JP2012528866A5 - - Google Patents
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- Publication number
- JP2012528866A5 JP2012528866A5 JP2012514044A JP2012514044A JP2012528866A5 JP 2012528866 A5 JP2012528866 A5 JP 2012528866A5 JP 2012514044 A JP2012514044 A JP 2012514044A JP 2012514044 A JP2012514044 A JP 2012514044A JP 2012528866 A5 JP2012528866 A5 JP 2012528866A5
- Authority
- JP
- Japan
- Prior art keywords
- poly
- tyrosine
- derived
- composition
- subject
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims 22
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims 20
- 239000000203 mixture Substances 0.000 claims 20
- 229920006149 polyester-amide block copolymer Polymers 0.000 claims 16
- 229920000954 Polyglycolide Polymers 0.000 claims 12
- 229920000642 polymer Polymers 0.000 claims 11
- 239000004599 antimicrobial Substances 0.000 claims 10
- 238000000034 method Methods 0.000 claims 10
- 229920001244 Poly(D,L-lactide) Polymers 0.000 claims 8
- 229920001432 poly(L-lactide) Polymers 0.000 claims 8
- 229920001610 polycaprolactone Polymers 0.000 claims 8
- 239000004632 polycaprolactone Substances 0.000 claims 8
- 229920000331 Polyhydroxybutyrate Polymers 0.000 claims 6
- 239000011230 binding agent Substances 0.000 claims 6
- 239000005015 poly(hydroxybutyrate) Substances 0.000 claims 6
- 201000001231 mediastinitis Diseases 0.000 claims 5
- -1 polypropylene fumarate Polymers 0.000 claims 5
- 208000005489 Esophageal Perforation Diseases 0.000 claims 4
- 206010030181 Oesophageal perforation Diseases 0.000 claims 4
- 229920003171 Poly (ethylene oxide) Polymers 0.000 claims 4
- 239000002202 Polyethylene glycol Substances 0.000 claims 4
- 229920001245 poly(D,L-lactide-co-caprolactone) Polymers 0.000 claims 4
- 229920001223 polyethylene glycol Polymers 0.000 claims 4
- 239000004633 polyglycolic acid Substances 0.000 claims 4
- 239000002253 acid Substances 0.000 claims 3
- HCZQSLKOEQURLM-ZETCQYMHSA-N (4S)-4-amino-5-[2-[(2-methylpropan-2-yl)oxy]-2-oxoethoxy]-5-oxopentanoic acid Chemical compound CC(C)(C)OC(=O)COC(=O)[C@@H](N)CCC(O)=O HCZQSLKOEQURLM-ZETCQYMHSA-N 0.000 claims 2
- JRFXQKZEGILCCO-UHFFFAOYSA-N 5,5-dimethyl-1,3-dioxan-2-one Chemical compound CC1(C)COC(=O)OC1 JRFXQKZEGILCCO-UHFFFAOYSA-N 0.000 claims 2
- 229910019142 PO4 Inorganic materials 0.000 claims 2
- 229920001710 Polyorthoester Polymers 0.000 claims 2
- 239000003242 anti bacterial agent Substances 0.000 claims 2
- 230000000845 anti-microbial effect Effects 0.000 claims 2
- 230000001580 bacterial effect Effects 0.000 claims 2
- 230000003115 biocidal effect Effects 0.000 claims 2
- 150000002148 esters Chemical class 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 239000004220 glutamic acid Substances 0.000 claims 2
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 claims 2
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 claims 2
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 claims 2
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 claims 2
- 239000010452 phosphate Substances 0.000 claims 2
- 229920006209 poly(L-lactide-co-D,L-lactide) Polymers 0.000 claims 2
- 229920000233 poly(alkylene oxides) Polymers 0.000 claims 2
- 229920001308 poly(aminoacid) Polymers 0.000 claims 2
- 229920006210 poly(glycolide-co-caprolactone) Polymers 0.000 claims 2
- 229920000747 poly(lactic acid) Polymers 0.000 claims 2
- 229920002463 poly(p-dioxanone) polymer Polymers 0.000 claims 2
- 229920002627 poly(phosphazenes) Polymers 0.000 claims 2
- 229920000515 polycarbonate Polymers 0.000 claims 2
- 239000004417 polycarbonate Substances 0.000 claims 2
- 239000000622 polydioxanone Substances 0.000 claims 2
- 229920002643 polyglutamic acid Polymers 0.000 claims 2
- 239000004626 polylactic acid Substances 0.000 claims 2
- 229920001299 polypropylene fumarate Polymers 0.000 claims 2
- JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 claims 2
- 229960001225 rifampicin Drugs 0.000 claims 2
- YFHICDDUDORKJB-UHFFFAOYSA-N trimethylene carbonate Chemical compound O=C1OCCCO1 YFHICDDUDORKJB-UHFFFAOYSA-N 0.000 claims 2
- 125000001493 tyrosinyl group Chemical group [H]OC1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])(N([H])[H])C(*)=O 0.000 claims 2
- FFTVPQUHLQBXQZ-KVUCHLLUSA-N (4s,4as,5ar,12ar)-4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide Chemical compound C1C2=C(N(C)C)C=CC(O)=C2C(O)=C2[C@@H]1C[C@H]1[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]1(O)C2=O FFTVPQUHLQBXQZ-KVUCHLLUSA-N 0.000 claims 1
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims 1
- 229930182555 Penicillin Natural products 0.000 claims 1
- 239000004698 Polyethylene Substances 0.000 claims 1
- 239000004098 Tetracycline Substances 0.000 claims 1
- 230000000844 anti-bacterial effect Effects 0.000 claims 1
- 229940088710 antibiotic agent Drugs 0.000 claims 1
- 239000003899 bactericide agent Substances 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229920001577 copolymer Polymers 0.000 claims 1
- 239000006071 cream Substances 0.000 claims 1
- 239000006260 foam Substances 0.000 claims 1
- 239000000499 gel Substances 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000003120 macrolide antibiotic agent Substances 0.000 claims 1
- 229940041033 macrolides Drugs 0.000 claims 1
- 229960004023 minocycline Drugs 0.000 claims 1
- 239000002674 ointment Substances 0.000 claims 1
- 230000000278 osteoconductive effect Effects 0.000 claims 1
- 230000002138 osteoinductive effect Effects 0.000 claims 1
- 239000006072 paste Substances 0.000 claims 1
- 150000002960 penicillins Chemical class 0.000 claims 1
- 239000002745 poly(ortho ester) Substances 0.000 claims 1
- 229920000728 polyester Polymers 0.000 claims 1
- 229920000573 polyethylene Polymers 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 235000019364 tetracycline Nutrition 0.000 claims 1
- 150000003522 tetracyclines Chemical class 0.000 claims 1
- 229940040944 tetracyclines Drugs 0.000 claims 1
- 230000000699 topical effect Effects 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47576109A | 2009-06-01 | 2009-06-01 | |
| US12/475,761 | 2009-06-01 | ||
| PCT/US2010/036910 WO2010141475A1 (en) | 2009-06-01 | 2010-06-01 | Compositions and methods for preventing sternal wound infections |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012528866A JP2012528866A (ja) | 2012-11-15 |
| JP2012528866A5 true JP2012528866A5 (https=) | 2013-07-18 |
| JP5847706B2 JP5847706B2 (ja) | 2016-01-27 |
Family
ID=43298082
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012514044A Active JP5847706B2 (ja) | 2009-06-01 | 2010-06-01 | 胸骨創感染症を予防するための組成物および方法 |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP2437724B1 (https=) |
| JP (1) | JP5847706B2 (https=) |
| WO (1) | WO2010141475A1 (https=) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9023114B2 (en) | 2006-11-06 | 2015-05-05 | Tyrx, Inc. | Resorbable pouches for implantable medical devices |
| JP6031033B2 (ja) * | 2010-08-25 | 2016-11-24 | タイレックス・インコーポレイテッドＴｙｒｘ Ｉｎｃ． | 医療デバイスの新規なコーティング |
| AU2011326417A1 (en) | 2010-11-12 | 2013-05-09 | Tyrx, Inc. | Anchorage devices comprising an active pharmaceutical ingredient |
| AU2012283875B2 (en) * | 2011-07-20 | 2016-05-12 | Medtronic, Inc. | Drug eluting mesh to prevent infection of indwelling transdermal devices |
| WO2015069305A1 (en) * | 2013-11-08 | 2015-05-14 | Tyrx, Inc. | Antimicrobial compositions and methods for preventing infection in surgical incision sites |
| RU2539394C1 (ru) * | 2014-01-15 | 2015-01-20 | государственное бюджетное образовательное учреждение высшего профессионального образования "Сибирский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ГБОУ ВПО СибГМУ Минздрава России) | Способ лечения стерномедиастинита |
| US10767006B2 (en) * | 2017-06-07 | 2020-09-08 | Medtronic, Inc. | Hydrogenation of tyrosine derived polyarylates |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5487897A (en) * | 1989-07-24 | 1996-01-30 | Atrix Laboratories, Inc. | Biodegradable implant precursor |
| US5099060A (en) | 1990-06-12 | 1992-03-24 | Rutgers, The State University Of New Jersey | Synthesis of amino acid-derived bioerodible polymers |
| US5216115A (en) | 1990-06-12 | 1993-06-01 | Rutgers, The State University Of New Jersey | Polyarylate containing derivatives of the natural amino acid L-tyrosine |
| US8795242B2 (en) * | 1994-05-13 | 2014-08-05 | Kensey Nash Corporation | Resorbable polymeric device for localized drug delivery |
| US6120491A (en) | 1997-11-07 | 2000-09-19 | The State University Rutgers | Biodegradable, anionic polymers derived from the amino acid L-tyrosine |
| EP1263453A4 (en) * | 1999-12-31 | 2008-02-20 | Univ Rutgers | PHARMACEUTICAL FORMULATION CONSISTING OF A POLYMERMATRIX, FOR REGULATING THE TIME-CONTROLLED RELEASE OF BIOLOGICALLY ACTIVE SUBSTANCES |
| JP2003155404A (ja) * | 2001-11-22 | 2003-05-30 | Yasuhiko Tabata | 抗菌剤・高分子複合物及びその製造方法 |
| WO2005074894A1 (en) * | 2004-01-30 | 2005-08-18 | Corium International | Rapidly dissolving film for delivery of an active agent |
| US8591531B2 (en) * | 2006-02-08 | 2013-11-26 | Tyrx, Inc. | Mesh pouches for implantable medical devices |
| EP2114298B1 (en) * | 2006-02-08 | 2022-10-19 | Medtronic, Inc. | Temporarily stiffened mesh prostheses |
| EP2079491B1 (en) * | 2006-10-17 | 2013-02-27 | Reva Medical, Inc. | N-substituted monomers and polymers |
| MX2009004821A (es) * | 2006-11-06 | 2009-11-23 | Tyrx Pharma Inc | Bolsas de malla para dispositivos medicos implantables. |
| EP2166981B1 (en) * | 2007-06-21 | 2016-09-07 | Tyrx, Inc. | Phenyl ester side chains to increase polymer resorptivity |
-
2010
- 2010-06-01 EP EP10783928.4A patent/EP2437724B1/en active Active
- 2010-06-01 WO PCT/US2010/036910 patent/WO2010141475A1/en not_active Ceased
- 2010-06-01 JP JP2012514044A patent/JP5847706B2/ja active Active
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