JP2013256473A5 - - Google Patents

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JP2013256473A5
JP2013256473A5 JP2012134048A JP2012134048A JP2013256473A5 JP 2013256473 A5 JP2013256473 A5 JP 2013256473A5 JP 2012134048 A JP2012134048 A JP 2012134048A JP 2012134048 A JP2012134048 A JP 2012134048A JP 2013256473 A5 JP2013256473 A5 JP 2013256473A5
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formula
hydrogen atom
compound represented
hydroxyl group
methyl group
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JP2012134048A
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JP2013256473A (en
JP6061508B2 (en
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Figure 2013256473
Figure 2013256473

Claims (5)

下記式（１）：
Figure 2013256473
 〔式中、Ｒ１〜Ｒ５及びＲ８は独立して水素原又はメチル基を示し、Ｒ６及びＲ７は水素原子、水酸基又はメチル基を示す（但し、Ｒ６及びＲ７のいずれか一方は水酸基である）。〕
で表される化合物を有効成分とするＴＲＰＡ１活性抑制剤。 Following formula (1):
Figure 2013256473
 [Wherein, R 1 to R 5 and R 8 independently represent a hydrogen atom or a methyl group, and R 6 and R 7 represent a hydrogen atom, a hydroxyl group or a methyl group (provided that any one of R 6 and R 7 One is a hydroxyl group). ]
TRPA1 activity inhibitor which uses the compound represented by these as an active ingredient. 式（１）で表される化合物が、イソボルネオール、フェンチルアルコール、ボルネオール又はメチルフェンコールである、請求項１記載のＴＲＰＡ１活性抑制剤。  The TRPA1 activity inhibitor according to claim 1, wherein the compound represented by the formula (1) is isoborneol, fentyl alcohol, borneol or methylphenchol. 下記式（１）： Following formula (1):
Figure 2013256473
Figure 2013256473
 〔式中、Ｒ[In the formula, R １1 〜Ｒ~ R ５5 及びＲAnd R ８8 は独立して水素原又はメチル基を示し、ＲIndependently represents a hydrogen atom or a methyl group, R ６6 及びＲAnd R ７7 は水素原子、水酸基又はメチル基を示す（但し、ＲRepresents a hydrogen atom, a hydroxyl group or a methyl group (provided that R represents ６6 及びＲAnd R ７7 のいずれか一方は水酸基である）。〕Any one of which is a hydroxyl group). ]
で表される化合物を有効成分とする皮膚の刺激感緩和剤。A skin irritation relieving agent comprising a compound represented by the formula: 式（１）で表される化合物が、イソボルネオール、フェンチルアルコール、ボルネオール又はメチルフェンコールである、請求項３記載の皮膚の刺激感緩和剤。  The skin irritation reducing agent according to claim 3, wherein the compound represented by the formula (1) is isoborneol, fentyl alcohol, borneol or methylphenchol. 化粧品に配合して使用される請求項３又は４記載の皮膚の刺激感緩和剤。The skin irritation mitigation agent according to claim 3 or 4, which is used in cosmetics.
JP2012134048A 2012-06-13 2012-06-13 TRPA1 activity inhibitor Active JP6061508B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2012134048A JP6061508B2 (en) 2012-06-13 2012-06-13 TRPA1 activity inhibitor

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2012134048A JP6061508B2 (en) 2012-06-13 2012-06-13 TRPA1 activity inhibitor

Publications (3)

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JP2013256473A JP2013256473A (en) 2013-12-26
JP2013256473A5 true JP2013256473A5 (en) 2014-10-09
JP6061508B2 JP6061508B2 (en) 2017-01-18

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JP2012134048A Active JP6061508B2 (en) 2012-06-13 2012-06-13 TRPA1 activity inhibitor

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Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP6410352B2 (en) * 2014-10-10 2018-10-24 花王株式会社 Irritation mitigation agent
JP6804162B2 (en) * 2018-09-14 2020-12-23 株式会社マンダム Topical skin agent

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2003206239A (en) * 2001-12-28 2003-07-22 Lion Corp Warming composition and external agent composition
JP2007077143A (en) * 2005-08-19 2007-03-29 Rohto Pharmaceut Co Ltd Acitazanolast-containing composition
CN101292976B (en) * 2008-06-26 2010-07-28 贵州宏宇药业有限公司 Medicament combination containing 1,8-eudesmin and flavanones, and uses thereof
RU2573293C2 (en) * 2010-03-26 2016-01-20 Филип Моррис Продактс С.А. Inhibition of irritating sensations in process of non-smoking tobacco products consumptions

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