JP2013501224A - 葉酸を標的とした診断及び処置 - Google Patents
葉酸を標的とした診断及び処置 Download PDFInfo
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- JP2013501224A JP2013501224A JP2012523104A JP2012523104A JP2013501224A JP 2013501224 A JP2013501224 A JP 2013501224A JP 2012523104 A JP2012523104 A JP 2012523104A JP 2012523104 A JP2012523104 A JP 2012523104A JP 2013501224 A JP2013501224 A JP 2013501224A
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- 210000001364 upper extremity Anatomy 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
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- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/041—Heterocyclic compounds
- A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
- A61K51/0459—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
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- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/60—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances involving radioactive labelled substances
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/94—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving narcotics or drugs or pharmaceuticals, neurotransmitters or associated receptors
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| PT2187965T (pt) | 2007-08-17 | 2020-01-17 | Purdue Research Foundation | Conjugados ligando-ligante de ligação a psma e métodos para utilização |
| US9951324B2 (en) | 2010-02-25 | 2018-04-24 | Purdue Research Foundation | PSMA binding ligand-linker conjugates and methods for using |
| KR20130140032A (ko) | 2010-11-12 | 2013-12-23 | 엔도사이트, 인코포레이티드 | 암을 치료하는 방법들 |
| KR20140022879A (ko) * | 2011-04-12 | 2014-02-25 | 엔도사이트, 인코포레이티드 | 고체 약학 조성물 |
| US9636413B2 (en) | 2012-11-15 | 2017-05-02 | Endocyte, Inc. | Conjugates for treating diseases caused by PSMA expressing cells |
| US20140154702A1 (en) * | 2012-11-30 | 2014-06-05 | Endocyte, Inc. | Methods For Treating Cancer Using Combination Therapies |
| US10188738B2 (en) | 2013-10-16 | 2019-01-29 | Université Libre de Bruxelles | Formulations useful in the treatment of proliferative diseases affecting the respiratory tract |
| AU2014336638C1 (en) | 2013-10-18 | 2020-09-17 | Novartis Ag | Labeled inhibitors of prostate specific membrane antigen (PSMA), their use as imaging agents and pharmaceutical agents for the treatment of prostate cancer |
| EP4541378A3 (en) | 2013-11-14 | 2025-07-30 | Endocyte, Inc. | Compounds for positron emission tomography |
| US11162937B2 (en) | 2013-11-19 | 2021-11-02 | Purdue Research Foundation | Patient selection method for inflammation |
| US10188759B2 (en) | 2015-01-07 | 2019-01-29 | Endocyte, Inc. | Conjugates for imaging |
| US20170368208A1 (en) * | 2015-01-11 | 2017-12-28 | Endocyte, Inc. | Cancer imaging agent |
| IL237525A (en) | 2015-03-03 | 2017-05-29 | Shalom Eli | Method for labeling a prostate-specific membrane antigen with a radioactive isotope |
| WO2018182776A1 (en) * | 2016-03-29 | 2018-10-04 | Endocyte, Inc. | Folate conjugate for use in targeting tumor associated macrophages |
| US10940112B2 (en) | 2016-05-04 | 2021-03-09 | L.E.A.F. Holdings Group Llc | Targeted liposomal gemcitabine compositions and methods thereof |
| CN114903890A (zh) * | 2016-05-25 | 2022-08-16 | 普渡研究基金会 | 通过靶向骨髓衍生的抑制细胞而治疗癌症的方法 |
| CN112368024A (zh) | 2018-04-17 | 2021-02-12 | 恩多塞特公司 | 治疗癌症的方法 |
| JP7604397B2 (ja) | 2019-05-20 | 2024-12-23 | エンドサイト・インコーポレイテッド | Ｐｓｍａコンジュゲートの調製方法 |
Citations (4)
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| WO2008051525A2 (en) * | 2006-10-25 | 2008-05-02 | Schering Corporation | Methods of treating ovarian cancer |
| JP2008537778A (ja) * | 2005-03-30 | 2008-09-25 | パーデュー・リサーチ・ファウンデーション | 細胞の葉酸ビタミン受容体の定量化による癌予後診断法 |
| WO2009002993A1 (en) * | 2007-06-25 | 2008-12-31 | Endocyte, Inc. | Conjugates containing hydrophilic spacer linkers |
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| AR042942A1 (es) * | 2003-01-27 | 2005-07-06 | Endocyte Inc | Conjugados de administracion de drogas de union de receptores de vitaminas |
| MX2007007471A (es) * | 2004-12-21 | 2007-07-20 | Nektar Therapeutics Al Corp | Reactivos de tiol polimericos estabilizados. |
| CN101128152A (zh) * | 2004-12-23 | 2008-02-20 | 普渡研究基金会 | 发射正电子段层成像方法 |
| CN101175757B (zh) * | 2005-03-16 | 2012-11-14 | 恩多塞特公司 | 蝶酸及其缀合物的合成和纯化 |
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| JP2008537778A (ja) * | 2005-03-30 | 2008-09-25 | パーデュー・リサーチ・ファウンデーション | 細胞の葉酸ビタミン受容体の定量化による癌予後診断法 |
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| WO2008051525A2 (en) * | 2006-10-25 | 2008-05-02 | Schering Corporation | Methods of treating ovarian cancer |
| WO2009002993A1 (en) * | 2007-06-25 | 2008-12-31 | Endocyte, Inc. | Conjugates containing hydrophilic spacer linkers |
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Also Published As
| Publication number | Publication date |
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| IL217744A0 (en) | 2012-03-29 |
| EP2460013A4 (en) | 2013-04-03 |
| NZ598145A (en) | 2014-10-31 |
| CA2769754A1 (en) | 2011-02-03 |
| RU2012105641A (ru) | 2013-09-10 |
| EP2460013A1 (en) | 2012-06-06 |
| IN2012DN01708A (OSRAM) | 2015-06-05 |
| US20120128587A1 (en) | 2012-05-24 |
| KR20120050462A (ko) | 2012-05-18 |
| CN104857534A (zh) | 2015-08-26 |
| CN102549434A (zh) | 2012-07-04 |
| WO2011014821A1 (en) | 2011-02-03 |
| AU2010278734A1 (en) | 2012-02-23 |
| US20140140925A1 (en) | 2014-05-22 |
| BR112012002064A2 (pt) | 2017-05-09 |
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