JP2013063944A - Pack agent - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide an agent for preparing a hydrous viscous composition, which has excellent solubility and dispersibility in mixing when in use and secures such a viscosity as to stand still on the skin even without using force of sheet material, etc.SOLUTION: In the agent for preparing a hydrous viscous composition, which has two or more chemicals and in which when the two or more chemicals are mixed, carbon dioxide is generated to give a hydrous viscous composition containing the carbon dioxide, the two or more chemicals include (1) a first chemical that is a liquid or viscous composition containing a carbonate and a second chemical that is a liquid or viscous composition containing a buffer solution or (2) the first chemical that is a liquid or viscous composition that contains a basic substance to become a buffer solution in combination with an acid and a carbonate and the second chemical that is a liquid or viscous composition containing an acid. At least one of the chemicals contains a thickener.

Description

  The present invention relates to a hydrous viscous composition preparation agent that creates a hydrous viscous composition in which, for example, two or more agents are mixed during use to generate carbon dioxide.

  Conventionally, carbon dioxide is known to be suitable for promoting blood circulation and is used in various fields. For example, there has been proposed a method in which a carbonate and an acid are reacted to generate carbon dioxide and the generated carbon dioxide is used (see Patent Documents 1 and 2).

JP-A-8-268828 Patent No. 4659980 The pack cosmetic of Patent Document 1 conveys a pleasant irritation and a comfortable warm feeling on the skin by blending carbonate, organic acid, pyrogen and foam stabilizer, and promotes blood circulation. It is said to be excellent.

  The carbon dioxide-containing viscous composition of Patent Document 2 is composed of a combination of a hydrous viscous composition containing carbonate and sodium alginate and a granule containing acid, and the like, in which the carbonate and acid are reacted in the hydrous viscous composition. Thus, a carbon dioxide-containing viscous composition containing bubble-like carbon dioxide is obtained. Thus, it can be used as a cosmetic composition for partial obesity improvement, athlete's foot, atopic dermatitis, or a pharmaceutical composition for treating wounds.

  However, the pack cosmetic disclosed in Patent Document 1 has a low viscosity and cannot stand on the human body stably by itself. For this reason, in the examples, an aluminum sheet is laid on the bed, a sample is mixed with water and applied, and a towel is put on a towel on a towel, etc. Was necessary.

  In addition, the carbon dioxide-containing viscous composition of Patent Document 2 can be used in the form of a gel or the like by mixing the granules and the hydrous viscous composition at the time of use. There remains a problem in sex. That is, since the granules are used, it is difficult to uniformly mix, and there remains a problem that unevenness is likely to occur in the mixed state. Moreover, since it is the user himself (that is, the customer) that mixes, it is impossible to thoroughly stir using a stick or the like, and the situation after mixing varies depending on the user. There was no way to eliminate it.

  In view of the above-described problems, the present invention is superior in solubility or dispersibility in mixing at the time of use, and can produce a hydrous viscous composition that can secure a viscosity that can be kept on the skin without borrowing the power of a sheet material or the like. The purpose is to provide an agent and improve the satisfaction of users.

  This invention has two or more agents, and when the two or more agents are mixed, carbon dioxide is generated, and the hydrous viscous composition preparation agent that obtains the hydrous viscous composition having the carbon dioxide is obtained, The two or more agents are: (1) first agent: liquid or viscous composition containing carbonate, second agent: liquid or viscous composition containing buffer solution, or (2) first agent: acid A liquid or viscous composition containing a basic substance and a carbonate that becomes a buffer solution in combination with a second agent: a liquid or viscous composition containing an acid, and at least one agent contains a thickener. It is a water-containing viscous composition preparation agent to contain.

  The buffer is selected from lactate buffer, citrate buffer, citrate-phosphate buffer, tartrate buffer, malate buffer, succinate buffer, glycine-hydrochloric acid buffer, and acetate buffer Can be included. Among them, the buffer solution may contain at least one selected from a lactic acid buffer solution, a citrate buffer solution, a tartrate buffer solution, and a malate buffer solution. Moreover, it is preferable to use a buffer solution having a water content of 55% or less.

  According to the present invention, there is provided a hydrous viscous composition preparation agent that is excellent in solubility or dispersibility in mixing at the time of use, and that can secure a viscosity that can stand on the skin without borrowing the power of a sheet material or the like. Satisfaction can be improved.

  The present inventor has prepared an agent for preparing a hydrous viscous composition having high solubility or dispersibility so that even if a general customer who is not an expert performs the work of mixing two or more agents at the time of use, it can be mixed evenly. We worked hard to provide it. And by using carbonate (including bicarbonate) and a buffer solution, and using all of the first agent and the second agent containing these respectively in liquid or viscous form, the solubility is much higher than that of granules. Alternatively, the present invention capable of obtaining dispersibility was obtained. In addition, you may use a buffer solution by dividing into a 1st agent and a 2nd agent in the isolation | separation state of an acid and the basic substance which has a buffer capacity with respect to a hydrogen ion combining with this acid.

  Furthermore, when the present inventor diligently researched what can be mixed and practically used at the time of use, when the water-containing viscous composition after mixing is applied to human skin to some extent, it is somewhat There is a problem that viscosity must be ensured, and if the amount of carbon dioxide is large, the viscosity tends to decrease due to the inclusion of a large amount of gas in the hydrous viscous composition (gel cosmetic) after use. The problem of being seen has arisen.

  The present invention has at least a first agent and a second agent, and mixes all agents (two in the case of two of the first agent and the second agent) at the time of use. A thickener is contained in at least one of the first agent and the second agent, or the third agent.

  The first agent and the second agent have (1) a first agent: a liquid or viscous composition containing carbonate, a second agent: a liquid or viscous composition containing a buffer solution, or ( 2) First agent: a liquid or viscous composition containing carbonate and a basic substance that is combined with an acid to become a buffer solution, and second agent: a liquid or viscous composition containing an acid.

When at least one of the first agent and the second agent contains a thickener, there are the following combinations.
<Combination 1>
First agent: Viscous composition containing carbonate and thickener Second agent: Liquid composition containing buffer <Combination 2>
First agent: Liquid composition containing carbonate Second agent: Viscous composition containing buffer and thickener <Combination 3>
First agent: viscous composition containing carbonate and thickener Second agent: viscous composition containing buffer and thickener <Combination 4>
First agent: a viscous composition containing a basic substance that becomes a buffer solution in combination with an acid, a carbonate, and a thickener,
Second agent: Liquid composition containing acid <Combination 5>
First agent: a liquid composition containing a basic substance and a carbonate which are combined with an acid to become a buffer,
Second agent: Viscous composition containing acid and thickener <Combination 6>
First agent: a viscous composition containing a basic substance that becomes a buffer solution in combination with an acid, a carbonate, and a thickener,
Second agent: Viscous composition containing acid and thickener

<Carbonate>
The carbonate is for reacting with an acid to generate carbon dioxide, and those usually used as a component of a skin external preparation in the quasi-drug and cosmetic fields can be used.
Accordingly, carbonates are, for example, sodium carbonate, potassium carbonate, sodium bicarbonate, potassium bicarbonate, calcium carbonate, magnesium carbonate, calcium bicarbonate, magnesium bicarbonate, ammonium carbonate, ammonium bicarbonate, sodium sesquicarbonate, potassium sesquicarbonate. And one or more selected from the group consisting of calcium sesquicarbonate and the like.
Among the above, carbonates having high solubility in water are preferable. For example, sodium carbonate, sodium hydrogen carbonate, and the like are preferable.

<Acid>
The acid is basically an acid that generates carbon dioxide when mixed with a carbonate, and can be used as a component of a skin external preparation in the field of quasi drugs and cosmetics. Specifically, phosphoric acid or hydrochloric acid can be used as the inorganic acid, and acrylic acid, adipic acid, ascorbic acid, aspartic acid, azelaic acid, β-alanine, benzoic acid, isovaleric acid, isobutyric acid can be used as the organic acid. , Formic acid, valeric acid, citric acid, glycolic acid, glutamic acid, glutaric acid, succinic acid, acetic acid, tartaric acid, oxalic acid, lactic acid, barbituric acid, P-hydroxybenzoic acid, pimelic acid, fumaric acid, propionic acid, phthalic acid, One or two or more kinds selected from the group consisting of isophthalic acid, terephthalic acid, malonic acid, butyric acid, malic acid, levulinic acid and the like can be used, and salts thereof can be used.
Among them, ascorbic acid, tartaric acid, citric acid, succinic acid, lactic acid, and malic acid are preferable, and tartaric acid, citric acid, lactic acid, and malic acid are more preferable, and lactic acid is particularly preferable.
The acid is preferably a liquid acid considering the solubility in water. From this viewpoint, for example, acrylic acid, formic acid, acetic acid, butyric acid, isobutyric acid, valeric acid, isovaleric acid, lactic acid and the like are preferable.
Further, considering that the acid is used in cosmetics, an acid having an obstacle in terms of irritation and odor is not preferable. From this point of view, it is considered that an acid having no hindrance in terms of irritation and odor, such as lactic acid, is optimal.
This lactic acid has optical isomers such as L-form, D-form and DL-form. Both L and D isomers are solids having a melting point of about 53 ° C., but only the DL isomer has a melting point of 16.8 and exists as a viscous liquid at room temperature. Therefore, lactic acid can be used in any of L-form, D-form, and DL-form, but DL-form lactic acid is particularly suitable.

<Basic substance>
The basic substance is a basic substance that clears the conditions for the acid to have a buffering capacity against hydrogen ions, and those that are usually used as a component of a skin external preparation in the field of quasi drugs and cosmetics can be used. This basic substance is, for example, one or two selected from the group consisting of sodium lactate, potassium lactate, trisodium citrate, sodium tartrate, disodium malate, disodium succinate, glycine, and sodium phosphate. This can be done.
In order to add an acid without lowering the viscosity of the hydrous viscous composition after mixing, the basic substance is preferably one that can prepare an aqueous solution having high solubility and 50% or more. For this reason, the basic substance is preferably liquid sodium lactate, for example. Further, from the viewpoint of moisture retention, the basic substance is preferably sodium lactate or potassium lactate.

<Buffer solution>
Moreover, since the buffer solution mainly composed of a basic substance and an acid is mixed with a carbonate, it needs to be an acid stronger than carbonic acid. For this reason, the buffer solution is hydrochloric acid-potassium chloride buffer, glycine-hydrochloric acid buffer, acetic acid buffer, citrate buffer, citric acid-phosphate buffer, lactic acid buffer, tartaric acid buffer, malic acid buffer, A succinic acid buffer and the like are preferable, and a buffer using at least one of lactic acid and lactate is preferable. Further, the buffer solution preferably has a water content of 55% or less, more preferably a water content of 15% to 50%. Furthermore, when the buffer solution is a lactic acid buffer solution, sodium lactate / (lactic acid + lactic acid) Assuming that the weight percentage of (sodium) is 10% to 90% (pH 3 to 5), the moisture content is more preferably 16.68% to 47.5%. Moreover, it is preferable to adjust a buffer solution to pH 3-5, and it is more preferable to adjust to pH 3-4.

<Thickener>
The thickener may be one or more selected from the group consisting of natural polymers, semi-synthetic polymers, synthetic polymers, and inorganic substances.
The natural polymer as a thickener is one or two selected from the group consisting of carrageenan, agar, quince seed, guar gum, mannan, locust bean gum, xanthan gum, dextran, hyaluronic acid, pullulan, collagen, gelatin and the like. It can be more than seeds.
Semi-synthetic polymers as thickeners include ethyl cellulose, carboxymethyl cellulose and salts thereof, carboxymethyl ethyl cellulose and salts thereof, carboxymethyl starch and salts thereof, crystalline cellulose, cellulose acetate, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, Stearoxyhydroxypropyl methylcellulose, sodium stearoxy PG hydroxyethylcellulose sulfonate, hydroxypropylmethylcellulose phthalate, powdered cellulose, methylcellulose, methylhydroxypropylcellulose, pregelatinized starch, partially pregelatinized starch, carboxymethyl starch, dextrin, sodium alginate, propylene glycol alginate Esther, co Doroichin sodium sulfate, it can be one or more selected from the group consisting of sodium hyaluronate.
Synthetic polymers as thickeners include: carboxyvinyl polymer, (acryloyldimethyltaurine ammonium beheneth-25 methacrylate) crosspolymer, sodium polyacrylate, polyvinyl acetal diethylaminoacetate, polyvinyl alcohol, polyvinyl pyrrolidone, methacrylic acid-acrylic acid Ethyl copolymer, methacrylic acid-ethyl methacrylate copolymer, ethyl methacrylate / methacrylic acid trimethylammonium ethyl copolymer, dimethylaminoethyl methacrylate / methyl methacrylate copolymer (hydroxyethyl acrylate / acryloyldimethyltaurine Na) ) One or more selected from the group consisting of copolymers and the like.
The inorganic substance as the thickener may be one or more selected from the group consisting of hydrous silicon dioxide, light anhydrous silicic acid, colloidal alumina, bentonite, laponite and the like.

  Examples of the present invention will be specifically described below. In addition, this invention is not limited to this Example. First, Examples 1 to 15 of the present invention are shown using Tables 1 to 5. In Examples 1 to 15 of the present invention, a first agent and a second agent are stirred and mixed to prepare a cosmetic (particularly, a cosmetic for a pack) as a hydrous viscous composition.

  The first agent of formulation examples A to E shown in Table 1 and the second agent of formulation examples 1 to 8 shown in Table 2 are prepared in advance, and the first formulation in Examples 1 to 15 shown in Table 3 to Table 5 is used. The 1st agent and the 2nd agent were stirred and mixed, respectively, and evaluated. The lactic acid in Formulation Examples 1 to 3 shown in Table 2 uses DL form. In addition, Formulation Example 8 is an example in which the second agent is a granular composition for reference.

<Evaluation 1: Foamability>
The volume increase rate after stirring and mixing from the volume before stirring and mixing was evaluated in the following four stages.
◎: 70% or more ○: 50-70%
Δ: 30-50%
×: 30% or less

<Evaluation 2: Bubble persistence>
The volume reduction rate after 1 hour from the volume 1 minute after stirring and mixing was evaluated in the following four stages.
◎: 30% or less ○: 30-50%
Δ: 50-70%
×: 70% or more

<Evaluation 3: Dissolution or dispersibility of the second agent>
The solubility or dispersibility of the second agent when the second agent was stirred and mixed with the first agent was evaluated in the following four stages.
◎: melts well ○: melts Δ: hardly melts X: does not melt Note that Δ (hardly melted) is in a state where it remains undissolved and remains a lump.

<Evaluation 4: Dripping of water-containing viscous composition>
After 4 g of the hydrous viscous composition obtained by stirring and mixing the first agent and the second agent was applied almost uniformly over the upper surface of a transparent acrylic plate placed almost horizontally over an application area of 9 cm ² , the acrylic plate Was tilted from a substantially horizontal state to 60 ° C. and allowed to stand for 30 minutes. The dripping of the hydrous viscous composition was visually confirmed, and evaluated in the following four stages.
A: Not dripping (0.5 cm or less),
○: Almost no dripping (0.5 cm to 1 cm),
Δ: Slightly droop (1 cm to 2 cm),
X: droop (2 cm or more)

<Evaluation 5: Stimulus>
Expert panelists (3 persons) evaluated the feeling of irritation when each hydrous viscous composition was applied to the face in three stages as follows.
◎: None △: Feeling slightly ×: Feeling strongly Note that the irritation feeling evaluated by two or more people was taken as the irritation feeling of each hydrous viscous composition. Moreover, when each panelist evaluated differently, it was set as the irritation | stimulation feeling of "(triangle | delta)".

<Evaluation 6: Overall evaluation>
Based on each evaluation, comprehensive evaluation was evaluated in four stages as follows.
◎: All evaluation items ◎
○: Two or more ◎ △: No x, ◎ or one or more x: Other than the above

<Evaluation 7: Skin reaction by carbon dioxide absorption>
An external preparation was applied to the inner side of the left arm forearm of the subjects (3 persons), and after 5 minutes of application, the applied part was confirmed and evaluated in the following four stages.
◎: Remarkable reaction ○: Moderate reaction △: Slight reaction ×: No reaction

  As shown in Test Example 1 of Table 3, in Examples 1 to 5, the blending of the second agent was fixed and the blending of the first agent was changed. In all of Examples 1 to 5, good results (results in which evaluation of foamability and sustainability of foaming were all ◎ or one each of ◎ and ○) were obtained. For this reason, in Test Examples 2 and 3 in Table 4 and Table 5 below, the mixing of the first agent is fixed to Compounding Example A, and a plurality of types of second agents having different formulations are mixed with stirring. . In Test Examples 2 and 3, it is considered that the same results can be obtained even when Formulation Examples B to E other than Formulation Example A are used as the first agent.

  As shown in Test Example 2 in Table 4, in Example 1 and Examples 6 to 15, good results were obtained in the solubility or dispersibility of the second agent. The difference is remarkable when compared with Reference Example 1 using Formulation Example 8 using granules. Thus, by using a liquid or viscous buffer without using the acid of granules (fine granules, powder), very good solubility or dispersibility was obtained compared to the case of using granules. .

  As shown in the test results, lactic acid buffer (Examples 1, 6, 7), citrate buffer (Example 8), tartrate buffer (Example 9), malate buffer (Example 10), Alternatively, a succinic acid buffer (Example 11) was used to obtain a hydrous viscous composition preparation agent having excellent solubility or dispersibility.

  Among these, use of lactic acid buffer (Examples 1, 6, 7), citrate buffer (Example 8), tartrate buffer (Example 9), or malate buffer (Example 10), The water-containing viscous composition is preferable because of less dripping, and among them, the lactic acid buffer (Examples 1, 6 and 7) or the malic acid buffer (Example 10) is more preferable, and the lactic acid buffer (Example 1, 6) is more preferable.

  In addition, from the comprehensive evaluation including the solubility or dispersibility of the second agent and the dripping of the water-containing viscous composition, including irritation, lactate buffer (Examples 1, 6 and 7), tartaric acid buffer (Example 9) ) Or malate buffer (Example 10) is preferred, and among them, lactate buffer (Examples 1, 6, and 7) or malate buffer (Example 10) is more preferred. When the lactic acid buffer is used, the weight ratio% of lactate is preferably about 10% to 70%, more preferably 30 to 50%, based on the total weight of lactic acid and lactate.

  In addition, the water content of the buffer solution (the amount of purified water in each table) is 55% or less, and good results are obtained. Among them, 50% or less is better, and further 15% to 50%. Things are better, and 16.68% -47.5% is better.

  Test Example 3 in Table 5 shows the results of changing the blending ratios using Formulation Examples 1 and A, which were the most suitable. As shown in the test results, from the comprehensive evaluation of the dripping of the hydrous viscous composition, the irritation, and the skin reaction due to carbon dioxide absorption, with respect to 15 parts by weight of the first agent having carbonate and thickener, As for the weight part of the 2nd agent containing a lactic acid buffer solution, about 0.5-1.5 are preferred.

  In addition, as for the water-containing viscous composition obtained by stirring and mixing the 1st agent of Examples 1-15 of these Table 3-Table 5, and a 2nd agent, all become pH within the range of 7-4. It has been adjusted. That is, it is preferable to adjust each compounding of the first agent and the second agent and the amount of the first agent and the second agent so that the pH of the hydrous viscous composition is in the range of 7 to 4.

  Next, Examples 16 to 24 of the present invention are shown using Tables 6 to 8. In Examples 16 to 24, lactic acid is used as an acid, lactate (sodium lactate) is used as a basic substance that becomes a buffer solution in combination with an acid, a lactic acid buffer solution is used as a buffer solution, and a thickener is included. Thus, the mixing ratio of the first agent and the second agent is changed. In Examples 16 to 24, the first agent and the second agent are stirred and mixed to prepare a cosmetic (particularly, a cosmetic for a pack) as a hydrous viscous composition.

  The first agent of Formulation Examples F to I shown in Table 6 and the second agent of Formulation Examples 1 and 9 to 14 shown in Table 7 are prepared in advance, and the first formulation is the formulation of Examples 16 to 24 shown in Table 8. The agent and the second agent were mixed with stirring, and evaluated. The lactic acid in Formulation Examples 1 and 9 to 14 shown in Table 7 uses DL.

Formulation Example F is a viscous composition containing carbonate and a thickener, and Formulation Example C is simplified and slightly diluted.
Formulation Example G is a viscous composition containing a basic substance that is combined with an acid to form a buffer, a carbonate, and a thickener.
Formulation example H is a liquid composition containing carbonate.
Formulation Example I is a liquid composition containing a basic substance that becomes a buffer solution in combination with an acid and a carbonate.

  As shown in Table 6, there is no particular problem even if sodium lactate (basic substance that becomes a buffer solution in combination with an acid) is combined with the first agent. Further, there is no particular problem as a preparation even if the thickener is not present in the first agent.

Formulation Example 1 is a liquid composition containing a buffer solution.
Formulation examples 9, 10, and 13 are viscous compositions containing a buffer and a thickener.
Formulation Example 11 is a liquid composition containing an acid.
Formulation examples 12 and 14 are viscous compositions containing an acid and a thickener.

  As shown in Formulation Example 9 and Formulation Example 10 in Table 7, if an acid-resistant salt-resistant thickener (in the examples, stearoxyhydroxypropylmethylcellulose or sodium stearoxyPGhydroxyethylcellulose sulfonate) is used, the buffer solution also increases. Can stick.

  Further, when the second agent contains a thickener, it is preferable that the pH is higher even if it is an acid-resistant thickener. For example, pH 2.5 or higher is preferable in consideration of thickening, and pH 3 or higher is particularly preferable. .

Example 16 corresponds to <Combination 1>.
Examples 21 and 23 correspond to <Combination 2>.
Examples 17 and 18 correspond to <Combination 3>.
Example 19 corresponds to <Combination 4>.
Examples 22 and 24 correspond to <Combination 5>.
Example 20 corresponds to <Combination 6>.

  Evaluation 1: Foaming property, Evaluation 2: Persistence of bubbles, Evaluation 3: Dissolution or dispersibility of the second agent, Evaluation 4: Dripping of hydrous viscous composition, Evaluation 5: Irritation, Evaluation 6: Overall evaluation, And Evaluation 7: Skin reaction due to carbon dioxide absorption was evaluated by the evaluation method in Examples 1 to 15 described above.

  As shown in Examples 16 to 24, when the carbonate and the buffer solution are contained separately in the first agent and the second agent, and the basic substance and the carbonate containing the basic solution that becomes a buffer solution in combination with the acid. Good results were obtained in either case of using one agent and a second agent containing an acid.

  Moreover, even if the thickener was contained in one or both of the first agent and the second agent, good results were obtained. In particular, as shown in Examples 1, 17, 18, and 20, better results were obtained when the first agent containing carbonate or the thickener was added to both the first and second agents. It was. For example, in Example 1, where the amount of the thickener of the first agent is larger than that in Example 16, the evaluation about the dripping of the external preparation is slightly higher.

  Moreover, as shown in Example 17 and Example 18, even if the amount of the thickener of the first agent was reduced, good results were obtained when used in combination with the viscous second agent.

  In addition, the two thickeners (stearoxyhydroxypropylmethylcellulose and stearoxy PGhydroxyethylcellulose sodium sulfonate) used this time were not significantly different in each evaluation item.

  Further, as can be seen from the fact that there is no significant difference between Example 19 and Example 16, Example 20 and Example 17, the basic substance that becomes a buffer solution in combination with acid is included in the first agent. However, the effect of the invention could be obtained without any particular problem.

  Further, as shown in Example 21, the amount of the thickener in the present formulation example 9 is sufficient for the total amount of the thickener in the hydrous viscous composition obtained by stirring and mixing the first agent and the second agent. Absent. Therefore, the results were somewhat unsatisfactory regarding the persistence of bubbles, solubility or dispersibility, dripping of external preparations, and skin reaction due to carbon dioxide absorption.

  In Example 23, the amount of the thickener of the second agent was doubled in order to solve the difficulty of Example 21, and this gave good results. In addition, since stearoxy PG hydroxyethyl cellulose sodium sulfonate was easy to mix | blend a thickener with a high density | concentration, the thickener was changed.

  Therefore, the total amount of the thickener contained in one or both of the first agent and the second agent is preferably 1% to 10%, preferably 1.4% to the total amount of the first agent and the second agent. 7.6% is more preferable, and 3% to 5% is preferable.

  In Examples 22 and 24, the evaluation as the final hydrous viscous composition was the same as that in Examples 21 and 23, respectively. However, in Examples 22 and 24, since the pH of the second agent is low, it is slightly difficult to increase the viscosity. When the second agent contains a thickener, the pH should be high even if it is an acid-resistant thickener, and the pH is preferably 2.5 or higher, especially pH 3 or higher, considering only the thickening. is there. Therefore, when lactic acid is used as the acid, it is preferable to use sodium lactate in combination with the second agent (this is not the case with other acids).

  Further, the amount of carbonate of the first agent is preferably 10% or less of the total amount of the first agent and the second agent, more preferably 0.5% to 5%, and further preferably 1 to 3%.

  Moreover, when using a buffer solution, 15% or less of the total amount of a 1st agent and a 2nd agent is preferable, as for the quantity of the buffer solution of a 2nd agent, 1-11% is more preferable, and 2-8% is further more preferable. 3 to 6% is preferable.

  In addition, the amount of the basic substance that becomes a buffer solution in combination with the acid in the first agent is preferably 5% or less of the total amount of the first agent and the second agent, more preferably 3.5% or less, 2% is more preferable.

  Further, the amount of the acid of the second agent is preferably 10% or less of the total amount of the first agent and the second agent, more preferably 0.3 to 8%, and further preferably 2 to 5%.

  Next, Examples 25 to 32 of the present invention are shown using Tables 9 to 10. In Examples 25 to 32, lactic acid, citric acid, tartaric acid, or ascorbic acid is used as an acid, and lactate (sodium lactate) or malate (disodium malate) is used as a basic substance in combination with the acid to form a buffer solution. ) And a buffer solution of these acids and basic substances was used as a buffer solution. In Examples 25 to 32, the first agent and the second agent are stirred and mixed to prepare a cosmetic (particularly, a cosmetic for a pack) as a hydrous viscous composition.

  The first agent of Formulation Example A shown in Table 1 and the second agent of Formulation Examples 15 to 22 shown in Table 9 are prepared in advance, and the first agent is blended in Examples 25 to 32 shown in Table 10. Each second agent was stirred and mixed for evaluation. DL is used for all of the lactic acids in Formulation Examples 15 to 16 and 20 to 22 shown in Table 10.

この表１０の実施例２５に示すように第２剤に酸に組み合わせて緩衝液になる塩基性物質が含まれていないものよりも、他の実施例の方が刺激スコアが良いため、酸に組み合わせて緩衝液になる塩基性物質を第２剤に含有することが好ましい。
実施例２６は良好な結果であった。

As shown in Example 25 of Table 10, since the stimulation score of the other examples is better than that in which the second agent does not contain a basic substance that becomes a buffer solution in combination with an acid, It is preferable that the second agent contains a basic substance that is combined to form a buffer solution.
Example 26 gave good results.

  In Examples 27 and 28, since the amount of water contained in the second agent is large, the viscosity of the hydrous viscous composition is slightly low, and as a result, the durability of the bubbles and the dripping of the external preparation are somewhat poor. It has become. However, there is no major problem in usability, and this formulation can also be used.

  In addition, as shown in Example 29, when an acid (ascorbic acid) having a slightly lower solubility in water is used, the amount of water contained in the second agent is larger, resulting in a lower viscosity of the hydrous viscous composition. However, good results can be obtained by using together with other acids (lactic acid) as shown in Example 30.

In addition, as shown in Example 31, two or more basic substances that are combined with the acid mixed with the second agent to become a buffer solution can be used without any particular problems.
Further, in Example 32, since the amount of water contained in the second agent is large, the viscosity of the hydrous viscous composition is slightly low, and as a result, the durability of the bubbles and the dripping of the external preparation are a little bad. Yes. However, there is no major problem in usability, and this formulation can also be used.

  As described above, the water-containing viscous composition preparation agent has two or more agents, and when the two or more agents are mixed, carbon dioxide is generated and a water-containing viscous composition containing the carbon dioxide is obtained. By mixing the second agent containing an acid or buffer for reacting with carbonate to generate carbon dioxide into a liquid or viscous composition instead of granules, it is easy to mix and has good solubility or dispersibility An agent for preparing a hydrous viscous composition can be obtained. Moreover, since the granule is not used, it can be easily adjusted in a short time when the first agent and the second agent are stirred and mixed. And since the granule is not used, it can apply | coat to skin smoothly and can provide the cosmetics of a smooth feeling of use.

  In addition, the type using the granule of Japanese Patent No. 4659980 of the conventional example is difficult to determine how much the acid of the granule could be dissolved at the time of use, and the customer must use it without knowing whether it was dissolved uniformly. In the invention, a dissolved buffer solution (containing an acid) is used, so that it can be used in a state of being uniformly dissolved. That is, it is possible to prevent the acid from being applied to the skin in a state where the acid is not completely dissolved as in the conventional example.

  In addition, when granules are used as in the past, there is a risk that some granules may dissolve when used in wet hands or water. However, liquid or viscous buffer solution is used, so there are problems with wet hands. It can be used without.

  In addition, liquid cosmetic ingredients cannot be added to conventional granules, but by using a liquid or viscous composition, liquid cosmetic ingredients can be added and cosmetics with high cosmetic effects can be provided. .

  In addition, the acid used to react with the carbonate to generate carbon dioxide was used as a buffer solution, so that if there is a lot of acid, the reactivity will increase, but the irritation will be too high. It is possible to solve the conflicting problem that the reactivity can be reduced but the reactivity can be reduced, and the user can have a good feeling of use by reducing the irritation while securing the reactivity. Moreover, since the acid made to react with carbonate is made into the buffer solution, various thickeners can be utilized and appropriate viscosity can be ensured easily, Therefore It can apply | coat thickly on skin.

  At the time of use, a water-containing viscous composition can be obtained simply by mixing the first and second agents that are easy to mix, so that it can be easily used by general customers. Also, in service facilities such as salons and clinics, the service person stirs and mixes the first agent and the second agent, applies the obtained hydrous viscous composition to the customer's skin, and after a predetermined time, the hydrous viscous composition by face washing or the like. Services for removing objects can be easily performed. Since the second agent containing the buffer solution (or acid) has good solubility or dispersibility, it is not necessary for the service staff to be skilled, and service with stable quality can be easily performed.

  Moreover, since it can suppress the fall of pH and aluminum does not react (it does not melt | dissolve), a 1st agent and a 2nd agent (especially 2nd agent) can be preserve | saved in aluminum containers, such as an aluminum pouch. Thereby, the first agent and the second agent are put into the first container and the second container such as an aluminum pouch, respectively, once in use, and the two agents are taken out from both containers at the time of use and stirred and mixed. it can.

  Further, as the thickener, it is possible to use the same sodium alginate as in Patent No. 4659980 of the conventional example using granular acid, but as shown in the test examples of Tables 3 to 5, alginic acid is used. Other thickeners such as carrageenan, locust bean gum, and xanthan gum can be used without any problem without using sodium. Therefore, there is a high degree of freedom in selecting the thickener, and it is possible to provide a water-containing viscous composition material and a water-containing viscous composition using various thickeners.

  In the above embodiment, a gel-like water-containing viscous composition is obtained. However, the present invention is not limited to this, and any suitable form that can be used without being dripped off such as cream or gel is applied. You may adjust a 1st agent and a 2nd agent so that it may become a water-containing viscous composition.

  Further, the water-containing viscous composition after stirring and mixing is not limited to being applied directly to the application part such as the face alone, but the skin so that the water-containing viscous composition contacts the skin after being applied to a sheet material such as a nonwoven fabric. You may use it on top.

  In addition, the hydrous viscous composition preparation agent (first agent and second agent) obtained in the above examples is used as a pack by applying the hydrous viscous composition mixed with stirring to the face, etc. Not limited to this, it can be used for various cosmetics and external preparations in which carbon dioxide is effective.

  The present invention can be used as a cosmetic, and in particular, can be used for a pack applied to the skin such as the face. In addition, it can be used for various external preparations in pharmaceuticals and quasi drugs.

The present invention relates to a pack agent for preparing a hydrous viscous composition in which, for example, two or more agents are mixed during use to generate carbon dioxide.

  Conventionally, carbon dioxide is known to be suitable for promoting blood circulation and is used in various fields. For example, there has been proposed a method in which a carbonate and an acid are reacted to generate carbon dioxide and the generated carbon dioxide is used (see Patent Documents 1 and 2).

JP-A-8-268828 Patent No. 4659980 The pack cosmetic of Patent Document 1 conveys a pleasant irritation and a comfortable warm feeling on the skin by blending carbonate, organic acid, pyrogen and foam stabilizer, and promotes blood circulation. It is said to be excellent.

  The carbon dioxide-containing viscous composition of Patent Document 2 is composed of a combination of a hydrous viscous composition containing carbonate and sodium alginate and a granule containing acid, and the like, in which the carbonate and acid are reacted in the hydrous viscous composition. Thus, a carbon dioxide-containing viscous composition containing bubble-like carbon dioxide is obtained. Thus, it can be used as a cosmetic composition for partial obesity improvement, athlete's foot, atopic dermatitis, or a pharmaceutical composition for treating wounds.

  However, the pack cosmetic disclosed in Patent Document 1 has a low viscosity and cannot stand on the human body stably by itself. For this reason, in the examples, an aluminum sheet is laid on the bed, a sample is mixed with water and applied, and a towel is put on a towel on a towel, etc. Was necessary.

  In addition, the carbon dioxide-containing viscous composition of Patent Document 2 can be used in the form of a gel or the like by mixing the granules and the hydrous viscous composition at the time of use. There remains a problem in sex. That is, since the granules are used, it is difficult to uniformly mix, and there remains a problem that unevenness is likely to occur in the mixed state. Moreover, since it is the user himself (that is, the customer) that mixes, it is impossible to thoroughly stir using a stick or the like, and the situation after mixing varies depending on the user. There was no way to eliminate it.

In view of the above-described problems, the present invention provides a pack agent that is excellent in solubility or dispersibility in mixing at the time of use, and can secure a viscosity that can be kept on the skin without borrowing the power of a sheet material or the like. And to improve user satisfaction.

This invention has two or more agents, said a least two agents when mixing pack agent hydrous viscous composition is obtained which carbon dioxide is generated to hold the carbon dioxide, the two or more The agent is either (1) first agent: liquid or viscous composition containing carbonate, second agent: liquid or viscous composition containing buffer solution, or (2) first agent: buffered in combination with acid A liquid or viscous composition containing a basic substance and a carbonate that becomes a liquid, second agent: a liquid or viscous composition containing an acid, and at least one agent contains a thickener, The hydrous viscous composition after mixing one agent and the second agent is a pack agent having a gel-like and foaming property .

  The buffer is selected from lactate buffer, citrate buffer, citrate-phosphate buffer, tartrate buffer, malate buffer, succinate buffer, glycine-hydrochloric acid buffer, and acetate buffer Can be included. Among them, the buffer solution may contain at least one selected from a lactic acid buffer solution, a citrate buffer solution, a tartrate buffer solution, and a malate buffer solution. Moreover, it is preferable to use a buffer solution having a water content of 55% or less.

According to the present invention, providing a pack agent that is excellent in solubility or dispersibility in mixing at the time of use, and can secure a viscosity that can stand on the skin without borrowing the power of a sheet material, etc., and user satisfaction Can be improved.

The present inventor has a hydrous viscous composition as a pack agent with high solubility or dispersibility so that even if a general customer who is not an expert performs the work of mixing two or more agents at the time of use, it can be mixed evenly. We conducted extensive research to provide product preparation agents. And by using carbonate (including bicarbonate) and a buffer solution, and using all of the first agent and the second agent containing these respectively in liquid or viscous form, the solubility is much higher than that of granules. Alternatively, the present invention capable of obtaining dispersibility was obtained. In addition, you may use a buffer solution by dividing into a 1st agent and a 2nd agent in the isolation | separation state of an acid and the basic substance which has a buffer capacity with respect to a hydrogen ion combining with this acid.

  Furthermore, when the present inventor diligently researched what can be mixed and practically used at the time of use, when the water-containing viscous composition after mixing is applied to human skin to some extent, it is somewhat There is a problem that viscosity must be ensured, and if the amount of carbon dioxide is large, the viscosity tends to decrease due to the inclusion of a large amount of gas in the hydrous viscous composition (gel cosmetic) after use. The problem of being seen has arisen.

  The present invention has at least a first agent and a second agent, and mixes all agents (two in the case of two of the first agent and the second agent) at the time of use. A thickener is contained in at least one of the first agent and the second agent, or the third agent.

  The first agent and the second agent have (1) a first agent: a liquid or viscous composition containing carbonate, a second agent: a liquid or viscous composition containing a buffer solution, or ( 2) First agent: a liquid or viscous composition containing carbonate and a basic substance that is combined with an acid to become a buffer solution, and second agent: a liquid or viscous composition containing an acid.

When at least one of the first agent and the second agent contains a thickener, there are the following combinations.
<Combination 1>
First agent: Viscous composition containing carbonate and thickener Second agent: Liquid composition containing buffer <Combination 2>
First agent: Liquid composition containing carbonate Second agent: Viscous composition containing buffer and thickener <Combination 3>
First agent: viscous composition containing carbonate and thickener Second agent: viscous composition containing buffer and thickener <Combination 4>
First agent: a viscous composition containing a basic substance that becomes a buffer solution in combination with an acid, a carbonate, and a thickener,
Second agent: Liquid composition containing acid <Combination 5>
First agent: a liquid composition containing a basic substance and a carbonate which are combined with an acid to become a buffer,
Second agent: Viscous composition containing acid and thickener <Combination 6>
First agent: a viscous composition containing a basic substance that becomes a buffer solution in combination with an acid, a carbonate, and a thickener,
Second agent: Viscous composition containing acid and thickener

<Carbonate>
The carbonate is for reacting with an acid to generate carbon dioxide, and those usually used as a component of a skin external preparation in the quasi-drug and cosmetic fields can be used.
Accordingly, carbonates are, for example, sodium carbonate, potassium carbonate, sodium bicarbonate, potassium bicarbonate, calcium carbonate, magnesium carbonate, calcium bicarbonate, magnesium bicarbonate, ammonium carbonate, ammonium bicarbonate, sodium sesquicarbonate, potassium sesquicarbonate. And one or more selected from the group consisting of calcium sesquicarbonate and the like.
Among the above, carbonates having high solubility in water are preferable. For example, sodium carbonate, sodium hydrogen carbonate, and the like are preferable.

<Acid>
The acid is basically an acid that generates carbon dioxide when mixed with a carbonate, and can be used as a component of a skin external preparation in the field of quasi drugs and cosmetics. Specifically, phosphoric acid or hydrochloric acid can be used as the inorganic acid, and acrylic acid, adipic acid, ascorbic acid, aspartic acid, azelaic acid, β-alanine, benzoic acid, isovaleric acid, isobutyric acid can be used as the organic acid. , Formic acid, valeric acid, citric acid, glycolic acid, glutamic acid, glutaric acid, succinic acid, acetic acid, tartaric acid, oxalic acid, lactic acid, barbituric acid, P-hydroxybenzoic acid, pimelic acid, fumaric acid, propionic acid, phthalic acid, One or two or more kinds selected from the group consisting of isophthalic acid, terephthalic acid, malonic acid, butyric acid, malic acid, levulinic acid and the like can be used, and salts thereof can be used.
Among them, ascorbic acid, tartaric acid, citric acid, succinic acid, lactic acid, and malic acid are preferable, and tartaric acid, citric acid, lactic acid, and malic acid are more preferable, and lactic acid is particularly preferable.
The acid is preferably a liquid acid considering the solubility in water. From this viewpoint, for example, acrylic acid, formic acid, acetic acid, butyric acid, isobutyric acid, valeric acid, isovaleric acid, lactic acid and the like are preferable.
Further, considering that the acid is used in cosmetics, an acid having an obstacle in terms of irritation and odor is not preferable. From this point of view, it is considered that an acid having no hindrance in terms of irritation and odor, such as lactic acid, is optimal.
This lactic acid has optical isomers such as L-form, D-form and DL-form. Both L and D isomers are solids having a melting point of about 53 ° C., but only the DL isomer has a melting point of 16.8 and exists as a viscous liquid at room temperature. Therefore, lactic acid can be used in any of L-form, D-form, and DL-form, but DL-form lactic acid is particularly suitable.

<Basic substance>
The basic substance is a basic substance that clears the conditions for the acid to have a buffering capacity against hydrogen ions, and those that are usually used as a component of a skin external preparation in the field of quasi drugs and cosmetics can be used. This basic substance is, for example, one or two selected from the group consisting of sodium lactate, potassium lactate, trisodium citrate, sodium tartrate, disodium malate, disodium succinate, glycine, and sodium phosphate. This can be done.
In order to add an acid without lowering the viscosity of the hydrous viscous composition after mixing, the basic substance is preferably one that can prepare an aqueous solution having high solubility and 50% or more. For this reason, the basic substance is preferably liquid sodium lactate, for example. Further, from the viewpoint of moisture retention, the basic substance is preferably sodium lactate or potassium lactate.

<Buffer solution>
Moreover, since the buffer solution mainly composed of a basic substance and an acid is mixed with a carbonate, it needs to be an acid stronger than carbonic acid. For this reason, the buffer solution is hydrochloric acid-potassium chloride buffer, glycine-hydrochloric acid buffer, acetic acid buffer, citrate buffer, citric acid-phosphate buffer, lactic acid buffer, tartaric acid buffer, malic acid buffer, A succinic acid buffer and the like are preferable, and a buffer using at least one of lactic acid and lactate is preferable. Further, the buffer solution preferably has a water content of 55% or less, more preferably a water content of 15% to 50%. Furthermore, when the buffer solution is a lactic acid buffer solution, sodium lactate / (lactic acid + lactic acid) Assuming that the weight percentage of (sodium) is 10% to 90% (pH 3 to 5), the moisture content is more preferably 16.68% to 47.5%. Moreover, it is preferable to adjust a buffer solution to pH 3-5, and it is more preferable to adjust to pH 3-4.

<Thickener>
The thickener may be one or more selected from the group consisting of natural polymers, semi-synthetic polymers, synthetic polymers, and inorganic substances.
The natural polymer as a thickener is one or two selected from the group consisting of carrageenan, agar, quince seed, guar gum, mannan, locust bean gum, xanthan gum, dextran, hyaluronic acid, pullulan, collagen, gelatin and the like. It can be more than seeds.
Semi-synthetic polymers as thickeners include ethyl cellulose, carboxymethyl cellulose and salts thereof, carboxymethyl ethyl cellulose and salts thereof, carboxymethyl starch and salts thereof, crystalline cellulose, cellulose acetate, hydroxyethyl cellulose, hydroxypropyl cellulose, hydroxypropyl methylcellulose, Stearoxyhydroxypropyl methylcellulose, sodium stearoxy PG hydroxyethylcellulose sulfonate, hydroxypropylmethylcellulose phthalate, powdered cellulose, methylcellulose, methylhydroxypropylcellulose, pregelatinized starch, partially pregelatinized starch, carboxymethyl starch, dextrin, sodium alginate, propylene glycol alginate Esther, co Doroichin sodium sulfate, it can be one or more selected from the group consisting of sodium hyaluronate.
Synthetic polymers as thickeners include: carboxyvinyl polymer, (acryloyldimethyltaurine ammonium beheneth-25 methacrylate) crosspolymer, sodium polyacrylate, polyvinyl acetal diethylaminoacetate, polyvinyl alcohol, polyvinyl pyrrolidone, methacrylic acid-acrylic acid Ethyl copolymer, methacrylic acid-ethyl methacrylate copolymer, ethyl methacrylate / methacrylic acid trimethylammonium ethyl copolymer, dimethylaminoethyl methacrylate / methyl methacrylate copolymer (hydroxyethyl acrylate / acryloyldimethyltaurine Na) ) One or more selected from the group consisting of copolymers and the like.
The inorganic substance as the thickener may be one or more selected from the group consisting of hydrous silicon dioxide, light anhydrous silicic acid, colloidal alumina, bentonite, laponite and the like.

  Examples of the present invention will be specifically described below. In addition, this invention is not limited to this Example. First, Examples 1 to 15 of the present invention are shown using Tables 1 to 5. In Examples 1 to 15 of the present invention, a first agent and a second agent are stirred and mixed to prepare a cosmetic (particularly, a cosmetic for a pack) as a hydrous viscous composition.

  The first agent of formulation examples A to E shown in Table 1 and the second agent of formulation examples 1 to 8 shown in Table 2 are prepared in advance, and the first formulation in Examples 1 to 15 shown in Table 3 to Table 5 is used. The 1st agent and the 2nd agent were stirred and mixed, respectively, and evaluated. The lactic acid in Formulation Examples 1 to 3 shown in Table 2 uses DL form. In addition, Formulation Example 8 is an example in which the second agent is a granular composition for reference.

<Evaluation 1: Foamability>
The volume increase rate after stirring and mixing from the volume before stirring and mixing was evaluated in the following four stages.
◎: 70% or more ○: 50-70%
Δ: 30-50%
×: 30% or less

<Evaluation 2: Bubble persistence>
The volume reduction rate after 1 hour from the volume 1 minute after stirring and mixing was evaluated in the following four stages.
◎: 30% or less ○: 30-50%
Δ: 50-70%
×: 70% or more

<Evaluation 3: Dissolution or dispersibility of the second agent>
The solubility or dispersibility of the second agent when the second agent was stirred and mixed with the first agent was evaluated in the following four stages.
◎: melts well ○: melts Δ: hardly melts X: does not melt Note that Δ (hardly melted) is in a state where it remains undissolved and remains a lump.

<Evaluation 4: Dripping of water-containing viscous composition>
After 4 g of the hydrous viscous composition obtained by stirring and mixing the first agent and the second agent was applied almost uniformly over the upper surface of a transparent acrylic plate placed almost horizontally over an application area of 9 cm 2, Inclined to 60 ° C. from a substantially horizontal state and allowed to stand for 30 minutes, the dripping of the hydrous viscous composition was confirmed visually, and evaluated in the following four stages.
A: Not dripping (0.5 cm or less),
○: Almost no dripping (0.5 cm to 1 cm),
Δ: Slightly droop (1 cm to 2 cm),
X: droop (2 cm or more)

<Evaluation 5: Stimulus>
Expert panelists (3 persons) evaluated the feeling of irritation when each hydrous viscous composition was applied to the face in three stages as follows.
◎: None △: Feeling slightly ×: Feeling strongly Note that the irritation feeling evaluated by two or more people was taken as the irritation feeling of each hydrous viscous composition. Moreover, when each panelist evaluated differently, it was set as the irritation | stimulation feeling of "(triangle | delta)".

<Evaluation 6: Overall evaluation>
Based on each evaluation, comprehensive evaluation was evaluated in four stages as follows.
◎: All evaluation items ◎
○: Two or more ◎ △: No x, ◎ or one or more x: Other than the above

<Evaluation 7: Skin reaction by carbon dioxide absorption>
An external preparation was applied to the inner side of the left arm forearm of the subjects (3 persons), and after 5 minutes of application, the applied part was confirmed and evaluated in the following four stages.
◎: Remarkable reaction ○: Moderate reaction △: Slight reaction ×: No reaction

  As shown in Test Example 1 of Table 3, in Examples 1 to 5, the blending of the second agent was fixed and the blending of the first agent was changed. In all of Examples 1 to 5, good results (results in which evaluation of foamability and sustainability of foaming were all ◎ or one each of ◎ and ○) were obtained. For this reason, in Test Examples 2 and 3 in Table 4 and Table 5 below, the mixing of the first agent is fixed to Compounding Example A, and a plurality of types of second agents having different formulations are mixed with stirring. . In Test Examples 2 and 3, it is considered that the same results can be obtained even when Formulation Examples B to E other than Formulation Example A are used as the first agent.

  As shown in Test Example 2 in Table 4, in Example 1 and Examples 6 to 15, good results were obtained in the solubility or dispersibility of the second agent. The difference is remarkable when compared with Reference Example 1 using Formulation Example 8 using granules. Thus, by using a liquid or viscous buffer without using the acid of granules (fine granules, powder), very good solubility or dispersibility was obtained compared to the case of using granules. .

  As shown in the test results, lactic acid buffer (Examples 1, 6, 7), citrate buffer (Example 8), tartrate buffer (Example 9), malate buffer (Example 10), Alternatively, a succinic acid buffer (Example 11) was used to obtain a hydrous viscous composition preparation agent having excellent solubility or dispersibility.

  Among these, use of lactic acid buffer (Examples 1, 6, 7), citrate buffer (Example 8), tartrate buffer (Example 9), or malate buffer (Example 10), The water-containing viscous composition is preferable because of less dripping, and among them, the lactic acid buffer (Examples 1, 6 and 7) or the malic acid buffer (Example 10) is more preferable, and the lactic acid buffer (Example 1, 6) is more preferable.

  In addition, from the comprehensive evaluation including the solubility or dispersibility of the second agent and the dripping of the water-containing viscous composition, including irritation, lactate buffer (Examples 1, 6 and 7), tartaric acid buffer (Example 9) ) Or malate buffer (Example 10) is preferred, and among them, lactate buffer (Examples 1, 6, and 7) or malate buffer (Example 10) is more preferred. When the lactic acid buffer is used, the weight ratio% of lactate is preferably about 10% to 70%, more preferably 30 to 50%, based on the total weight of lactic acid and lactate.

  In addition, the water content of the buffer solution (the amount of purified water in each table) is 55% or less, and good results are obtained. Among them, 50% or less is better, and further 15% to 50%. Things are better, and 16.68% -47.5% is better.

  Test Example 3 in Table 5 shows the results of changing the blending ratios using Formulation Examples 1 and A, which were the most suitable. As shown in the test results, from the comprehensive evaluation of the dripping of the hydrous viscous composition, the irritation, and the skin reaction due to carbon dioxide absorption, with respect to 15 parts by weight of the first agent having carbonate and thickener, As for the weight part of the 2nd agent containing a lactic acid buffer solution, about 0.5-1.5 are preferred.

  In addition, as for the water-containing viscous composition obtained by stirring and mixing the 1st agent of Examples 1-15 of these Table 3-Table 5, and a 2nd agent, all become pH within the range of 7-4. It has been adjusted. That is, it is preferable to adjust each compounding of the first agent and the second agent and the amount of the first agent and the second agent so that the pH of the hydrous viscous composition is in the range of 7 to 4.

  Next, Examples 16 to 24 of the present invention are shown using Tables 6 to 8. In Examples 16 to 24, lactic acid is used as an acid, lactate (sodium lactate) is used as a basic substance that becomes a buffer solution in combination with an acid, a lactic acid buffer solution is used as a buffer solution, and a thickener is included. Thus, the mixing ratio of the first agent and the second agent is changed. In Examples 16 to 24, the first agent and the second agent are stirred and mixed to prepare a cosmetic (particularly, a cosmetic for a pack) as a hydrous viscous composition.

  The first agent of Formulation Examples F to I shown in Table 6 and the second agent of Formulation Examples 1 and 9 to 14 shown in Table 7 are prepared in advance, and the first formulation is the formulation of Examples 16 to 24 shown in Table 8. The agent and the second agent were mixed with stirring, and evaluated. The lactic acid in Formulation Examples 1 and 9 to 14 shown in Table 7 uses DL.

Formulation Example F is a viscous composition containing carbonate and a thickener, and Formulation Example C is simplified and slightly diluted.
Formulation Example G is a viscous composition containing a basic substance that is combined with an acid to form a buffer, a carbonate, and a thickener.
Formulation example H is a liquid composition containing carbonate.
Formulation Example I is a liquid composition containing a basic substance that becomes a buffer solution in combination with an acid and a carbonate.

  As shown in Table 6, there is no particular problem even if sodium lactate (basic substance that becomes a buffer solution in combination with an acid) is combined with the first agent. Further, there is no particular problem as a preparation even if the thickener is not present in the first agent.

Formulation Example 1 is a liquid composition containing a buffer solution.
Formulation examples 9, 10, and 13 are viscous compositions containing a buffer and a thickener.
Formulation Example 11 is a liquid composition containing an acid.
Formulation examples 12 and 14 are viscous compositions containing an acid and a thickener.

  As shown in Formulation Example 9 and Formulation Example 10 in Table 7, if an acid-resistant salt-resistant thickener (in the examples, stearoxyhydroxypropylmethylcellulose or sodium stearoxyPGhydroxyethylcellulose sulfonate) is used, the buffer solution also increases. Can stick.

  Further, when the second agent contains a thickener, it is preferable that the pH is higher even if it is an acid-resistant thickener. For example, pH 2.5 or higher is preferable in consideration of thickening, and pH 3 or higher is particularly preferable. .

Example 16 corresponds to <Combination 1>.
Examples 21 and 23 correspond to <Combination 2>.
Examples 17 and 18 correspond to <Combination 3>.
Example 19 corresponds to <Combination 4>.
Examples 22 and 24 correspond to <Combination 5>.
Example 20 corresponds to <Combination 6>.

  Evaluation 1: Foaming property, Evaluation 2: Persistence of bubbles, Evaluation 3: Dissolution or dispersibility of the second agent, Evaluation 4: Dripping of hydrous viscous composition, Evaluation 5: Irritation, Evaluation 6: Overall evaluation, And Evaluation 7: Skin reaction due to carbon dioxide absorption was evaluated by the evaluation method in Examples 1 to 15 described above.

  As shown in Examples 16 to 24, when the carbonate and the buffer solution are contained separately in the first agent and the second agent, and the basic substance and the carbonate containing the basic solution that becomes a buffer solution in combination with the acid. Good results were obtained in either case of using one agent and a second agent containing an acid.

  Moreover, even if the thickener was contained in one or both of the first agent and the second agent, good results were obtained. In particular, as shown in Examples 1, 17, 18, and 20, better results were obtained when the first agent containing carbonate or the thickener was added to both the first and second agents. It was. For example, in Example 1, where the amount of the thickener of the first agent is larger than that in Example 16, the evaluation about the dripping of the external preparation is slightly higher.

  Moreover, as shown in Example 17 and Example 18, even if the amount of the thickener of the first agent was reduced, good results were obtained when used in combination with the viscous second agent.

  In addition, the two thickeners (stearoxyhydroxypropylmethylcellulose and stearoxy PGhydroxyethylcellulose sodium sulfonate) used this time were not significantly different in each evaluation item.

  Further, as can be seen from the fact that there is no significant difference between Example 19 and Example 16, Example 20 and Example 17, the basic substance that becomes a buffer solution in combination with acid is included in the first agent. However, the effect of the invention could be obtained without any particular problem.

  Further, as shown in Example 21, the amount of the thickener in the present formulation example 9 is sufficient for the total amount of the thickener in the hydrous viscous composition obtained by stirring and mixing the first agent and the second agent. Absent. Therefore, the results were somewhat unsatisfactory regarding the persistence of bubbles, solubility or dispersibility, dripping of external preparations, and skin reaction due to carbon dioxide absorption.

  In Example 23, the amount of the thickener of the second agent was doubled in order to solve the difficulty of Example 21, and this gave good results. In addition, since stearoxy PG hydroxyethyl cellulose sodium sulfonate was easy to mix | blend a thickener with a high density | concentration, the thickener was changed.

  Therefore, the total amount of the thickener contained in one or both of the first agent and the second agent is preferably 1% to 10%, preferably 1.4% to the total amount of the first agent and the second agent. 7.6% is more preferable, and 3% to 5% is preferable.

  In Examples 22 and 24, the evaluation as the final hydrous viscous composition was the same as that in Examples 21 and 23, respectively. However, in Examples 22 and 24, since the pH of the second agent is low, it is slightly difficult to increase the viscosity. When the second agent contains a thickener, the pH should be high even if it is an acid-resistant thickener, and the pH is preferably 2.5 or higher, especially pH 3 or higher, considering only the thickening. is there. Therefore, when lactic acid is used as the acid, it is preferable to use sodium lactate in combination with the second agent (this is not the case with other acids).

  Further, the amount of carbonate of the first agent is preferably 10% or less of the total amount of the first agent and the second agent, more preferably 0.5% to 5%, and further preferably 1 to 3%.

  Moreover, when using a buffer solution, 15% or less of the total amount of a 1st agent and a 2nd agent is preferable, as for the quantity of the buffer solution of a 2nd agent, 1-11% is more preferable, and 2-8% is further more preferable. 3 to 6% is preferable.

  In addition, the amount of the basic substance that becomes a buffer solution in combination with the acid in the first agent is preferably 5% or less of the total amount of the first agent and the second agent, more preferably 3.5% or less, 2% is more preferable.

  Further, the amount of the acid of the second agent is preferably 10% or less of the total amount of the first agent and the second agent, more preferably 0.3 to 8%, and further preferably 2 to 5%.

  Next, Examples 25 to 32 of the present invention are shown using Tables 9 to 10. In Examples 25 to 32, lactic acid, citric acid, tartaric acid, or ascorbic acid is used as an acid, and lactate (sodium lactate) or malate (disodium malate) is used as a basic substance in combination with the acid to form a buffer solution. ) And a buffer solution of these acids and basic substances was used as a buffer solution. In Examples 25 to 32, the first agent and the second agent are stirred and mixed to prepare a cosmetic (particularly, a cosmetic for a pack) as a hydrous viscous composition.

  The first agent of Formulation Example A shown in Table 1 and the second agent of Formulation Examples 15 to 22 shown in Table 9 are prepared in advance, and the first agent is blended in Examples 25 to 32 shown in Table 10. Each second agent was stirred and mixed for evaluation. DL is used for all of the lactic acids in Formulation Examples 15 to 16 and 20 to 22 shown in Table 10.

この表１０の実施例２５に示すように第２剤に酸に組み合わせて緩衝液になる塩基性物質が含まれていないものよりも、他の実施例の方が刺激スコアが良いため、酸に組み合わせて緩衝液になる塩基性物質を第２剤に含有することが好ましい。
実施例２６は良好な結果であった。

As shown in Example 25 of Table 10, since the stimulation score of the other examples is better than that in which the second agent does not contain a basic substance that becomes a buffer solution in combination with an acid, It is preferable that the second agent contains a basic substance that is combined to form a buffer solution.
Example 26 gave good results.

  In Examples 27 and 28, since the amount of water contained in the second agent is large, the viscosity of the hydrous viscous composition is slightly low, and as a result, the durability of the bubbles and the dripping of the external preparation are somewhat poor. It has become. However, there is no major problem in usability, and this formulation can also be used.

  In addition, as shown in Example 29, when an acid (ascorbic acid) having a slightly lower solubility in water is used, the amount of water contained in the second agent is larger, resulting in a lower viscosity of the hydrous viscous composition. However, good results can be obtained by using together with other acids (lactic acid) as shown in Example 30.

In addition, as shown in Example 31, two or more basic substances that are combined with the acid mixed with the second agent to become a buffer solution can be used without any particular problems.
Further, in Example 32, since the amount of water contained in the second agent is large, the viscosity of the hydrous viscous composition is slightly low, and as a result, the durability of the bubbles and the dripping of the external preparation are a little bad. Yes. However, there is no major problem in usability, and this formulation can also be used.

  As described above, the water-containing viscous composition preparation agent has two or more agents, and when the two or more agents are mixed, carbon dioxide is generated and a water-containing viscous composition containing the carbon dioxide is obtained. By mixing the second agent containing an acid or buffer for reacting with carbonate to generate carbon dioxide into a liquid or viscous composition instead of granules, it is easy to mix and has good solubility or dispersibility An agent for preparing a hydrous viscous composition can be obtained. Moreover, since the granule is not used, it can be easily adjusted in a short time when the first agent and the second agent are stirred and mixed. And since the granule is not used, it can apply | coat to skin smoothly and can provide the cosmetics of a smooth feeling of use.

  In addition, the type using the granule of Japanese Patent No. 4659980 of the conventional example is difficult to determine how much the acid of the granule could be dissolved at the time of use, and the customer must use it without knowing whether it was dissolved uniformly. In the invention, a dissolved buffer solution (containing an acid) is used, so that it can be used in a state of being uniformly dissolved. That is, it is possible to prevent the acid from being applied to the skin in a state where the acid is not completely dissolved as in the conventional example.

  In addition, when granules are used as in the past, there is a risk that some granules may dissolve when used in wet hands or water. However, liquid or viscous buffer solution is used, so there are problems with wet hands. It can be used without.

  In addition, liquid cosmetic ingredients cannot be added to conventional granules, but by using a liquid or viscous composition, liquid cosmetic ingredients can be added and cosmetics with high cosmetic effects can be provided. .

  In addition, the acid used to react with the carbonate to generate carbon dioxide was used as a buffer solution, so that if there is a lot of acid, the reactivity will increase, but the irritation will be too high. It is possible to solve the conflicting problem that the reactivity can be reduced but the reactivity can be reduced, and the user can have a good feeling of use by reducing the irritation while securing the reactivity. Moreover, since the acid made to react with carbonate is made into the buffer solution, various thickeners can be utilized and appropriate viscosity can be ensured easily, Therefore It can apply | coat thickly on skin.

  At the time of use, a water-containing viscous composition can be obtained simply by mixing the first and second agents that are easy to mix, so that it can be easily used by general customers. Also, in service facilities such as salons and clinics, the service person stirs and mixes the first agent and the second agent, applies the obtained hydrous viscous composition to the customer's skin, and after a predetermined time, the hydrous viscous composition by face washing or the like. Services for removing objects can be easily performed. Since the second agent containing the buffer solution (or acid) has good solubility or dispersibility, it is not necessary for the service staff to be skilled, and service with stable quality can be easily performed.

  Moreover, since it can suppress the fall of pH and aluminum does not react (it does not melt | dissolve), a 1st agent and a 2nd agent (especially 2nd agent) can be preserve | saved in aluminum containers, such as an aluminum pouch. Thereby, the first agent and the second agent are put into the first container and the second container such as an aluminum pouch, respectively, once in use, and the two agents are taken out from both containers at the time of use and stirred and mixed. it can.

  Further, as the thickener, it is possible to use the same sodium alginate as in Patent No. 4659980 of the conventional example using granular acid, but as shown in the test examples of Tables 3 to 5, alginic acid is used. Other thickeners such as carrageenan, locust bean gum, and xanthan gum can be used without any problem without using sodium. Therefore, there is a high degree of freedom in selecting the thickener, and it is possible to provide a water-containing viscous composition material and a water-containing viscous composition using various thickeners.

In the above examples, a gel-like water-containing viscous composition was obtained, but the first agent was prepared so as to obtain a water-containing viscous composition in an appropriate form that can be used without sagging when applied on the skin. And the second agent may be adjusted.

  Further, the water-containing viscous composition after stirring and mixing is not limited to being applied directly to the application part such as the face alone, but the skin so that the water-containing viscous composition contacts the skin after being applied to a sheet material such as a nonwoven fabric. You may use it on top.

Moreover, the hydrous viscous composition preparation agent (the 1st agent and the 2nd agent) obtained in said Example apply | coats the hydrous viscous composition mixed by stirring to the face etc., and uses it as a pack .

  The present invention can be used as a cosmetic, and in particular, can be used for a pack applied to the skin such as the face. In addition, it can be used for various external preparations in pharmaceuticals and quasi drugs.

This invention has two or more agents, and when the two or more agents are mixed, carbon dioxide is generated and a hydrous viscous composition containing the carbon dioxide is obtained. agent, first: composition of liquid or viscous and a carbonate, and, second agents: which has a liquid or viscous composition comprises a buffer of acidic, containing at least one agent is a thickening agent The water-containing viscous composition after mixing the first agent and the second agent is a gel-like and foaming pack agent.

Claims (7)

A water-containing viscous composition preparation agent that has two or more agents, and when the two or more agents are mixed, carbon dioxide is generated and a water-containing viscous composition containing the carbon dioxide is obtained,
The two or more agents are
(1) First agent: liquid or viscous composition containing carbonate,
Second agent: liquid or viscous composition containing a buffer,
Or
(2) First agent: a liquid or viscous composition containing a basic substance that becomes a buffer solution in combination with an acid and a carbonate,
Second agent: A hydrous viscous composition preparation agent containing a liquid or viscous composition containing an acid and at least one agent containing a thickener. The buffer is
At least one selected from lactate buffer, citrate buffer, citrate-phosphate buffer, tartrate buffer, malate buffer, succinate buffer, glycine-HCl buffer, and acetate buffer The water-containing viscous composition preparation agent of Claim 1 containing. The water-containing viscous composition preparation agent according to claim 1 or 2, wherein the buffer solution has a water content of 55% or less. The first agent and the second agent are:
(1) First agent: a viscous composition containing carbonate and a thickener,
The agent for preparing a hydrous viscous composition according to claim 1, 2 or 3, wherein the second agent is a liquid or viscous composition containing a buffer solution. Use the hydrous viscous composition preparation agent according to any one of claims 1 to 4,
A method for preparing a hydrous viscous composition, wherein the hydrous viscous composition is prepared by mixing the two or more agents. Use the hydrous viscous composition preparation agent according to any one of claims 1 to 4,
Mixing the two or more agents to create a hydrous viscous composition,
Apply the prepared hydrous viscous composition to the customer's skin,
A method for using a hydrous viscous composition, wherein the hydrous viscous composition is removed from the skin of the customer after a predetermined time has elapsed. For the total amount of the first agent and the second agent,
The total amount of the thickener contained in one or both of the first agent and the second agent is 1% or more,
The amount of carbonate of the first agent is 10% or less,
The amount of the buffer solution of the first agent is 15% or less, or the amount of the basic substance of the first agent is 5% or less, and the amount of acid of the second agent is the total amount of the first agent and the second agent The water-containing viscous composition preparation agent according to any one of claims 1 to 4, which is 10% or less.