JP2013514291A - ペプチド - Google Patents
ペプチド Download PDFInfo
- Publication number
- JP2013514291A JP2013514291A JP2012543571A JP2012543571A JP2013514291A JP 2013514291 A JP2013514291 A JP 2013514291A JP 2012543571 A JP2012543571 A JP 2012543571A JP 2012543571 A JP2012543571 A JP 2012543571A JP 2013514291 A JP2013514291 A JP 2013514291A
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- seq
- skin
- amino acid
- present
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/06—Linear peptides containing only normal peptide links having 5 to 11 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Obesity (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Child & Adolescent Psychology (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Cosmetics (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
Abstract
Description
本願発明の第一の態様に従って、
(i)アミノ酸残基-Leu-Ser-Arg-His-Val-Leu-Gln-(LSRHVLQ)を含む、分子量700から20000ダルトンの配列番号1を有するペプチド(i);または
(ii) アミノ酸残基-His-Gly-His-Pro-Phe-Ala-Pro-(HGHPFAP)を含む配列番号2を有するペプチド(ii)
より選択されるペプチドが提供される。
本願発明においては、二つのペプチドすなわち配列番号1を有するペプチド(i)または配列番号2を有するペプチド(ii)の権利を請求している。これら二つの新規ペプチドは、α-MSH(α-メラノサイト刺激ホルモン)に優先的に結合し、α-MSHのMC1R上への結合を阻害する。この阻害は、局所用および食品組成物中で前記ペプチドを使用した際に、肌美白、免疫調節および体重調節の分野において利点を提供する。前記の二つのペプチドは、ファージディスプレイ、すなわち生物工学領域における、標的分子に特異的に結合するペプチドを同定するために使用される手法を使用して、同定された。約10億の候補から、二つのペプチドを最終候補に選ぶ過程全体は、以下に示す過程を含む。
様々な物質の肌美白剤として作用する能力を、メラニン含量アッセイを用いて測定した。以下の手順に従って実験を実施した。
Claims (13)
- (i)アミノ酸残基-Leu-Ser-Arg-His-Val-Leu-Gln-(LSRHVLQ)を含む700から20000ダルトンの分子量を有し配列番号1を有するペプチド(i);または
(ii) アミノ酸残基-His-Gly-His-Pro-Phe-Ala-Pro-(HGHPFAP)を含む配列番号2を有するペプチド(ii)
より選択されたペプチド。 - 配列番号1を有するペプチド(i)が、下記環状アミノ酸残基を含む、請求項1に記載のペプチド。
- 配列番号1を有するペプチド(i)が、下記環状アミノ酸残基を含む、請求項2に記載のペプチド。
- 配列番号1を有するペプチド(i)が、1000から8000ダルトンの分子量を有する、請求項1から3のいずれか一項に記載のペプチド。
- 配列番号2を有するペプチド(ii) が下記環状アミノ酸残基を含む、請求項1に記載のペプチド。
- 配列番号2を有するペプチド(ii)が下記アミノ酸残基を含む、請求項5に記載のペプチド。
- 配列番号1を有する前記ペプチド(i)または配列番号2を有するペプチド(ii)が好ましくはポリエチレングリコールである肌用の実質的なポリマーで誘導体化された、請求項1に記載のペプチド。
- 請求項1から7のいずれか一項に記載のペプチドおよび美容的に許容可能なベースを含む肌美白組成物。
- 前記ペプチドを0.0001から10重量%含む請求項8に記載の肌美白組成物。
- 請求項1から7のいずれか一項に記載のペプチドを肌に塗布すること含む肌美白の方法。
- 肌美白のための請求項1から7のいずれか一項に記載のペプチドの使用。
- 免疫調節のための請求項1から7のいずれか一項に記載のペプチドの使用。
- 体重調節のための請求項1から7のいずれか一項に記載のペプチドの使用。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN2898/MUM/2009 | 2009-12-16 | ||
IN2898MU2009 | 2009-12-16 | ||
PCT/EP2010/067972 WO2011072991A1 (en) | 2009-12-16 | 2010-11-23 | Peptide |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2013514291A true JP2013514291A (ja) | 2013-04-25 |
JP5752145B2 JP5752145B2 (ja) | 2015-07-22 |
Family
ID=43533119
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2012543571A Expired - Fee Related JP5752145B2 (ja) | 2009-12-16 | 2010-11-23 | ペプチド |
Country Status (11)
Country | Link |
---|---|
US (1) | US8580920B2 (ja) |
EP (1) | EP2512496B1 (ja) |
JP (1) | JP5752145B2 (ja) |
CN (1) | CN103313723B (ja) |
BR (1) | BR112012013095A2 (ja) |
CA (1) | CA2782131C (ja) |
EA (1) | EA022214B1 (ja) |
ES (1) | ES2541364T3 (ja) |
MX (1) | MX2012007034A (ja) |
WO (1) | WO2011072991A1 (ja) |
ZA (1) | ZA201203722B (ja) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT3058936T (pt) * | 2013-10-18 | 2019-06-14 | Univ Do Minho | Composição peptídica e respetivos usos |
US11712410B2 (en) | 2018-09-05 | 2023-08-01 | K18, Inc. | Composition for improving hair health |
WO2023119230A1 (en) | 2021-12-22 | 2023-06-29 | L'oreal | Coagulation pathway and nicotinamide-adenine dinucleotide pathway modulating compositions and methods of their use |
Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001088088A2 (en) * | 2000-05-18 | 2001-11-22 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0389950A1 (en) | 1989-03-23 | 1990-10-03 | Lion Corporation | Melanocyte-stimulating hormone inhibitor and external preparation containing the same |
GB9719195D0 (en) * | 1997-09-09 | 1997-11-12 | Unilever Plc | Skin lightening composition |
JP2001002527A (ja) | 1999-06-22 | 2001-01-09 | Lion Corp | 皮膚外用剤組成物 |
US20070060743A1 (en) * | 2001-05-16 | 2007-03-15 | Tang Y Tom | Novel nucleic acids and polypeptides |
EP1615991A4 (en) | 2003-04-03 | 2007-12-19 | Bristol Myers Squibb Co | POLYNUCLEOTIDE ENCODING A NEW HUMAN P2X7 SPLICE VARIANT CALLED HBMYP2X7V |
EP2090662A3 (en) | 2006-04-05 | 2012-10-31 | Metanomics GmbH | Process for the production of a fine chemical |
FR2900573B1 (fr) * | 2006-05-05 | 2014-05-16 | Sederma Sa | Nouvelles compositions cosmetiques renfermant au moins un peptide contenant au moins un cycle aromatique bloque |
EP2009023A1 (en) * | 2007-06-04 | 2008-12-31 | Rentschler Beteiligungs GmbH | Novel peptides and their use for the treatment of edema |
-
2010
- 2010-11-23 EP EP10779020.6A patent/EP2512496B1/en not_active Not-in-force
- 2010-11-23 JP JP2012543571A patent/JP5752145B2/ja not_active Expired - Fee Related
- 2010-11-23 WO PCT/EP2010/067972 patent/WO2011072991A1/en active Application Filing
- 2010-11-23 BR BR112012013095A patent/BR112012013095A2/pt not_active IP Right Cessation
- 2010-11-23 MX MX2012007034A patent/MX2012007034A/es active IP Right Grant
- 2010-11-23 CN CN201080057793.0A patent/CN103313723B/zh not_active Expired - Fee Related
- 2010-11-23 ES ES10779020.6T patent/ES2541364T3/es active Active
- 2010-11-23 EA EA201200889A patent/EA022214B1/ru not_active IP Right Cessation
- 2010-11-23 CA CA2782131A patent/CA2782131C/en active Active
- 2010-11-23 US US13/515,074 patent/US8580920B2/en active Active
-
2012
- 2012-05-22 ZA ZA2012/03722A patent/ZA201203722B/en unknown
Patent Citations (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2001088088A2 (en) * | 2000-05-18 | 2001-11-22 | Hyseq, Inc. | Novel nucleic acids and polypeptides |
Non-Patent Citations (1)
Title |
---|
JPN6014053410; Frangeul, L: Genbank [online] , 2007 * |
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WO2011072991A1 (en) | 2011-06-23 |
ZA201203722B (en) | 2013-08-28 |
EP2512496A1 (en) | 2012-10-24 |
US8580920B2 (en) | 2013-11-12 |
JP5752145B2 (ja) | 2015-07-22 |
CA2782131A1 (en) | 2011-06-23 |
EA022214B1 (ru) | 2015-11-30 |
EP2512496B1 (en) | 2015-04-01 |
EA201200889A1 (ru) | 2013-01-30 |
CN103313723A (zh) | 2013-09-18 |
CA2782131C (en) | 2018-12-11 |
US20120263665A1 (en) | 2012-10-18 |
CN103313723B (zh) | 2015-02-04 |
ES2541364T3 (es) | 2015-07-17 |
BR112012013095A2 (pt) | 2017-05-16 |
MX2012007034A (es) | 2012-07-04 |
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