JP2013544854A5 - - Google Patents
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- Publication number
- JP2013544854A5 JP2013544854A5 JP2013542356A JP2013542356A JP2013544854A5 JP 2013544854 A5 JP2013544854 A5 JP 2013544854A5 JP 2013542356 A JP2013542356 A JP 2013542356A JP 2013542356 A JP2013542356 A JP 2013542356A JP 2013544854 A5 JP2013544854 A5 JP 2013544854A5
- Authority
- JP
- Japan
- Prior art keywords
- heteroaryl
- group
- independently selected
- compound
- substituents
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
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- 125000001072 heteroaryl group Chemical group 0.000 claims description 10
- 125000003226 pyrazolyl group Chemical group 0.000 claims description 3
- 125000004076 pyridyl group Chemical group 0.000 claims description 3
- 125000000714 pyrimidinyl group Chemical group 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 claims 11
- 125000001424 substituent group Chemical group 0.000 claims 9
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 7
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 125000001475 halogen functional group Chemical group 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 1
- 201000001320 Atherosclerosis Diseases 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 0 CC(C)(*)CC(C)(C)*C(C(*)=C*1N)=NC1=O Chemical compound CC(C)(*)CC(C)(C)*C(C(*)=C*1N)=NC1=O 0.000 description 1
- 125000002541 furyl group Chemical group 0.000 description 1
- 125000005842 heteroatom Chemical group 0.000 description 1
- 125000002883 imidazolyl group Chemical group 0.000 description 1
- 125000001786 isothiazolyl group Chemical group 0.000 description 1
- 125000000842 isoxazolyl group Chemical group 0.000 description 1
- 125000001715 oxadiazolyl group Chemical group 0.000 description 1
- 125000002971 oxazolyl group Chemical group 0.000 description 1
- -1 oxo-pyridyl Chemical group 0.000 description 1
- 125000003373 pyrazinyl group Chemical group 0.000 description 1
- 125000002098 pyridazinyl group Chemical group 0.000 description 1
- 125000000168 pyrrolyl group Chemical group 0.000 description 1
- 125000006413 ring segment Chemical group 0.000 description 1
- 125000003831 tetrazolyl group Chemical group 0.000 description 1
- 125000001113 thiadiazolyl group Chemical group 0.000 description 1
- 125000000335 thiazolyl group Chemical group 0.000 description 1
- 125000001544 thienyl group Chemical group 0.000 description 1
- 125000004306 triazinyl group Chemical group 0.000 description 1
- 125000001425 triazolyl group Chemical group 0.000 description 1
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN2010079463 | 2010-12-06 | ||
CNPCT/CN2010/079463 | 2010-12-06 | ||
PCT/CN2011/083465 WO2012075917A1 (en) | 2010-12-06 | 2011-12-05 | Compounds |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2013544854A JP2013544854A (ja) | 2013-12-19 |
JP2013544854A5 true JP2013544854A5 (US07714131-20100511-C00001.png) | 2015-01-29 |
Family
ID=46206620
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2013542356A Withdrawn JP2013544854A (ja) | 2010-12-06 | 2011-12-05 | 化合物 |
Country Status (4)
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2820408C (en) * | 2010-12-06 | 2018-03-06 | Glaxo Group Limited | Pyrimidinone compounds for use in the treatment of diseases or conditions mediated by lp-pla2 |
KR20190075172A (ko) | 2011-09-01 | 2019-06-28 | 글락소 그룹 리미티드 | 신규한 결정 형태 |
AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
CN104684900B (zh) | 2012-10-25 | 2017-04-12 | 沈阳中化农药化工研发有限公司 | 取代嘧啶类化合物及其用途 |
AU2014210260B2 (en) * | 2013-01-25 | 2016-08-04 | Glaxosmithkline Intellectual Property Development Limited | Bicyclic pyrimidone compounds as inhibitors of Lp-PLA2 |
MX2015009633A (es) * | 2013-01-25 | 2015-11-30 | Glaxosmithkline Ip Dev Ltd | Inhibidores de fosfolipasa a2 asociada con lipoproteinas basados en 2,3-dihidroimidazol[1,2-c] pirimidin-5(1h)-ona. |
EP2764866A1 (en) | 2013-02-07 | 2014-08-13 | IP Gesellschaft für Management mbH | Inhibitors of nedd8-activating enzyme |
CA2943363A1 (en) | 2014-04-02 | 2015-10-08 | Intermune, Inc. | Anti-fibrotic pyridinones |
CN105777653A (zh) * | 2014-12-26 | 2016-07-20 | 中国科学院上海药物研究所 | 用作Lp-PLA2抑制剂的嘧啶酮类化合物及其药物组合物 |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2203988T3 (es) | 1997-11-06 | 2004-04-16 | Smithkline Beecham Plc | Compuestos de pirimidinona y composiciones farmaceuticas que los contienen. |
EP1105377B1 (en) * | 1998-08-21 | 2003-10-08 | SmithKline Beecham plc | Pyrimidinone derivatives for the treatment of atherosclerosis |
EP1686119B1 (en) * | 2000-02-16 | 2009-07-29 | Smithkline Beecham Plc | Pyrimidine-5-one derivatives as LDL-PLA2 inhibitors |
GB0024808D0 (en) | 2000-10-10 | 2000-11-22 | Smithkline Beecham Plc | Novel compounds |
AU2002228922A1 (en) * | 2000-12-12 | 2002-06-24 | Cytovia, Inc. | Substituted 2-aryl-4-arylaminopyrimidines and analogs as activators of caspases and inducers of apoptosis and the use thereof |
US7973060B2 (en) | 2005-10-13 | 2011-07-05 | Crystalgenomics, Inc. | Fab I inhibitor and process for preparing same |
CA2820408C (en) * | 2010-12-06 | 2018-03-06 | Glaxo Group Limited | Pyrimidinone compounds for use in the treatment of diseases or conditions mediated by lp-pla2 |
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2011
- 2011-12-05 EP EP11847368.5A patent/EP2649050A4/en not_active Withdrawn
- 2011-12-05 JP JP2013542356A patent/JP2013544854A/ja not_active Withdrawn
- 2011-12-05 WO PCT/CN2011/083465 patent/WO2012075917A1/en active Application Filing
- 2011-12-05 US US13/991,953 patent/US8859573B2/en not_active Expired - Fee Related