JP2012532889A5 - - Google Patents
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- JP2012532889A5 JP2012532889A5 JP2012519777A JP2012519777A JP2012532889A5 JP 2012532889 A5 JP2012532889 A5 JP 2012532889A5 JP 2012519777 A JP2012519777 A JP 2012519777A JP 2012519777 A JP2012519777 A JP 2012519777A JP 2012532889 A5 JP2012532889 A5 JP 2012532889A5
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- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- silicone
- days
- administered
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000008194 pharmaceutical composition Substances 0.000 claims description 25
- 239000003246 corticosteroid Substances 0.000 claims description 7
- 229920001296 polysiloxane Polymers 0.000 claims description 7
- 229920000642 polymer Polymers 0.000 claims description 6
- UQEAIHBTYFGYIE-UHFFFAOYSA-N Hexamethyldisiloxane Chemical group C[Si](C)(C)O[Si](C)(C)C UQEAIHBTYFGYIE-UHFFFAOYSA-N 0.000 claims description 5
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 5
- 229940121363 anti-inflammatory agents Drugs 0.000 claims description 5
- 229940008099 dimethicone Drugs 0.000 claims description 5
- 239000004205 dimethyl polysiloxane Substances 0.000 claims description 5
- 235000013870 dimethyl polysiloxane Nutrition 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims description 5
- -1 thixocortol Chemical compound 0.000 claims description 5
- 231100000241 scar Toxicity 0.000 claims description 4
- 229940086555 cyclomethicone Drugs 0.000 claims description 3
- 229920002545 silicone oil Polymers 0.000 claims description 3
- 102000015439 Phospholipases Human genes 0.000 claims description 2
- 108010064785 Phospholipases Proteins 0.000 claims description 2
- LRJOMUJRLNCICJ-JZYPGELDSA-N Prednisolone acetate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)C)(O)[C@@]1(C)C[C@@H]2O LRJOMUJRLNCICJ-JZYPGELDSA-N 0.000 claims description 2
- 230000015572 biosynthetic process Effects 0.000 claims description 2
- 239000003255 cyclooxygenase 2 inhibitor Substances 0.000 claims description 2
- 238000005755 formation reaction Methods 0.000 claims description 2
- 229960001293 methylprednisolone acetate Drugs 0.000 claims description 2
- PLBHSZGDDKCEHR-LFYFAGGJSA-N methylprednisolone acetate Chemical compound C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@](O)(C(=O)COC(C)=O)CC[C@H]21 PLBHSZGDDKCEHR-LFYFAGGJSA-N 0.000 claims description 2
- 229960002800 prednisolone acetate Drugs 0.000 claims description 2
- URZHQOCYXDNFGN-UHFFFAOYSA-N 2,4,6-trimethyl-2,4,6-tris(3,3,3-trifluoropropyl)-1,3,5,2,4,6-trioxatrisilinane Chemical compound FC(F)(F)CC[Si]1(C)O[Si](C)(CCC(F)(F)F)O[Si](C)(CCC(F)(F)F)O1 URZHQOCYXDNFGN-UHFFFAOYSA-N 0.000 claims 3
- 239000004744 fabric Substances 0.000 claims 3
- 229940064701 Corticosteroid nasal preparations for topical use Drugs 0.000 claims 2
- 229960001334 Corticosteroids Drugs 0.000 claims 2
- WBGKWQHBNHJJPZ-LECWWXJVSA-N Desonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O WBGKWQHBNHJJPZ-LECWWXJVSA-N 0.000 claims 2
- 229960003662 desonide Drugs 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 229940083878 topical for treatment of hemorrhoids and anal fissures Corticosteroids Drugs 0.000 claims 2
- UREBDLICKHMUKA-DVTGEIKXSA-N Betamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-DVTGEIKXSA-N 0.000 claims 1
- 229960004436 Budesonide Drugs 0.000 claims 1
- VOVIALXJUBGFJZ-VXKMTNQYSA-N Budesonide Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1C[C@H]3O[C@@H](CCC)O[C@@]3(C(=O)CO)[C@@]1(C)C[C@@H]2O VOVIALXJUBGFJZ-VXKMTNQYSA-N 0.000 claims 1
- JYGXADMDTFJGBT-VWUMJDOOSA-N Cortisol Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims 1
- MFYSYFVPBJMHGN-ZPOLXVRWSA-N Cortisone Chemical compound O=C1CC[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 MFYSYFVPBJMHGN-ZPOLXVRWSA-N 0.000 claims 1
- 229960002593 Desoximetasone Drugs 0.000 claims 1
- 229960003957 Dexamethasone Drugs 0.000 claims 1
- UREBDLICKHMUKA-CXSFZGCWSA-N Dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 1
- AAXVEMMRQDVLJB-BULBTXNYSA-N Fludrocortisone Chemical compound O=C1CC[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 AAXVEMMRQDVLJB-BULBTXNYSA-N 0.000 claims 1
- 229960002011 Fludrocortisone Drugs 0.000 claims 1
- UUOUOERPONYGOS-CLCRDYEYSA-N Fluocinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3C[C@H](F)C2=C1 UUOUOERPONYGOS-CLCRDYEYSA-N 0.000 claims 1
- WJOHZNCJWYWUJD-IUGZLZTKSA-N Fluocinonide Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)COC(=O)C)[C@@]2(C)C[C@@H]1O WJOHZNCJWYWUJD-IUGZLZTKSA-N 0.000 claims 1
- MGNNYOODZCAHBA-GQKYHHCASA-N Fluticasone Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@@H](C)[C@@](C(=O)SCF)(O)[C@@]2(C)C[C@@H]1O MGNNYOODZCAHBA-GQKYHHCASA-N 0.000 claims 1
- VHRSUDSXCMQTMA-PJHHCJLFSA-N Methylprednisolone Chemical compound C([C@@]12C)=CC(=O)C=C1[C@@H](C)C[C@@H]1[C@@H]2[C@@H](O)C[C@]2(C)[C@@](O)(C(=O)CO)CC[C@H]21 VHRSUDSXCMQTMA-PJHHCJLFSA-N 0.000 claims 1
- 229960001664 Mometasone Drugs 0.000 claims 1
- 229940086541 PEG-12 GLYCERYL DIMYRISTATE Drugs 0.000 claims 1
- FNPXMHRZILFCKX-KAJVQRHHSA-N Prednicarbate Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@@](C(=O)COC(=O)CC)(OC(=O)OCC)[C@@]1(C)C[C@@H]2O FNPXMHRZILFCKX-KAJVQRHHSA-N 0.000 claims 1
- OIGNJSKKLXVSLS-VWUMJDOOSA-N Prednisolone Chemical compound O=C1C=C[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 OIGNJSKKLXVSLS-VWUMJDOOSA-N 0.000 claims 1
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N Prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 claims 1
- GFNANZIMVAIWHM-OBYCQNJPSA-N Triamcinolone Chemical compound O=C1C=C[C@]2(C)[C@@]3(F)[C@@H](O)C[C@](C)([C@@]([C@H](O)C4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 GFNANZIMVAIWHM-OBYCQNJPSA-N 0.000 claims 1
- LEHFPXVYPMWYQD-XHIJKXOTSA-N Ulobetasol Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H](C)[C@@](C(=O)CCl)(O)[C@@]2(C)C[C@@H]1O LEHFPXVYPMWYQD-XHIJKXOTSA-N 0.000 claims 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- 229960002537 betamethasone Drugs 0.000 claims 1
- FCSHDIVRCWTZOX-DVTGEIKXSA-N clobetasol Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@H](C)[C@@](C(=O)CCl)(O)[C@@]1(C)C[C@@H]2O FCSHDIVRCWTZOX-DVTGEIKXSA-N 0.000 claims 1
- 229960002842 clobetasol Drugs 0.000 claims 1
- 229960004544 cortisone Drugs 0.000 claims 1
- VWVSBHGCDBMOOT-IIEHVVJPSA-N desoximetasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@H](C(=O)CO)[C@@]1(C)C[C@@H]2O VWVSBHGCDBMOOT-IIEHVVJPSA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940043075 fluocinolone Drugs 0.000 claims 1
- 229960000785 fluocinonide Drugs 0.000 claims 1
- 229960002714 fluticasone Drugs 0.000 claims 1
- 229940115747 halobetasol Drugs 0.000 claims 1
- 229960000890 hydrocortisone Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229960004584 methylprednisolone Drugs 0.000 claims 1
- QLIIKPVHVRXHRI-CXSFZGCWSA-N mometasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(Cl)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CCl)(O)[C@@]1(C)C[C@@H]2O QLIIKPVHVRXHRI-CXSFZGCWSA-N 0.000 claims 1
- 229960002794 prednicarbate Drugs 0.000 claims 1
- 229960005205 prednisolone Drugs 0.000 claims 1
- 229960004618 prednisone Drugs 0.000 claims 1
- 229960005294 triamcinolone Drugs 0.000 claims 1
- IMAYJYGCQCZYID-UHFFFAOYSA-N 1,3,5,7,9,11-hexaoxa-2,4,6,8,10,12-hexasilacyclododecane Chemical compound O1[SiH2]O[SiH2]O[SiH2]O[SiH2]O[SiH2]O[SiH2]1 IMAYJYGCQCZYID-UHFFFAOYSA-N 0.000 description 2
- XMSXQFUHVRWGNA-UHFFFAOYSA-N Decamethylcyclopentasiloxane Chemical compound C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1 XMSXQFUHVRWGNA-UHFFFAOYSA-N 0.000 description 2
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22440809P | 2009-07-09 | 2009-07-09 | |
| US61/224,408 | 2009-07-09 | ||
| US22621609P | 2009-07-16 | 2009-07-16 | |
| US61/226,216 | 2009-07-16 | ||
| PCT/US2010/041576 WO2011006100A1 (en) | 2009-07-09 | 2010-07-09 | Method of wound healing and scar modulation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012532889A JP2012532889A (ja) | 2012-12-20 |
| JP2012532889A5 true JP2012532889A5 (US20080070878A1-20080320-C00003.png) | 2013-09-05 |
Family
ID=43427950
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012519777A Pending JP2012532889A (ja) | 2009-07-09 | 2010-07-09 | 創傷治療方法及び傷跡変性方法 |
Country Status (10)
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20100322875A1 (en) | 2009-06-18 | 2010-12-23 | Advanced Bio-Technologies, Inc. | Silicone scar treatment preparation |
| US8623040B2 (en) | 2009-07-01 | 2014-01-07 | Alcon Research, Ltd. | Phacoemulsification hook tip |
| WO2012012390A1 (en) | 2010-07-19 | 2012-01-26 | Marvphyt Development Llc | Botanical composition and methods of manufacture and use |
| US10258505B2 (en) | 2010-09-17 | 2019-04-16 | Alcon Research, Ltd. | Balanced phacoemulsification tip |
| ITMI20111050A1 (it) * | 2011-06-10 | 2012-12-11 | Sevecom Spa | Uso di emulsionanti in associazione con oleine vegetali in un alimento per animali. |
| WO2012175626A1 (en) | 2011-06-24 | 2012-12-27 | Merz Pharma Gmbh & Co. Kgaa | Composition comprising an onion extract and liposomes |
| US9364510B2 (en) | 2011-07-19 | 2016-06-14 | Marvphyt Development Llc | Botanical composition and methods of manufacture and use |
| RS56823B1 (sr) | 2011-07-29 | 2018-04-30 | Karyopharm Therapeutics Inc | Modulatori nukleusnog transporta koji sadrže hidrazid i njihove upotrebe |
| KR101966293B1 (ko) * | 2011-09-13 | 2019-04-08 | 브라이엄 영 유니버시티 | 손상조직 치유용 제품 |
| US9474685B2 (en) | 2011-09-28 | 2016-10-25 | Sure-Shot Medical Device Inc. | Apparatus for localized dermatological treatment |
| GB201120724D0 (en) * | 2011-12-01 | 2012-01-11 | Gauthier Rene | System and method for alleviating the appearance of scars and/or scar tissue |
| FR2985064B1 (fr) * | 2011-12-23 | 2016-02-26 | Oreal | Procede pour delivrer un conseil cosmetique |
| EP2841106A1 (en) * | 2012-04-27 | 2015-03-04 | Dow Corning Corporation | Topical formulation compositions containing silicone based excipients to deliver actives to a substrate |
| US9096543B2 (en) | 2012-05-09 | 2015-08-04 | Karyopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
| US11458199B2 (en) * | 2012-08-21 | 2022-10-04 | Opko Pharmaceuticals, Llc | Liposome formulations |
| US9808654B2 (en) * | 2013-02-11 | 2017-11-07 | Jan Marini Skin Research | Post procedure skin care gel and methods of use thereof |
| EP2968278B8 (en) * | 2013-03-15 | 2019-05-22 | Karyopharm Therapeutics Inc. | Methods of promoting wound healing using crm1 inhibitors |
| WO2014175861A1 (en) * | 2013-04-23 | 2014-10-30 | Hewlett-Packard Development Company, L.P. | Recovering from compromised system boot code |
| US9738624B2 (en) | 2013-06-21 | 2017-08-22 | Karyopharm Therapeutics Inc. | Nuclear transport modulators and uses thereof |
| US11432990B2 (en) | 2013-08-30 | 2022-09-06 | ISOS Solutions, LLC | Textured apparatus with therapeutic material incorporated therein and methods of manufacturing same |
| US9226890B1 (en) | 2013-12-10 | 2016-01-05 | Englewood Lab, Llc | Polysilicone base for scar treatment |
| WO2015099660A1 (en) * | 2013-12-23 | 2015-07-02 | Intel Corporation | Integrated component interconnect |
| JP7017311B2 (ja) * | 2014-06-09 | 2022-02-08 | 広東科洛克生物医薬集団有限公司 | シリコンベースの生体光組成物およびその使用 |
| CN106535656A (zh) | 2014-07-21 | 2017-03-22 | 赛富康公司 | 用于动物饲料的粉末状乳化剂 |
| EA201790384A1 (ru) | 2014-08-15 | 2017-08-31 | Кариофарм Терапевтикс, Инк. | Полиморфы селинексора |
| EP3397634A1 (en) | 2015-12-31 | 2018-11-07 | Karyopharm Therapeutics, Inc. | Nuclear transport modulators and uses thereof |
| MA43529A (fr) | 2015-12-31 | 2018-11-07 | Karyopharm Therapeutics Inc | Modulateurs de transport nucléaire et leurs utilisations |
| US11602530B2 (en) | 2016-11-28 | 2023-03-14 | Biogen Ma Inc. | CRM1 inhibitors for treating epilepsy |
| US11690847B2 (en) | 2016-11-30 | 2023-07-04 | Case Western Reserve University | Combinations of 15-PGDH inhibitors with corticosteroids and/or TNF inhibitors and uses thereof |
| WO2018145080A1 (en) | 2017-02-06 | 2018-08-09 | Case Western Reserve University | Compositions and methods of modulating short-chain dehydrogenase activity |
| WO2020069448A1 (en) * | 2018-09-28 | 2020-04-02 | Joel Studin | Transpore delivery of steroids and large molecules |
| US20200397720A1 (en) * | 2019-06-23 | 2020-12-24 | Charles Huntington Gallina | Method and formulation for treatment of wounds by new tissue regeneration with reduced trauma and scar tissue formation |
| CN110368498A (zh) * | 2019-08-26 | 2019-10-25 | 瑞希(重庆)生物科技有限公司 | 一种促进伤口愈合的制剂及其制备方法 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6337076B1 (en) * | 1999-11-17 | 2002-01-08 | Sg Licensing Corporation | Method and composition for the treatment of scars |
| KR100362924B1 (ko) * | 2000-01-11 | 2002-11-30 | 주식회사 동구약품 | 외피용약제 조성물 |
| CN1443062A (zh) * | 2000-05-23 | 2003-09-17 | 荷兰联合利华有限公司 | 除臭剂和/或防汗剂组合物 |
| GB0018466D0 (en) * | 2000-07-27 | 2000-09-13 | Strakan Pharm Ltd | Keloid Treatment |
| US6610322B1 (en) * | 2000-12-20 | 2003-08-26 | Brian Charles Keller | Self forming, thermodynamically stable liposomes and their applications |
| US6495596B1 (en) * | 2001-03-23 | 2002-12-17 | Biozibe Laboratories, Inc. | Compounds and methods for inhibition of phospholipase A2 and cyclooxygenase-2 |
| US6998421B2 (en) * | 2001-06-07 | 2006-02-14 | Biozone Laboratories, Inc. | Compounds and methods for inhibition of phospholipase A2 and cyclooxygenase - 2 |
| JP4450545B2 (ja) * | 2001-07-05 | 2010-04-14 | ロート製薬株式会社 | エアゾール製剤 |
| JP4549006B2 (ja) * | 2002-05-07 | 2010-09-22 | ロート製薬株式会社 | ゲル軟膏 |
| GB0216427D0 (en) * | 2002-07-16 | 2002-08-21 | Advanced Biotechnologies Inter | Wound dressing |
| US20040220155A1 (en) * | 2003-03-28 | 2004-11-04 | Pharmacia Corporation | Method of providing a steroid-sparing benefit with a cyclooxygenase-2 inhibitor and compositions therewith |
| WO2005009342A2 (en) * | 2003-07-16 | 2005-02-03 | Pharmacia Corporation | Method for the treatment or prevention of dermatological disorders with a cyclooxygenase-2 inhibitor alone and in combination with a dermatological treatment agent and compositions therewith |
| CA2567636A1 (en) * | 2004-06-17 | 2005-12-29 | Galderma S.A. | Composition for the treatment of psoriasis comprising a silicone agent, a corticosteroid and vitamin d or a derivative thereof |
| EP1901709A2 (en) * | 2005-06-10 | 2008-03-26 | Galderma S.A. | Controlled release of a drug through skin on the basis of a topical composition comprising a drug, a film-forming silicone and at least one volatile solvent |
| MX2009009557A (es) * | 2007-03-08 | 2010-08-10 | Crescendo Therapeutics Llc | Formulaciones de aposito para prevenir o reducir la cicatrizacion. |
| US20080317830A1 (en) * | 2007-06-25 | 2008-12-25 | Liolabs Llc | Compositions and Methods for the Treatment of Wounds and Scar Tissue |
| DE102009030931A1 (de) * | 2009-06-24 | 2010-12-30 | Eberhard-Karls-Universität Tübingen Universitätsklinikum | Chirurgisches Wundverschlusselement |
-
2010
- 2010-07-09 MX MX2012000434A patent/MX2012000434A/es not_active Application Discontinuation
- 2010-07-09 BR BRBR112012001098-0A patent/BR112012001098A2/pt not_active IP Right Cessation
- 2010-07-09 CN CN2010800392366A patent/CN102480969A/zh active Pending
- 2010-07-09 CA CA2767661A patent/CA2767661A1/en not_active Abandoned
- 2010-07-09 EP EP10797937A patent/EP2451280A4/en not_active Withdrawn
- 2010-07-09 US US12/833,902 patent/US20110009374A1/en not_active Abandoned
- 2010-07-09 WO PCT/US2010/041576 patent/WO2011006100A1/en active Application Filing
- 2010-07-09 AU AU2010271205A patent/AU2010271205A1/en not_active Abandoned
- 2010-07-09 JP JP2012519777A patent/JP2012532889A/ja active Pending
- 2010-07-12 AR ARP100102522A patent/AR077410A1/es unknown
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