JP2013528368A - 個の医療のための幹細胞バンク - Google Patents
個の医療のための幹細胞バンク Download PDFInfo
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| PCT/IL2011/000362 WO2011138786A2 (en) | 2010-05-06 | 2011-05-05 | Stem cell bank for personalized medicine |
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| JP2018072255A Pending JP2018121650A (ja) | 2010-05-06 | 2018-04-04 | 個の医療のための幹細胞バンク |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015030149A1 (ja) * | 2013-08-29 | 2015-03-05 | 国立大学法人鳥取大学 | 細胞のアンチエイジングに関連する生体分子群 |
| WO2017090509A1 (ja) * | 2015-11-24 | 2017-06-01 | ロート製薬株式会社 | 脂肪組織由来間質細胞を含む肝疾患治療剤およびその製造方法 |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US9480549B2 (en) | 2008-04-25 | 2016-11-01 | Allosource | Multi-layer tissue patches |
| US9358320B2 (en) | 2008-04-25 | 2016-06-07 | Allosource | Multi-layer tissue patches |
| US9162011B2 (en) | 2011-12-19 | 2015-10-20 | Allosource | Flowable matrix compositions and methods |
| JP2015521630A (ja) * | 2012-06-26 | 2015-07-30 | ラスティー プロパティー ホールディングス プロプライエタリー リミテッド | 頭痛の頻度および／または重症度を下げるための組成物および方法 |
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| US20150216539A1 (en) * | 2014-02-06 | 2015-08-06 | Stryker European Holdings I, Llc | Bone marrow harvesting and storage |
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| US10264976B2 (en) | 2014-12-26 | 2019-04-23 | The University Of Akron | Biocompatible flavonoid compounds for organelle and cell imaging |
| EP3273881B1 (en) | 2015-03-24 | 2019-10-09 | Stryker European Holdings I, LLC | Bone marrow harvesting device |
| GB201600597D0 (en) * | 2016-01-12 | 2016-02-24 | Occhipinti Luigi G And Pluchino Stefano And Cambridge Innovation Technologies Consulting Ltd | Banking of stem cells and business methods related to the same |
| US10221395B2 (en) | 2016-06-16 | 2019-03-05 | Cedars-Sinai Medical Center | Efficient method for reprogramming blood to induced pluripotent stem cells |
| US11572545B2 (en) | 2016-06-16 | 2023-02-07 | Cedars-Sinai Medical Center | Efficient method for reprogramming blood to induced pluripotent stem cells |
| WO2018026576A1 (en) * | 2016-08-04 | 2018-02-08 | Good Start Genetics, Inc. | Genomic analysis of cord blood |
| US20210290835A1 (en) * | 2016-08-05 | 2021-09-23 | Jay Yadav | Plasma banking to mitigate aging |
| US10772986B2 (en) | 2017-01-26 | 2020-09-15 | Allosource | Fascia fibrous compositions and methods for their use and manufacture |
| TW201835798A (zh) * | 2017-03-14 | 2018-10-01 | 美商歐瑞３恩公司 | 誘導多能幹細胞之以人類白細胞索引之抗原儲存庫及誘導多能幹細胞衍生之幹細胞及相關系統及方法 |
| KR20200064077A (ko) * | 2017-09-01 | 2020-06-05 | 오리그3엔, 인코포레이티드 | Ipsc-유래 분비단백체 조성물, 및 관련된 시스템 및 방법 |
| US20200206267A1 (en) * | 2017-09-01 | 2020-07-02 | Orig3N, Inc. | Allogeneic car-t platform using hla-matched bank of ipscs, and related compositions, systems, and methods |
| US11646103B2 (en) * | 2017-09-06 | 2023-05-09 | Nant Holdings Ip, Llc | HLA tissue matching and methods therefor |
| US20190338244A1 (en) * | 2017-11-30 | 2019-11-07 | New York Medical College | Multipotent adult stem cells: characterization and use |
| EP3901959A4 (en) * | 2018-12-21 | 2023-01-04 | I Peace, Inc. | HEALTH RISK INFORMATION MANAGEMENT DEVICE, METHOD AND PROGRAM |
| CN114242191A (zh) * | 2021-10-29 | 2022-03-25 | 南京国青血液净化科技有限公司 | 干细胞自助配型方法及配型装置 |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040258673A1 (en) * | 2003-04-03 | 2004-12-23 | Hirose Thomas Gordon | Elective collection and banking of autologous peripheral blood stem cells |
| WO2007059084A2 (en) * | 2005-11-14 | 2007-05-24 | The New England Medical Center Hospitals, Inc. | Methods for preparing cord matrix stem cells (cmsc) for long term storage and for preparing a segment of umbilical cord for cryopreservation |
| US20070116691A1 (en) * | 2005-10-18 | 2007-05-24 | National Jewish Medical And Research Center | Conditionally immortalized long-term stem cells and methods of making and using such cells |
| WO2008127670A1 (en) * | 2007-04-11 | 2008-10-23 | Alecia Hathaway | Autologous/allogeneic human dna grafting, anti-and reserve aging stem cell, and bone marrow compositions/methods |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040091936A1 (en) * | 2002-05-24 | 2004-05-13 | Michael West | Bank of stem cells for producing cells for transplantation having HLA antigens matching those of transplant recipients, and methods for making and using such a stem cell bank |
| CN1961283A (zh) * | 2004-03-26 | 2007-05-09 | 细胞基因公司 | 建立干细胞库的系统和方法 |
| US20090227032A1 (en) * | 2005-12-13 | 2009-09-10 | Kyoto University | Nuclear reprogramming factor and induced pluripotent stem cells |
| CN101389754A (zh) * | 2005-12-29 | 2009-03-18 | 人类起源公司 | 胎盘干细胞和第二来源干细胞的联合培养 |
| US20080038231A1 (en) * | 2006-06-15 | 2008-02-14 | Rodgerson Denis O | Processing procedure for peripheral blood stem cells |
-
2011
- 2011-05-05 CA CA2798571A patent/CA2798571A1/en not_active Abandoned
- 2011-05-05 CN CN2011800335103A patent/CN103025865A/zh active Pending
- 2011-05-05 EP EP11777360.6A patent/EP2566955A4/en not_active Withdrawn
- 2011-05-05 JP JP2013508612A patent/JP2013528368A/ja active Pending
- 2011-05-05 WO PCT/IL2011/000362 patent/WO2011138786A2/en not_active Ceased
- 2011-05-05 US US13/696,383 patent/US20130052169A1/en not_active Abandoned
- 2011-05-05 AU AU2011249406A patent/AU2011249406B2/en not_active Ceased
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2016
- 2016-01-15 US US14/996,408 patent/US20160122709A1/en not_active Abandoned
- 2016-06-01 JP JP2016109872A patent/JP2016189783A/ja active Pending
-
2018
- 2018-04-04 JP JP2018072255A patent/JP2018121650A/ja active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040258673A1 (en) * | 2003-04-03 | 2004-12-23 | Hirose Thomas Gordon | Elective collection and banking of autologous peripheral blood stem cells |
| US20070116691A1 (en) * | 2005-10-18 | 2007-05-24 | National Jewish Medical And Research Center | Conditionally immortalized long-term stem cells and methods of making and using such cells |
| WO2007059084A2 (en) * | 2005-11-14 | 2007-05-24 | The New England Medical Center Hospitals, Inc. | Methods for preparing cord matrix stem cells (cmsc) for long term storage and for preparing a segment of umbilical cord for cryopreservation |
| WO2008127670A1 (en) * | 2007-04-11 | 2008-10-23 | Alecia Hathaway | Autologous/allogeneic human dna grafting, anti-and reserve aging stem cell, and bone marrow compositions/methods |
Non-Patent Citations (1)
| Title |
|---|
| JPN6015027730; Ｎａｔｕｒｅ Ｂｉｏｔｅｃｈｎｏｌｏｇｙ Ｖｏｌ．２６, 2008, ｐ．７３９-７４０ * |
Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015030149A1 (ja) * | 2013-08-29 | 2015-03-05 | 国立大学法人鳥取大学 | 細胞のアンチエイジングに関連する生体分子群 |
| JPWO2015030149A1 (ja) * | 2013-08-29 | 2017-03-02 | 国立大学法人鳥取大学 | 細胞のアンチエイジングに関連する生体分子群 |
| US10265347B2 (en) | 2013-08-29 | 2019-04-23 | Norimasa Miura | Biomolecular group related to cell anti-aging |
| WO2017090509A1 (ja) * | 2015-11-24 | 2017-06-01 | ロート製薬株式会社 | 脂肪組織由来間質細胞を含む肝疾患治療剤およびその製造方法 |
| JPWO2017090509A1 (ja) * | 2015-11-24 | 2018-09-06 | ロート製薬株式会社 | 脂肪組織由来間質細胞を含む肝疾患治療剤およびその製造方法 |
| JP7244991B2 (ja) | 2015-11-24 | 2023-03-23 | ロート製薬株式会社 | 脂肪組織由来間質細胞を含む肝疾患治療剤およびその製造方法 |
Also Published As
| Publication number | Publication date |
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| EP2566955A2 (en) | 2013-03-13 |
| WO2011138786A2 (en) | 2011-11-10 |
| US20160122709A1 (en) | 2016-05-05 |
| US20130052169A1 (en) | 2013-02-28 |
| EP2566955A4 (en) | 2014-10-29 |
| WO2011138786A3 (en) | 2012-04-12 |
| AU2011249406A1 (en) | 2012-11-29 |
| CN103025865A (zh) | 2013-04-03 |
| JP2016189783A (ja) | 2016-11-10 |
| JP2018121650A (ja) | 2018-08-09 |
| CA2798571A1 (en) | 2011-11-10 |
| AU2011249406B2 (en) | 2015-05-14 |
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