JP2013530238A - Ｐｉ３ｋ活性の阻害剤としての複素環化合物及びその使用 - Google Patents

Ｐｉ３ｋ活性の阻害剤としての複素環化合物及びその使用 Download PDF

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JP2013530238A
JP2013530238A JP2013518692A JP2013518692A JP2013530238A JP 2013530238 A JP2013530238 A JP 2013530238A JP 2013518692 A JP2013518692 A JP 2013518692A JP 2013518692 A JP2013518692 A JP 2013518692A JP 2013530238 A JP2013530238 A JP 2013530238A
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alkyl
amino
haloalkyl
ethyl
halo
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JP2013530238A5 (OSRAM
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ブイ，ミナ・フエ・タン
フイツシヤー，ベンジヤミン
ハオ，シヤオリン
ルーカス，ブライアン
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アムジエン・インコーポレーテツド
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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    • C—CHEMISTRY; METALLURGY
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings

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  • Biomedical Technology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Transplantation (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2013518692A 2010-07-01 2011-06-30 Ｐｉ３ｋ活性の阻害剤としての複素環化合物及びその使用 Withdrawn JP2013530238A (ja)

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US36073110P 2010-07-01 2010-07-01
US61/360,731 2010-07-01
PCT/US2011/042525 WO2012003274A1 (en) 2010-07-01 2011-06-30 Heterocyclic compounds and their use as inhibitors of pi3k activity

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JP2013530238A true JP2013530238A (ja) 2013-07-25
JP2013530238A5 JP2013530238A5 (OSRAM) 2014-08-14

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US (1) US20130085131A1 (OSRAM)
EP (1) EP2588467A1 (OSRAM)
JP (1) JP2013530238A (OSRAM)
AU (1) AU2011272853A1 (OSRAM)
CA (1) CA2803009A1 (OSRAM)
MX (1) MX2012015135A (OSRAM)
WO (1) WO2012003274A1 (OSRAM)

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JP2013527123A (ja) * 2009-06-25 2013-06-27 アムジエン・インコーポレーテツド ピリジンの多環式誘導体ならびに（とりわけ）リウマチ性関節炎および同様の疾患の治療におけるそれらの使用
JP2018507222A (ja) * 2015-03-06 2018-03-15 南京▲聖▼和▲薬業▼股▲ふん▼有限公司Ｎａｎｊｉｎｇ Ｓａｎｈｏｍｅ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｃｏ．， Ｌｔｄ． ホスファチジルイノシトール３−キナーゼδ阻害剤としての置換ピリミジン化合物及びその使用

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HRP20140754T2 (hr) 2009-06-29 2015-07-17 Incyte Corporation Pirimidinoni kao inhibitori pi3k
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US8759359B2 (en) 2009-12-18 2014-06-24 Incyte Corporation Substituted heteroaryl fused derivatives as PI3K inhibitors
WO2011130342A1 (en) 2010-04-14 2011-10-20 Incyte Corporation FUSED DERIVATIVES AS ΡI3Κδ INHIBITORS
EP2571357B1 (en) 2010-05-21 2016-07-06 Infinity Pharmaceuticals, Inc. Chemical compounds, compositions and methods for kinase modulation
US9062055B2 (en) 2010-06-21 2015-06-23 Incyte Corporation Fused pyrrole derivatives as PI3K inhibitors
WO2012087881A1 (en) 2010-12-20 2012-06-28 Incyte Corporation N-(1-(substituted-phenyl)ethyl)-9h-purin-6-amines as pi3k inhibitors
GB201100181D0 (en) 2011-01-06 2011-02-23 Eisai Ltd Fused aminodihydrothiazine derivatives
GB201101139D0 (en) 2011-01-21 2011-03-09 Eisai Ltd Fused aminodihydrothiazine derivatives
SG191710A1 (en) 2011-01-21 2013-08-30 Eisai R&D Man Co Ltd Methods and compounds useful in the synthesis of fused aminodihydrothiazine derivatives
GB201101140D0 (en) 2011-01-21 2011-03-09 Eisai Ltd Fused aminodihydrothiazine derivatives
WO2012125629A1 (en) 2011-03-14 2012-09-20 Incyte Corporation Substituted diamino-pyrimidine and diamino-pyridine derivatives as pi3k inhibitors
WO2012135009A1 (en) 2011-03-25 2012-10-04 Incyte Corporation Pyrimidine-4,6-diamine derivatives as pi3k inhibitors
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LT3196202T (lt) 2011-09-02 2019-07-10 Incyte Holdings Corporation Heterociklilaminai, kaip pi3k slopikliai
AR090548A1 (es) 2012-04-02 2014-11-19 Incyte Corp Azaheterociclobencilaminas biciclicas como inhibidores de pi3k
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AU2013364068B2 (en) 2012-12-21 2016-10-20 Gilead Calistoga Llc Substituted pyrimidine aminoalkyl-quinazolones as phosphatidylinositol 3-kinase inhibitors
US9481667B2 (en) 2013-03-15 2016-11-01 Infinity Pharmaceuticals, Inc. Salts and solid forms of isoquinolinones and composition comprising and methods of using the same
TWI644909B (zh) 2013-06-14 2018-12-21 基利科學股份有限公司 磷脂酸肌醇３－激酶抑制劑
WO2015168286A1 (en) * 2014-04-30 2015-11-05 The Trustees Of Columbia University In The City Of New York Substituted 4-phenylpiperidines, their preparaiton and use
US10077277B2 (en) 2014-06-11 2018-09-18 Incyte Corporation Bicyclic heteroarylaminoalkyl phenyl derivatives as PI3K inhibitors
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JP6399518B2 (ja) * 2014-12-18 2018-10-03 インターナショナル・ビジネス・マシーンズ・コーポレーションＩｎｔｅｒｎａｔｉｏｎａｌ Ｂｕｓｉｎｅｓｓ Ｍａｃｈｉｎｅｓ Ｃｏｒｐｏｒａｔｉｏｎ 処理装置、処理方法、およびプログラム
CN117736209A (zh) 2015-02-27 2024-03-22 因赛特控股公司 Pi3k抑制剂的盐及其制备方法
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US9732097B2 (en) 2015-05-11 2017-08-15 Incyte Corporation Process for the synthesis of a phosphoinositide 3-kinase inhibitor
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TW201815787A (zh) 2016-09-23 2018-05-01 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
TW201813963A (zh) 2016-09-23 2018-04-16 美商基利科學股份有限公司 磷脂醯肌醇3-激酶抑制劑
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AR065948A1 (es) 2007-04-06 2009-07-15 Neurocrine Biosciences Inc Antagonistas del receptor de la hormona liberadora de gonadotropina y procedimientos relacionados con los mismos
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JP2013527123A (ja) * 2009-06-25 2013-06-27 アムジエン・インコーポレーテツド ピリジンの多環式誘導体ならびに（とりわけ）リウマチ性関節炎および同様の疾患の治療におけるそれらの使用
JP2018507222A (ja) * 2015-03-06 2018-03-15 南京▲聖▼和▲薬業▼股▲ふん▼有限公司Ｎａｎｊｉｎｇ Ｓａｎｈｏｍｅ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｃｏ．， Ｌｔｄ． ホスファチジルイノシトール３−キナーゼδ阻害剤としての置換ピリミジン化合物及びその使用
US10077258B2 (en) 2015-03-06 2018-09-18 Nanjing Sanhome Pharmaceutical Co., Ltd. Substituted pyrimidine compounds as phosphatidylinositol 3-kinase delta inhibitor and use thereof

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WO2012003274A1 (en) 2012-01-05
US20130085131A1 (en) 2013-04-04
EP2588467A1 (en) 2013-05-08
AU2011272853A1 (en) 2013-01-10
MX2012015135A (es) 2013-05-06

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