JP2012524029A5 - - Google Patents
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- Publication number
- JP2012524029A5 JP2012524029A5 JP2012505008A JP2012505008A JP2012524029A5 JP 2012524029 A5 JP2012524029 A5 JP 2012524029A5 JP 2012505008 A JP2012505008 A JP 2012505008A JP 2012505008 A JP2012505008 A JP 2012505008A JP 2012524029 A5 JP2012524029 A5 JP 2012524029A5
- Authority
- JP
- Japan
- Prior art keywords
- peptide
- seq
- clusterin
- cargo molecule
- imaging
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims 18
- 238000003384 imaging method Methods 0.000 claims 7
- 102000003780 Clusterin Human genes 0.000 claims 6
- 108090000197 Clusterin Proteins 0.000 claims 6
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 102000004190 Enzymes Human genes 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 229940127089 cytotoxic agent Drugs 0.000 claims 1
- 239000002254 cytotoxic agent Substances 0.000 claims 1
- 231100000599 cytotoxic agent Toxicity 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 230000018732 detection of tumor cell Effects 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000007705 epithelial mesenchymal transition Effects 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 239000002122 magnetic nanoparticle Substances 0.000 claims 1
- 238000002595 magnetic resonance imaging Methods 0.000 claims 1
- 238000012634 optical imaging Methods 0.000 claims 1
- 238000002600 positron emission tomography Methods 0.000 claims 1
- 238000002603 single-photon emission computed tomography Methods 0.000 claims 1
- 210000004881 tumor cell Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US20291009P | 2009-04-17 | 2009-04-17 | |
| US61/202,910 | 2009-04-17 | ||
| PCT/CA2010/000566 WO2010118521A1 (en) | 2009-04-17 | 2010-04-15 | Peptide ligands for clusterin and uses thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012524029A JP2012524029A (ja) | 2012-10-11 |
| JP2012524029A5 true JP2012524029A5 (cg-RX-API-DMAC10.html) | 2013-05-30 |
| JP5861242B2 JP5861242B2 (ja) | 2016-02-16 |
Family
ID=42982086
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012505008A Active JP5861242B2 (ja) | 2009-04-17 | 2010-04-15 | クラステリンのペプチドリガンド及びその使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8629240B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP2419440B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP5861242B2 (cg-RX-API-DMAC10.html) |
| AU (1) | AU2010237569B2 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2756570C (cg-RX-API-DMAC10.html) |
| WO (1) | WO2010118521A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2928846A1 (en) | 2009-11-24 | 2011-06-03 | Alethia Biotherapeutics Inc. | Anti-clusterin antibodies and antigen binding fragments and their use to reduce tumor volume |
| CA2862739A1 (en) | 2012-02-22 | 2013-08-29 | Alethia Biotherapeutics Inc. | Co-use of a clusterin inhibitor with an egfr inhibitor to treat cancer |
| US10800817B2 (en) | 2016-12-19 | 2020-10-13 | Morehouse School Of Medicine | Compositions and methods for treating diseases by inhibiting exosome release |
| US10040831B2 (en) | 2016-12-19 | 2018-08-07 | Morehouse School Of Medicine | Compositions and methods for treating diseases by inhibiting exosome release |
| US11180534B1 (en) | 2021-06-04 | 2021-11-23 | Morehouse School Of Medicine | Compositions and methods for treating SARS-CoV-2 infections |
| CN119874833A (zh) * | 2025-01-14 | 2025-04-25 | 广州中医药大学(广州中医药研究院) | Clusterin亲和肽及其修饰的长循环纳米粒的制备方法和应用 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU9312598A (en) * | 1997-09-10 | 1999-03-29 | Allegheny University Of The Health Sciences | Inhibitors of collagen assembly |
| AU748700B2 (en) * | 1998-06-12 | 2002-06-13 | Aventis Pasteur | HIV virus mimotopes |
| JP2002518521A (ja) * | 1998-06-20 | 2002-06-25 | ワシントン・ユニバーシティ | 医用画像解析、診断および治療のための膜透過性ペプチド錯体 |
| US20050208558A1 (en) * | 1999-10-19 | 2005-09-22 | Applera Corporation | Detection kits, such as nucleic acid arrays, for detecting the expression or 10,000 or more Drosophila genes and uses thereof |
| ITRM20040098A1 (it) * | 2004-02-25 | 2004-05-25 | Univ Roma | Anticorpi oligoclonali anticlasterina per la diagnosi di neoplasie e la predizione del loro grado di malignita', metodo diagnostico e kit relativi. |
| ES2543341T3 (es) | 2005-09-13 | 2015-08-18 | National Research Council Of Canada | Métodos y composiciones para modular la actividad de células tumorales |
| EP2087152B1 (en) * | 2006-10-27 | 2015-03-11 | Walfish, Paul | Endometrial biomarkers |
-
2010
- 2010-04-15 CA CA2756570A patent/CA2756570C/en active Active
- 2010-04-15 AU AU2010237569A patent/AU2010237569B2/en active Active
- 2010-04-15 EP EP10764019.5A patent/EP2419440B1/en active Active
- 2010-04-15 JP JP2012505008A patent/JP5861242B2/ja active Active
- 2010-04-15 WO PCT/CA2010/000566 patent/WO2010118521A1/en not_active Ceased
- 2010-04-15 US US13/260,676 patent/US8629240B2/en active Active
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