JP2012527438A - 正常駆出率心不全の治療 - Google Patents
正常駆出率心不全の治療 Download PDFInfo
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- JP2012527438A JP2012527438A JP2012511329A JP2012511329A JP2012527438A JP 2012527438 A JP2012527438 A JP 2012527438A JP 2012511329 A JP2012511329 A JP 2012511329A JP 2012511329 A JP2012511329 A JP 2012511329A JP 2012527438 A JP2012527438 A JP 2012527438A
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- perhexiline
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4458—Non condensed piperidines, e.g. piperocaine only substituted in position 2, e.g. methylphenidate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
Landscapes
- Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/GB2009/050539 WO2010133815A1 (en) | 2009-05-20 | 2009-05-20 | Treatment of heart failure with normal ejection fraction |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015075231A Division JP2015147787A (ja) | 2015-04-01 | 2015-04-01 | 正常駆出率心不全の治療 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012527438A true JP2012527438A (ja) | 2012-11-08 |
| JP2012527438A5 JP2012527438A5 (enExample) | 2014-07-24 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012511329A Pending JP2012527438A (ja) | 2009-05-20 | 2009-05-20 | 正常駆出率心不全の治療 |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US8440697B2 (enExample) |
| EP (1) | EP2432470A1 (enExample) |
| JP (1) | JP2012527438A (enExample) |
| CN (1) | CN102573844A (enExample) |
| AU (1) | AU2009346606B2 (enExample) |
| BR (1) | BRPI0924398A2 (enExample) |
| CA (1) | CA2816448A1 (enExample) |
| IL (1) | IL216362A0 (enExample) |
| MX (1) | MX2011012310A (enExample) |
| WO (1) | WO2010133815A1 (enExample) |
| ZA (1) | ZA201109332B (enExample) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0405381D0 (en) | 2004-03-10 | 2004-04-21 | Univ Wales Medicine | A method and means for treating heart failure |
| GB0908193D0 (en) | 2009-05-13 | 2009-06-24 | Albright Patents | Treatment of disease state |
| EP2432470A1 (en) | 2009-05-20 | 2012-03-28 | Heart Metabolics Limited | Treatment of heart failure with normal ejection fraction |
| AU2012297569B2 (en) | 2011-08-16 | 2017-11-09 | Baker Heart and Diabetes Institute | Controlled-release formulation |
| EP2892529A4 (en) * | 2012-09-05 | 2016-01-20 | Adelaide Res &Innovation Pty Ltd | USES OF (-) - PERHEXILINE |
| MX2017008248A (es) * | 2014-12-22 | 2018-02-19 | Cardiora Pty Ltd | Metodo de tratamiento. |
| BR112019012214A8 (pt) | 2016-12-15 | 2023-03-28 | Baxter Int | Sistema e método para monitorar e determinar parâmetros do paciente a partir de forma de onda venosa detectada |
| US11039754B2 (en) | 2018-05-14 | 2021-06-22 | Baxter International Inc. | System and method for monitoring and determining patient parameters from sensed venous waveform |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007528378A (ja) * | 2004-03-10 | 2007-10-11 | ハート メタボリクス リミテッド | 慢性心不全を治療するためのペルヘキシリン |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPN380695A0 (en) | 1995-06-23 | 1995-07-20 | Queen Elizabeth Hospital, The | Methods related to the treatment of and isolation of compounds for treatment of ischaemic conditions |
| US20030162824A1 (en) * | 2001-11-12 | 2003-08-28 | Krul Elaine S. | Methods of treating or preventing a cardiovascular condition using a cyclooxygenase-1 inhibitor |
| CL2004000366A1 (es) * | 2003-02-26 | 2005-01-07 | Pharmacia Corp Sa Organizada B | USO DE UNA COMBINACION DE UN COMPUESTO DERIVADO DE PIRAZOL INHIBIDOR DE QUINASA p38, Y UN INHIBIDOR DE ACE PARA TRATAR DISFUNCION RENAL, ENFERMEDAD CARDIOVASCULAR Y VASCULAR, RETINOPATIA, NEUROPATIA, EDEMA, DISFUNCION ENDOTELIAL O INSULINOPATIA. |
| AU2005230811A1 (en) | 2004-04-06 | 2005-10-20 | Angiogenetics Sweden Ab | Angiogenesis-affecting compounds and methods of use thereof |
| PL1959951T3 (pl) | 2005-12-01 | 2010-06-30 | Hoffmann La Roche | Heteroarylo-podstawione pochodne piperydyny jako inhibitory l-cpt1 |
| ITRM20060090A1 (it) | 2006-02-22 | 2007-08-23 | Sigma Tau Ind Farmaceuti | Nuovi composti inibitori cpt a livello del snc come farmaci antidiabetici e o antiobesita |
| GB0723100D0 (en) * | 2007-11-23 | 2008-01-02 | Heart Metabolics Ltd | Treatment of HFnEF |
| GB0908193D0 (en) * | 2009-05-13 | 2009-06-24 | Albright Patents | Treatment of disease state |
| EP2432470A1 (en) | 2009-05-20 | 2012-03-28 | Heart Metabolics Limited | Treatment of heart failure with normal ejection fraction |
| US20140019207A1 (en) | 2012-07-11 | 2014-01-16 | Sap Ag | Interactive in-memory based sales forecasting |
| EP2892529A4 (en) | 2012-09-05 | 2016-01-20 | Adelaide Res &Innovation Pty Ltd | USES OF (-) - PERHEXILINE |
| WO2015131231A1 (en) | 2014-03-03 | 2015-09-11 | Adelaide Research & Innovation Pty Ltd | Methods for using (-)-perhexiline |
-
2009
- 2009-05-20 EP EP09785222A patent/EP2432470A1/en not_active Withdrawn
- 2009-05-20 BR BRPI0924398A patent/BRPI0924398A2/pt not_active IP Right Cessation
- 2009-05-20 JP JP2012511329A patent/JP2012527438A/ja active Pending
- 2009-05-20 MX MX2011012310A patent/MX2011012310A/es unknown
- 2009-05-20 AU AU2009346606A patent/AU2009346606B2/en not_active Ceased
- 2009-05-20 CN CN2009801606783A patent/CN102573844A/zh active Pending
- 2009-05-20 WO PCT/GB2009/050539 patent/WO2010133815A1/en not_active Ceased
- 2009-05-20 CA CA2816448A patent/CA2816448A1/en not_active Abandoned
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2010
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- 2011-11-14 IL IL216362A patent/IL216362A0/en unknown
- 2011-12-19 ZA ZA2011/09332A patent/ZA201109332B/en unknown
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007528378A (ja) * | 2004-03-10 | 2007-10-11 | ハート メタボリクス リミテッド | 慢性心不全を治療するためのペルヘキシリン |
Non-Patent Citations (4)
| Title |
|---|
| CSNC201000308024; 大塚 美里: '心エコ-を用いた心不全の病態解析と重症度判定 Echacardiographic evaluation of ventricular systol' 医学のあゆみ 第216巻、第1号, 2006, 第99-104頁 * |
| JPN5012013363; COATS C J: 'CURRENT MANAGEMENT OF HYPERTROPHIC CARDIOMYOPATHY' Current Treatment Options in Cardiovascular Medicine V10 N6, 2008, P496-504 * |
| JPN6013059053; K. Yamamoto, et. al.: 'Heart Failure With Preserved Ejection Fraction-What is Known and Unknown-' Circulation Journal Vol.73, 200903, p.404-410 * |
| JPN6013059055; 大塚 美里: '心エコ-を用いた心不全の病態解析と重症度判定 Echacardiographic evaluation of ventricular systol' 医学のあゆみ 第216巻、第1号, 2006, 第99-104頁 * |
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|---|---|
| AU2009346606B2 (en) | 2016-06-02 |
| US20100331364A1 (en) | 2010-12-30 |
| US9457017B2 (en) | 2016-10-04 |
| MX2011012310A (es) | 2012-04-11 |
| US8440697B2 (en) | 2013-05-14 |
| US20130210720A1 (en) | 2013-08-15 |
| CN102573844A (zh) | 2012-07-11 |
| CA2816448A1 (en) | 2010-11-25 |
| US20130210719A1 (en) | 2013-08-15 |
| WO2010133815A1 (en) | 2010-11-25 |
| BRPI0924398A2 (pt) | 2019-09-24 |
| ZA201109332B (en) | 2012-08-29 |
| AU2009346606A1 (en) | 2012-01-19 |
| IL216362A0 (en) | 2012-01-31 |
| US9468634B2 (en) | 2016-10-18 |
| EP2432470A1 (en) | 2012-03-28 |
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