JP2013523769A5 - - Google Patents
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- JP2013523769A5 JP2013523769A5 JP2013502865A JP2013502865A JP2013523769A5 JP 2013523769 A5 JP2013523769 A5 JP 2013523769A5 JP 2013502865 A JP2013502865 A JP 2013502865A JP 2013502865 A JP2013502865 A JP 2013502865A JP 2013523769 A5 JP2013523769 A5 JP 2013523769A5
- Authority
- JP
- Japan
- Prior art keywords
- formulation
- msm
- dmso
- disorder
- amount
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 42
- 238000009472 formulation Methods 0.000 claims 36
- 239000000203 mixture Substances 0.000 claims 36
- 229940016409 methylsulfonylmethane Drugs 0.000 claims 22
- HHVIBTZHLRERCL-UHFFFAOYSA-N sulfonyldimethane Chemical compound CS(C)(=O)=O HHVIBTZHLRERCL-UHFFFAOYSA-N 0.000 claims 22
- 150000001875 compounds Chemical class 0.000 claims 8
- 206010003805 Autism Diseases 0.000 claims 7
- 208000020706 Autistic disease Diseases 0.000 claims 7
- NIJJYAXOARWZEE-UHFFFAOYSA-N Valproic acid Chemical compound CCCC(C(O)=O)CCC NIJJYAXOARWZEE-UHFFFAOYSA-N 0.000 claims 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 208000035475 disorder Diseases 0.000 claims 6
- 230000000694 effects Effects 0.000 claims 6
- LNEPOXFFQSENCJ-UHFFFAOYSA-N haloperidol Chemical compound C1CC(O)(C=2C=CC(Cl)=CC=2)CCN1CCCC(=O)C1=CC=C(F)C=C1 LNEPOXFFQSENCJ-UHFFFAOYSA-N 0.000 claims 6
- 229960001534 risperidone Drugs 0.000 claims 5
- RAPZEAPATHNIPO-UHFFFAOYSA-N risperidone Chemical compound FC1=CC=C2C(C3CCN(CC3)CCC=3C(=O)N4CCCCC4=NC=3C)=NOC2=C1 RAPZEAPATHNIPO-UHFFFAOYSA-N 0.000 claims 5
- 235000015097 nutrients Nutrition 0.000 claims 4
- AHOUBRCZNHFOSL-YOEHRIQHSA-N (+)-Casbol Chemical compound C1=CC(F)=CC=C1[C@H]1[C@H](COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-YOEHRIQHSA-N 0.000 claims 3
- RTHCYVBBDHJXIQ-MRXNPFEDSA-N (R)-fluoxetine Chemical compound O([C@H](CCNC)C=1C=CC=CC=1)C1=CC=C(C(F)(F)F)C=C1 RTHCYVBBDHJXIQ-MRXNPFEDSA-N 0.000 claims 3
- KWTSXDURSIMDCE-QMMMGPOBSA-N (S)-amphetamine Chemical compound C[C@H](N)CC1=CC=CC=C1 KWTSXDURSIMDCE-QMMMGPOBSA-N 0.000 claims 3
- 208000006096 Attention Deficit Disorder with Hyperactivity Diseases 0.000 claims 3
- GDLIGKIOYRNHDA-UHFFFAOYSA-N Clomipramine Chemical compound C1CC2=CC=C(Cl)C=C2N(CCCN(C)C)C2=CC=CC=C21 GDLIGKIOYRNHDA-UHFFFAOYSA-N 0.000 claims 3
- DUGOZIWVEXMGBE-UHFFFAOYSA-N Methylphenidate Chemical compound C=1C=CC=CC=1C(C(=O)OC)C1CCCCN1 DUGOZIWVEXMGBE-UHFFFAOYSA-N 0.000 claims 3
- AHOUBRCZNHFOSL-UHFFFAOYSA-N Paroxetine hydrochloride Natural products C1=CC(F)=CC=C1C1C(COC=2C=C3OCOC3=CC=2)CNCC1 AHOUBRCZNHFOSL-UHFFFAOYSA-N 0.000 claims 3
- KLBQZWRITKRQQV-UHFFFAOYSA-N Thioridazine Chemical compound C12=CC(SC)=CC=C2SC2=CC=CC=C2N1CCC1CCCCN1C KLBQZWRITKRQQV-UHFFFAOYSA-N 0.000 claims 3
- 229940025084 amphetamine Drugs 0.000 claims 3
- 229960002430 atomoxetine Drugs 0.000 claims 3
- VHGCDTVCOLNTBX-QGZVFWFLSA-N atomoxetine Chemical compound O([C@H](CCNC)C=1C=CC=CC=1)C1=CC=CC=C1C VHGCDTVCOLNTBX-QGZVFWFLSA-N 0.000 claims 3
- SNPPWIUOZRMYNY-UHFFFAOYSA-N bupropion Chemical compound CC(C)(C)NC(C)C(=O)C1=CC=CC(Cl)=C1 SNPPWIUOZRMYNY-UHFFFAOYSA-N 0.000 claims 3
- 229960001058 bupropion Drugs 0.000 claims 3
- QWCRAEMEVRGPNT-UHFFFAOYSA-N buspirone Chemical compound C1C(=O)N(CCCCN2CCN(CC2)C=2N=CC=CN=2)C(=O)CC21CCCC2 QWCRAEMEVRGPNT-UHFFFAOYSA-N 0.000 claims 3
- 229960002495 buspirone Drugs 0.000 claims 3
- FFGPTBGBLSHEPO-UHFFFAOYSA-N carbamazepine Chemical compound C1=CC2=CC=CC=C2N(C(=O)N)C2=CC=CC=C21 FFGPTBGBLSHEPO-UHFFFAOYSA-N 0.000 claims 3
- 229960000623 carbamazepine Drugs 0.000 claims 3
- 229960004606 clomipramine Drugs 0.000 claims 3
- 229960004170 clozapine Drugs 0.000 claims 3
- QZUDBNBUXVUHMW-UHFFFAOYSA-N clozapine Chemical compound C1CN(C)CCN1C1=NC2=CC(Cl)=CC=C2NC2=CC=CC=C12 QZUDBNBUXVUHMW-UHFFFAOYSA-N 0.000 claims 3
- ODQWQRRAPPTVAG-GZTJUZNOSA-N doxepin Chemical compound C1OC2=CC=CC=C2C(=C/CCN(C)C)/C2=CC=CC=C21 ODQWQRRAPPTVAG-GZTJUZNOSA-N 0.000 claims 3
- 229960005426 doxepin Drugs 0.000 claims 3
- 229960002464 fluoxetine Drugs 0.000 claims 3
- CJOFXWAVKWHTFT-XSFVSMFZSA-N fluvoxamine Chemical compound COCCCC\C(=N/OCCN)C1=CC=C(C(F)(F)F)C=C1 CJOFXWAVKWHTFT-XSFVSMFZSA-N 0.000 claims 3
- 229960004038 fluvoxamine Drugs 0.000 claims 3
- 229960003878 haloperidol Drugs 0.000 claims 3
- BCGWQEUPMDMJNV-UHFFFAOYSA-N imipramine Chemical compound C1CC2=CC=CC=C2N(CCCN(C)C)C2=CC=CC=C21 BCGWQEUPMDMJNV-UHFFFAOYSA-N 0.000 claims 3
- 229960004801 imipramine Drugs 0.000 claims 3
- -1 lanzapine Chemical compound 0.000 claims 3
- 229940071264 lithium citrate Drugs 0.000 claims 3
- WJSIUCDMWSDDCE-UHFFFAOYSA-K lithium citrate (anhydrous) Chemical compound [Li+].[Li+].[Li+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WJSIUCDMWSDDCE-UHFFFAOYSA-K 0.000 claims 3
- 229960001344 methylphenidate Drugs 0.000 claims 3
- VRBKIVRKKCLPHA-UHFFFAOYSA-N nefazodone Chemical compound O=C1N(CCOC=2C=CC=CC=2)C(CC)=NN1CCCN(CC1)CCN1C1=CC=CC(Cl)=C1 VRBKIVRKKCLPHA-UHFFFAOYSA-N 0.000 claims 3
- 229960001800 nefazodone Drugs 0.000 claims 3
- 229960002296 paroxetine Drugs 0.000 claims 3
- NRNCYVBFPDDJNE-UHFFFAOYSA-N pemoline Chemical compound O1C(N)=NC(=O)C1C1=CC=CC=C1 NRNCYVBFPDDJNE-UHFFFAOYSA-N 0.000 claims 3
- 229960000761 pemoline Drugs 0.000 claims 3
- VGKDLMBJGBXTGI-SJCJKPOMSA-N sertraline Chemical compound C1([C@@H]2CC[C@@H](C3=CC=CC=C32)NC)=CC=C(Cl)C(Cl)=C1 VGKDLMBJGBXTGI-SJCJKPOMSA-N 0.000 claims 3
- 229960002073 sertraline Drugs 0.000 claims 3
- 239000007787 solid Substances 0.000 claims 3
- 208000024891 symptom Diseases 0.000 claims 3
- 229960002784 thioridazine Drugs 0.000 claims 3
- 229960000604 valproic acid Drugs 0.000 claims 3
- PNVNVHUZROJLTJ-UHFFFAOYSA-N venlafaxine Chemical compound C1=CC(OC)=CC=C1C(CN(C)C)C1(O)CCCCC1 PNVNVHUZROJLTJ-UHFFFAOYSA-N 0.000 claims 3
- 229960004688 venlafaxine Drugs 0.000 claims 3
- 208000036864 Attention deficit/hyperactivity disease Diseases 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 2
- 208000020358 Learning disease Diseases 0.000 claims 2
- 208000021384 Obsessive-Compulsive disease Diseases 0.000 claims 2
- 208000012202 Pervasive developmental disease Diseases 0.000 claims 2
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims 2
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 2
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 2
- 208000029560 autism spectrum disease Diseases 0.000 claims 2
- 239000011230 binding agent Substances 0.000 claims 2
- 230000037396 body weight Effects 0.000 claims 2
- 239000004202 carbamide Substances 0.000 claims 2
- 230000002496 gastric effect Effects 0.000 claims 2
- 208000035231 inattentive type attention deficit hyperactivity disease Diseases 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 201000003723 learning disability Diseases 0.000 claims 2
- 239000012669 liquid formulation Substances 0.000 claims 2
- URKOMYMAXPYINW-UHFFFAOYSA-N quetiapine Chemical compound C1CN(CCOCCO)CCN1C1=NC2=CC=CC=C2SC2=CC=CC=C12 URKOMYMAXPYINW-UHFFFAOYSA-N 0.000 claims 2
- 229960004431 quetiapine Drugs 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 239000011593 sulfur Substances 0.000 claims 2
- 206010002820 Antisocial behaviour Diseases 0.000 claims 1
- 208000036640 Asperger disease Diseases 0.000 claims 1
- 201000006062 Asperger syndrome Diseases 0.000 claims 1
- 206010012559 Developmental delay Diseases 0.000 claims 1
- 201000004311 Gilles de la Tourette syndrome Diseases 0.000 claims 1
- 208000000323 Tourette Syndrome Diseases 0.000 claims 1
- 208000016620 Tourette disease Diseases 0.000 claims 1
- 206010047700 Vomiting Diseases 0.000 claims 1
- 208000024823 antisocial personality disease Diseases 0.000 claims 1
- 230000006399 behavior Effects 0.000 claims 1
- 238000011260 co-administration Methods 0.000 claims 1
- 239000000796 flavoring agent Substances 0.000 claims 1
- 235000013355 food flavoring agent Nutrition 0.000 claims 1
- 208000013403 hyperactivity Diseases 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 235000019645 odor Nutrition 0.000 claims 1
- 230000003989 repetitive behavior Effects 0.000 claims 1
- 208000013406 repetitive behavior Diseases 0.000 claims 1
- 229940126570 serotonin reuptake inhibitor Drugs 0.000 claims 1
- 239000003772 serotonin uptake inhibitor Substances 0.000 claims 1
- 230000003997 social interaction Effects 0.000 claims 1
- 238000013268 sustained release Methods 0.000 claims 1
- 239000012730 sustained-release form Substances 0.000 claims 1
- 208000016686 tic disease Diseases 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- 229940045136 urea Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31982710P | 2010-03-31 | 2010-03-31 | |
| US61/319,827 | 2010-03-31 | ||
| PCT/US2011/030806 WO2011123695A1 (en) | 2010-03-31 | 2011-03-31 | Dimethy sulfoxxide (dmso) formulations for treating autism |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013523769A JP2013523769A (ja) | 2013-06-17 |
| JP2013523769A5 true JP2013523769A5 (enExample) | 2014-05-15 |
| JP5902148B2 JP5902148B2 (ja) | 2016-04-13 |
Family
ID=44712638
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013502865A Expired - Fee Related JP5902148B2 (ja) | 2010-03-31 | 2011-03-31 | 自閉症治療用ジメチルスルホキシド（ｄｍｓｏ）製剤 |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US20130018059A1 (enExample) |
| EP (1) | EP2552200B1 (enExample) |
| JP (1) | JP5902148B2 (enExample) |
| CA (1) | CA2793612C (enExample) |
| WO (1) | WO2011123695A1 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007033082A2 (en) * | 2005-09-12 | 2007-03-22 | Abela Pharmaceuticals, Inc. | Compositions comprising dimethyl sulfoxide (dmso) |
| AU2006291134C1 (en) | 2005-09-12 | 2013-08-15 | Abela Pharmaceuticals, Inc. | Systems for removing dimethyl sulfoxide (DMSO) or related compounds, or odors associated with same |
| US8435224B2 (en) | 2005-09-12 | 2013-05-07 | Abela Pharmaceuticals, Inc. | Materials for facilitating administration of dimethyl sulfoxide (DMSO) and related compounds |
| BRPI0921494A2 (pt) * | 2008-11-03 | 2018-10-30 | Prad Reasearch And Development Ltd | método de planejamento de uma operação de amostragem para uma formação subterrãnea, método de contolar uma operação de amostragem de formação subterrânea, método de controlar uma operação de perfuração para uma formação subterrãnea, e método de realizar uma amostragem durante a operação de perfuração. |
| US9839609B2 (en) | 2009-10-30 | 2017-12-12 | Abela Pharmaceuticals, Inc. | Dimethyl sulfoxide (DMSO) and methylsulfonylmethane (MSM) formulations to treat osteoarthritis |
| CA2816595C (en) * | 2010-10-07 | 2018-11-27 | Eaglepharma Pty Ltd | Combination therapy for the treatment of depression and other non-infectious diseases |
| US9682048B1 (en) | 2010-10-12 | 2017-06-20 | Gene S. Rosen | Multi-component formulations for the treatment of cognitive decline including Alzheimer's disease |
| KR101681305B1 (ko) | 2014-08-01 | 2016-12-02 | 주식회사 하이딥 | 터치 입력 장치 |
| KR101452302B1 (ko) | 2013-07-29 | 2014-10-22 | 주식회사 하이딥 | 터치 센서 패널 |
| PT2838510T (pt) | 2013-11-08 | 2016-11-23 | Lilly Co Eli | Solução de atomoxetina |
| KR101712346B1 (ko) | 2014-09-19 | 2017-03-22 | 주식회사 하이딥 | 터치 입력 장치 |
| JP6527343B2 (ja) | 2014-08-01 | 2019-06-05 | 株式会社 ハイディープＨｉＤｅｅｐ Ｉｎｃ． | タッチ入力装置 |
| CA3044746A1 (en) * | 2016-11-24 | 2018-05-31 | Sigmadrugs Kutato Korlatolt Felelossegu Tarsasag | Compositions for organ preservation |
| US10183053B1 (en) | 2017-06-19 | 2019-01-22 | Gene S. Rosen | Multi-component formulations |
| US20200276200A1 (en) * | 2019-02-28 | 2020-09-03 | Clark Gerald Sullivan | Treatment of cns and developmental disorders using high-dose 5-formyl-(6s)-tetrahydrofolate |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4559329A (en) * | 1982-09-14 | 1985-12-17 | Herschler R J | Dietary and pharmaceutical uses of methyl-sulfonylmethane and compositions comprising it |
| US4514421A (en) * | 1979-08-30 | 1985-04-30 | Herschler R J | Dietary and pharmaceutical uses of methylsulfonylmethane and compositions comprising it |
| WO1994005273A1 (en) * | 1992-09-04 | 1994-03-17 | Aws Shakir Mustafa Salim | Gastrointestinal compositions containing dimethylsulfone and dimethylsulfoxide |
| US6197746B1 (en) * | 1998-05-19 | 2001-03-06 | Repligen Corporation | Method of using secretin for treating autism |
| WO2005115478A2 (en) * | 2004-05-11 | 2005-12-08 | The Regents Of The University Of California | Methods and compositions for autism spectrum disorders |
| CA2580619C (en) * | 2004-09-20 | 2013-11-12 | Mount Sinai School Of Medicine | Use of memantine (namenda) to treat autism, compulsivity, and impulsivity |
| WO2007033082A2 (en) * | 2005-09-12 | 2007-03-22 | Abela Pharmaceuticals, Inc. | Compositions comprising dimethyl sulfoxide (dmso) |
| WO2007049262A1 (en) * | 2005-10-27 | 2007-05-03 | Berand Limited | Methods and compositions for the promotion of neuronal growth and the treatment of asociality and affective disorders |
| WO2008091704A2 (en) * | 2007-01-25 | 2008-07-31 | Georgetown University | Treatment of cushing's syndrome and autism |
| WO2009158013A1 (en) * | 2008-06-26 | 2009-12-30 | Nano Terra Inc. | Methods for reducing the sensory effects of odorous compounds |
| AU2010313228B2 (en) * | 2009-10-30 | 2014-05-29 | Biogenic Innovations, Llc | Methylsulfonylmethane (MSM) for treatment of drug resistant microorganisms |
-
2011
- 2011-03-31 WO PCT/US2011/030806 patent/WO2011123695A1/en not_active Ceased
- 2011-03-31 JP JP2013502865A patent/JP5902148B2/ja not_active Expired - Fee Related
- 2011-03-31 EP EP11763467.5A patent/EP2552200B1/en not_active Not-in-force
- 2011-03-31 CA CA2793612A patent/CA2793612C/en active Active
- 2011-03-31 US US13/635,383 patent/US20130018059A1/en not_active Abandoned
-
2019
- 2019-10-10 US US16/598,940 patent/US20200179306A1/en not_active Abandoned
-
2022
- 2022-07-08 US US17/861,122 patent/US20230095199A1/en not_active Abandoned
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