JP2012517965A5 - - Google Patents

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Publication number
JP2012517965A5
JP2012517965A5 JP2011549472A JP2011549472A JP2012517965A5 JP 2012517965 A5 JP2012517965 A5 JP 2012517965A5 JP 2011549472 A JP2011549472 A JP 2011549472A JP 2011549472 A JP2011549472 A JP 2011549472A JP 2012517965 A5 JP2012517965 A5 JP 2012517965A5
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JP
Japan
Prior art keywords
formula
reaction
above meanings
compound
dmf
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2011549472A
Other languages
English (en)
Japanese (ja)
Other versions
JP5667085B2 (ja
JP2012517965A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2010/000717 external-priority patent/WO2010091824A1/en
Publication of JP2012517965A publication Critical patent/JP2012517965A/ja
Publication of JP2012517965A5 publication Critical patent/JP2012517965A5/ja
Application granted granted Critical
Publication of JP5667085B2 publication Critical patent/JP5667085B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2011549472A 2009-02-13 2010-02-05 Ａｋｔインヒビターとしての融合されたピリミジン Expired - Fee Related JP5667085B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP09152805 2009-02-13
EP09152805.9 2009-02-13
PCT/EP2010/000717 WO2010091824A1 (en) 2009-02-13 2010-02-05 Fused pyrimidines as akt inhibitors

Publications (3)

Publication Number Publication Date
JP2012517965A JP2012517965A (ja) 2012-08-09
JP2012517965A5 true JP2012517965A5 (OSRAM) 2014-09-04
JP5667085B2 JP5667085B2 (ja) 2015-02-12

Family

ID=42019301

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011549472A Expired - Fee Related JP5667085B2 (ja) 2009-02-13 2010-02-05 Ａｋｔインヒビターとしての融合されたピリミジン

Country Status (7)

Country Link
US (1) US20130310362A1 (OSRAM)
EP (1) EP2396331B1 (OSRAM)
JP (1) JP5667085B2 (OSRAM)
CN (1) CN102361872B (OSRAM)
CA (1) CA2752114C (OSRAM)
ES (1) ES2435804T3 (OSRAM)
WO (1) WO2010091824A1 (OSRAM)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2608395T3 (es) 2013-01-23 2017-04-10 Astrazeneca Ab Compuestos químicos
EP3044338B1 (en) 2013-09-12 2021-11-24 Dana-Farber Cancer Institute, Inc. Methods for evaluating and treating waldenstrom's macroglobulinemia
WO2015123437A1 (en) 2014-02-13 2015-08-20 Incyte Corporation Cyclopropylamines as lsd1 inhibitors
US9670210B2 (en) 2014-02-13 2017-06-06 Incyte Corporation Cyclopropylamines as LSD1 inhibitors
TWI720451B (zh) 2014-02-13 2021-03-01 美商英塞特控股公司 作為lsd1抑制劑之環丙胺
EP2907811A1 (en) 2014-02-14 2015-08-19 Actelion Pharmaceuticals Ltd. Process for manufacturing pyrimidine sulfamide derivatives
WO2016007722A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Triazolopyridines and triazolopyrazines as lsd1 inhibitors
TWI687419B (zh) 2014-07-10 2020-03-11 美商英塞特公司 作為ｌｓｄ１抑制劑之咪唑并吡啶及咪唑并吡嗪
WO2016007736A1 (en) 2014-07-10 2016-01-14 Incyte Corporation Imidazopyrazines as lsd1 inhibitors
MX373154B (es) 2015-04-03 2020-04-22 Incyte Holdings Corp Compuestos heterocíclicos como inhibidores de demetilasa 1 específica de lisina (lsd1).
LT3334709T (lt) 2015-08-12 2025-03-10 Incyte Holdings Corporation Lsd1 inhibitoriaus druskos
US10968200B2 (en) 2018-08-31 2021-04-06 Incyte Corporation Salts of an LSD1 inhibitor and processes for preparing the same

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1509526A2 (en) * 2002-04-19 2005-03-02 Cellular Genomics Inc. Imidazo(1,2-a)pyrazin-8-ylamines, method of making, and method of use thereof
ATE512957T1 (de) 2003-04-24 2011-07-15 Merck Sharp & Dohme Hemmer der akt aktivität
ATE499364T1 (de) 2004-04-09 2011-03-15 Merck Sharp & Dohme Hemmer der akt aktivität
CA2576172A1 (en) 2004-08-23 2006-04-06 Merck & Co., Inc. Inhibitors of akt activity
DE602005023333D1 (de) * 2004-10-15 2010-10-14 Takeda Pharmaceutical Kinaseinhibitoren
CA2589084A1 (en) * 2004-12-15 2006-06-22 Merck & Co., Inc. Inhibitors of akt activity
CA2597456A1 (en) 2005-02-14 2006-08-31 Merck & Co., Inc. Inhibitors of akt activity
AU2006258124B8 (en) 2005-06-10 2010-01-07 Merck Sharp & Dohme Corp. Inhibitors of Akt activity
DE102007012645A1 (de) * 2007-03-16 2008-09-18 Bayer Healthcare Ag Substituierte Imidazo- und Triazolopyrimidine
TW200924761A (en) * 2007-08-14 2009-06-16 Bayer Schering Pharma Ag Fused bicyclic imidazoles
EA020996B1 (ru) * 2007-08-14 2015-03-31 Байер Интеллекчуал Проперти Гмбх Конденсированные бициклические пиримидины

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