JP2014000998A - Packaging bag and package body - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a packaging bag for in-vitro diagnostic medicine which has superior opening easiness at a low price.SOLUTION: There is provided a packaging bag formed by putting a hydroscopic laminate 10 comprising an outer covering layer 11, a barrier layer 16, and a hygroscopic layer 12, and an easy-to-open laminate 20 comprising a base material layer 21, a barrier layer 26, and a sealant layer 22 with peeling easiness one over the other such that the hygroscopic layer 12 and sealant layer 22 face each other. The hygroscopic layer 12 comprises an outer skin layer 13 made of a polyolefin-based resin, an intermediate layer 14 made of a mixture of a polyolefin-based resin and a moisture absorbent, and an inner skin layer 15 made of a polyolefin-based resin, heat seal strength of the hygroscopic layer 12 and sealant layer 22 measured by JIS Z 0238 being 2.9 N/15 mm or more, or 5.8 N/15 mm or less.

Description

  The present invention relates to a packaging bag for individually packaging an in vitro diagnostic agent and a package in which the in vitro diagnostic agent is packaged using the packaging bag.

  As an in vitro diagnostic agent to measure blood glucose level and uric acid level in blood, and to determine pregnancy and HIV infection, a specimen such as blood or urine is given to the test paper, and the color of the test paper discolored with a specific tester In-vitro diagnostics are widely used in the form of measuring the concentration and visually determining marks and discoloration appearing on the test paper. Such an in-vitro diagnostic agent is used disposable for each specimen, but it is necessary to store it in a dry state in order to prevent the medicine contained in the test paper from being deteriorated by moisture. For example, Patent Document 1 discloses a container for a blood glucose level test chip made of a laminated film containing a desiccant. Since the container itself contains a desiccant, there is no need to load the container with the desiccant, and there is an advantage that there is no fear of a desiccant loading error.

JP 2012-6651 A

  However, in the case of the container disclosed in Patent Document 1, easy-opening properties such as notching the container and using a uniaxially stretched film for the laminated film so that the in-vitro diagnostic agent can be easily taken out during use. Must be added to the container, leading to an increase in manufacturing costs. In addition, in-vitro diagnostic agents such as blood glucose levels may be used by patients themselves, and further easy-openability has been required so that even elderly people with weak physical strength can easily open them.

  The subject of this invention is providing the packaging bag for in-vitro diagnostic agents which solved the said problem and was excellent in easy-opening property more cheaply.

The packaging bag of the present invention includes at least a moisture-absorbing laminate having an exterior layer and a moisture-absorbing layer,
At least an easily peelable laminate having a base material layer and a sealant layer with easy peel properties,
The hygroscopic layer and the sealant layer are stacked so as to face each other, and a peripheral bag is heat-sealed, a packaging bag for enclosing an in vitro diagnostic agent,
The moisture absorption layer is laminated from the exterior layer side in the order of an outer skin layer, an intermediate layer, and an inner skin layer,
The intermediate layer is made of a mixture of a polyolefin resin and a hygroscopic agent,
The outer skin layer and the inner skin layer are made of polyolefin resin,
The heat seal strength measured according to JIS Z 0238 between the moisture absorption layer and the sealant layer is 2.9 N / 15 mm or more and 5.8 N / 15 mm or less.

  And the package of this invention has the above-mentioned packaging bag of this invention, and the in-vitro diagnostic agent enclosed in the said packaging bag, It is characterized by the above-mentioned.

  The package of the present invention uses a moisture-absorbing laminate provided with a moisture-absorbing layer and an easily peelable laminate provided with a sealant layer having an easy peel property, and a package in which the peelability of the heat seal part is appropriately adjusted. Since the bag is used, the heat seal part can be peeled off and easily opened. In addition, since it is not necessary to tear the packaging bag itself at the time of opening, it is not necessary to use a highly tearable material such as a uniaxially stretched film as a packaging material, or to provide a notch, which can be provided at a lower cost.

It is sectional drawing which shows typically the laminated structure of the moisture absorption laminated body and easily peelable laminated body which comprise the packaging bag of this invention. It is a plane schematic diagram of the package of the Example of this invention. It is a plane schematic diagram which shows the application example of the knob | pick part of the package of this invention.

  The present inventors have found that a packaging bag for in-vitro diagnostic agents can impart high easy-openability with a simple configuration by adjusting the strength of the heat seal part, and achieved the present invention. That is, the packaging bag of the present invention comprises a moisture-absorbing laminate provided with a moisture-absorbing layer and an easily peelable laminate provided with a sealant layer having an easy peel property, and the strength of the heat seal portion is within a predetermined range. It has the feature in adjusting. Hereinafter, the configuration of the present invention will be described in detail with reference to the drawings.

  FIG. 1 is a cross-sectional view schematically showing a laminated structure of a hygroscopic laminate and an easily peelable laminate constituting the packaging bag of the present invention. In the figure, 10 is a moisture absorbing laminate, 11 is an exterior layer, 12 is a moisture absorbing layer, 13 is an outer skin layer, 14 is an intermediate layer, 15 is an inner skin layer, 16 is a barrier layer, 20 is an easily peelable laminate, 21 Is a base material layer, 22 is a sealant layer, and 26 is a barrier layer.

  The packaging bag of this invention consists of the moisture absorption laminated body 10 and the easily peelable laminated body 20, as shown in FIG. The moisture-absorbing laminate 10 has at least an exterior layer 11 and a moisture-absorbing layer 12, and the moisture-absorbing layer 12 includes an outer skin layer 13, an intermediate layer 14, and an inner skin layer 15 from the exterior layer 11 side. The easily peelable laminate 20 has at least a base material layer 21 and a sealant layer 22 having easy peel properties. The packaging bag of the present invention is formed by stacking the hygroscopic laminate 10 and the easily peelable laminate 20 so that the hygroscopic layer 12 and the sealant layer 22 face each other, and heat-sealing the periphery.

  As the exterior layer 11 of the moisture absorption laminated body 10 which concerns on this invention, polyester films, such as a polyethylene terephthalate (PET) film, polyamide films, such as a nylon film, a polypropylene film, and a polyethylene film are used preferably. Moreover, the barrier layer 16 is provided between the moisture absorption layers 12 as needed. As the barrier layer 16, an aluminum foil, a biaxially stretched polypropylene film, or the like can be used. A composite film having a barrier layer can also be used as the outer layer 11, and examples thereof include a silica / alumina-deposited polyester film, a silica / alumina-deposited nylon film, and a vinylidene chloride-coated film.

  The intermediate layer 14 of the hygroscopic layer 12 is made of a mixture of a polyolefin resin and a hygroscopic agent. Examples of the polyolefin resin include polyethylene (PE), polypropylene (PP), ethylene-vinyl acetate copolymer (EVA), and chlorination. Polypropylene, saturated polyester, ethylene-acrylic acid copolymer (EAA), ethylene-methacrylic acid copolymer (EMAA), ethylene-ethyl acrylate copolymer (EEA), ethylene-methyl acrylate copolymer (EMAC), ionomer , Carboxylic acid-modified polyethylene, carboxylic acid-modified polypropylene, carboxylic acid-modified EVA, polyvinyl chloride (PVC), polystyrene, etc., at least one of which uses a resin having an MFR of 10 or more, one or more Can be used in a blend. As the polyethylene, low density polyethylene (LDPE) and linear low density polyethylene (LLDPE) are preferably used. As the hygroscopic agent, zeolite such as natural zeolite, artificial zeolite and synthetic zeolite, calcium oxide, magnesium sulfate, silica gel, calcium chloride, quicklime and aluminum oxide are preferably used. As the synthetic zeolite, molecular sieves 3A, 4A, 5A, and 13X are preferably used.

  The intermediate layer 14 is formed by forming a resin pellet obtained by kneading the above-described polyolefin resin with a hygroscopic agent into a film shape or a sheet shape by an inflation method, a T-die method, a coextrusion method, or the like.

  Further, the outer skin layer 13 and the inner skin layer 15 sandwiching the intermediate layer 14 are made of a polyolefin-based resin. Specifically, the adhesion with the intermediate layer 14 is improved, and warpage and wrinkle due to shrinkage of the hygroscopic 12 are generated. In order to suppress it, the polyolefin resin used in the intermediate layer 14 is preferably used. The outer skin layer 13 and the inner skin layer 15 may each be formed as a single layer into a film shape or a sheet shape by a known molding method. It is preferable to mold by an extrusion method or the like.

  In the hygroscopic layer 12, the intermediate layer 14 preferably has a thickness of 10 μm to 190 μm, and the outer skin layer 13 and the inner skin layer 15 preferably have a thickness of 5 μm to 190 μm, respectively.

  The easily peelable laminate 20 according to the present invention includes at least a base material layer 21 and a sealant layer 22, and a barrier layer 26 is disposed between the base material layer 21 and the sealant layer 22 as necessary. As the base material layer 21 and the barrier layer 26, the same material as the exterior layer 11 and the barrier layer 16 of the moisture-absorbing laminate 10 is preferably used.

  Moreover, as the sealant layer 22 of the easily peelable laminate 20, a layer having an easy peel property and exhibiting an appropriate heat seal strength when heat-sealed with the moisture-absorbing layer 12 of the moisture-absorbing laminate 10 is used. Specifically, the heat seal strength measured by JIS Z 0238 between the moisture absorption layer 12 and the sealant layer 22 is 2.9 N / 15 mm or more and 5.8 N / 15 mm or less. If the heat seal strength is less than 2.9 N / 15 mm, the heat seal part may be peeled off during storage of the in-vitro diagnostic agent or during transportation of the package, and if it exceeds 5.8 N / 15 mm, Since it is not easy to open, neither is preferable.

  In the present invention, a commercially available easy peel film such as polyolefin is preferably used as long as such heat seal strength is obtained.

  In the packaging bag of the present invention, the moisture-absorbing laminate 10 and the easily peelable laminate 20 are overlapped so that the moisture-absorbing layer 12 and the sealant layer 22 face each other, and the periphery is heat-sealed leaving a part. Is obtained. And after accommodating an in-vitro diagnostic agent from the opening part which is not sealed of this packaging bag, the package of this invention is obtained by heat-sealing and sealing this opening part. Alternatively, when the absorbent laminate 10 and the easily peelable laminate 20 are superposed, an in-vitro diagnostic agent is sandwiched between them and the periphery is heat-sealed to form a packaging bag and at the same time as a packaging body.

  FIG. 2 is a schematic plan view of an embodiment of the package of the present invention, in which 31 is a heat seal part and 32 is a knob part. Since the package of the present invention includes a moisture absorption layer, the inside of the package can be kept dry after the in vitro diagnostic agent is enclosed.

  In the package of the present invention, for easy opening at the time of opening, as shown in FIG. 2, a region that is not heat-sealed is provided on the end side in a part of the periphery, and such a region is defined as a knob 32. At the time of opening, if the picking portion 32 is picked with a finger and pulled to widen the heat seal portion 31, the heat seal strength of the heat seal portion 31 is adjusted to an appropriate range in the present invention. The part 31 can be easily peeled off and the package can be opened. In order to make it easier to pick the knob 32, for example, as shown in FIG. 3A, a recess 32a is provided in one knob 32 of the hygroscopic laminate 10 and the easily peelable laminate 20, or FIG. As shown in FIG. 5, a configuration in which the convex portion 32b is provided is preferably applied.

  The packaging bag of the present invention is preferably used for individual packaging of in-vitro diagnostic agents used for measurement of blood glucose level, uric acid level, cholesterol level, determination of HIV, pregnancy, hepatitis B, hepatitis C and the like.

  As described above, since the packaging bag of the present invention is used for packaging in vitro diagnostic agents, the preferred size is 20 mm × 40 mm to 80 mm × 200 mm, and the seal width of the heat seal part is 3 to 15 mm.

  An intermediate layer formed by mixing zeolite (“Molecular Sieve 3A”, manufactured by Union Showa Co., Ltd.) with EMMA (“Nucleel 4214C”, manufactured by Mitsui DuPont Polychemical Co., Ltd.) so that the amount is 55% by mass in the intermediate layer. A 50 μm thick hygroscopic film having an inner skin layer and an outer skin layer made of LLDPE (“Evolue”, manufactured by Prime Polymer Co., Ltd.) using a multilayer inflation film forming machine (“3SOIB”, manufactured by Placo Corporation) To form a film. A 12 μm thick PET film (“E5100”, manufactured by Toyobo Co., Ltd.) and a 9 μm thick aluminum foil (“Vespa”, Sumikara Aluminum Foil Co., Ltd.) are dry-laminated and bonded to the aluminum foil PET film. The moisture-absorbing film was dry-laminated on the non-coated side to prepare a moisture-absorbing laminate.

  In addition, a 12 μm thick PET film (“E5100”, manufactured by Toyobo Co., Ltd.) and a 9 μm thick aluminum foil (“Vespa”, Sumikari Aluminum Foil Co., Ltd.) are laminated in addition to an aluminum foil. A commercially available easy peel film having a thickness of 30 μm shown in Table 1 was dry-laminated on the side not bonded to the PET film to prepare an easily peelable laminate.

  As shown in FIG. 2, the moisture-absorbing laminate and the easily peelable laminate are cut into 30 mm × 60 mm, overlapped so that the moisture-absorbing film and the easy peel film face each other, and the periphery is heated at 140 ° C. with a width of 5 mm. Sealed and package samples (Comparative Examples 1 to 4, Examples 1 to 6) were prepared. In addition, nothing is enclosed in the packaging bag. Moreover, about one side with a length of 30 mm, the heat seal part 31 was brought inward, and the area | region which does not heat-seal of 3 mm width was formed in the edge as the pick part 32. FIG. For heat sealing, a heat sealing machine ("Impulse Sealer FA-300", manufactured by Fuji Impulse Co., Ltd.) was used.

  In addition, a package (Comparative Example 5) in which two moisture-absorbing laminates are used and heat-absorbing films are overlapped and heat-sealed, and an easy peel film of an easily peelable laminate is a PE sealant film that does not have easy peel properties. A package (Comparative Example 6) instead of “Suzuron” (manufactured by Aicello Chemical Co., Ltd.) was produced in the same manner.

  The heat seal strength at 140 ° C. was measured using a tensile tester according to JIS Z 0238 in the same combination as the sample of the package.

  Moreover, about the obtained package, 10 persons 60 years or older picked the pick part which is not heat-sealed with the left and right fingers, respectively, and evaluated the easy-openability which opens by expanding a heat seal part. The case where everyone was easy to open was marked as ◯, and even when one person was difficult to open, it was marked as x. Table 2 shows the layer structure (two layers heat-sealed with each other), heat-seal strength, and easy-openability evaluation of the package sample.

  As shown in Table 2, Comparative Examples 1 and 2 having high heat seal strength had low easy-openability, and it was difficult for elderly people to open. Moreover, although it was easy to open about Comparative Examples 3 and 4, since the heat seal strength was too low, there existed a possibility that a heat seal part might peel before use. Moreover, about the comparative example 3 which heat-sealed moisture-absorbing films, and the comparative example 4 using the sealant film which does not have easy peel property, heat seal strength was too high and easy-openability was not obtained.

  10: Hygroscopic laminate, 11: Exterior layer, 12: Hygroscopic layer, 13: Outer skin layer, 14: Intermediate layer, 15: Inner skin layer, 16: Barrier layer, 20: Easy peelable laminate, 21: Base material Layer, 22: sealant layer, 26: barrier layer, 31: heat seal part, 32: knob part, 32a: concave part, 32b: convex part

Claims (2)

At least a moisture-absorbing laminate having an exterior layer and a moisture-absorbing layer;
At least an easily peelable laminate having a base material layer and a sealant layer with easy peel properties,
The hygroscopic layer and the sealant layer are stacked so as to face each other, and a peripheral bag is heat-sealed, a packaging bag for enclosing an in vitro diagnostic agent,
The moisture absorption layer is laminated from the exterior layer side in the order of an outer skin layer, an intermediate layer, and an inner skin layer,
The intermediate layer is made of a mixture of a polyolefin resin and a hygroscopic agent,
The outer skin layer and the inner skin layer are made of polyolefin resin,
The packaging bag characterized by the heat seal strength measured by JISZ0238 between the said moisture absorption layer and the said sealant layer being 2.9N / 15mm or more and 5.8N / 15mm or less.   A package comprising the packaging bag according to claim 1 and an in vitro diagnostic agent enclosed in the packaging bag.

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