JP2012518399A - 抗原結合性構築物 - Google Patents
抗原結合性構築物 Download PDFInfo
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- JP2012518399A JP2012518399A JP2011550602A JP2011550602A JP2012518399A JP 2012518399 A JP2012518399 A JP 2012518399A JP 2011550602 A JP2011550602 A JP 2011550602A JP 2011550602 A JP2011550602 A JP 2011550602A JP 2012518399 A JP2012518399 A JP 2012518399A
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- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
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- General Chemical & Material Sciences (AREA)
- Physical Education & Sports Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Immunology (AREA)
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- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
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- Neurology (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pain & Pain Management (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US15489209P | 2009-02-24 | 2009-02-24 | |
| US61/154,892 | 2009-02-24 | ||
| PCT/EP2010/052284 WO2010097386A1 (en) | 2009-02-24 | 2010-02-23 | Antigen-binding constructs |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012518399A true JP2012518399A (ja) | 2012-08-16 |
| JP2012518399A5 JP2012518399A5 (enExample) | 2013-04-11 |
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| JP2011550602A Pending JP2012518399A (ja) | 2009-02-24 | 2010-02-23 | 抗原結合性構築物 |
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| US (1) | US20110305693A1 (enExample) |
| EP (1) | EP2401297A1 (enExample) |
| JP (1) | JP2012518399A (enExample) |
| CA (1) | CA2753332A1 (enExample) |
| WO (1) | WO2010097386A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2763493A1 (en) * | 2009-05-28 | 2010-12-02 | Glaxo Group Ltd. | Antigen-binding proteins |
| CN102352368B (zh) * | 2011-09-29 | 2013-12-04 | 苏州大学 | Ing4与osm双基因共表达载体及其应用 |
| GB201614627D0 (en) * | 2016-08-30 | 2016-10-12 | Glaxosmithkline Ip Dev Ltd | Antigen binding proteins |
| TW201829462A (zh) * | 2016-11-02 | 2018-08-16 | 英商葛蘭素史克智慧財產（第二）有限公司 | 結合蛋白 |
| CN110057877A (zh) * | 2018-12-24 | 2019-07-26 | 中山大学 | 可重复修饰的用于检测肿瘤细胞的生物传感器及其制备法 |
| US20250297020A1 (en) * | 2021-11-23 | 2025-09-25 | Adalta Limited | Rank-l binding molecules |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007095338A2 (en) * | 2006-02-15 | 2007-08-23 | Imclone Systems Incorporated | Functional antibodies |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| AU600575B2 (en) | 1987-03-18 | 1990-08-16 | Sb2, Inc. | Altered antibodies |
| US4873316A (en) | 1987-06-23 | 1989-10-10 | Biogen, Inc. | Isolation of exogenous recombinant proteins from the milk of transgenic mammals |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
| ATE408012T1 (de) | 1991-12-02 | 2008-09-15 | Medical Res Council | Herstellung von autoantikörpern auf phagenoberflächen ausgehend von antikörpersegmentbibliotheken |
| US5733743A (en) | 1992-03-24 | 1998-03-31 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| ATE149570T1 (de) | 1992-08-17 | 1997-03-15 | Genentech Inc | Bispezifische immunoadhesine |
| US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| GB9424449D0 (en) | 1994-12-02 | 1995-01-18 | Wellcome Found | Antibodies |
| US5702892A (en) | 1995-05-09 | 1997-12-30 | The United States Of America As Represented By The Department Of Health And Human Services | Phage-display of immunoglobulin heavy chain libraries |
| CA2229043C (en) | 1995-08-18 | 2016-06-07 | Morphosys Gesellschaft Fur Proteinoptimierung Mbh | Protein/(poly)peptide libraries |
| DK1801214T3 (da) | 1997-07-07 | 2011-01-24 | Medical Res Council | In vitro sorteringsfremgangsmåde |
| DE19742706B4 (de) | 1997-09-26 | 2013-07-25 | Pieris Proteolab Ag | Lipocalinmuteine |
| GB9722131D0 (en) | 1997-10-20 | 1997-12-17 | Medical Res Council | Method |
| GB9806530D0 (en) * | 1998-03-26 | 1998-05-27 | Glaxo Group Ltd | Inflammatory mediator |
| GB9809839D0 (en) | 1998-05-09 | 1998-07-08 | Glaxo Group Ltd | Antibody |
| ATE380865T1 (de) | 1998-05-13 | 2007-12-15 | Domantis Ltd | Phagen-display-selektionssystem für korrekt gefaltete proteine |
| IL127127A0 (en) | 1998-11-18 | 1999-09-22 | Peptor Ltd | Small functional units of antibody heavy chain variable regions |
| US7115396B2 (en) | 1998-12-10 | 2006-10-03 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
| US6818418B1 (en) | 1998-12-10 | 2004-11-16 | Compound Therapeutics, Inc. | Protein scaffolds for antibody mimics and other binding proteins |
| GB9900298D0 (en) | 1999-01-07 | 1999-02-24 | Medical Res Council | Optical sorting method |
| JP2003523742A (ja) | 2000-02-03 | 2003-08-12 | ドマンティス リミテッド | コンビナトリアルタンパク質ドメイン |
| EP1332209B1 (en) | 2000-09-08 | 2009-11-11 | Universität Zürich | Collections of repeat proteins comprising repeat modules |
| ES2706902T3 (es) | 2001-06-26 | 2019-04-01 | Amgen Inc | Anticuerpos para OPGL |
| CA2457636C (en) | 2001-08-10 | 2012-01-03 | Aberdeen University | Antigen binding domains |
| CA2531238C (en) | 2003-07-04 | 2015-02-24 | Affibody Ab | Polypeptides having binding affinity for her2 |
| WO2005019255A1 (en) | 2003-08-25 | 2005-03-03 | Pieris Proteolab Ag | Muteins of tear lipocalin |
| KR20060129246A (ko) | 2003-12-05 | 2006-12-15 | 컴파운드 쎄라퓨틱스, 인크. | 타입 2 혈관 내피 성장 인자 수용체의 억제제 |
| US7476724B2 (en) | 2004-08-05 | 2009-01-13 | Genentech, Inc. | Humanized anti-cmet antibodies |
| US10155816B2 (en) | 2005-11-28 | 2018-12-18 | Genmab A/S | Recombinant monovalent antibodies and methods for production thereof |
| EP1958957A1 (en) | 2007-02-16 | 2008-08-20 | NascaCell Technologies AG | Polypeptide comprising a knottin protein moiety |
| CN101796072B (zh) * | 2007-05-24 | 2014-09-24 | 埃博灵克斯股份有限公司 | 用于治疗骨疾病和病症的针对rank-l的氨基酸序列以及包括其的多肽 |
| SG191639A1 (en) * | 2008-06-03 | 2013-07-31 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
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2010
- 2010-02-23 EP EP10704579A patent/EP2401297A1/en not_active Withdrawn
- 2010-02-23 CA CA2753332A patent/CA2753332A1/en not_active Abandoned
- 2010-02-23 JP JP2011550602A patent/JP2012518399A/ja active Pending
- 2010-02-23 WO PCT/EP2010/052284 patent/WO2010097386A1/en not_active Ceased
- 2010-02-23 US US13/202,998 patent/US20110305693A1/en not_active Abandoned
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007095338A2 (en) * | 2006-02-15 | 2007-08-23 | Imclone Systems Incorporated | Functional antibodies |
Non-Patent Citations (2)
| Title |
|---|
| JPN5012008421; ＫＡＭＩＪＯ， Ｓ． ｅｔ ａｌ．: 'ＡＭＥＬＩＯＲＡＴＩＯＮ ＯＦ ＢＯＮＥ ＬＯＳＳ ＩＮ ＣＯＬＬＡＧＥＮ-ＩＮＤＵＣＥＤ ＡＲＴＨＲＩＴＩＳ ＢＹ ＮＥＵＴＲＡＬＩＺＩＮＧ ＡＮＴＩ-ＲＡＮＫＬ ＭＯＮＯＣＬＯＮＡＬ ＡＮＴＩＢＯ' ＢＩＯＣＨＥＭＩＣＡＬ ＡＮＤ ＢＩＯＰＨＹＳＩＣＡＬ ＲＥＳＥＡＲＣＨ ＣＯＭＭＵＮＩＣＡＴＩＯＮＳ Ｖｏｌ．３４７， Ｎｏ．１, 20060818, ｐ．１２４-１３２ * |
| JPN5012008423; ＨＵＩ， Ｗ． ｅｔ ａｌ．: 'Ａ ＭＯＤＥＬ ＯＦ ＩＮＦＬＡＭＭＡＴＯＲＹ ＡＲＴＨＲＩＴＩＳ ＨＩＧＨＬＩＧＨＴＳ Ａ ＲＯＬＥ ＦＯＲ ＯＮＣＯＳＴＡＴＩＮ Ｍ ＩＮ ＰＲＯ-ＩＮＦＬＡＭＭＡＴＯＲＹ ＣＹＴＯＫＩＮＥ-ＩＮ' ＡＲＴＨＲＩＴＩＳ ＲＥＳＥＡＲＣＨ ＆ ＴＨＥＲＡＰＹ Ｖｏｌ．７， Ｎｏ．１, 20041110, ｐ．Ｒ５７-Ｒ６４ * |
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| Publication number | Publication date |
|---|---|
| EP2401297A1 (en) | 2012-01-04 |
| CA2753332A1 (en) | 2010-09-02 |
| WO2010097386A1 (en) | 2010-09-02 |
| US20110305693A1 (en) | 2011-12-15 |
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