JP2012520126A5 - - Google Patents
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- Publication number
- JP2012520126A5 JP2012520126A5 JP2011554096A JP2011554096A JP2012520126A5 JP 2012520126 A5 JP2012520126 A5 JP 2012520126A5 JP 2011554096 A JP2011554096 A JP 2011554096A JP 2011554096 A JP2011554096 A JP 2011554096A JP 2012520126 A5 JP2012520126 A5 JP 2012520126A5
- Authority
- JP
- Japan
- Prior art keywords
- base material
- medical catheter
- coating
- chlorhexidine
- mixing
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000000034 method Methods 0.000 claims 21
- 239000000463 material Substances 0.000 claims 12
- 239000011248 coating agent Substances 0.000 claims 8
- 238000000576 coating method Methods 0.000 claims 8
- GHXZTYHSJHQHIJ-UHFFFAOYSA-N Chlorhexidine Chemical compound C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 GHXZTYHSJHQHIJ-UHFFFAOYSA-N 0.000 claims 5
- ZXJXZNDDNMQXFV-UHFFFAOYSA-M crystal violet Chemical compound [Cl-].C1=CC(N(C)C)=CC=C1[C+](C=1C=CC(=CC=1)N(C)C)C1=CC=C(N(C)C)C=C1 ZXJXZNDDNMQXFV-UHFFFAOYSA-M 0.000 claims 5
- BQCADISMDOOEFD-UHFFFAOYSA-N Silver Chemical compound [Ag] BQCADISMDOOEFD-UHFFFAOYSA-N 0.000 claims 4
- 239000004332 silver Substances 0.000 claims 4
- 229910052709 silver Inorganic materials 0.000 claims 4
- 230000000845 anti-microbial effect Effects 0.000 claims 3
- 239000004599 antimicrobial Substances 0.000 claims 3
- 229960003260 chlorhexidine Drugs 0.000 claims 3
- 229960001235 gentian violet Drugs 0.000 claims 3
- 239000003242 anti bacterial agent Substances 0.000 claims 2
- 230000003115 biocidal effect Effects 0.000 claims 2
- 229960001506 brilliant green Drugs 0.000 claims 2
- HXCILVUBKWANLN-UHFFFAOYSA-N brilliant green cation Chemical compound C1=CC(N(CC)CC)=CC=C1C(C=1C=CC=CC=1)=C1C=CC(=[N+](CC)CC)C=C1 HXCILVUBKWANLN-UHFFFAOYSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- CXKWCBBOMKCUKX-UHFFFAOYSA-M methylene blue Chemical compound [Cl-].C1=CC(N(C)C)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 CXKWCBBOMKCUKX-UHFFFAOYSA-M 0.000 claims 2
- 229960000907 methylthioninium chloride Drugs 0.000 claims 2
- 239000002105 nanoparticle Substances 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- YEESUBCSWGVPCE-UHFFFAOYSA-N azanylidyneoxidanium iron(2+) pentacyanide Chemical compound [Fe++].[C-]#N.[C-]#N.[C-]#N.[C-]#N.[C-]#N.N#[O+] YEESUBCSWGVPCE-UHFFFAOYSA-N 0.000 claims 1
- WDRFFJWBUDTUCA-UHFFFAOYSA-N chlorhexidine acetate Chemical compound CC(O)=O.CC(O)=O.C=1C=C(Cl)C=CC=1NC(N)=NC(N)=NCCCCCCN=C(N)N=C(N)NC1=CC=C(Cl)C=C1 WDRFFJWBUDTUCA-UHFFFAOYSA-N 0.000 claims 1
- 229960001884 chlorhexidine diacetate Drugs 0.000 claims 1
- XEYBHCRIKKKOSS-UHFFFAOYSA-N disodium;azanylidyneoxidanium;iron(2+);pentacyanide Chemical compound [Na+].[Na+].[Fe+2].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].[O+]#N XEYBHCRIKKKOSS-UHFFFAOYSA-N 0.000 claims 1
- POULHZVOKOAJMA-UHFFFAOYSA-M dodecanoate Chemical compound CCCCCCCCCCCC([O-])=O POULHZVOKOAJMA-UHFFFAOYSA-M 0.000 claims 1
- IPCSVZSSVZVIGE-UHFFFAOYSA-M hexadecanoate Chemical compound CCCCCCCCCCCCCCCC([O-])=O IPCSVZSSVZVIGE-UHFFFAOYSA-M 0.000 claims 1
- 238000002844 melting Methods 0.000 claims 1
- 230000008018 melting Effects 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 229960002460 nitroprusside Drugs 0.000 claims 1
- 229920000642 polymer Polymers 0.000 claims 1
- 229920002635 polyurethane Polymers 0.000 claims 1
- 239000004814 polyurethane Substances 0.000 claims 1
- JQXXHWHPUNPDRT-WLSIYKJHSA-N rifampicin Chemical compound O([C@](C1=O)(C)O/C=C/[C@@H]([C@H]([C@@H](OC(C)=O)[C@H](C)[C@H](O)[C@H](C)[C@@H](O)[C@@H](C)\C=C\C=C(C)/C(=O)NC=2C(O)=C3C([O-])=C4C)C)OC)C4=C1C3=C(O)C=2\C=N\N1CC[NH+](C)CC1 JQXXHWHPUNPDRT-WLSIYKJHSA-N 0.000 claims 1
- 229960001225 rifampicin Drugs 0.000 claims 1
- 229940083618 sodium nitroprusside Drugs 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/401,829 US20100233288A1 (en) | 2009-03-11 | 2009-03-11 | Medical devices containing nitroprusside and antimicrobial agents |
| US12/401,829 | 2009-03-11 | ||
| PCT/US2010/026339 WO2010104760A1 (en) | 2009-03-11 | 2010-03-05 | Medical devices containing nitroprusside and antimicrobial agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012520126A JP2012520126A (ja) | 2012-09-06 |
| JP2012520126A5 true JP2012520126A5 (https=) | 2013-04-25 |
Family
ID=42728677
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011554096A Pending JP2012520126A (ja) | 2009-03-11 | 2010-03-05 | ニトロプルシド及び抗菌剤を含有する医療機器 |
Country Status (5)
| Country | Link |
|---|---|
| US (3) | US20100233288A1 (https=) |
| EP (2) | EP2416731B1 (https=) |
| JP (1) | JP2012520126A (https=) |
| ES (1) | ES2530731T3 (https=) |
| WO (1) | WO2010104760A1 (https=) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8545459B2 (en) * | 2009-02-25 | 2013-10-01 | Teleflex Medical Incorporated | Stabilized enzyme compositions |
| US9333280B2 (en) | 2009-02-25 | 2016-05-10 | Teleflex Medical Incorporated | Stabilized enzyme compositions |
| DE102011014386A1 (de) * | 2011-03-11 | 2012-09-13 | Hemoteq Ag | Endoprothese mit einer Wirkstoffbeschichtung |
| US9545301B2 (en) | 2013-03-15 | 2017-01-17 | Covidien Lp | Coated medical devices and methods of making and using same |
| US9320592B2 (en) | 2013-03-15 | 2016-04-26 | Covidien Lp | Coated medical devices and methods of making and using same |
| WO2014172569A2 (en) | 2013-04-18 | 2014-10-23 | Board Of Regents, The University Of Texas System | Antimicrobial catheters |
| US9668890B2 (en) | 2013-11-22 | 2017-06-06 | Covidien Lp | Anti-thrombogenic medical devices and methods |
| US9789228B2 (en) | 2014-12-11 | 2017-10-17 | Covidien Lp | Antimicrobial coatings for medical devices and processes for preparing such coatings |
| US12070532B2 (en) | 2019-11-18 | 2024-08-27 | Becton, Dickinson And Company | Nitric oxide and chlorhexidine releasing catheter for anti-platelet and antimicrobial dual functionality |
| CN115252884B (zh) * | 2022-07-11 | 2023-07-14 | 湖北工业大学 | 一种粉剂组合物及在制备宠物伤口粉剂敷料中的应用 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5019096A (en) * | 1988-02-11 | 1991-05-28 | Trustees Of Columbia University In The City Of New York | Infection-resistant compositions, medical devices and surfaces and methods for preparing and using same |
| IE64997B1 (en) * | 1989-01-18 | 1995-10-04 | Becton Dickinson Co | Anti-infection and antithrombogenic medical articles and method for their preparation |
| US5536241A (en) * | 1990-12-05 | 1996-07-16 | The General Hospital Corporation | Methods and devices for relaxing smooth muscle contractions |
| US6087479A (en) * | 1993-09-17 | 2000-07-11 | Nitromed, Inc. | Localized use of nitric oxide-adducts to prevent internal tissue damage |
| US5707385A (en) * | 1994-11-16 | 1998-01-13 | Advanced Cardiovascular Systems, Inc. | Drug loaded elastic membrane and method for delivery |
| US5772640A (en) | 1996-01-05 | 1998-06-30 | The Trustees Of Columbia University Of The City Of New York | Triclosan-containing medical devices |
| US5797887A (en) * | 1996-08-27 | 1998-08-25 | Novovasc Llc | Medical device with a surface adapted for exposure to a blood stream which is coated with a polymer containing a nitrosyl-containing organo-metallic compound which releases nitric oxide from the coating to mediate platelet aggregation |
| US6530951B1 (en) * | 1996-10-24 | 2003-03-11 | Cook Incorporated | Silver implantable medical device |
| US20060194008A1 (en) * | 1999-09-22 | 2006-08-31 | Princeton University | Devices with multiple surface functionality |
| EP1267837A4 (en) * | 2000-03-20 | 2006-05-03 | Novovascular Inc | MATRICES COMPRISING NITRIC OXIDE DONORS AND REDUCING AGENTS AND THEIR USE |
| US7771468B2 (en) * | 2001-03-16 | 2010-08-10 | Angiotech Biocoatings Corp. | Medicated stent having multi-layer polymer coating |
| US20040247640A1 (en) * | 2001-07-23 | 2004-12-09 | Yi-Ju Zhao | Nitric oxide releasing eptfe coated medical device sandwich |
| DE60321773D1 (de) * | 2002-03-14 | 2008-08-07 | Ash Access Technology Inc | Medizinische vorrichtungen mit antibakteriellen eigenschaften |
| US7008979B2 (en) * | 2002-04-30 | 2006-03-07 | Hydromer, Inc. | Coating composition for multiple hydrophilic applications |
| US20070010702A1 (en) * | 2003-04-08 | 2007-01-11 | Xingwu Wang | Medical device with low magnetic susceptibility |
| US7077831B2 (en) * | 2003-12-11 | 2006-07-18 | Stephanie Skolik | Ophthalmic fluid dispenser |
| JP2007522835A (ja) * | 2004-01-20 | 2007-08-16 | ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム | 医療装置に消毒組成物をコーティングする、および含浸させる方法 |
| US8361553B2 (en) * | 2004-07-30 | 2013-01-29 | Kimberly-Clark Worldwide, Inc. | Methods and compositions for metal nanoparticle treated surfaces |
| CA2608071A1 (en) | 2005-03-24 | 2006-09-28 | Nolabs Ab | Intravascular, interstitial or intraorgan medical access device, and manufacturing method thereof, involving nitric oxide |
| EP1704879A1 (en) | 2005-03-24 | 2006-09-27 | NOLabs AB | Intravascular, interstitial or intraorgan medical device comprising a nitric oxide eluting polymer |
| WO2006125262A1 (en) * | 2005-05-24 | 2006-11-30 | Environmental Biotechnology Crc Pty Limited | Methods and compositions for regulating biofilm development |
| US20070129690A1 (en) * | 2005-12-02 | 2007-06-07 | Joel Rosenblatt | Catheter with polymeric coating |
| KR20160023926A (ko) * | 2006-02-28 | 2016-03-03 | 벡톤 디킨슨 앤드 컴퍼니 | 카테테르 잠금을 위한 항미생물성 조성물 및 방법 |
| US20070224235A1 (en) * | 2006-03-24 | 2007-09-27 | Barron Tenney | Medical devices having nanoporous coatings for controlled therapeutic agent delivery |
| WO2007127488A1 (en) * | 2006-04-27 | 2007-11-08 | Shenoy Narmada R | Compositions and methods for treating or preventing diseases of body passageways |
| DE102006033312A1 (de) * | 2006-07-17 | 2008-01-31 | Heraeus Kulzer Gmbh | Dentales Implantatsystemteil mit einer Beschichtung |
| WO2008150375A1 (en) | 2007-06-01 | 2008-12-11 | Arrow International, Inc. | Combined fibrinolytic and antimicrobial catheter and uses thereof |
| US20100069854A1 (en) * | 2008-09-12 | 2010-03-18 | Onajite Okoh | Elastomeric Devices Containing Chlorhexidine/Fatty Acid Salts Made From Fatty Acids of 12 to 18 Carbons |
-
2009
- 2009-03-11 US US12/401,829 patent/US20100233288A1/en not_active Abandoned
-
2010
- 2010-03-05 JP JP2011554096A patent/JP2012520126A/ja active Pending
- 2010-03-05 EP EP10751217.0A patent/EP2416731B1/en not_active Not-in-force
- 2010-03-05 EP EP14157870.8A patent/EP2754413B1/en active Active
- 2010-03-05 ES ES10751217T patent/ES2530731T3/es active Active
- 2010-03-05 WO PCT/US2010/026339 patent/WO2010104760A1/en not_active Ceased
-
2011
- 2011-11-09 US US13/292,636 patent/US20120052185A1/en not_active Abandoned
-
2016
- 2016-07-26 US US15/219,829 patent/US20160331871A1/en not_active Abandoned
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