JP2013234194A5 - - Google Patents

Download PDF

Info

Publication number
JP2013234194A5
JP2013234194A5 JP2013153374A JP2013153374A JP2013234194A5 JP 2013234194 A5 JP2013234194 A5 JP 2013234194A5 JP 2013153374 A JP2013153374 A JP 2013153374A JP 2013153374 A JP2013153374 A JP 2013153374A JP 2013234194 A5 JP2013234194 A5 JP 2013234194A5
Authority
JP
Japan
Prior art keywords
formula
compound
magunesato
iii
magnesium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2013153374A
Other languages
Japanese (ja)
Other versions
JP2013234194A (en
JP5646706B2 (en
Filing date
Publication date
Application filed filed Critical
Priority to JP2013153374A priority Critical patent/JP5646706B2/en
Priority claimed from JP2013153374A external-priority patent/JP5646706B2/en
Publication of JP2013234194A publication Critical patent/JP2013234194A/en
Priority to PCT/JP2014/068386 priority patent/WO2015012110A1/en
Priority to TW103125071A priority patent/TW201602128A/en
Publication of JP2013234194A5 publication Critical patent/JP2013234194A5/ja
Application granted granted Critical
Publication of JP5646706B2 publication Critical patent/JP5646706B2/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Claims (3)

式（Ｉ）：
Figure 2013234194
 で示される化合物とマグネシウムアート錯体との臭素・マグネシウム交換反応によってアリールマグネサートを得ること；
得られたアリールマグネサートを、式（ＩＩ）：
Figure 2013234194
 ［式中、ＴＭＳはトリメチルシリル基を示す］
で示される化合物と反応させて、更にＨ＋／ＭｅＯＨで処理し脱ＴＭＳ化とメトキシ化を行うことで、式（ＩＩＩ）：
Figure 2013234194
 ［式中、Ｍｅはメチル基を示す］
で示される化合物を得ること、
を含む、式（ＩＩＩ）の化合物の製造方法。 Formula (I):
Figure 2013234194
 In the bromine-magnesium exchange reaction between the compound and the magnesium ate complex represented to obtain aryl Magunesato;
The resulting aryl Magunesato, formula (II):
Figure 2013234194
 [Wherein TMS represents a trimethylsilyl group]
In shown is reacted with a compound, further by performing the H + / MeOH treated with de-TMS reduction and methoxylation, formula (III):
Figure 2013234194
 [Wherein Me represents a methyl group]
To obtain a compound represented by
A process for the preparation of a compound of formula (III). 前記マグネシウムアート錯体が、リチウムトリ（ｎ−ブチル）マグネサートである、請求項１に記載の方法。   The method of claim 1, wherein the magnesium ate complex is lithium tri (n-butyl) magnesate. 式（Ｉ）：
Figure 2013234194
 で示される化合物とマグネシウムアート錯体との臭素・マグネシウム交換反応によってアリールマグネサートを得ること；
得られたアリールマグネサートを、式（ＩＩ）：
Figure 2013234194
 ［式中、ＴＭＳはトリメチルシリル基を示す］
で示される化合物と反応させて、更にＨ＋／ＭｅＯＨで処理し脱ＴＭＳ化とメトキシ化を行うことで、式（ＩＩＩ）：
Figure 2013234194
 ［式中、Ｍｅはメチル基を示す］
で示される化合物を得ること；
式（ＩＩＩ）の化合物から−ＯＭｅ基を脱離させること；
を含む、式（ＩＶ）：
Figure 2013234194
 の化合物の製造方法。
Formula (I):
Figure 2013234194
 In the bromine-magnesium exchange reaction between the compound and the magnesium ate complex represented to obtain aryl Magunesato;
The resulting aryl Magunesato, formula (II):
Figure 2013234194
 [Wherein TMS represents a trimethylsilyl group]
Is reacted with a compound represented by formula (III): and further treated with H + / MeOH to perform deTMS and methoxylation.
Figure 2013234194
 [Wherein Me represents a methyl group]
To obtain a compound represented by:
Removing the -OMe group from the compound of formula (III);
Including formula (IV):
Figure 2013234194
 A method for producing the compound.
JP2013153374A 2013-07-24 2013-07-24 Method for producing C-glycoside derivative Expired - Fee Related JP5646706B2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP2013153374A JP5646706B2 (en) 2013-07-24 2013-07-24 Method for producing C-glycoside derivative
PCT/JP2014/068386 WO2015012110A1 (en) 2013-07-24 2014-07-10 Method for manufacturing c-glycoside derivative
TW103125071A TW201602128A (en) 2013-07-24 2014-07-22 Method for manufacturing c-glycoside derivative

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2013153374A JP5646706B2 (en) 2013-07-24 2013-07-24 Method for producing C-glycoside derivative

Publications (3)

Publication Number Publication Date
JP2013234194A JP2013234194A (en) 2013-11-21
JP2013234194A5 true JP2013234194A5 (en) 2014-10-30
JP5646706B2 JP5646706B2 (en) 2014-12-24

Family

ID=49760574

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2013153374A Expired - Fee Related JP5646706B2 (en) 2013-07-24 2013-07-24 Method for producing C-glycoside derivative

Country Status (3)

Country Link
JP (1) JP5646706B2 (en)
TW (1) TW201602128A (en)
WO (1) WO2015012110A1 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015101916A1 (en) 2013-12-30 2015-07-09 Mylan Laboratories Ltd. Process for the preparation of empagliflozin
CN106188022A (en) * 2015-04-30 2016-12-07 上海医药工业研究院 The preparation method that Yi Gelie is clean
JP2022028986A (en) * 2018-12-17 2022-02-17 株式会社トクヤマ Method for producing c-arylhydroxy glycoxide derivative
WO2020129899A1 (en) * 2018-12-17 2020-06-25 株式会社トクヤマ Method for producing c-aryl hydroxy glycoxide derivatives
EP4249462A4 (en) 2020-11-18 2024-10-16 Tokuyama Corp Method for producing ketone derivative

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL1609785T3 (en) * 2003-03-14 2016-07-29 Astellas Pharma Inc C-glycoside derivatives and salts thereof
KR101100072B1 (en) * 2006-12-21 2011-12-29 고토부키 세이야쿠 가부시키가이샤 Method for producing C-glycoside derivative and intermediate for synthesis thereof
EP2125768A1 (en) * 2007-02-21 2009-12-02 Boehringer Ingelheim International GmbH Tetrasubstituted glucopyranosylated benzene derivatives, medicaments containing such compounds, their use and process for their manufacture
AU2009270936B2 (en) * 2008-07-15 2014-12-18 Theracos, Inc. Deuterated benzylbenzene derivatives and methods of use

Similar Documents

Publication Publication Date Title
JP2013234194A5 (en)
JP2009138000A5 (en)
JP2015518463A5 (en)
JP2015129106A5 (en)
JP2010174033A5 (en)
JP2009149903A5 (en)
JP2010095546A5 (en)
JP2011518833A5 (en)
JP2013136051A5 (en) Method of removing one or more metals from a medium containing metals
JP2016188255A5 (en)
JP2013532130A5 (en)
JP2012149068A5 (en)
JP2012094862A5 (en)
JP2011116782A5 (en)
JP2017515919A5 (en)
JP2014528463A5 (en)
JP2011037885A5 (en)
JP2019048806A5 (en)
JP2013518047A5 (en)
JP2007045816A5 (en) Carbazole derivative, preparation method of anthracene derivative used as material for light emitting device
JP2011192640A5 (en)
JP2017533926A5 (en)
JP2013100237A5 (en)
JP2016516744A5 (en)
JP2014520075A5 (en)