18) amidopropyl betaine, 2-alkyl. -N-carboxymethyl-N-hydroxyethyl imidazolinium betaine, lauric acid amidopropyl betaine and the like are preferable.
前記両性界面活性剤の配合量は、0.2〜40重量%であることが好ましく、0.25〜30重量%であることがさらに好ましく、0.3〜20重量%であることが最も好ましい。この範囲にあると、水溶性でシラミなどの衛生害虫を駆除する効果が高い製剤を得ることができる。なお、前記両性界面活性剤は1種類のみ、又は2種類以上組み合わせて用いることができる。 The compounding amount of the amphoteric surfactant is preferably 0.2 to 40% by weight, more preferably 0.25 to 30% by weight, and most preferably 0.3 to 20% by weight. . When the amount is within this range, a preparation that is water-soluble and highly effective in combating sanitary pests such as lice can be obtained. The amphoteric surfactant can be used alone or in combination of two or more.
前記アニオン界面活性剤と前記両性界面活性剤の配合比率は、アニオン界面活性剤/両性界面活性剤=12/1〜1/33であることが好ましく、9/1〜1/19であることがさらに好ましい。さらに、アニオン界面活性剤及び両性界面活性剤の総量が0.5〜95重量%であることが好ましく、0.75〜80重量%であることがさらに好ましく、0.9〜60重量%であることが最も好ましい。これらの範囲にあると、アニオン界面活性剤と両性界面活性剤との相乗効果により、フェノトリンなどのピレスロイド系化合物を使用しない場合においても、水溶性で、水によるすすぎが良好で、シラミ、ダニ、ノミなどの衛生害虫を駆除する効果が高い製剤を得ることができる。 The blending ratio of the anionic surfactant and the amphoteric surfactant is preferably anionic surfactant / amphoteric surfactant = 12/1 to 1/33, and preferably 9/1 to 1/19. Further preferred. Furthermore, the total amount of the anionic surfactant and the amphoteric surfactant is preferably 0.5 to 95% by weight, more preferably 0.75 to 80% by weight, and 0.9 to 60% by weight. Most preferred. Within these ranges, due to the synergistic effect of an anionic surfactant and an amphoteric surfactant, even when a pyrethroid compound such as phenothrin is not used, it is water-soluble and is well rinsed with water. It is possible to obtain a preparation having a high effect of controlling sanitary pests such as fleas.
本発明において使用される水は、日本薬局方規格の水が好ましく、例えば、水道水、井戸水などである常水、そして、蒸留、イオン交換膜によるイオン交換処理、限外ろ過膜による限外ろ過処理のいずれか、またはそれらの組み合わせにより常水を処理した精製水、そして、加熱等により精製水を滅菌処理した滅菌精製水などが挙げられる。また、前記アニオン界面活性剤、前記両性界面活性剤が水溶液の場合、それらに含有される水であってもよい。 The water used in the present invention is preferably Japanese Pharmacopoeia standard water, for example, tap water, well water such as well water, and distillation, ion exchange treatment with an ion exchange membrane, ultrafiltration with an ultrafiltration membrane. Examples thereof include purified water obtained by treating normal water by any of the treatments or a combination thereof, and sterilized purified water obtained by sterilizing purified water by heating or the like. Moreover, when the anionic surfactant and the amphoteric surfactant are aqueous solutions, water contained therein may be used.
また、前記水の含有割合は、5〜99.5重量%の範囲であることが好ましく、20〜99.25重量%の範囲であることがさらに好ましく、40〜99.1重量%の範囲であることが最も好ましい。この範囲にあると、シラミ、ダニ、ノミなどの衛生害虫を駆除するための駆除成分である前記アニオン界面活性剤と前記両性界面活性剤を洗い流し易い。 The water content is preferably in the range of 5 to 99.5% by weight, more preferably in the range of 20 to 99.25% by weight, and in the range of 40 to 99.1% by weight. Most preferably it is. When it is in this range, the anionic surfactant and the amphoteric surfactant, which are controlling components for controlling sanitary pests such as lice, mites, and fleas, can be easily washed away.
本発明において、ピレスロイド系化合物を使用しなくても良いが、使用することを妨げるものではなく、種々のピレスロイド系殺虫剤を添加することができる。例えば、アレスリン、テトラメスリン、プラレトリン、フェノトリン、レスメトリン、シフェノトリン、ペルメトリン、シペルメトリン、デルタメトリン、トラロメトリン、シフルトリン、フラメトリン、イミプロトリン、エトフェンプロックス、フェンバレレート、フェンプロパスリン、シラフルオフェン、テラレトリン、ビフェントリン、エンペントリン、ピレトリンなどが好ましい。なお、前記ピレスロイド系化合物は1種類のみ、又は2種類以上組み合わせて用いることができる。 In the present invention, it is not necessary to use a pyrethroid compound, but this does not prevent the use, and various pyrethroid insecticides can be added. For example, allethrin, tetramethrin, praretrin, phenothrin, resmethrin, ciphenothrin, permethrin, cypermethrin, deltamethrin, tralomethrin, cyfluthrin, flamethrin, imiprotorin, etofenprox, fenvalerate, fenpropathrin, silafluentrin, penalentrin, penfenthrin Etc. are preferable. The pyrethroid compounds can be used alone or in combination of two or more.
そして、衛生害虫を駆除する所望の効果を生じる範囲で、製剤を長期保存しても分離しない安定性を付与するため、起泡性を良くするため、使用感の向上のためなどの目的で、前記以外の界面活性剤などを添加することができる。例えば、非イオン界面活性剤が好ましく、モノラウリン酸グリセリン、モノステアリン酸グリセリン、モノラウリン酸ソルビタンなどのエステル型、ペンタエチレングリコ−ルモノドデシルエーテル、ポリオキシエチレンポリオキシプロピレングリコールなどのエーテル型、ポリオキシエチレンソルビタン脂肪酸エステル、ポリオキシエチレングリセリン脂肪酸エステル、ポリオキシエチレンポリグリセリン脂肪酸エステルなどのエステルエーテル型、ラウリン酸ジエタノールアミド、オレイン酸ジエタノールアミド、ステアリン酸ジエタノールアミドなどのアルカノールアミド型、オクチルグルコシド、デシルグルコシド、ラウリルグルコシドなどのアルキルグリコシド型、セタノール、ステアリルアルコール、オレイルアルコールなどの高級アルコールなどであることがさらに好ましい。なお、前記非イオン界面活性剤は1種類のみ、又は2種類以上組み合わせて用いることができる。 And, in order to give the stability that does not separate even if the formulation is stored for a long time, in order to give the desired effect of combating sanitary pests, to improve foaming, for the purpose of improving the feeling of use, Surfactants other than those described above can be added. For example, nonionic surfactants are preferred, ester types such as glycerol monolaurate, glycerol monostearate, sorbitan monolaurate, ether types such as pentaethylene glycol monododecyl ether, polyoxyethylene polyoxypropylene glycol, polyoxyethylene Sorbitan fatty acid ester, polyoxyethylene glycerin fatty acid ester, ester ether type such as polyoxyethylene polyglycerin fatty acid ester, alkanolamide type such as lauric acid diethanolamide, oleic acid diethanolamide, stearic acid diethanolamide, octyl glucoside, decyl glucoside, Alkyl glycoside types such as lauryl glucoside, cetanol, stearyl alcohol, oleyl alcohol, etc. More preferably in the like grade alcohol. The nonionic surfactant can be used alone or in combination of two or more.
さらに製剤の酸化による劣化などの腐食を防止するため、ビタミンC(アスコルビン酸)、ビタミンE(α−トコフェロール)、BHT(ジブチルヒドロキシトルエン)、BHA(ブチルヒドロキシアニソール)、ソルビン酸、ソルビン酸カリウム、亜硫酸ナトリウムなどの酸化防止剤を添加することができる。また、防腐を目的に、パラオキシ安息香酸エステルを添加することもできる。また、抗炎症作用などを目的に、グリチルリチン酸二カリウムを添加することもできる。また、製剤のpHを調整することを目的に、リン酸緩衝液などを添加することもできる。 Furthermore, in order to prevent corrosion such as deterioration due to oxidation of the preparation, vitamin C (ascorbic acid), vitamin E (α-tocopherol), BHT (dibutylhydroxytoluene), BHA (butylhydroxyanisole), sorbic acid, potassium sorbate, Antioxidants such as sodium sulfite can be added. Moreover, paraoxybenzoic acid ester can also be added for the purpose of antiseptic. Moreover, dipotassium glycyrrhizinate can also be added for the purpose of anti-inflammatory action. A phosphate buffer solution or the like can also be added for the purpose of adjusting the pH of the preparation.
さらに、爽快感を付与するためにl−メントールや、香りを付けるために種々の香料を添加することができる。 Furthermore, 1-menthol for imparting a refreshing feeling and various fragrances for adding a fragrance can be added.
以下、本発明の実施例について具体的に説明する。なお、本発明は以下の実施例に限定されるものではない。 Examples of the present invention will be specifically described below. In addition, this invention is not limited to a following example.
<実施例1>
容量が200mlのグリフィンビーカーに、アニオン界面活性剤としてラウリル硫酸ナトリウム(商品名「エマール0」、花王株式会社製)9.0g、両性界面活性剤としてアルキル(炭素数8〜18)ジメチルアミンオキサイド<N,N−ジメチルアルキル(C8〜18)アミンオキサイド>(商品名「アロモックスDMCW−I」29重量%水溶液、ライオン株式会社製)3.4g(実質成分量1.0g)、日本薬局方精製水87.6gを室温である25℃において作成した。すなわち、ラウリル硫酸ナトリウム9.0g、アルキル(炭素数8〜18)ジメチルアミンオキサイド1.0g、水90.0gからなる製剤を作成した。そして、これを40℃のウォーターバスで間接的に加温しながら均一になるまで攪拌混合した後に、放冷して衛生害虫駆除剤を得た。その結果を、表1に示す。
<Example 1>
In a Griffin beaker having a capacity of 200 ml, 9.0 g of sodium lauryl sulfate (trade name “Emar 0”, manufactured by Kao Corporation) as an anionic surfactant, alkyl (carbon number 8 to 18) dimethylamine oxide as an amphoteric surfactant < N, N-dimethylalkyl (C8-18) amine oxide> (trade name “Aromox DMCW-I” 29% by weight aqueous solution, manufactured by Lion Corporation) 3.4 g (substance amount 1.0 g), Japanese Pharmacopoeia purified water 87.6 g was prepared at 25 ° C., which is room temperature. That is, a preparation comprising 9.0 g of sodium lauryl sulfate, 1.0 g of alkyl (carbon number 8 to 18) dimethylamine oxide, and 90.0 g of water was prepared. And after stirring and mixing until it became uniform, heating this indirectly with a 40 degreeC water bath, it stood to cool and obtained the sanitary insect pest control agent. The results are shown in Table 1.
得られた衛生害虫駆除剤の効力については、衛生害虫としてシラミを用いて以下の試験方法で確認した。すなわち、20匹のコロモジラミをシャーレに入れ、そこに実施例1の製剤を精製水で5倍に希釈した後、当該シラミを5分間浸漬させ処理した後に引き上げ、24時間経過後の状態を観察した。24時間経過後に観察し、動き回り生存している匹数(生存数)と、静止しており死亡またはそれに準じる状態の匹数(死虫数)を数え、駆除率(%)={死虫数/(生存数+死虫数)}×100で記載される計算式より効力を百分率により算出し、3回実施した試験における各駆除率の平均である平均駆除率が60%以上の場合をシラミの駆除効果があると判断した。その結果を表1に併せて示す。なお、浴室や洗面所において頭髪や衣服が含水している状態を想定して、得られた衛生害虫駆除剤を精製水で5倍に希釈して効果を確認したものであり、原液で、又は、他の希釈倍率で効果を確認することを妨げるものではなく、その場合駆除効果があると判断する駆除率の基準数値も変動しうる。 The efficacy of the obtained sanitary pest control agent was confirmed by the following test method using lice as sanitary pests. That is, 20 body lice were put in a petri dish, and after the preparation of Example 1 was diluted 5 times with purified water, the lice were soaked for 5 minutes and then pulled up, and the state after 24 hours was observed. . Observe after 24 hours, count the number of surviving animals (number of survivors) and the number of animals that are stationary and die or are in a similar state (number of dead insects), and the extermination rate (%) = {number of dead insects / (Number of survivors + number of dead insects)} × 100, the efficacy is calculated as a percentage, and when the average control rate is 60% or more, which is the average of each control rate in the test conducted three times, lice It was judged that there was an extermination effect. The results are also shown in Table 1. Assuming that the hair and clothes are wet in bathrooms and toilets, the hygienic pest control agent obtained was diluted 5 times with purified water and the effect was confirmed. This does not prevent the effect from being confirmed at other dilution ratios, and in that case, the reference value of the removal rate at which it is judged that there is a removal effect may also vary.
なお、松崎沙和子氏及び武衛和雄氏による「都市害虫百科」(朝倉書店 1993年06月発行 p.34−36)によると、アタマジラミは分類学上ヒトジラミ(学名:Pediculus humanus)とよばれ、頭髪に寄生するアタマジラミと衣服に寄生するコロモジラミに分けられるが、分類学では同一種として扱われており、アタマジラミはヒトジラミの変種であると記述されている。そのため、コロモジラミを用いて試験を行った。 According to “Urban Pest Encyclopedia” by Sawako Matsuzaki and Kazuo Takee (Asakura Shoten, published in June 1993, pages 34-36), head lice are taxonomically called human lice (scientific name: Pediculus humanus) and hair. It is divided into head lice that parasitize and body lice that parasitize clothes, but they are treated as the same species in taxonomy, and head lice are described as variants of human lice. Therefore, the test was conducted using a body lice.
<実施例2〜12>
実施例1と同じ商品を用いて、ラウリル硫酸ナトリウム、アルキル(炭素数8〜18)ジメチルアミンオキサイド、水の配合比率、濃度を種々変更し、同様の製剤を作成した。そして、実施例1と同様に18〜22匹のコロモジラミを用いて効力を駆除率にて算出し、3回実施した試験における各駆除率の平均である平均駆除率を得た。その結果を表1に示す。
<Examples 2 to 12>
Using the same product as in Example 1, various blending ratios and concentrations of sodium lauryl sulfate, alkyl (8 to 18 carbon atoms) dimethylamine oxide, and water were variously prepared. And the efficacy was calculated by the extermination rate using 18-22 body lice like Example 1, and the average extermination rate which is the average of each extermination rate in the test implemented 3 times was obtained. The results are shown in Table 1.
<比較例1〜6>
実施例1と同じ商品を用いて、ラウリル硫酸ナトリウム、アルキル(炭素数8〜18)ジメチルアミンオキサイド、水の配合比率、濃度を種々変更し、同様の製剤を作成した。そして、実施例1と同様に18〜22匹のコロモジラミを用いて効力を駆除率にて算出し、3回実施した試験における各駆除率の平均である平均駆除率を得た。その結果を表2に示す。
<Comparative Examples 1-6>
Using the same product as in Example 1, various blending ratios and concentrations of sodium lauryl sulfate, alkyl (8 to 18 carbon atoms) dimethylamine oxide, and water were variously prepared. And the efficacy was calculated by the extermination rate using 18-22 body lice like Example 1, and the average extermination rate which is the average of each extermination rate in the test implemented 3 times was obtained. The results are shown in Table 2.
<実施例13〜19>
アニオン界面活性剤としてラウリル硫酸ナトリウム(商品名「エマール0」、花王株式会社製)7.0gを用い、両性界面活性剤の種類を変更して、実施例1と同様に製剤を作成し、そして18〜22匹のコロモジラミを用いて駆除率を算出し、3回実施した試験における各駆除率の平均である平均駆除率を得た。すなわち、両性界面活性剤は、実施例13においてラウリルジメチルアミンオキサイド(商品名「アンヒトール20N」35重量%水溶液、花王株式会社製)8.57g(実質成分量3.0g)、実施例14においてヤシアルキルジメチルアミンオキサイド(商品名「アロモックスDMC−W」31重量%水溶液、ライオン株式会社製)9.7g(実質成分量3.0g)、実施例15においてデシルジメチルアミンオキサイド(商品名「アロモックスDM10D−W」40.3重量%水溶液、ライオン株式会社製)7.4g(実質成分量3.0g)、実施例16においてミリスチルジメチルアミンオキサイド(商品名「アロモックスDM14D−N」25.1重量%水溶液、ライオン株式会社製)12.0g(実質成分量3.0g)、実施例17においてジヒドロキシエチルラウリルアミンオキサイド(商品名「ユニセーフA−LE」41.1重量%水溶液、日油株式会社製)7.3g(実質成分量3.0g)、実施例18においてラウリルジメチルアミノ酢酸ベタイン(商品名「アンヒトール20BS」30重量%水溶液、花王株式会社製)10.0g(実質成分量3.0g)、実施例19においてラウリルヒドロキシスルホベタイン(商品名「アンヒトール20HD」30.8重量%水溶液、花王株式会社製)9.7g(実質成分量3.0g)を用いた。その結果を表3に示す。
<Examples 13 to 19>
Using 7.0 g of sodium lauryl sulfate (trade name “Emar 0”, manufactured by Kao Corporation) as an anionic surfactant, changing the type of amphoteric surfactant, a formulation was prepared as in Example 1, and The control rate was calculated using 18 to 22 body lice, and an average control rate that was the average of each control rate in the test carried out three times was obtained. That is, the amphoteric surfactant was 8.57 g (substantially component amount 3.0 g) of lauryl dimethylamine oxide (trade name “Amphithol 20N” 35 wt% aqueous solution, manufactured by Kao Corporation) in Example 13; 9.7 g of alkyldimethylamine oxide (trade name “Aromox DMC-W”, 31% by weight aqueous solution, manufactured by Lion Corporation) (actual component amount: 3.0 g), decyldimethylamine oxide (trade name “Aromox DM10D-” in Example 15) W "40.3% by weight aqueous solution, manufactured by Lion Corporation) 7.4 g (substantial component amount 3.0 g), in Example 16, myristyl dimethylamine oxide (trade name" Aromox DM14D-N "25.1% by weight aqueous solution, Lion Co., Ltd.) 12.0g (Substance content 3.0g), Examples In Example 7, dihydroxyethyl laurylamine oxide (trade name “Unisafe A-LE” 41.1 wt% aqueous solution, manufactured by NOF Corporation) 7.3 g (substantial component amount 3.0 g), in Example 18, lauryl dimethylaminoacetic acid betaine (Trade name “Amphithol 20BS” 30% by weight aqueous solution, manufactured by Kao Corporation) 10.0 g (substantial component amount 3.0 g), Example 19 lauryl hydroxysulfobetaine (trade name “Amphitol 20HD” 30.8% by weight aqueous solution 9.7 g (substantial component amount: 3.0 g) was used. The results are shown in Table 3.
<実施例20〜33>
両性界面活性剤としてアルキル(炭素数8〜18)ジメチルアミンオキサイド<N,N−ジメチルアルキル(C8〜18)アミンオキサイド>(商品名「アロモックスDMCW−I」29重量%水溶液、ライオン株式会社製)10.34g(実質成分量3.0g)を用い、アニオン界面活性剤の種類を変更して、実施例1と同様に製剤を作成し、そして18〜22匹のコロモジラミを用いて駆除率を算出し、3回実施した試験における各駆除率の平均である平均駆除率を得た。すなわち、アニオン界面活性剤は、実施例20においてラウリン酸ナトリウム(商品名「ノンサールLN−1」、日油株式会社製)7.0g、実施例21においてステアリン酸ナトリウム(商品名「ノンサールSN−1」、日油株式会社製)7.0g、実施例22においてラウレス−6カルボン酸ナトリウム<ポリオキシエチレン(4.5)ラウリルエーテル酢酸ナトリウム>(商品名「カオーアキポRLM−45NV」23.5重量%水溶液、花王株式会社製)29.8g(実質成分量7.0g)、実施例23においてミリスチル硫酸ナトリウム(商品名「NIKKOL SMS−F」、日光ケミカルズ株式会社製)7.0g、実施例24においてセチル硫酸ナトリウム(商品名「NIKKOL SCS」、日光ケミカルズ株式会社製)7.0g、実施例25においてココグリセリル硫酸ナトリウム<硬化ヤシ油脂肪酸グリセリル硫酸ナトリウム>(商品名「NIKKOL SGC−80N」、日光ケミカルズ株式会社製)7.0g、実施例26においてラウリル硫酸トリエタノールアミン(商品名「エマール TD」40重量%水溶液、花王株式会社製)17.5g(実質成分7.0g)、実施例27においてラウリル硫酸アンモニウム(商品名「エマール AD−25R」22.8重量%水溶液、花王株式会社製)30.7g(実質成分7.0g)、実施例28においてラウレス硫酸トリエタノールアミン<ポリオキシエチレン(3)ラウリルエーテル硫酸トリエタノールアミン>(商品名「エマール 20T」40.6重量%水溶液、花王株式会社製)17.2g(実質成分7.0g)、実施例29においてラウレス硫酸ナトリウム<ポリオキシエチレン(3)ラウリルエーテル硫酸ナトリウム>(商品名「パーソフトEF」25重量%水溶液、日油株式会社製)28.0g(実質成分7.0g)、実施例30においてラウリルスルホ酢酸ナトリウム(商品名「NIKKOL LSA−F」、日光ケミカルズ株式会社製)7.0g、実施例31においてラウリルリン酸ナトリウム(商品名「NIKKOL SLP−N」、日光ケミカルズ株式会社製)7.0g、実施例32においてポリオキシエチレンセチルエーテルリン酸ナトリウム<ポリオキシエチレン(5)セチルエーテルリン酸ナトリウム>(商品名「NIKKOL TCP−5」、日光ケミカルズ株式会社製)7.0g、実施例33においてラウロイルサルコンシンナトリウム(商品名「NIKKOL サルコシネートLN」、日光ケミカルズ株式会社製)7.0gを用いた。その結果を表4に示す。
<Examples 20 to 33>
As an amphoteric surfactant, alkyl (carbon number 8-18) dimethylamine oxide <N, N-dimethylalkyl (C8-18) amine oxide> (trade name "Aromox DMCW-I" 29 wt% aqueous solution, manufactured by Lion Corporation) Using 10.34 g (substantial component amount: 3.0 g), changing the kind of anionic surfactant, preparing a preparation in the same manner as in Example 1, and calculating the extermination rate using 18-22 body lice And the average removal rate which is the average of each removal rate in the test implemented 3 times was obtained. That is, the anionic surfactant was sodium laurate (trade name “NONSAR LN-1”, manufactured by NOF Corporation) 7.0 g in Example 20, and sodium stearate (trade name “NONSAL SN-1” in Example 21). ”, Manufactured by NOF Corporation) 7.0 g, sodium laureth-6 carboxylate <polyoxyethylene (4.5) sodium lauryl ether acetate> in Example 22 (trade name“ Kao Akipo RLM-45NV ”23.5 wt% In aqueous solution, manufactured by Kao Corporation 29.8 g (substantial component amount 7.0 g), in Example 23, sodium myristyl sulfate (trade name “NIKKOL SMS-F”, manufactured by Nikko Chemicals Co., Ltd.) 7.0 g, in Example 24 6. Cetyl sodium sulfate (trade name “NIKKOL SCS”, manufactured by Nikko Chemicals Co., Ltd.) g, Sodium cocoglyceryl sulfate in Example 25 <Hardened coconut oil fatty acid sodium glyceryl sulfate> (trade name “NIKKOL SGC-80N”, manufactured by Nikko Chemicals Co., Ltd.) 7.0 g, In Example 26, lauryl sulfate triethanolamine (commodity) Name “Emar TD” 40 wt% aqueous solution, Kao Corporation 17.5 g (substantially 7.0 g), Example 27 ammonium lauryl sulfate (trade name “Emar AD-25R” 22.8 wt% aqueous solution, Kao Stock 30.7 g (manufactured by the company) (substantially 7.0 g), in Example 28 laureth sulfate triethanolamine <polyoxyethylene (3) lauryl ether sulfate triethanolamine> (trade name “Emar 20T” 40.6 wt% aqueous solution , Produced by Kao Corporation) 17.2 g (substance 7.0) ) In Example 29, sodium laureth sulfate <polyoxyethylene (3) sodium lauryl ether sulfate> (trade name “Persoft EF” 25 wt% aqueous solution, manufactured by NOF Corporation) 28.0 g (substantially 7.0 g) In Example 30, sodium lauryl sulfoacetate (trade name “NIKKOL LSA-F”, manufactured by Nikko Chemicals Co., Ltd.) 7.0 g, and in Example 31, sodium lauryl phosphate (trade name “NIKKOL SLP-N”, Nikko Chemicals Co., Ltd.) 7.0 g, sodium polyoxyethylene cetyl ether phosphate in Example 32 <polyoxyethylene (5) sodium cetyl ether phosphate> (trade name “NIKKOL TCP-5”, manufactured by Nikko Chemicals Co., Ltd.) 0 g, lauroyl sarconsinna in Example 33 7.0 g of thorium (trade name “NIKKOL Sarcosinate LN”, manufactured by Nikko Chemicals Co., Ltd.) was used. The results are shown in Table 4.
<実施例34〜43>
さらに両性界面活性剤及びアニオン界面活性剤の種類を変更して、実施例1と同様に製剤を作成し、そして18〜22匹のコロモジラミを用いて駆除率を算出し、3回実施した試験における各駆除率の平均である平均駆除率を得た。すなわち、実施例34においてアニオン界面活性剤としてラウリン酸ナトリウム(商品名「ノンサールLN−1」、日油株式会社製)7.0g、両性界面活性剤としてジヒドロキシエチルラウリルアミンオキサイド(商品名「ユニセーフA−LE」41.1重量%水溶液、日油株式会社製)7.0g(実質成分量2.9g)、実施例35においてアニオン界面活性剤としてラウリン酸ナトリウム(商品名「ノンサールLN−1」、日油株式会社製)7.0g、両性界面活性剤としてラウリルジメチルアミノ酢酸ベタイン(商品名「アンヒトール20BS」30重量%水溶液、花王株式会社製)10.0g(実質成分量3.0g)、実施例36においてアニオン界面活性剤としてラウリン酸ナトリウム(商品名「ノンサールLN−1」、日油株式会社製)7.0g、両性界面活性剤としてラウリルヒドロキシスルホベタイン(商品名「アンヒトール20HD」30.8重量%水溶液、花王株式会社製)10.0g(実質成分量3.1g)、実施例37においてアニオン界面活性剤としてセチル硫酸ナトリウム(商品名「NIKKOL SCS」、日光ケミカルズ株式会社製)7.0g、両性界面活性剤として2−アルキル−N−カルボキシメチル−N−ヒドロキシエチルイミダゾリニウムベタイン(商品名「アンヒトール20YB」40重量%水溶液、花王株式会社製)8.0g(実質成分量3.2g)、実施例38においてアニオン界面活性剤としてラウリルスルホ酢酸ナトリウム(商品名「NIKKOL LSA−F」、日光ケミカルズ株式会社製)7.0g、両性界面活性剤としてジヒドロキシエチルラウリルアミンオキサイド(商品名「ユニセーフA−LE」41.1重量%水溶液、日油株式会社製)7.0g(実質成分量2.9g)、実施例39においてアニオン界面活性剤としてラウリルスルホ酢酸ナトリウム(商品名「NIKKOL LSA−F」、日光ケミカルズ株式会社製)7.0g、両性界面活性剤としてラウリルジメチルアミノ酢酸ベタイン(商品名「アンヒトール20BS」30重量%水溶液、花王株式会社製)10.0g(実質成分量3.0g)、実施例40においてアニオン界面活性剤としてラウリルスルホ酢酸ナトリウム(商品名「NIKKOL LSA−F」、日光ケミカルズ株式会社製)7.0g、両性界面活性剤としてラウリルヒドロキシスルホベタイン(商品名「アンヒトール20HD」30.8重量%水溶液、花王株式会社製)10.0g(実質成分量3.1g)、実施例41においてアニオン界面活性剤としてラウリルリン酸ナトリウム(商品名「NIKKOL SLP−N」、日光ケミカルズ株式会社製)7.0g、両性界面活性剤としてジヒドロキシエチルラウリルアミンオキサイド(商品名「ユニセーフA−LE」41.1重量%水溶液、日油株式会社製)7.0g(実質成分量2.9g)、実施例42においてアニオン界面活性剤としてラウリルリン酸ナトリウム(商品名「NIKKOL SLP−N」、日光ケミカルズ株式会社製)7.0g、両性界面活性剤としてラウリルジメチルアミノ酢酸ベタイン(商品名「アンヒトール20BS」30重量%水溶液、花王株式会社製)10.0g(実質成分量3.0g)、実施例43においてアニオン界面活性剤としてラウリルリン酸ナトリウム(商品名「NIKKOL SLP−N」、日光ケミカルズ株式会社製)7.0g、両性界面活性剤としてラウリルヒドロキシスルホベタイン(商品名「アンヒトール20HD」30.8重量%水溶液、花王株式会社製)10.0g(実質成分量3.1g)を用いた。その結果を表5に示す。
<Examples 34 to 43>
Further, the types of amphoteric surfactants and anionic surfactants were changed, preparations were prepared in the same manner as in Example 1, and the extermination rate was calculated using 18 to 22 body lice. The average removal rate, which is the average of each removal rate, was obtained. That is, in Example 34, 7.0 g of sodium laurate (trade name “Nonsar LN-1”, manufactured by NOF Corporation) as an anionic surfactant and dihydroxyethyl laurylamine oxide (trade name “Unisafe A” as an amphoteric surfactant) -LE "41.1% by weight aqueous solution, manufactured by NOF Corporation) 7.0 g (substantial component amount 2.9 g), sodium laurate (trade name" NONSAR LN-1 "as an anionic surfactant in Example 35, 7.0 g of NOF Corporation), 10.0 g of lauryldimethylaminoacetate betaine (trade name “Amphitol 20BS”, 30% by weight aqueous solution, Kao Corporation) as an amphoteric surfactant, implemented In Example 36, sodium laurate (trade name “Nonsar LN-1”, NOF Corporation as an anionic surfactant) 7.0 g, lauryl hydroxysulfobetaine (trade name “Amphithol 20HD” 30.8 wt% aqueous solution, manufactured by Kao Corporation) as an amphoteric surfactant, 10.0 g (substantial component amount 3.1 g), Example 37 7.0 g of sodium cetyl sulfate (trade name “NIKKOL SCS”, manufactured by Nikko Chemicals Co., Ltd.) as an anionic surfactant and 2-alkyl-N-carboxymethyl-N-hydroxyethylimidazolinium betaine (as an amphoteric surfactant) Trade name “Amphitol 20YB” 40% by weight aqueous solution, manufactured by Kao Corporation) 8.0 g (substantial component amount 3.2 g), sodium lauryl sulfoacetate (trade name “NIKKOL LSA-F” as an anionic surfactant in Example 38) 7.0g, manufactured by Nikko Chemicals Co., as an amphoteric surfactant Dihydroxyethyl lauryl amine oxide (trade name “Unisafe A-LE” 41.1% by weight aqueous solution, manufactured by NOF Corporation) 7.0 g (substantially 2.9 g), lauryl sulfo as an anionic surfactant in Example 39 Sodium acetate (trade name “NIKKOL LSA-F”, manufactured by Nikko Chemicals Co., Ltd.) 7.0 g, lauryldimethylaminoacetic acid betaine (trade name “Amphitol 20BS”, 30% by weight aqueous solution, manufactured by Kao Corporation) as an amphoteric surfactant 10 0.0 g (substantial component amount 3.0 g), 7.0 g of sodium lauryl sulfoacetate (trade name “NIKKOL LSA-F”, manufactured by Nikko Chemicals Co., Ltd.) as an anionic surfactant in Example 40, lauryl as an amphoteric surfactant Hydroxysulfobetaine (trade name “Amphitor 20HD” 0.8% by weight aqueous solution, manufactured by Kao Corporation 10.0 g (substantially component amount 3.1 g), sodium lauryl phosphate (trade name “NIKKOL SLP-N”, Nikko Chemicals Co., Ltd.) as an anionic surfactant in Example 41 7.0 g, dihydroxyethyl laurylamine oxide (trade name “Unisafe A-LE” 41.1 wt% aqueous solution, manufactured by NOF Corporation) as an amphoteric surfactant, 7.0 g (substantial component amount 2.9 g) In Example 42, 7.0 g of sodium lauryl phosphate (trade name “NIKKOL SLP-N”, manufactured by Nikko Chemicals Co., Ltd.) as an anionic surfactant and betaine lauryl dimethylaminoacetate (trade name “Amphithol 20BS” as an amphoteric surfactant) "30% by weight aqueous solution, manufactured by Kao Corporation" 10.0 g (substantial component amount 3.0 g), fruit In Example 43, 7.0 g of sodium lauryl phosphate (trade name “NIKKOL SLP-N”, manufactured by Nikko Chemicals Co., Ltd.) as an anionic surfactant, and 30% of lauryl hydroxysulfobetaine (trade name “Amphitol 20HD” as an amphoteric surfactant). 10.0 g (substantially component amount 3.1 g) of 8 wt% aqueous solution, manufactured by Kao Corporation was used. The results are shown in Table 5.
表1、表2に示すように、実施例1〜12では、シラミに対してアニオン界面活性剤と両性界面活性剤とを所定の配合比率で含有する水溶液である製剤を使用すると、シラミのうち60%以上を駆除することができ、比較例1〜6では、アニオン界面活性剤と両性界面活性剤のうち一方を配合しない場合にはシラミを駆除する効果があらわれず、また、アニオン界面活性剤と両性界面活性剤とを所定の配合比率の範囲外で配合してもシラミを駆除する効果があらわれなかった。このことから、アニオン界面活性剤と両性界面活性剤とを所定の配合比率で含有することによる相乗効果として、シラミなどの害虫に対して高い駆除効果があらわれることが明らかとなった。 As shown in Table 1 and Table 2, in Examples 1 to 12, when using a preparation that is an aqueous solution containing an anionic surfactant and an amphoteric surfactant in a predetermined mixing ratio with respect to lice, 60% or more can be extinguished. In Comparative Examples 1 to 6, when one of the anionic surfactant and the amphoteric surfactant is not blended, the effect of eliminating lice does not appear, and the anionic surfactant Even if the amphoteric surfactant and the amphoteric surfactant were blended out of the predetermined blending ratio, the effect of controlling lice did not appear. From this, it has been clarified that as a synergistic effect by containing an anionic surfactant and an amphoteric surfactant at a predetermined blending ratio, a high extermination effect against pests such as lice appears.
そして、表3に示すように、両性界面活性剤を他のアミンオキサイド型の化合物に変更しても、さらに、ベタイン型の化合物に変更しても、アニオン界面活性剤との相乗効果として、シラミなどの害虫に対して高い駆除効果があらわれることが明らかとなった。 And as shown in Table 3, even if the amphoteric surfactant is changed to another amine oxide type compound, and further changed to a betaine type compound, as a synergistic effect with the anionic surfactant, It became clear that a high extermination effect was exhibited against pests such as.
そして、表4に示すように、アニオン界面活性剤を他の硫酸エステル型の化合物に変更しても、さらに、カルボン酸型の化合物、スルホン酸型の化合物、リン酸エステル型の化合物に変更しても、両性界面活性剤との相乗効果として、シラミなどの害虫に対して高い駆除効果があらわれることが明らかとなった。 As shown in Table 4, even if the anionic surfactant is changed to another sulfate ester type compound, it is further changed to a carboxylic acid type compound, a sulfonic acid type compound, or a phosphate ester type compound. However, as a synergistic effect with the amphoteric surfactant, it was revealed that a high extermination effect was exhibited against pests such as lice.
そして、表5に示すように、さらに、アニオン界面活性として、硫酸エステル型、カルボン酸型、スルホン酸型、リン酸エステル型を用いて、両性界面活性剤として、アミンオキサイド型、ベタイン型を用いたいずれの組み合わせにおいても、アニオン界面活性及び両性界面活性剤との相乗効果として、シラミなどの害虫に対して高い駆除効果があらわれることが明らかとなった。 Further, as shown in Table 5, the anionic surfactant is sulfate type, carboxylic acid type, sulfonic acid type, and phosphate ester type, and the amphoteric surfactant is amine oxide type and betaine type. In any of the combinations, it was clarified that as a synergistic effect with the anionic surfactant and the amphoteric surfactant, a high extermination effect against pests such as lice was exhibited.
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TWI797299B (en) * | 2018-04-02 | 2023-04-01 | 日商大阪製藥股份有限公司 | Lice Repellent |
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