JP2013233333A - Unit and system for purifying blood - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a unit for purifying blood which prevents an increase in risk of a thrombus while suppressing the amount of escaping blood stream to a low value.SOLUTION: A unit 100 for purifying blood is used for a system 1 for purifying blood which performs purification of blood. The system 1 for purifying blood includes a bypass circuit 40 connected to a part of an artery-side circuit 20 and to a part of a vein-side circuit 30 in a manner to bypass a blood purifier 10. The unit 100 has at least a blood pump 120 which is so constituted that it can be disposed at a position located in a region from an escaping blood port 26 to the portion of connection with the bypass circuit 40 in the artery-side circuit 20, and is provided for sending the blood on the artery-side circuit 20 toward the blood purifier 10, a pump 122 for the bypass circuit which is so constituted that it can be disposed on the bypass circuit 40 and is provided for sending the blood on the bypass circuit 40 toward the side of the artery-side circuit 20 from the side of the vein-side circuit 30, and a control part 150 which controls driving of each of the pumps 120 and 122.

Description

  The present invention relates to a blood purification system for purifying blood and a blood purification apparatus used therefor.

  Conventionally, blood purification therapy such as continuous hemodiafiltration (CHDF) has been performed in order to purify the blood of patients with acute renal failure, for example. Many have been developed (see, for example, Patent Documents 1 and 2).

Japanese Unexamined Patent Publication No. 2001-541 Japanese Unexamined Patent Publication No. 2003-126247

  By the way, in the medical field, there is a case where it is desired to suppress the blood flow to be removed according to the age and condition of the patient (hereinafter referred to as blood removal) to a low value of about 1 to 30 mL / min. In that case, the blood flow rate can be reduced by using a pump excellent in flow rate control at a low flow rate as a blood pump.

  However, if a low-flow pump is used as a blood pump, the blood flow velocity in the entire extracorporeal circuit also decreases, which may cause blood to coagulate in the blood purifier and increase the risk of blood clots. Is done.

  Accordingly, the present invention has been made to solve such a problem, and provides a blood purification device and a blood purification system that do not increase the risk of thrombus generation while suppressing the blood removal rate to a low value. Objective.

  A blood purification apparatus (100) according to the present invention is a blood purification apparatus used in a blood purification system (1) for performing blood purification, and the blood purification system (1) includes a blood purification device (10) and a removal device. An artery side circuit (20) having a blood port (26) and connected to the blood purifier (10), and a vein having a blood return port (36) and connected to the blood purifier (10) A bypass circuit (40) connected to a part of the arterial circuit (20) and a part of the venous circuit (30) so as to bypass the side circuit (30) and the blood purifier (10) And a blood purification device (100) having at least a plurality of pumps (120, 122) and a control unit (150) for controlling the driving of the plurality of pumps. As a pump, before the arterial circuit (20) In order to send the liquid on the artery side circuit (20) toward the blood purifier (10), which can be arranged at a position from the blood removal port (26) to the connection portion with the bypass circuit (40). The blood pump (120) and the bypass circuit (40) can be disposed, and the fluid on the bypass circuit (40) is allowed to flow from the venous circuit (30) side to the arterial circuit (20). And a bypass circuit pump (122) for sending toward the side.

  According to the blood purification apparatus of the present invention, since the bypass circuit pump is provided, a part of blood flowing through the venous circuit is drawn into the bypass circuit by the bypass circuit pump. The blood drawn into the bypass circuit passes through the bypass circuit, eventually reaches the connection with the arterial circuit, and returns to the venous circuit again via the arterial circuit and blood purifier. The flow rate of blood flowing through the blood purifier at that time is approximately equal to the original flow rate of the blood pump plus the flow rate of the bypass circuit pump. On the other hand, the amount of blood removal depends on the flow rate of the blood pump, and does not depend on the flow rate of the bypass circuit pump disposed on a circuit different from the artery side circuit. That is, by using the blood purification apparatus of the present invention in a blood purification system including a bypass circuit, it is possible to increase the flow rate of blood flowing through the blood purification device while keeping the flow rate of the blood pump at a low value. If the flow rate of the blood flowing through the blood purifier is increased, the blood is less likely to clot in the blood purifier, so that the risk of blood clots does not increase.

  Therefore, the blood purification apparatus of the present invention is a blood purification apparatus that does not increase the risk of thrombus generation while suppressing the blood removal rate to a low value.

  In the blood purification apparatus (100) of the present invention, the low-flow mode in which the bypass pump (122) is stopped while the blood pump (120) is driven by an external operation, and the blood pump (120) and further includes a mode selection unit (148) for selecting one of the high flow rate modes for driving the bypass circuit pump (122), and the control unit (150) includes the mode selection unit (148). It is preferable to further have a mode corresponding function for controlling the driving of the blood pump (120) and the bypass circuit pump (122) in accordance with the mode selected by (1).

  With this configuration, switching operation between the low flow rate mode and the high flow rate mode can be performed.

  In the blood purification device (100) of the present invention, the first occlusion means (130) configured to be electrically occluded / opened in the vicinity of the connection portion between the bypass circuit (40) and the artery side circuit (20). A second closing means (132) configured to electrically close and open the vicinity of the connection portion of the bypass circuit (40) with the vein side circuit (30), and the control unit (150) includes: The control unit (150) further includes a blocking unit control function for controlling a closing / opening operation of the first blocking unit (130) and the second blocking unit (132), and the control unit (150) includes the mode selection unit (148). When the low flow rate mode is selected by the control, the first closing means (130) and the second closing means (132) are controlled so as to close each part of the bypass circuit (40), and the mode selection part 148), when the high flow rate mode is selected, it is preferable to control the first closing means (130) and the second closing means (132) so as to open each part of the bypass circuit (40). .

  With this configuration, when the low flow rate mode is selected, the flow to the bypass circuit can be cut off, and a smooth flow from the artery side circuit to the blood purifier can be formed. On the other hand, when the high flow rate mode is selected, the blocking state of the bypass circuit is released, so that the inflow of blood into the bypass circuit is not hindered by each blocking means.

  In the blood purification apparatus (300) of the present invention, the bypass circuit pump (122) is a roller pump, and the fluid on the bypass circuit (40) is supplied from the arterial circuit (20) side to the vein. It is preferable to be configured so that it can be sent toward the side circuit (30).

  Although details will be described later, by configuring as described above, for example, only the blood purifier can be replaced while performing extracorporeal circulation, or two blood purifiers having the same or different performance can be used properly. For example, it is possible to derive a new effect that cannot be considered in the past.

  The blood purification system (1) of the present invention is a blood purification system for purifying blood, and has a blood purification device (10) and a blood removal port (26). The artery side circuit (20) to be connected and the blood return port (36) have a venous side circuit (30) connected to the blood purifier (10) and bypass the blood purifier (10). Thus, at least a bypass circuit (40) connected to a part of the artery side circuit (20) and a part of the vein side circuit (30), and the blood purification apparatus (100) of the present invention are provided.

  For this reason, according to the blood purification system of the present invention, since the excellent blood purification apparatus of the present invention is provided, the blood purification system does not increase the risk of thrombus generation while suppressing the blood removal rate to a low value. .

  According to the blood purification apparatus of the present invention, it is possible to provide a blood purification apparatus that does not increase the risk of thrombus generation while suppressing the blood removal rate to a low value.

  In addition, although each member etc. which were described in the claim is attached | subjected with the code | symbol in parenthesis in order to make an understanding of an invention easy, this invention is limitedly interpreted based on those code | symbols. Absent.

FIG. 1 is a diagram for explaining a blood purification system 1 according to the first embodiment. FIG. 2 is a block diagram showing an electrical configuration of the blood purification apparatus 100 according to the first embodiment. FIG. 3 is a view for explaining the operation mode of the blood purification apparatus 100. FIG. 3A is a diagram for explaining the operation of the pumps 120 and 122 and the closing means 130 and 132 when the low flow rate mode is selected, and FIG. 3B is the selection of the high flow rate mode. It is a figure shown in order to demonstrate operation | movement of each pump 120,122 and each obstruction | occlusion means 130,132 when it is carried out. FIG. 4 is a view for explaining the blood purification system 2 according to the second embodiment. FIG. 5 is a block diagram showing an electrical configuration of the blood purification apparatus 200 according to the second embodiment. FIG. 6 is a diagram for explaining the blood purification system 3 according to the third embodiment. FIG. 7 is a block diagram showing an electrical configuration of the blood purification apparatus 300 according to the third embodiment. FIG. 8 is a diagram for explaining the operation mode of blood purification apparatus 300.

  Hereinafter, a blood purification device and a blood purification system of the present invention will be described based on the embodiments shown in the drawings.

[First Embodiment]
First, the structure of the blood purification system 1 and the blood purification apparatus 100 which concern on 1st Embodiment is demonstrated using FIG.1 and FIG.2.
FIG. 1 is a diagram for explaining a blood purification system 1 according to the first embodiment. FIG. 2 is a block diagram showing an electrical configuration of the blood purification apparatus 100 according to the first embodiment.

  As shown in FIG. 1, the blood purification system 1 according to the first embodiment bypasses the blood purifier 10, the artery side circuit 20 and the vein side circuit 30 connected to the blood purifier 10, and the blood purifier 10. As shown, a bypass circuit 40 connected to a part of the arterial circuit 20 and a part of the venous circuit 30 and a blood purification device 100 (see FIG. 2) are provided. The blood purification system 1 is a blood purification system for implementing, for example, blood adsorption therapy (HA).

  The blood purifier 10 is a so-called adsorptive blood purifier, although detailed explanation by illustration is omitted, and inside the cylindrical housing, unnecessary substances, toxic substances, excessive drugs, etc. from the flowing blood are introduced. An adsorbent column for removal is arranged. The housing is provided with a blood inflow portion 12 through which blood flows and a blood outflow portion 14 through which blood that has passed through the adsorbent column flows out.

  The arterial circuit 20 is connected to the blood inlet 12 of the blood purifier 10. An air trap 22 and a rolling tube portion 24 are provided in the middle of the artery side circuit 20. A blood removal port 26 for introducing blood from a patient is provided at the opposite end of the arterial circuit 20 to the connection with the blood purifier 10. Although not shown in FIG. 1, an anticoagulant injection line for introducing an anticoagulant into the circuit is connected to the middle of the artery side circuit 20.

  The venous circuit 30 is connected to the blood outflow part 14 of the blood purifier 10. An air trap 32 is provided in the middle of the venous circuit 30. A blood return port 36 for returning blood to the patient is provided at the end of the vein side circuit 30 opposite to the connection with the blood purifier 10. Although not shown in FIG. 1, a bubble detector is provided in the middle of the venous circuit 30, and a pressure sensor is connected to the air trap 32.

  One end of the bypass circuit 40 is connected to a position from the rolling tube portion 24 to the air trap 22 in the artery side circuit 20. The other end portion of the bypass circuit 40 is connected to a position from the connection portion with the blood purifier 10 to the air trap 32 in the vein side circuit 30. A rolling tube portion 44 is provided in the middle of the bypass circuit 40.

  As shown in FIGS. 1 and 2, the blood purification apparatus 100 directs the blood on the artery side circuit 20 toward the blood purification device 10 and the blood on the bypass circuit 40 in a predetermined direction. The first occlusion means 130 configured to be electrically occluded / opened in the vicinity of the connection portion between the bypass circuit pump 122 and the artery side circuit 20 in the bypass circuit 40, and the vein side circuit 30 in the bypass circuit 40 The second closing means 132 configured to be electrically occluded / openable in the vicinity of the connecting portion, the power supply unit 140 for supplying power to each part in the blood purification apparatus 100, and various operations from the operator An operation unit 142, a display unit 144 that displays various information such as temperature information of blood flowing in the circuit and pressure information measured by a pressure sensor, a storage unit 146 that stores various types of information, and a mode It includes a selection unit 148, and a control unit 150 for generally controlling the respective units of the blood purification apparatus 100.

  The blood pump 120 is a so-called roller pump, and employs a pump excellent in flow rate control at a low flow rate. Although explanation by illustration is omitted, the blood in the artery side circuit 20 is rotated by rotating the roller part of the blood pump 120 in contact with the rolling tube part 24 of the artery side circuit 20 (handles the rolling tube part 24). Can be fed in a predetermined direction.

  The bypass circuit pump 122 is also a roller pump as in the case of the blood pump 120, and rotates while the roller portion of the bypass circuit pump 122 is in contact with the rolling tube portion 44 of the bypass circuit 40 (the rolling tube portion 44 is The blood in the bypass circuit 40 can be sent in a predetermined direction.

  The first closing means 130 and the second closing means 132 are electric clamp members provided so as to sandwich a part of each circuit. The first closing means 130 and the second closing means 132 are configured such that a part of each circuit can be electrically closed / opened according to an instruction from the control unit 150.

  Although not illustrated, the blood pump 120, the bypass circuit pump 122, the first closing means 130, and the second closing means 132 are disposed on the outer surface of the blood purification apparatus 100.

  Although the detailed description by illustration is abbreviate | omitted, the operation part 142 is comprised so that the flow value of each pump can be set and input, and the operation mode of the blood purification apparatus 100 can be selected and operated. The operation mode will be described later in detail.

  Although the description by illustration is abbreviate | omitted, the operation part 142 and the display part 144 are arrange | positioned at the housing | casing outer surface of the blood purification apparatus 100. FIG. The operation unit 142 and the display unit 144 may be configured as separate bodies, or may be a touch panel display in which an input part and a display part are integrated, for example.

  The storage unit 146 stores information such as the performance data of the blood purifier 10 used and the flow rate values of the blood pump 120 and the bypass circuit pump 122.

  The mode selection unit 148 outputs information related to the mode to the control unit 150 according to the mode selected by the operation unit 142.

  The control unit 150 controls the driving of the blood pump 120 and the bypass circuit pump 122 (pump drive control function) and the mode selected by the mode selection unit 148 and the blood pump 120 and the bypass circuit pump 122. At least a function for controlling the driving (mode corresponding function) and a function for controlling the closing / opening operation of the first closing means 130 and the second closing means 132 (closing means control function).

Next, the operation mode of the blood purification apparatus 100 will be described with reference to FIG.
FIG. 3 is a view for explaining the operation mode of the blood purification apparatus 100. FIG. 3A is a diagram for explaining the operation of the pumps 120 and 122 and the closing means 130 and 132 when the low flow rate mode is selected, and FIG. 3B is the selection of the high flow rate mode. It is a figure shown in order to demonstrate operation | movement of each pump 120,122 and each obstruction | occlusion means 130,132 when it is carried out.

  In the blood purification apparatus 100, as a selectable operation mode, a “low flow mode” in which the drive of the bypass circuit pump 122 is stopped in a state where the blood pump 120 is driven, and the bypass circuit pump 122 together with the blood pump 120 are also provided. There are two "high flow modes" to drive.

  When the “low flow rate mode” is selected by the operation unit 142, the mode selection unit 148 outputs information related to the mode to the control unit 150. The control unit 150 that has received the information controls each unit so that only the blood pump 120 is driven in a state in which the closing means 130 and 132 are closed as shown in FIG. Thereby, the blood flowing through the artery side circuit 20 flows through the blood purifier 10 to the vein side circuit 30 without passing through the bypass circuit 40. At this time, since the blood pump 120 is driven at a relatively low flow rate, the blood removal rate can be suppressed to a low value.

  On the other hand, when the “high flow rate mode” is selected by the operation unit 142, the mode selection unit 148 outputs information related to the mode to the control unit 150. Upon receiving the information, the control unit 150 controls each unit so as to drive both the blood pump 120 and the bypass circuit pump 122 with the closing means 130 and 132 opened, as shown in FIG. To do. At this time, the bypass circuit pump 122 is driven and controlled so as to send blood from the venous circuit 30 side to the arterial circuit 20 side. Thereby, the blood flowing through the artery side circuit 20 reaches the venous circuit 30 through the blood purifier 10, and a part of the blood flowing through the venous circuit 30 is drawn into the bypass circuit 40 by the bypass circuit pump 122. Will be. The blood drawn into the bypass circuit 40 passes through the bypass circuit 40 and eventually merges with the arterial circuit 20. The merged blood reaches the venous circuit 30 through the blood purifier 10 again.

  According to the blood purification apparatus 100 according to the first embodiment configured as described above, since the bypass circuit pump 122 is provided, the blood from the patient follows the route shown in FIG. The flow rate of blood flowing through the blood purifier 10 is approximately equal to the original flow rate of the blood pump 120 plus the flow rate of the bypass circuit pump 122. On the other hand, the amount of blood removal depends on the flow rate of the blood pump 120 and does not depend on the flow rate of the bypass circuit pump 122 arranged on a circuit different from the artery side circuit 20. That is, by using the blood purification apparatus 100 including the bypass circuit pump 122 in the blood purification system 1 including the bypass circuit 40, the flow rate of the blood flowing through the blood purifier 10 while keeping the flow rate of the blood pump 120 at a low value. Can be accelerated. If the flow velocity of the blood flowing through the blood purifier 10 is increased, the blood is less likely to coagulate in the blood purifier 10, so that the risk of blood clots does not increase.

  Therefore, the blood purification apparatus 100 according to the first embodiment is a blood purification apparatus that does not increase the risk of thrombus generation while suppressing the blood removal rate to a low value.

  In the blood purification apparatus 100 according to the first embodiment, since the control unit 150 has the above-described mode-compatible function, it is possible to perform a switching operation between the low flow rate mode and the high flow rate mode.

  In the blood purification device 100 according to the first embodiment, when the low flow rate mode is selected by the mode selection unit 148, the control unit 150 closes the first blocking unit 130 and the first blocking unit 130 so as to block each part of the bypass circuit 40. When the high flow rate mode is selected by the mode selection unit 148, the first closing unit 130 and the second closing unit 132 are controlled so as to open each part of the bypass circuit 40. Thereby, when the low flow rate mode is selected, the flow to the bypass circuit 40 can be cut off, and a smooth flow from the artery side circuit 20 to the blood purifier 10 can be formed. On the other hand, when the high flow mode is selected, the blocking state of the bypass circuit 40 is released, so that the inflow of blood into the bypass circuit 40 is not hindered by the blocking means 130 and 132.

  Since the blood purification system 1 according to the first embodiment includes the blood purification device 100 described above, the blood purification system 1 does not increase the risk of thrombosis while suppressing the blood removal rate to a low value.

[Second Embodiment]
FIG. 4 is a view for explaining the blood purification system 2 according to the second embodiment. FIG. 5 is a block diagram showing an electrical configuration of the blood purification apparatus 200 according to the second embodiment.

  As shown in FIG. 4, the blood purification system 2 according to the second embodiment bypasses the blood purification device 50, the artery side circuit 20 and the vein side circuit 30 connected to the blood purification device 50, and the blood purification device 50. As described above, a detour circuit 40 connected to a part of the arterial circuit 20 and a part of the venous circuit 30, and a waste liquid circuit connected to the blood purifier 50 and through which the waste liquid from the second outflow part 56 passes. 60, a storage liquid circuit 70 connected in the middle of the venous circuit 30, a storage container 72, and a blood purification device 200 (see FIG. 5). The blood purification system 2 is a blood purification system for performing, for example, simple plasma exchange (PE).

  The blood purifier 50 is a so-called membrane-type blood purifier, although detailed description thereof is omitted, and is a selective separation membrane that separates inflowing blood into a blood cell component and a plasma component inside a cylindrical housing. Is arranged. The housing is separated by a blood inflow portion 52 into which blood flows, a first outflow portion 54 through which a liquid mainly containing blood cell components out of the blood separated by the selective separation membrane, and the selective separation membrane. A second outflow portion 56 through which a liquid mainly containing plasma components out of blood flows out is provided.

  The artery side circuit 20 is connected to the blood inflow portion 52 of the blood purifier 50. The venous circuit 30 is connected to the first outflow part 54 of the blood purifier 50. One end of the bypass circuit 40 is connected to a position from the rolling tube portion 24 to the air trap 22 in the artery side circuit 20, and the other end is connected to the blood purifier 50 in the vein side circuit 30. It is connected to a position from the part to the air trap 32. The configurations of the arterial circuit 20, the venous circuit 30, and the bypass circuit 40 have been described in the first embodiment, and thus detailed description thereof is omitted.

  A rolling tube portion 74 is provided in the middle of the storage liquid circuit 70. The end of the reservoir circuit 70 is connected to the air trap 32 of the venous circuit 30.

  The storage container 72 is, for example, a plastic storage bag. As the liquid stored in the storage container 72, fresh frozen plasma (FFP) as a replacement liquid, a 5% to 25% albumin solution, or the like can be suitably used.

  As shown in FIG. 5, the blood purification apparatus 200 according to the second embodiment has basically the same configuration as the blood purification apparatus 100 (see FIG. 2) according to the first embodiment, but the waste liquid pump 224. And the replacement fluid pump 226 is different from the blood purification device 100 according to the first embodiment.

  The waste liquid pump 224 and the replacement liquid pump 226 are so-called roller pumps, similarly to the other blood pump 220 and the bypass circuit pump 222. The blood pump 220 and the bypass circuit pump 222 are the same as the blood pump 120 and the bypass circuit pump 122 described in the first embodiment, and thus description thereof is omitted.

  The control unit 250 controls the drive of the four pumps 220 to 226 (pump drive control function) and the function of controlling the drive of the four pumps 220 to 226 according to the mode selected by the mode selection unit 248. (Mode corresponding function) and at least a function (blocking means control function) for controlling the closing / opening operation of the first closing means 230 and the second closing means 232.

  In addition, about other members, such as the 1st obstruction | occlusion means 230, since it is the same as that of the corresponding member demonstrated in 1st Embodiment, description is abbreviate | omitted.

  As described above, the blood purification apparatus 200 according to the second embodiment differs from the blood purification apparatus 100 according to the first embodiment in that it includes the waste liquid pump 224 and the replacement liquid pump 226, but the first embodiment. Since the bypass circuit pump 222 is provided in the same manner as in the case of the blood purification apparatus 100 according to the present invention, the blood pump 220 is provided by using the blood purification apparatus 200 according to the second embodiment in the blood purification system 2 including the bypass circuit 40. The flow rate of the blood flowing through the blood purifier 50 can be increased while the flow rate of the blood is kept at a low value. If the flow velocity of the blood flowing through the blood purifier 50 is accelerated, the blood is less likely to coagulate in the blood purifier 50, so that the risk of blood clots does not increase.

  Therefore, the blood purification apparatus 200 according to the second embodiment is a blood purification apparatus that does not increase the risk of thrombus generation while suppressing the blood removal rate to a low value.

  The blood purification apparatus 200 according to the second embodiment has the same configuration as that of the blood purification apparatus 100 according to the first embodiment except that the blood purification apparatus 200 includes the waste liquid pump 224 and the replacement liquid pump 226, and thus the first embodiment. Among the effects of the blood purification apparatus 100 according to the above, the corresponding effects are directly provided.

  Since the blood purification system 2 according to the second embodiment includes the blood purification device 200 described above, the blood purification system 2 does not increase the risk of thrombus generation while suppressing the blood removal rate to a low value.

[Third Embodiment]
FIG. 6 is a diagram for explaining the blood purification system 3 according to the third embodiment. FIG. 7 is a block diagram showing an electrical configuration of the blood purification apparatus 300 according to the third embodiment. FIG. 8 is a diagram for explaining the operation mode of blood purification apparatus 300.
6 and 7, the same members as those in FIGS. 1 and 2 are denoted by the same reference numerals, and detailed description thereof is omitted.

  The blood purification apparatus 300 according to the third embodiment basically has the same configuration as the blood purification apparatus 100 according to the first embodiment, as can be seen from FIGS. 6 and 7, but selectable operation modes. However, it is different from the blood purification apparatus 100 according to the first embodiment.

  In the blood purification apparatus 300, as selectable operation modes, in addition to the “low flow mode” and the “high flow mode” described in the first embodiment (see FIGS. 3A and 3B). There is a “detour mode” in which the blood on the bypass circuit 40 is sent from the arterial circuit 20 side to the venous circuit 30 side.

  When the “detour mode” is selected by the operation unit 142, the mode selection unit 348 outputs information related to the mode to the control unit 350. Upon receiving the information, the control unit 350 controls each unit so as to drive both the blood pump 120 and the bypass circuit pump 122 in a state where the respective blocking means 130 and 132 are opened, as shown in FIG. At this time, the bypass circuit pump 122 is driven and controlled so as to send blood from the arterial circuit 20 side toward the venous circuit 30 side. As a result, most of the blood flowing through the artery side circuit 20 passes through the bypass circuit 40 and joins with the vein side circuit 30. Note that when the “detour mode” is selected and the locations indicated by reference signs A1 and A2 shown in FIG. 8 are closed with forceps or the like, blood does not flow through the blood purifier 10.

  As described above, the blood purification apparatus 300 according to the third embodiment differs from the blood purification apparatus 100 according to the first embodiment in selectable operation modes, but in the case of the blood purification apparatus 100 according to the first embodiment. Since the bypass circuit pump 122 is provided in the same manner as described above, by using the blood purification apparatus 300 including the bypass circuit pump 122 in the blood purification system 3 including the bypass circuit 40, the flow rate of the blood pump 120 is suppressed to a low value. It is possible to speed up the flow rate of the blood flowing through the blood purifier 10 without any change. If the flow velocity of the blood flowing through the blood purifier 10 is increased, the blood is less likely to coagulate in the blood purifier 10, so that the risk of blood clots does not increase.

  Therefore, the blood purification apparatus 300 according to the third embodiment is a blood purification apparatus that does not increase the risk of thrombus generation while suppressing the blood removal rate to a low value.

  As described above, the blood purification apparatus 300 according to the third embodiment is configured to be able to select the “detour mode”. Therefore, for example, when some trouble occurs in the blood purifier 10, the “detour mode” is set. In the selected state, the locations indicated by reference signs A1 and A2 shown in FIG. 8 are closed with forceps or the like, so that the blood flow into the blood purifier 10 is temporarily maintained while the blood removal / return line is secured. It can be avoided.

  By the way, in the “bypass mode”, the blood flow through the bypass circuit 40 is in the opposite direction to the “high flow mode”. However, in the blood purification apparatus 300 according to the third embodiment, the bypass circuit pump 122 is a roller. Since it is a pump, the flow of the detour circuit 40 can be reversed by reversing the rotation of the roller part forward and backward. That is, it is possible to realize relatively smooth mode switching from the “high flow mode” to the “detour mode” or from the “detour mode” to the “high flow mode”.

  The blood purification apparatus 300 according to the third embodiment has the same configuration as the blood purification apparatus 100 according to the first embodiment except that selectable operation modes are different, and thus the blood purification apparatus according to the first embodiment. 100 has the corresponding effect as it is.

  Since the blood purification system 3 according to the third embodiment includes the blood purification device 300 described above, the blood purification system 3 does not increase the risk of thrombus generation while suppressing the blood removal rate to a low value.

  As mentioned above, although the blood purification apparatus and the blood purification system of this invention were demonstrated based on said embodiment, this invention is not limited to said embodiment, In various aspects in the range which does not deviate from the summary. For example, the following modifications are possible.

(1) In the above embodiment, a case where a so-called roller pump is used as each pump has been described as an example. However, the present invention is not limited to this, and other known pumps such as a syringe pump are known. The liquid feeding means may be used.

(2) In the above embodiment, the case where the present invention is applied to a blood purification system for performing blood adsorption therapy or simple plasma exchange therapy has been described as an example, but the present invention is limited to this. is not. For example, the present invention can be applied to other blood purification therapies such as a double membrane plasmapheresis (DFPP).

(3) In the above-described embodiment, the first closing means and the second closing means have been described by exemplifying the clamp members configured to electrically close and open each circuit, but the present invention is limited to this. It is not something. For example, even when other closing means such as forceps are used, it goes without saying that they are included in the scope of the present invention.

1, 2, 3 Blood purification system 10, 50 Blood purifier 12, 52 Blood inflow section 14 Blood outflow section 20 Arterial circuit 22, 32 Air trap 24, 44, 64, 74 Rolling tube section 26 Blood removal port 30 Vein side Circuit 36 Blood return port 40 Bypass circuit 54 First outflow part 56 Second outflow part 60 Waste liquid circuit 70 Reservoir circuit 72 Reservoir container 100, 200, 300 Blood purification apparatus 120, 220 Blood pump 122, 222 Bypass circuit pump 130, 230 1st closing means 132,232 2nd closing means 140,240 Power supply part 142,242 Operation part 144,244 Display part 146,246 Storage part 148,248,348 Mode selection part 150,250,350 Control part 224 Waste liquid pump 226 Replacement fluid pump

Claims (5)

A blood purification apparatus for use in a blood purification system (1) for performing blood purification,
The blood purification system (1)
A blood purifier (10);
An arterial circuit (20) having a blood removal port (26) and connected to the blood purifier (10);
A venous circuit (30) having a blood return port (36) and connected to the blood purifier (10);
A bypass circuit (40) connected to a part of the artery side circuit (20) and a part of the vein side circuit (30) so as to bypass the blood purifier (10);
A system comprising at least a plurality of pumps (120, 122) and a blood purification device (100) having a control unit (150) for controlling driving of the plurality of pumps,
The blood purification apparatus, as the plurality of pumps,
The arterial circuit (20) is configured to be disposed at a position from the blood removal port (26) to the connection portion with the bypass circuit (40), and the liquid on the arterial circuit (20) is supplied to the blood A blood pump (120) for delivery to the purifier (10);
The detour is configured to be arranged on the detour circuit (40), and sends the liquid on the detour circuit (40) from the venous circuit (30) to the arterial circuit (20). A blood purification device (100) having at least a circuit pump (122). The blood purification apparatus according to claim 1, wherein
The bypass circuit pump (122) together with the blood pump (120) and the low flow rate mode in which the drive of the bypass circuit pump (122) is stopped in a state where the blood pump (120) is driven by an external operation. A mode selection unit (148) for selecting any one of the high flow modes for driving
The control unit (150) further has a mode-corresponding function for controlling the driving of the blood pump (120) and the bypass circuit pump (122) according to the mode selected by the mode selection unit (148). Blood purification apparatus (100). The blood purification apparatus according to claim 2,
A first occlusion means (130) configured to be electrically occluded / opened in the vicinity of a connection portion between the bypass circuit (40) and the artery side circuit (20);
A second occlusion means (132) configured to be electrically occluded / openable in the vicinity of the connection portion with the venous circuit (30) in the bypass circuit (40);
The controller (150) further has a closing means control function for controlling the closing / opening operation of the first closing means (130) and the second closing means (132),
The control unit (150)
When the low flow rate mode is selected by the mode selection unit (148), the first closing means (130) and the second closing means (132) are closed so as to close each part of the bypass circuit (40). Control
When the high flow rate mode is selected by the mode selection unit (148), the first closing means (130) and the second closing means (132) are opened so as to open each part of the bypass circuit (40). A blood purification device (100) to be controlled. In the blood purification apparatus as described in any one of Claims 1-3,
The bypass circuit pump (122) is a roller pump, and sends the liquid on the bypass circuit (40) from the artery side circuit (20) side toward the vein side circuit (30) side. A blood purification apparatus (300) configured to be able to. A blood purification system for purifying blood,
A blood purifier (10);
An arterial circuit (20) having a blood removal port (26) and connected to the blood purifier (10);
A venous circuit (30) having a blood return port (36) and connected to the blood purifier (10);
A bypass circuit (40) connected to a part of the artery side circuit (20) and a part of the vein side circuit (30) so as to bypass the blood purifier (10);
A blood purification system (1) comprising at least the blood purification device (100) according to any one of claims 1 to 4.