JP2013512268A5 - - Google Patents
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- Publication number
- JP2013512268A5 JP2013512268A5 JP2012541422A JP2012541422A JP2013512268A5 JP 2013512268 A5 JP2013512268 A5 JP 2013512268A5 JP 2012541422 A JP2012541422 A JP 2012541422A JP 2012541422 A JP2012541422 A JP 2012541422A JP 2013512268 A5 JP2013512268 A5 JP 2013512268A5
- Authority
- JP
- Japan
- Prior art keywords
- mitotic checkpoint
- compounds
- schmidt
- present
- inhibition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000017205 mitotic cell cycle checkpoint Effects 0.000 description 4
- 150000001875 compounds Chemical class 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 230000000144 pharmacologic effect Effects 0.000 description 2
- 208000005623 Carcinogenesis Diseases 0.000 description 1
- 206010059866 Drug resistance Diseases 0.000 description 1
- 206010024324 Leukaemias Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 102000030951 Phosphotransferases Human genes 0.000 description 1
- 108091000081 Phosphotransferases Proteins 0.000 description 1
- 206010039491 Sarcoma Diseases 0.000 description 1
- 231100001075 aneuploidy Toxicity 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000036952 cancer formation Effects 0.000 description 1
- 231100000504 carcinogenesis Toxicity 0.000 description 1
- 201000009030 carcinoma Diseases 0.000 description 1
- 230000022131 cell cycle Effects 0.000 description 1
- 230000001413 cellular Effects 0.000 description 1
- 230000002759 chromosomal Effects 0.000 description 1
- 230000003247 decreasing Effects 0.000 description 1
- 230000006882 induction of apoptosis Effects 0.000 description 1
- 230000036210 malignancy Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000002062 proliferating Effects 0.000 description 1
- 230000035755 proliferation Effects 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000012453 solvate Substances 0.000 description 1
- 150000008523 triazolopyridines Chemical class 0.000 description 1
- 210000004881 tumor cells Anatomy 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP09075534A EP2343295A1 (en) | 2009-11-30 | 2009-11-30 | Triazolopyridine derivates |
| EP09075534.9 | 2009-11-30 | ||
| PCT/EP2010/068298 WO2011064328A1 (en) | 2009-11-30 | 2010-11-26 | Triazolopyridine derivatives |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2013512268A JP2013512268A (ja) | 2013-04-11 |
| JP2013512268A5 true JP2013512268A5 (US20040106767A1-20040603-C00005.png) | 2014-01-09 |
| JP5805654B2 JP5805654B2 (ja) | 2015-11-04 |
Family
ID=42027882
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012541422A Expired - Fee Related JP5805654B2 (ja) | 2009-11-30 | 2010-11-26 | トリアゾロピリジン誘導体 |
Country Status (8)
Families Citing this family (26)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2343297A1 (en) | 2009-11-30 | 2011-07-13 | Bayer Schering Pharma AG | Triazolopyridines |
| UY33452A (es) | 2010-06-16 | 2012-01-31 | Bayer Schering Pharma Ag | Triazolopiridinas sustituidas |
| TWI541243B (zh) | 2010-09-10 | 2016-07-11 | 拜耳知識產權公司 | 經取代咪唑并嗒 |
| EP2651947B1 (en) | 2010-12-17 | 2014-12-10 | Bayer Intellectual Property GmbH | 6-thio-substituted imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders |
| EP2651950A1 (en) | 2010-12-17 | 2013-10-23 | Bayer Intellectual Property GmbH | 6 substituted imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders |
| CN103370322B (zh) | 2010-12-17 | 2016-02-10 | 拜耳知识产权有限责任公司 | 在过度增殖性病症的治疗中用作mps-1和tkk抑制剂的2-取代的咪唑并吡嗪 |
| EP2651945A1 (en) | 2010-12-17 | 2013-10-23 | Bayer Intellectual Property GmbH | 6-substituted imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment of hyperproliferative disorders |
| CN103443100B (zh) | 2010-12-17 | 2016-03-23 | 拜耳知识产权有限责任公司 | 在过度增殖性病症的治疗中用作mps-1和tkk抑制剂的取代的6-咪唑并吡嗪 |
| EP2651948A1 (en) | 2010-12-17 | 2013-10-23 | Bayer Intellectual Property GmbH | Imidazopyrazines for use as mps-1 and tkk inhibitors in the treatment hyperproliferative disorders |
| CA2831710A1 (en) | 2011-03-31 | 2012-10-04 | Bayer Intellectual Property Gmbh | Substituted benzimidazoles as mps-1 kinase inhibitors |
| US20140255392A1 (en) | 2011-04-06 | 2014-09-11 | Bayer Intellectual Property Gmbh | Substituted imidazopyridines and intermediates thereof |
| WO2012160029A1 (en) | 2011-05-23 | 2012-11-29 | Bayer Intellectual Property Gmbh | Substituted triazolopyridines |
| UA112096C2 (uk) * | 2011-12-12 | 2016-07-25 | Байєр Інтеллектуал Проперті Гмбх | Заміщені триазолопіридини та їх застосування як інгібіторів ttk |
| US9512126B2 (en) | 2012-03-14 | 2016-12-06 | Bayer Intellectual Property Gmbh | Substituted imidazopyridazines |
| EA027544B1 (ru) * | 2012-07-10 | 2017-08-31 | Байер Фарма Акциенгезельшафт | Способ получения замещенных триазолопиридинов |
| WO2014020043A1 (en) | 2012-08-02 | 2014-02-06 | Bayer Pharma Aktiengesellschaft | Combinations for the treatment of cancer |
| WO2014020041A1 (en) | 2012-08-02 | 2014-02-06 | Bayer Pharma Aktiengesellschaft | Combinations for the treatment of cancer |
| CN103965199B (zh) * | 2013-02-02 | 2017-07-07 | 广东东阳光药业有限公司 | 一种芳杂环化合物、包含它的药物组合物及其用途 |
| AR096469A1 (es) * | 2013-06-06 | 2015-12-30 | Bayer Pharma AG | Composiciones farmacéuticas que comprenden compuestos del tipo triazolpiridinas |
| PL3008062T3 (pl) | 2013-06-11 | 2017-08-31 | Bayer Pharma Aktiengesellschaft | Pochodne proleki podstawionych triazolopirydyn |
| EP3007692A1 (en) | 2013-06-11 | 2016-04-20 | Bayer Pharma Aktiengesellschaft | Combinations for the treatment of cancer comprising a mps-1 kinase inhibitor and a mitotic inhibitor |
| EP2860177A3 (en) | 2013-09-20 | 2015-06-10 | Bayer Intellectual Property GmbH | Synthesis of functionalized arenes |
| CA2981844A1 (en) | 2015-04-17 | 2016-10-20 | Netherlands Translational Research Center B.V. | Prognostic biomarkers for ttk inhibitor chemotherapy |
| GB201522532D0 (en) * | 2015-12-21 | 2016-02-03 | Cancer Rec Tech Ltd | Novel pyrrolo[3,2-c]pyridine-6-amino derivatives |
| CN107641118B (zh) * | 2016-07-22 | 2020-11-06 | 爱科诺生物医药股份有限公司 | 具有细胞坏死抑制活性的化合物及其组合物和应用 |
| AU2020257301A1 (en) | 2019-04-18 | 2021-11-11 | The Johns Hopkins University | Substituted 2-amino-pyrazolyl-(1,2,4)triazolo(1,5a) pyridine derivatives and use thereof |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5023252A (en) | 1985-12-04 | 1991-06-11 | Conrex Pharmaceutical Corporation | Transdermal and trans-membrane delivery of drugs |
| US5011472A (en) | 1988-09-06 | 1991-04-30 | Brown University Research Foundation | Implantable delivery system for biological factors |
| MX2007001943A (es) | 2004-08-17 | 2007-05-09 | Galderma Res & Dev | Nuevos compuestos biaromaticos activadores de los receptores del tipo receptor activado del proliferador de peroxisoma (ppar) y su uso en composiciones cosmeticas o farmaceuticas. |
| AU2007291190A1 (en) * | 2006-08-30 | 2008-03-06 | Cellzome Limited | Triazole derivatives as kinase inhibitors |
| JP2010533680A (ja) * | 2007-07-18 | 2010-10-28 | ノバルティス アーゲー | 二環ヘテロアリール化合物およびそれらのキナーゼ阻害剤としての使用 |
| NZ584138A (en) * | 2007-08-23 | 2011-10-28 | Astrazeneca Ab | 2-anilinopurin-8-ones as inhibitors of ttk/mps1 for the treatment of proliferative disorders |
| GB0719803D0 (en) | 2007-10-10 | 2007-11-21 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
| BRPI0819606A2 (pt) * | 2007-11-27 | 2017-05-09 | Cellzome Ltd | amino triazóis como inobidores de pi3k |
| WO2010092015A1 (en) * | 2009-02-10 | 2010-08-19 | Cellzome Limited | Urea triazololo [1, 5-a] pyridine derivatives as pi3k inhibitors |
| WO2010092041A1 (en) * | 2009-02-13 | 2010-08-19 | Fovea Pharmaceuticals Sa | [1, 2, 4] triazolo [1, 5 -a] pyridines as kinase inhibitors |
-
2009
- 2009-11-30 EP EP09075534A patent/EP2343295A1/en not_active Withdrawn
-
2010
- 2010-11-26 EP EP10787724.3A patent/EP2507236B1/en not_active Not-in-force
- 2010-11-26 CN CN201080061523.7A patent/CN102753547B/zh not_active Expired - Fee Related
- 2010-11-26 JP JP2012541422A patent/JP5805654B2/ja not_active Expired - Fee Related
- 2010-11-26 CA CA2782012A patent/CA2782012A1/en not_active Abandoned
- 2010-11-26 ES ES10787724.3T patent/ES2532655T3/es active Active
- 2010-11-26 US US13/512,721 patent/US20130121994A1/en not_active Abandoned
- 2010-11-26 WO PCT/EP2010/068298 patent/WO2011064328A1/en active Application Filing
-
2013
- 2013-04-17 HK HK13104655.3A patent/HK1177462A1/xx not_active IP Right Cessation
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