JP2013526531A - Dna修復酵素及びアノゲイスス抽出物を含有する組成物 - Google Patents
Dna修復酵素及びアノゲイスス抽出物を含有する組成物 Download PDFInfo
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- JP2013526531A JP2013526531A JP2013510229A JP2013510229A JP2013526531A JP 2013526531 A JP2013526531 A JP 2013526531A JP 2013510229 A JP2013510229 A JP 2013510229A JP 2013510229 A JP2013510229 A JP 2013510229A JP 2013526531 A JP2013526531 A JP 2013526531A
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Abstract
Description
アノゲイススは、アジア及びアフリカ原産の木の属であり、シクンシ科(Combretaceae)に属する。アノゲイスス属には、アノゲイスス・アクミンタタ(Anogeissus acumintata)、アノゲイスス・ベンチイ(Anogeissus bentii)、アノゲイスス・ドファリカ(Anogeissus dhofarica)、アノゲイスス・ラチフォリア(Anogeissus latifolia)、アノゲイスス・レイオカルプス(Anogeissus leiocarpus)、アノゲイスス・ロツンジフォリア(Anogeissus rotundifolia)、アノゲイスス・スキムペリ(Anogeissus schimperi)、及びアノゲイスス・セリケア(Anogeissus sericea)など、約8つの種がある。これらの抽出物は、葉、茎、種子、樹皮、花、根などに由来し得る。1つの実施形態では、抽出物は、植物部分の水性又は水性/アルコール抽出物であり得る。アノゲイスス抽出物は、約0.0001〜75%、好ましくは約0.0005〜65%、より好ましくは約0.001〜50%の範囲の量で組成物中に存在し得る。
本発明の組成物はまた、少なくとも1種のDNA修復酵素を含有する。推奨される範囲は、約0.00001〜約35%、好ましくは、約0.00005〜約30%、より好ましくは、約0.0001〜約25%の1種以上のDNA修復酵素である。
組成物は、水溶液、水性ゲル又は懸濁液の形態、又は油中水型若しくは水中油型エマルションの形態であり得る。組成物はまた、無水であってもよい。組成物は、液体、半固体、又は固体の形態であり得る。
組成物は、1種以上の湿潤剤を含有することができる。存在する場合、湿潤剤は、約0.1〜75%、好ましくは約0.5〜70%、より好ましくは約0.5〜40%の範囲となり得る。適当な湿潤剤の例には、グリコール、糖などが含まれる。適当なグリコールは、モノマー又はポリマーの形態であり、4〜10個の繰り返しエチレンオキシド単位を有するポリエチレングリコールであるPEG4〜10などのポリエチレン及びポリプロピレングリコール、並びにプロピレングリコール、ブチレングリコール、ペンチレングリコールなどのC1〜6アルキレングリコールが含まれる。いくつかは多価アルコールでもある適当な糖もまた、適当な湿潤剤である。かかる糖の例には、グルコース、フルクトース、ハチミツ、水素化ハチミツ、イノシトール、マルトース、マンニトール、マルチトール、ソルビトール、スクロース、キシリトール、キシロースなどが含まれる。また、尿素も適当である。好ましくは、本発明の組成物において用いられる湿潤剤は、C1〜6-、好ましくはC2〜4アルキレングリコールであり、とりわけ、ブチレングリコール、グリセリン、プロピレングリコール、又はヘキシレングリコールである。
アノゲイスス抽出物に加えて1種以上の植物抽出物を組成物に含有させることが望ましい場合もある。存在する場合、推奨される範囲は、約0.0001〜20%、好ましくは約0.0005〜15%、より好ましくは約0.001〜10%である。適当な植物抽出物には、花、果実、野菜などの植物(草本、根、花、果実、種子)由来の抽出物が挙げられ、例えば、酵母発酵抽出物、パディナ・パボニカ(Padina Pavonica)抽出物、サーマス・サーモフィリス(Thermus Thermophilis)発酵抽出物、カメリナ・サティバ(Camelina Sativa)種子油、ボスウェリア・セラータ(Boswellia Serrata)抽出物、オリーブ抽出物、フサアカシア(Acacia Dealbata)抽出物、アセル・サッカリナム(Acer Saccharinum)(サトウカエデ)、アシドフォルス(Acidopholus)、ショウブ(Acorus)、トチノキ属(Aesculus)、ハラタケ属(Agaricus)、リュウゼツラン属(Agave)、キンミズヒキ属(Agrimonia)、藻類、アロエ、柑橘類、アブラナ属(Brassica)、シナモン、オレンジ、リンゴ、ブルーベリー、クランベリー、モモ、西洋ナシ、レモン、ライム、エンドウ豆、海藻、カフェイン、緑茶、カモミール、ウィロウバーク(willowbark)、桑、ケシ及びCTFA Cosmetic Ingredient Handbook、第8版、第2巻の1646頁から1660頁に記載のものが挙げられる。さらなる具体例には、それだけには限らないが、カンゾウ(Glycyrrhiza Glabra)、サリックス・ニグラ(Salix Nigra)、マクロシクスティス・ピリフェラ(Macrocycstis Pyrifera)、ピルス・マルス(Pyrus Malus)、サクシフラガ・サルメントーサ(Saxifraga Sarmentosa)、ブドウ(Vitis Vinifera)、モルス・ニグラ(Morus Nigra)、コガネバナ(Scutellaria Baicalensis)、アンテミス・ノビリス(Anthemis Nobilis)、クラリセージ(Salvia Sclarea)、アーモンド(Prunus Amygdalus)、ロスマリヌス・オフィシナリス(Rosmarinus Officinalis)、サピンドゥス・ムクロッシ(Sapindus mukurossi)、カエサルピニア・スピノサ(Caesalpinia spinosa)、シトラス・メディカ・リモナム(Citrus Medica Limonum)、オタネニンジン(Panax Ginseng)、メナモミ(Siegesbeckia Orientalis)、マンギフェラ・インディキア(Mangifera Indicia)、フルクタス・ムメ(Fructus Mume)、シディウム・グァジャヴァ(Psidium Guajava)、アスコフィルム・ノドサム(Ascophyllum Nodosum)、センタウリウム・エリトリア(Centaurium erythrea)、グリシン・ソヤ(Glycine Soja)抽出物、サトウダイコン(Beta Vulgaris)、ハベルレア・ロドペンシス(Haberlea Rhodopensis)、ポリゴナム・クスピダタム(Polygonum Cuspidatum)、シトラス・アウランチウム・ダルシス(Citrus Aurantium Dulcis)、ブドウ(Vitis Vinifera)、イワヒバ(Selaginella Tamariscina)、ホップ(Humulus Lupulus)、ポンカン(Citrus Reticulata)ピール、ザクロ(Punica Granatum)、アスパラゴプシス(Asparagopsis)、ウコン(Curcuma Longa)、ミズガシワ(Menyanthes Trifoliata)、ヒマワリ(Helianthus Annuus)、オオムギ(Hordeum Vulgare)、ククミス・サチヴス(Cucumis Sativus)、ツノマタゴケ(Evernia Prunastri)、エベルニア・フルフラセア(Evernia Furfuracea)、コーラ・アクミナータ(Kola Acuminata)、グリチルレチン酸(glycyrretinic acid)、及びそれらの混合物が含まれる。
1つ以上のペプチドを組成物に含有させることが望まれる場合がある。「ペプチド」という用語は、ペプチド結合によって結合した2〜20個のアミノ酸を意味する。組成物がペプチドを含有する場合、推奨される範囲は、約0.001〜20%、好ましくは、約0.005〜15%、より好ましくは、約0.01〜10%である。好ましいのは、その全体を参照により本明細書に組み込むC.T.F.A.International Cosmetic Ingredient Dictionary and Handbook、第11版、2006年、2712頁に記載のものなど、生物学的に活性なペプチドである。かかるペプチドには、それだけには限らないが、CTFA名:アセチルヘキサペプチド-1、7、8;アセチルペンタペプチド-1、2、3、又は5;アセチルトリペプチド-1;アセチルジペプチド-1セチルエステル;アセチルグルタミルヘプタペプチド-3;アセチルグルタミルヘキサペプチド-6;アセチルモノフルオロペプチド-1;ヘプタペプチド-1、2、又は3;ヘキサペプチド-1、2、3、4、5、6、7、8、9、10、11、12、13、又は14;マンガントリペプチド-1;ミリストイルヘキサペプチド-5、12、又は13;ミリストイルノナペプチド-2;ミリストイルペンタペプチド-4;ミリストイルテトラペプチド-4又は6;ミリストイルトリペプチド-4;ナイシン、ノナペプチド-1又は2;オリゴペプチド-1、2、3、4、5、6、7、8、9又は10;パルミトイルヘキサペプチド-14;パルミトイルペンタペプチド-4;パルミトイルペンタペプチド-4又は5;パルミトイルトリペプチド-1又は5;ペンタペプチド-1、2、3、4、5、又は6;テトラペプチド-1、2、3、4、5、6、又は7;トリペプチド-1、2、3、4、又は5が含まれる。
組成物は、天然油、合成油又はシリコーン油の形態で1種以上の油を含むこともできる。「油」という用語は、成分が、室温、例えば、25℃で注ぐことができることを意味する。油は、揮発性でも不揮発性でもよい。「揮発性」という用語は、油が、20℃で水銀約2mmを超える蒸気圧を有することを意味する。「不揮発性」という用語は、油が、20℃で水銀約2mm未満の蒸気圧を有することを意味する。存在する場合、推奨される範囲は、約0.1〜60%、好ましくは約0.5〜45%である。
適当な増粘剤を、組成物に含有させることができる。その場合、推奨される範囲は、約0.0001〜45%であり、好ましくは、約0.0005〜40%である。
本発明の組成物は、適宜、1種以上の界面活性剤を含有することができる。これは、組成物が水性ゲル又はエマルションの形態である場合に特に望ましい。存在する場合、界面活性剤は組成物全体の約0.001〜50重量%、好ましくは約0.005〜40重量%、より好ましくは約0.01〜35重量%の範囲であり得る。適当な界面活性剤はシリコーン又は有機系、非イオン性、陰イオン性、両性又は双性イオン性であり得る。かかる界面活性剤として本明細書に記載されるものが挙げられるが、それらに限定されない。
を有する。1つの好ましい実施形態において、x、y、z、a及びbは、ポリマーの分子量が約5,000〜約500,000、より好ましくは約10,000〜100,000の範囲であり、最も好ましくは約50,000であるようなものであり、このポリマーは、一般に、ジメチコンコポリオールと呼ばれる。
組成物中に1種以上のビタミン又は酸化防止剤を含有させることが望ましい場合もある。存在する場合、推奨される範囲は、約0.001〜20%、好ましくは約0.005〜15%、より好ましくは、約0.010〜10%である。好ましくは、かかるビタミン、ビタミン誘導体及び/又は酸化防止剤は一重項酸素の形態で遊離基を捕捉することができる。かかるビタミンとして、トコフェロール又はその誘導体(例えば、酢酸トコフェロール、フェルラ酸トコフェロール);アスコルビン酸又はその誘導体(例えば、パルミチン酸アスコルビル、リン酸アスコルビルマグネシウム);ビタミンA又はその誘導体(例えば、パルミチン酸レチニル);又はビタミンD、K、B、若しくはそれらの誘導体を挙げることができる。
Claims (20)
- アノゲイスス(Anogeissus)属由来の少なくとも1種の抽出物及び少なくとも1種のDNA修復酵素を含む局所用組成物。
- 抽出物がアノゲイスス・レイオカルプス(Anogeissus Leiocarpus)由来である、請求項1に記載の組成物。
- 少なくとも1種のペプチドをさらに含む、請求項1に記載の組成物。
- 少なくとも1種のアノゲイスス・レイオカルプス(Anogeissus Leiocarpus)由来の抽出物約0.0001〜75%、少なくとも1種のDNA修復酵素約0.00001〜約35%、及び約2〜20個のアミノ酸を有する少なくとも1種のペプチド約0.001〜20%を含む、請求項1に記載の組成物。
- DNA修復酵素が、T-Tダイマー、8-オキソ-ジグアニン、又はO6-メチルグアニンヌクレオチド塩基突然変異損傷を修復することができる、請求項4に記載の組成物。
- DNA修復酵素が、1つ以上のOGG1であるか、又はミクロコッカス(Micrococcus)溶解物、ビフィズス菌(Bifidus)、シロイヌナズナ(Arabidopsis Thaliana)抽出物、ラクトバチルス(Lactobacillus)、プランクトン抽出物、又はそれらの混合物、又はそれらの発酵生成物において見出されるものである、請求項4に記載の組成物。
- ペプチドが、ヘキサペプチド、ペンタペプチド、トリペプチド、ジペプチド又はそれらの混合物から選択される、請求項4に記載の組成物。
- ペプチドが、アセチルヘキサペプチド、パルミトイルヘキサペプチド、パルミトイルペンタペプチド、パルミトイルトリペプチド、ペンタペプチド、テトラペプチド又はトリペプチドである、請求項4に記載の組成物。
- DNA修復酵素が、1つ以上のOGG1であるか、又はミクロコッカス(Micrococcus)溶解物、ビフィズス菌(Bifidus)、シロイヌナズナ(Arabidopsis Thaliana)抽出物、ラクトバチルス(Lactobacillu)、プランクトン抽出物、又はそれらの混合物若しくはそれらの発酵物において見出されるものであり、ペプチドがアセチルヘキサペプチド-8を含む、請求項4に記載の組成物。
- カフェインをさらに含む、請求項9に記載の組成物。
- コガネバナ(Scutellaria Baicalensis)、ピルス・マルス(Pyrus Malus)、ククミス・サチヴス(Cucumis Sativus)、グリチルレチン酸、マンギフェラ・インディキア(Mangifera Indicia)、シディウム・グァヴァ(Psidium guava)、ポリゴナム・クスピダタム(Polygonum Cuspidatum)、ロスマリヌス・オフィシナリス(Rosmarinus Officinalis)、アンテミス・ノビリス(Anthemis Nobilis)由来の1種以上の植物抽出物をさらに含む、請求項10に記載の組成物。
- グリセリン、ブチレングリコール、プロピレングリコール、又はそれらの混合物から選択される湿潤剤をさらに含む、請求項11に記載の組成物。
- 少なくとも1種のシリコーンエラストマーをさらに含む、請求項12に記載の組成物。
- 組成物全体の重量に基づいて、
少なくとも1種のアノゲイスス・レイオカルプス(Anogeissus Leiocarpus)由来の抽出物約0.0001〜75%、
少なくとも1種の1つ以上のOGG1を含むDNA修復酵素又はミクロコッカス(Micrococcus)溶解物、ビフィズス菌(Bifidus)、シロイヌナズナ(Arabidopsis Thaliana)抽出物、ラクトバチルス(Lactobacillus)、プランクトン抽出物、又はそれらの混合物若しくはそれらの発酵生成物において見出されるDNA修復酵素約0.00001〜約35%、
アセチルヘキサペプチド-8、パルミトイルオリゴペプチド又はそれらの混合物から選択される少なくとも1種のペプチド約0.001〜20%、
メチルトリメチコン、ジメチコン、及びそれらの混合物から選択される油約0.1〜60%、
コガネバナ(Scutellaria baicalensis)、ピルス・マルス(Pyrus malus)、ククミス・サチヴス(Cucumis sativus)、グリチルレチン酸、マンギフェラ・インディキア(Mangifera indicia)、シディウム・グァヴァ(Psidium guava)、ポリゴナム・クスピダタム(Polygonum cuspidatum)、ロスマリヌス・オフィシナリス(Rosmarinus officinalis)、アンテミス・ノビリス(Anthemis nobilis)及びそれらの混合物からなる群から選択される植物抽出物約0.0001〜25%、
グリセリン、プロピレングリコール、ブチレングリコール又はそれらの混合物から選択される湿潤剤約0.1〜75%
を含む水性ベース局所用スキンケア組成物。 - アクリロイルジメチルタウリンアンモニウム/VPコポリマー、アクリロイルジメチルタウリンアンモニウム/ベヘネス-25メタクリレートクロスポリマー、又はそれらの混合物を含む、少なくとも約1種の増粘剤をさらに含む、請求項14に記載の組成物。
- シリコーンエラストマーである少なくとも1種の増粘剤をさらに含む、請求項15に記載の組成物。
- シリコーンエラストマーである増粘剤をさらに含む、請求項1に記載の組成物。
- アクリロイルジメチルタウリンアンモニウム/VPコポリマー、アクリロイルジメチルタウリンアンモニウム/ベヘネス-25メタクリレートクロスポリマー、又はそれらの混合物から選択される増粘剤をさらに含む、請求項1に記載の組成物。
- シリコーンエラストマーが、ポリシリコーン-11を含む、請求項17に記載の組成物。
- 増粘剤が、ポリシリコーン-11及びアクリロイルジメチルタウリンポリマーの混合物を含む、請求項1に記載の組成物。
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US12/778,726 | 2010-05-12 | ||
US12/778,726 US20110280850A1 (en) | 2010-05-12 | 2010-05-12 | Compositions Containing DNA Repair Enzyme And Anogeissus Extract |
PCT/US2011/035857 WO2011143171A2 (en) | 2010-05-12 | 2011-05-10 | Compositions containing dna repair enzyme and anogeissus extract |
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JP5856150B2 JP5856150B2 (ja) | 2016-02-09 |
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US (1) | US20110280850A1 (ja) |
EP (1) | EP2568956A4 (ja) |
JP (1) | JP5856150B2 (ja) |
KR (2) | KR20130012075A (ja) |
CN (1) | CN102985067A (ja) |
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CA (1) | CA2799194C (ja) |
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JP2016014054A (ja) * | 2010-09-30 | 2016-01-28 | イーエルシー マネージメント エルエルシー | 亜鉛pca及びアノゲイスス抽出物を含有する組成物 |
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EP2537513A3 (en) * | 2011-03-11 | 2015-04-29 | ELC Management LLC | Use of anogeissus extract for fibrillin production in skin |
AU2012373282A1 (en) * | 2012-03-16 | 2014-10-23 | Revlon | Probiotic/antioxidant blend |
ES2831102T3 (es) | 2013-01-07 | 2021-06-07 | Elc Man Llc | Método y composiciones para mejorar la catabólisis selectiva y la viabilidad en células de superficies de queratina |
CN103520081B (zh) * | 2013-09-27 | 2015-10-28 | 无限极(中国)有限公司 | 一种调节皮肤免疫力、延缓皮肤老化的外用护肤品 |
ES2864716T3 (es) * | 2013-09-30 | 2021-10-14 | Elc Man Llc | Composición y métodos de loción acuosa para el cuidado de la piel |
WO2017019692A1 (en) | 2015-07-28 | 2017-02-02 | Mary Kay Inc. | Topical skin formulations |
AU2017240068B2 (en) | 2016-03-31 | 2022-12-15 | Gojo Industries, Inc. | Antimicrobial peptide stimulating cleansing composition |
JP2019510036A (ja) | 2016-03-31 | 2019-04-11 | ゴジョ・インダストリーズ・インコーポレイテッド | プロバイオティクス/プレバイオティクス有効成分を含む清浄剤組成物 |
CN106309204B (zh) * | 2016-09-12 | 2018-05-11 | 浙江生创精准医疗科技有限公司 | 一种用于皮肤修复的组合物 |
EP3544575A1 (en) | 2016-11-23 | 2019-10-02 | GOJO Industries, Inc. | Sanitizer composition with probiotic/prebiotic active ingredient |
CN109172396A (zh) * | 2018-09-18 | 2019-01-11 | 广州市爱百伊生物技术有限公司 | 一种眼部护理组合物及其制备方法 |
CN109943526B (zh) * | 2019-05-23 | 2019-09-13 | 广州赛莱拉干细胞科技股份有限公司 | 一种促间充质干细胞增殖的无血清多肽组合物 |
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- 2011-05-10 EP EP11781116.6A patent/EP2568956A4/en not_active Withdrawn
- 2011-05-10 KR KR1020127032365A patent/KR20130012075A/ko active Application Filing
- 2011-05-10 WO PCT/US2011/035857 patent/WO2011143171A2/en active Application Filing
- 2011-05-10 JP JP2013510229A patent/JP5856150B2/ja active Active
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- 2011-05-10 BR BR112012028802A patent/BR112012028802A2/pt not_active Application Discontinuation
- 2011-05-10 RU RU2012153674/15A patent/RU2559085C2/ru active
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Also Published As
Publication number | Publication date |
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BR112012028802A2 (pt) | 2016-07-26 |
WO2011143171A2 (en) | 2011-11-17 |
KR20150014518A (ko) | 2015-02-06 |
CN102985067A (zh) | 2013-03-20 |
RU2559085C2 (ru) | 2015-08-10 |
RU2012153674A (ru) | 2014-06-20 |
AU2011253185A1 (en) | 2012-12-13 |
CA2799194C (en) | 2015-11-17 |
AU2011253185B2 (en) | 2013-12-19 |
EP2568956A2 (en) | 2013-03-20 |
JP5856150B2 (ja) | 2016-02-09 |
EP2568956A4 (en) | 2013-11-20 |
KR20130012075A (ko) | 2013-01-31 |
WO2011143171A3 (en) | 2012-03-08 |
US20110280850A1 (en) | 2011-11-17 |
CA2799194A1 (en) | 2011-11-17 |
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