JP2012520142A - ガスクラスターイオンビーム技術の適用により生物学的材料の表面の湿潤性及び/又はその他の生体適合性特性を改質する方法と製造された生物学的材料 - Google Patents
ガスクラスターイオンビーム技術の適用により生物学的材料の表面の湿潤性及び/又はその他の生体適合性特性を改質する方法と製造された生物学的材料 Download PDFInfo
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Abstract
【選択図】図1
Description
Claims (19)
- 移植用の生物学的材料を調製する方法であって、
減圧チャンバを設けることと、
前記減圧チャンバの内部で第1のイオンビームを形成することと、
前記減圧チャンバの内部に生物学的材料を保持するホルダを設けることと、
前記減圧チャンバの中の前記ホルダの中で前記生物学的組織を位置合わせすることと、
前記生物学的材料の特性を変化させる、前記第1のイオンビームで前記生物学的材料の表面の少なくとも第1の部分を照射することと、
を含む方法。 - 前記特性の変化は、
前記表面の前記少なくとも第1の部分の湿潤性の増加と、
前記表面の前記少なくとも第1の部分の親水性の増加と、
前記表面の前記少なくとも第1の部分の化学的性質の改質と、
前記表面の前記少なくとも第1の部分の電荷状態の改質と、
からなる群より選択された変化を含む、請求項1に記載の方法。 - 前記生物学的組織を生体細胞に暴露することをさらに含み、
前記生体細胞は、
前記表面の前記少なくとも第1の部分への付着の増加と、
前記表面の前記少なくとも第1の部分での増殖の増加と、
前記表面の前記少なくとも第1の部分の中又は下での浸透の増加と、
前記表面の前記少なくとも第1の部分の上又は下での形成の増加と、
からなる群より選択された挙動を示す、請求項1に記載の方法。 - 前記生物学的組織は、
筋骨格系組織と、
結合組織と、
骨組織と、
腱組織と、
靱帯組織と、
軟骨組織と、
上皮組織と、
内皮組織と、
からなる群より選択された組織を含む、請求項1に記載の方法。 - 前記生物学的材料は、細胞組織又は脱細胞化組織を含む、請求項1に記載の方法。
- 前記生物学的材料は、哺乳類組織又は鳥類組織を含む、請求項1に記載の方法。
- 前記第1のイオンビームは、第1のガスクラスターイオンビームである、請求項1に記載の方法。
- 前記減圧チャンバの内部で第2のガスクラスターイオンビームを形成することと、
前記生物学的組織の前記表面の少なくとも第2の部分を前記第2のガスクラスターイオンビームで照射することと、
をさらに含む、請求項6に記載の方法。 - 前記第1のガスクラスターイオンビームは、第1のガスクラスターイオン組成及び第1のガスクラスターイオンビーム加速電位を有し、前記第2のガスクラスターイオンは、第2のガスクラスターイオン組成及び第2のガスクラスターイオンビーム加速電位を有し、
前記表面の前記少なくとも第1の部分を照射することは、第1のガスクラスターイオンビーム照射量で照射することを含み、前記表面の前記少なくとも第2の部分を照射することは、第2のガスクラスターイオンビーム照射量で照射することを含む、請求項7に記載の方法。 - 前記第1のガスクラスターイオン組成と前記第2のガスクラスターイオン組成とは、実質的に同一である、請求項8に記載の方法。
- 前記第1のガスクラスターイオンビーム加速電位と前記第2のガスクラスターイオン電位とは、実質的に同一である、請求項8に記載の方法。
- 前記第1のガスクラスターイオンビーム照射量と前記第2のガスクラスターイオンビーム照射量とは、実質的に同一である、請求項8に記載の方法。
- 前記第1のガスクラスターイオンビームは、
アルゴンと、
ネオンと、
キセノンと、
窒素と、
炭素と、
酸素と、
からなる群より選択された原子を含むガスクラスターイオンを含む、請求項6に記載の方法。 - 前記生物学的組織を生体細胞に暴露することをさらに含み、前記表面の少なくとも第3の部分は照射されず、前記少なくとも第1の部分に暴露された前記生体細胞は、前記少なくとも第3の部分に暴露された前記生体細胞と比べられたとき、異なる挙動を示し、前記挙動は、
表面付着と、
細胞増殖と、
細胞表面浸透と、
組織形成と、
からなる群より選択された特性を備える、請求項1に記載の方法。 - 表面を備える外科移植用の生物学的材料であって、
前記表面の少なくとも一部分は、改質された湿潤性又は改質された表面電荷状態を有し、
前記表面は、哺乳類に移植されたとき、細胞付着が改善される、生物学的材料。 - 前記生物学的材料は、
筋骨格系組織と、
結合組織と、
骨組織と、
腱組織と、
靱帯組織と、
軟骨組織と、
上皮組織と、
内皮組織と、
からなる群より選択された組織を含む、請求項15に記載の生物学的材料。 - 前記表面の前記少なくとも一部分は、前記表面にパターン化され、外科的移植の好ましい結果である細胞付着の改善を促進する、請求項15に記載の生物学的材料。
- 減圧チャンバを設けることと、
前記減圧チャンバの内部でガスクラスターイオンビームを形成することと、
前記減圧チャンバの内部に生物学的材料を保持するホルダを設けることと、
前記生物学的材料を前記減圧チャンバの中の前記ホルダに導入することと、
前記生物学的材料の表面の少なくとも一部分に前記ガスクラスターイオンビームを照射することと、
を含むプロセスによって形成された外科的移植用の生物学的組成物。 - 分化した組織型を形成するため前記生体細胞を分化することをさらに含む、請求項3に記載の方法。
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JPH09299474A (ja) * | 1996-05-17 | 1997-11-25 | Rikagaku Kenkyusho | 抗血栓材料及びその製造方法 |
JP2004532081A (ja) * | 2001-05-11 | 2004-10-21 | エピオン コーポレイション | 表面に薬剤を固着させて医療具の効果を高めるための方法とシステム |
JP2003325655A (ja) * | 2002-05-09 | 2003-11-18 | Inst Of Physical & Chemical Res | 血管内治療用ステントおよびステントグラフト |
JP2006223317A (ja) * | 2003-05-15 | 2006-08-31 | Univ Waseda | 細胞播種方法 |
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EP2405891A1 (en) | 2012-01-18 |
JP2012520143A (ja) | 2012-09-06 |
CN102348453A (zh) | 2012-02-08 |
US20100226897A1 (en) | 2010-09-09 |
EP2405891A4 (en) | 2014-04-30 |
CN102348795A (zh) | 2012-02-08 |
CN102348453B (zh) | 2016-11-16 |
WO2010105056A1 (en) | 2010-09-16 |
EP2405891B1 (en) | 2019-07-03 |
WO2010105054A1 (en) | 2010-09-16 |
JP5878374B2 (ja) | 2016-03-08 |
US8367092B2 (en) | 2013-02-05 |
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