JP2013129611A - Antibacterial and antifungal composition and wet wiper impregnated with the composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a composition exhibiting a sufficient antibacterial antifungal effect and containing a reduced amount of agent to give high safety in spite of use of a combination of two or three components with respect to prior art, and to provide a wet wiper using the composition.SOLUTION: The antibacterial and antifungal composition includes 0.2-0.3 wt.% of parahydroxybenzoic acid esters as first components, and 0.02-0.05 wt.% of chlorhexidine gluconate as a second component, and 0.05-0.1 wt.% of polyhexamethylene biguanide hydrochloride (PHMB) as a third component and/or 0.01-0.02 wt.% of 3-iodo-2-propynyl-N-butylcarbamate (IPBC) as a fourth component or a quaternary ammonium salt as a fifth component. The composition having high safety and excellent antibacterial and antifungal properties is produced by adjusting the compounding ratios of the added components within preset ranges.

Description

  The present invention relates to an antibacterial / antifungal composition that is excellent in safety and suppresses microbial contamination of the surroundings, and a wet wiper impregnated with the composition.

  As this kind of composition, a plurality of inventions (techniques) are known. As the first conventional technique, for example, 3-iodo-2-propynyl-N-butyl carbamate as a first component, polyhexamethylene piguanide hydrochloride and / or p-hydroxybenzoates as a second component An antibacterial composition containing the above-mentioned composition, which is added to a wet wiper base paper such as a paper towel, wet tissue, towel, or wipe sheet (see Patent Document 1).

  This composition is stable for a long period of time, imparts excellent antibacterial properties, controls microorganisms, and provides wet wipes having a strong antibacterial power that has been insufficient in the past alone.

  Further, as a second known prior art, a quaternary ammonium salt described in cosmetic standards, such as benzalkonium chloride, benzotonium chloride, cetyltrimethylammonium chloride, suaryltrimethylammonium chloride, and cetylpyridinium chloride. Of these, a combination of two or more kinds of wet towels / wet tissues with antibacterial and antifungal effects, or parabens described in cosmetic standards, methyl paraoxybenzoate, ethyl paraoxybenzoate, propyl paraoxybenzoate In addition, it is a hand towel / wet tissue having an antibacterial / antifungal effect, comprising at least one of butyl paraoxybenzoate (see Patent Document 2).

  This hand towel / wet tissue has the effect of suppressing the growth of fungi and mold when paper towels / wet tissues are stored weakly with a single component, and the synergistic effect of combining multiple components has brought about a sufficient effect. is there.

JP 2003-286115 A JP 2006-149989 A

  Various chemicals have been used to prevent contamination by microorganisms such as fungi (molds, mushrooms, yeasts, etc.) and bacteria against wipes, wet tissue, paper towels and the like. However, since a single preparation tends to cause the appearance of resistant bacteria, antibacterial agents using various combinations of two or three components have been used. In the first prior art, a combination of a plurality of components following this is not only problematic in that the amount of the pharmaceutical component is large, but also has good antibacterial efficacy for hygienic wet wiper products. However, it does not have sufficient antifungal efficacy.

  In the second prior art, a combination of one, two, three or four kinds of drug components is tried, and the results are shown in Table 2 for E. coli and staphylococci. However, the antifungal efficacy of 1 to 3 species is not recognized, and 4 species are partially effective.

  In any case, in the prior art, in order to have a sufficient antifungal effect, there is a tendency to increase the amount of the combination of two-component and three-component drugs, and safety to human skin becomes a problem. There are many.

  Therefore, the development of a composition having a sufficient safety, antibacterial and antifungal efficacy even if it is a combination of two components and three components compared to the prior art, and the composition There is a problem to be solved in providing a wet wiper that uses the above.

  As a specific means for solving the above-mentioned problems, the first invention according to the present invention comprises 0.2 to 0.3% by weight of paraoxybenzoic acid esters as the first component and 0.02 to 0.02 as the second component. 0.05% by weight chlorhexidine gluconate and 0.05 to 0.1% by weight polyhexamethylene biguanide hydrochloride (PHMB) as the third component and / or 0.01 to 0.02% by weight as the fourth component An antibacterial / antifungal composition characterized by containing 3% 3-iodo-2-propynyl-N-butylcarbamate (IPBC) or a quaternary ammonium salt as a fifth component.

  A second invention according to the present invention is a wet wiper wherein the antibacterial / antifungal composition of claim 1 is kneaded or impregnated in a wet wiper such as a towel, wet tissue or paper towel. Is to provide.

  The antibacterial and antifungal composition according to the first invention of the present invention is a combination of at least three components, and the amount of each drug added is too much or too little, and the planned safety, antibacterial and antifungal properties Although the effect does not occur, by making the blending ratio within the set range, it has excellent safety and antibacterial and antifungal effects.

  In addition, the wet wiper according to the second invention has excellent safety and antibacterial and antifungal effects by kneading or impregnating the antibacterial and antifungal composition according to the first invention. Play.

  The antibacterial / antifungal composition according to the present invention comprises 0.2 to 0.3% by weight of paraoxybenzoates as a first component, and 0.02 to 0.05% by weight of chlorhexidine gluconate as a second component. And / or 0.05 to 0.1% by weight of polyhexamethylene biguanide hydrochloride (PHMB) as the third component and / or 0.01 to 0.02% by weight of 3-iodo-2 as the fourth component. -Propinyl-N-butyl carbamate (IPBC) or a quaternary ammonium salt as the fifth component, which is a very excellent antibacterial / antifungal composition with good antibacterial activity even at low concentrations Wet wipes excellent in hygiene by applying impregnation treatment to wet wipes such as wipes, wet tissues and paper towels. It is possible to obtain.

  The active ingredient of the composition according to the present invention can be added to a wet wiper such as a wipe, wet tissue or paper towel. The activator and the like are not particularly limited, but it is preferable to select those that comply with cosmetic raw material standards from the viewpoint of safety to the human body. The shape (dosage form) as a preparation is not particularly limited. In the case of a liquid preparation, any of a water-soluble liquid agent, an oil-soluble liquid agent, an (aqueous or oil-based) O / W type emulsifier, and a blowable preparation may be used. In particular, by making the active ingredient into an O / W emulsifier in advance, it can be easily diluted with water to adjust to the required concentration, and has excellent stability after dilution, and the ingredients can be diffused uniformly.

Examples of the antibacterial / antifungal solubilizer used in the composition of the present invention include glycol-based solubilizers such as ethylene glycol, diethylene glycol, polyethylene glycol, and propylene glycol, ethylene glycol monomethyl ether, diethylene glycol monomethyl ether, and diethylene glycol monoethyl. Examples include ethers, glycol ether-based solubilizers such as propylene glycol monomethyl ether, and water. Of these, glycol-based solubilizers, higher fatty acid ester-based solubilizers, and water are preferable.
These solubilizers may be used alone or in combination of two or more.

  A surfactant may or may not be used, and when used, any of a nonionic surfactant, a cationic surfactant, and a zwitterionic surfactant may be used. Nonionic surfactants include, for example, polyoxyethylene alkyl phenyl ether, polyoxyethylene styryl phenyl ether, polyoxyethylene alkyl ether, sorbitan fatty acid ester, polyoxyethylene sorbitan fatty acid ester and the like, and cationic surfactant Examples of the agent include aliphatic amine salts and quaternary ammonium salts thereof, and examples of amphoteric surfactants include, but are not limited to, betaine surfactants and aminocarboxylates. These nonionic surfactants, cationic surfactants and amphoteric surfactants may be used alone or in combination of two or more.

  The composition according to the present invention can be used in combination with oil phase components, fats and oils, higher alcohols, fatty acids, active ingredients, moisturizing ingredients, fragrances and the like that are generally used in cosmetics.

Examples of the active ingredient include aloe extract, peach leaf extract, tea extract, rose extract, kumazasa leaf extract, acerola extract, placenta extract, tocopherol acetate and the like.
Examples of the moisturizing component include sodium hyaluronate, collagen, proteoglycan, ceramide and the like.
Examples of the thermal sensation component include ginger root extract, red pepper fruit extract, vanillyl butyl, peppermint, menthol, mint leaf extract, mint oil, ethanol and the like.

  Next, the present invention will be described with reference to some examples and comparative examples, but the present invention is not limited to these examples. Further, “%” indicating the blending ratio in the description including the table is “% by weight”.

  As shown in Attachment Table 1-1 and Table 1-2, Comparative Examples 1 to 5 and Examples 1 to 12 were respectively adjusted to form an antibacterial / antifungal composition. The performance was examined. Examples 1-12. Of the formulations shown in Table 1-1 and Table 1-2, each active ingredient was dissolved in an aqueous solution provided with a fragrance and stirred to obtain an antibacterial / antifungal composition.

Adjustment of antibacterial and antifungal composition:
(1) Toothpaste
Antibacterial / antifungal composition liquid described in Table 1-1 and Table 1-2 or prescription composition liquid (Table 30-1) (30 g) on a cotton towel (length × width = 28 × 28 cm, 20 g, 100% cotton) ) Was impregnated. 150% per dry weight of fabric. A non-woven wet towel was prepared in the same manner as the cotton towel.
(2) Wet tissue A wet tissue (length × width = 15.3 × 28 cm, 10 sheets, 11 g, polyester nonwoven fabric) was impregnated with the formulation composition (23 g) shown in Table 2-1. 230% per dry weight of fabric.
(3) Diaper A nonwoven fabric sheet of 60 parts of water-absorbing fiber (sodium polyacrylate) and 40 parts of polyester used for diapers was impregnated with the formulation composition shown in Table 2-1 (30 g). 300% per dry weight of fabric.

Paraoxybenzoates as the first component: butyl-p-hydroxybenzoate: butylparaben methylparaben, ethylparaben, propylparaben, isopropylparaben and the like.
As a second component, chlorhexidine gluconate.
Polyhexamethylene piguanide hydrochloride as the third component: PHMB.
3-Iodo-2-propynyl-N-butyl carbamate as the fourth component: IPBC.
Quaternary ammonium salts as the fifth component: N-alkyl-N, N-dimethyl-N-benzalkonium chloride: benzethonium chloride, benzalkonium chloride, cetylpyridinium chloride and the like.

For Comparative Example 6 and Examples 13-18:
The antibacterial composition was prepared as shown in Attachment 2-1 and the performance was examined by Test Examples 1 to 3.
In addition, the indication of the active ingredient in a table | surface is as having described in the said paragraph [0020].
In Comparative Example 6 and Examples 13 to 18, each active ingredient in the formulation shown in Table 2-1 is dissolved in an oil solvent, and an aqueous solution in which a water-soluble component is dissolved is gradually added while stirring by adding an emulsifier. Thus, an antibacterial / antifungal composition was obtained.

[Test Example 1] Wet wiper mold resistance test:
"Test sample preparation" cotton towel (Table 1-1 and Table 1-2 and Table 2-1), wet tissue made of polyester, towel made of polyester nonwoven fabric, nonwoven fabric sheet for diapers, (Table 2-1) A wet wiper was prepared as described in paragraph [0023] above, and a 5 cm × 5 cm cut was subjected to a mold prevention test.

[Test method]
The adjusted wet wiper sample conforms to the JIS Z-2911 mold resistance test.
Test Mold JIS Z-2911 Mold Resistance Test Fiber Test Designated Fiber Mold ・ Aspergillus niger ATCC 6275
Penicillium citrinum ATCC 9849
Chaetomium globosum ATCC 6205
Myrothecerium verrucaria ATCC 9095
Judgment method of the above 4 types Mold ... JIS Z-2911 Mold resistance test Mold growth by display method: (-) Mold growth is not recognized
(±) Slight growth
(+) To (++++) Mold growth is remarkable. Mold resistance display: 0 ... No mold growth on the sample
1 growth area of mold on ... sample the entire 1/3 mm ² or less
2 ... Mold growth area on the sample is 1/3 mm ² or more of the whole

[Test results]
As shown in Attachments 1-3 and 1-4 and Attachment 2-2, the evaluation results on the 14th day of the preparations containing the active ingredients of Comparative Examples 1 to 6 are ± to ++. In addition, the evaluation results of Examples 1 to 18 are-, and the wet wipes to which the preparations of Examples 1 to 18 are added have a significant antifungal effect compared to the active ingredient preparations of Comparative Examples 1 to 6. It was confirmed to show.

[Test Example 2] Antibacterial test:
"Test sample preparation" cotton towel (Table 1-1 and Table 1-2 and Table 2-1), wet tissue made of polyester, towel made of polyester nonwoven fabric, nonwoven fabric sheet for diapers, (Table 2-1) A wet wiper was prepared as described in paragraph [0023] above and cut into 5 cm × 5 cm for use in an antibacterial test.

[Test method]
The adjusted wet wiper sample conforms to the antibacterial test of JIS L-1902 fiber product.
Test bacteria Escherichia coli NBRC 3301 (E. coli)
・ Staphylococcus aureus NBRC 12732 (staphylococci)
Judgment method Bacteria ... Effective (-)
Slightly ineffective (±)
No effect (+)

[Test results]
As shown in Attachments 1-3 and 1-4 and Attachment 2-2, the evaluation results on the 14th day of the preparations containing the active ingredients of Comparative Examples 1 to 6 are ± to + The evaluation results of Examples 1 to 18 are-, and the wet wipes to which the preparations of Examples 1 to 18 are added have a remarkable antibacterial effect compared to the active ingredient preparations of Comparative Examples 1 to 6. It was confirmed.

[Test Example 3] Safety test (human patch test):
[Test method]
For the subject (various wet wipers), impregnated 2 drops of the subject (antibacterial and antifungal composition of various wet wipers) on the adhesive bandage pad (φ9 mm), and affixed the adhesive plaster to the forearm flexion side of a healthy person, Patched for 24 hours. After 24 hours, the adhesive bandage impregnated with the specimen was removed, and skin symptoms were observed 30 minutes and 24 hours after the removal.
Judgment method Skin reaction observation and judgment: Refer to Judgment Criteria of Patch Test Study Group Negative (-): No response False positive (±): Slight erythema Strong positive (++): Erythema + Edema Strong positive (++): Erythema + Edema + papules, small water bubbles

[Test results]
As shown in Tables 1-3 and 1-4 and Table 2-2, the preparations containing the active ingredients of Comparative Examples 1 to 6 had no response of ± 2 in 20 subjects even after 48 hours or Examples 1 to 18 were all results of no reaction, while they were slight erythema.

  The antibacterial / antifungal composition according to the present invention is used not only for impregnation in a towel, wet tissue or paper towel, but also for cleaning equipment and cooking utensils in a humid kitchen, or in a bathroom. Can be widely used for cleaning tile wall surfaces.

As a specific means for solving the above-mentioned problems, the first invention according to the present invention comprises 0.2 to 0.3% by weight of paraoxybenzoic acid esters as the first component and 0.02 to 0.02 as the second component. 0.05 wt% chlorhexidine gluconate and / or 0.05 to 0.1 wt% polyhexamethylene biguanide hydrochloride (PHMB) as the third component and / or 0.01 to 0.00 as the fourth component. An antibacterial / antifungal composition comprising 02% by weight of 3-iodo-2-propynyl-N-butylcarbamate (IPBC) and / or a quaternary ammonium salt as a fifth component It is.

Claims (2)

0.2 to 0.3% by weight of paraoxybenzoates as a first component,
And 0.02 to 0.05 wt% chlorhexidine gluconate as a second component,
And / or 0.05 to 0.1 wt% polyhexamethylene biguanide hydrochloride (PHMB) as a third component,
And / or 0.01-0.02 wt% 3-iodo-2-propynyl-N-butylcarbamate (IPBC) as the fourth component,
Alternatively, an antibacterial / antifungal composition comprising a quaternary ammonium salt as a fifth component. A wet wiper characterized in that the antibacterial / antifungal composition of claim 1 is kneaded or impregnated in a wet wiper such as a wipe, wet tissue or paper towel.