JP2012503985A5 - - Google Patents
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- Publication number
- JP2012503985A5 JP2012503985A5 JP2011529281A JP2011529281A JP2012503985A5 JP 2012503985 A5 JP2012503985 A5 JP 2012503985A5 JP 2011529281 A JP2011529281 A JP 2011529281A JP 2011529281 A JP2011529281 A JP 2011529281A JP 2012503985 A5 JP2012503985 A5 JP 2012503985A5
- Authority
- JP
- Japan
- Prior art keywords
- loci
- subject
- lupus
- variation
- prognosis
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 206010025135 Lupus erythematosus Diseases 0.000 claims 26
- 238000004393 prognosis Methods 0.000 claims 15
- 239000012472 biological sample Substances 0.000 claims 12
- 239000002773 nucleotide Substances 0.000 claims 10
- 125000003729 nucleotide group Chemical group 0.000 claims 10
- 102100002932 UBE2L3 Human genes 0.000 claims 9
- 101710021996 UBE2L3 Proteins 0.000 claims 9
- 108010051539 HLA-DR2 Antigen Proteins 0.000 claims 7
- 108010064885 HLA-DR3 Antigen Proteins 0.000 claims 7
- 102100016182 IRAK1 Human genes 0.000 claims 7
- 101700063385 IRAK1 Proteins 0.000 claims 7
- 102100013276 IRF5 Human genes 0.000 claims 7
- 101700047673 IRF5 Proteins 0.000 claims 7
- 108010019992 STAT4 Transcription Factor Proteins 0.000 claims 7
- 102000005886 STAT4 Transcription Factor Human genes 0.000 claims 7
- 102100011846 TNFSF4 Human genes 0.000 claims 7
- 101710025695 TNFSF4 Proteins 0.000 claims 7
- 238000003745 diagnosis Methods 0.000 claims 7
- 230000000875 corresponding Effects 0.000 claims 6
- 238000004166 bioassay Methods 0.000 claims 5
- 230000002068 genetic Effects 0.000 claims 5
- 230000014509 gene expression Effects 0.000 claims 4
- 108010092776 Autophagy-Related Protein 5 Proteins 0.000 claims 2
- 102000016614 Autophagy-Related Protein 5 Human genes 0.000 claims 2
- 102000014150 Interferons Human genes 0.000 claims 2
- 108010050904 Interferons Proteins 0.000 claims 2
- 229920000272 Oligonucleotide Polymers 0.000 claims 2
- 102100014221 PTTG1 Human genes 0.000 claims 2
- 101700005669 PTTG1 Proteins 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 229940079322 interferon Drugs 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 102000003852 Autoantibodies Human genes 0.000 claims 1
- 108090000206 Autoantibodies Proteins 0.000 claims 1
- 101700080605 NUC1 Proteins 0.000 claims 1
- 102000020497 RNA-Binding Proteins Human genes 0.000 claims 1
- 108091022184 RNA-Binding Proteins Proteins 0.000 claims 1
- 238000001514 detection method Methods 0.000 claims 1
- 238000009396 hybridization Methods 0.000 claims 1
- 230000001939 inductive effect Effects 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 101700006494 nucA Proteins 0.000 claims 1
- 230000001225 therapeutic Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10065908P | 2008-09-26 | 2008-09-26 | |
| US61/100,659 | 2008-09-26 | ||
| PCT/US2009/058478 WO2010036960A2 (fr) | 2008-09-26 | 2009-09-25 | Procédés pour traiter, diagnostiquer, et surveiller le lupus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012503985A JP2012503985A (ja) | 2012-02-16 |
| JP2012503985A5 true JP2012503985A5 (fr) | 2012-11-15 |
Family
ID=42060417
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011529281A Pending JP2012503985A (ja) | 2008-09-26 | 2009-09-25 | ループスの治療、診断、モニタリング方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20100099101A1 (fr) |
| EP (1) | EP2344674A4 (fr) |
| JP (1) | JP2012503985A (fr) |
| KR (1) | KR20110081161A (fr) |
| CN (1) | CN102224258A (fr) |
| AU (1) | AU2009296393A1 (fr) |
| BR (1) | BRPI0913778A2 (fr) |
| CA (1) | CA2736373A1 (fr) |
| IL (1) | IL211462A0 (fr) |
| MX (1) | MX2011003273A (fr) |
| WO (1) | WO2010036960A2 (fr) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2008254582A1 (en) * | 2007-05-21 | 2008-11-27 | Genentech, Inc. | Methods and compositions for identifying and treating lupus |
| EP2486152B1 (fr) | 2009-10-07 | 2017-12-06 | F. Hoffmann-La Roche AG | Procédés pour diagnostiquer le lupus |
| CA3091939A1 (fr) | 2009-11-02 | 2011-05-05 | University Of Washington | Compositions therapeutiques a base de nucleases et methodes |
| CN102465170A (zh) * | 2010-11-05 | 2012-05-23 | 复旦大学附属华山医院 | 一种检测bank1基因单核苷酸多态性的方法 |
| BR112013020498A2 (pt) * | 2011-02-10 | 2016-08-09 | Genqual Corp | método para determinar a capacidade de resposta a inibidores e para tratamento de um sujeito |
| CA2834626A1 (fr) | 2011-04-29 | 2012-11-01 | University Of Washington | Compositions a base de nuclease therapeutique et procedes associes |
| CN102360016A (zh) * | 2011-07-21 | 2012-02-22 | 南京工业大学 | 流式微球法对SLE的Sm-RNP抗体检测试剂盒的制备 |
| MX2015004145A (es) * | 2012-10-08 | 2015-07-06 | Hoffmann La Roche | Peptidos de penetracion celular que se unen a factor regulador de interferon 5. |
| KR101491214B1 (ko) * | 2012-10-10 | 2015-02-06 | 가톨릭대학교 산학협력단 | １ｑ２５．１(RABGAP1L) 위치, 6p21.32 (C4) 위치 및 １０ｑ２１．３위치의 ＤＮＡ 복제 수 변이 검출용 프라이머를 포함하는 전신성 홍반성 루푸스 발병 위험도 예측용 조성물 |
| WO2014058254A1 (fr) * | 2012-10-10 | 2014-04-17 | 가톨릭대학교 산학협력단 | Composition pour estimer le risque d'apparition d'un lupus érythémateux systémique, comprenant une amorce pour la détection de la variation du nombre de copies d'adn dans l'emplacement 1q25.1 (rabgap1l), l'emplacement 6p21.32 (c4) et l'emplacement 10.q21.3 |
| EP2954071B1 (fr) * | 2013-02-08 | 2020-08-12 | Allegheny-Singer Research Institute | Produits d'activation de complément liés à une cellule utilisés comme biomarqueurs diagnostiques pour le pré-lupus |
| US20140278133A1 (en) * | 2013-03-15 | 2014-09-18 | Advanced Throughput, Inc. | Systems and methods for disease associated human genomic variant analysis and reporting |
| CN103397103B (zh) * | 2013-08-26 | 2016-04-20 | 中国人民解放军第三军医大学第三附属医院 | 一种检测socs家族基因标签单核甘酸多态性位点的方法及试剂盒 |
| ES2759252T3 (es) | 2013-10-31 | 2020-05-08 | Resolve Therapeutics Llc | Fusiones y métodos terapéuticos de nucleasa-albúmina |
| EP2886140A1 (fr) | 2013-12-17 | 2015-06-24 | University of Limerick | Appareil pour le traitement extracorporel du sang |
| US20170269075A1 (en) * | 2014-05-12 | 2017-09-21 | Biogen Ma Inc. | Biomarkers predictive of lupus progression and uses thereof |
| AU2017290389B2 (en) | 2016-07-01 | 2024-09-26 | Resolve Therapeutics, Llc | Optimized binuclease fusions and methods |
| AU2018321359B2 (en) | 2017-08-22 | 2023-11-30 | Sanabio, Llc | Soluble interferon receptors and uses thereof |
| KR20240089752A (ko) * | 2021-10-18 | 2024-06-20 | 카스턴 매뉴팩츄어링 코오포레이숀 | 골프 클럽 센서 하우징 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7022476B2 (en) * | 2002-02-26 | 2006-04-04 | New York Society For Ruptured And Crippled Maintaining The Hospital For Special Surgery | Human FcγRIIB gene polymorphisms for assessing development of systemic lupus erythematosus and compositions for use thereof |
| US20070269827A1 (en) * | 2006-05-18 | 2007-11-22 | Oklahoma Medical Research Foundation | Predicting and Diagnosing Patients With Autoimmune Disease |
| AU2008254582A1 (en) * | 2007-05-21 | 2008-11-27 | Genentech, Inc. | Methods and compositions for identifying and treating lupus |
| US20110319288A1 (en) * | 2009-03-03 | 2011-12-29 | Merck Serono S.A. | Bank1 related snps and sle and/or ms susceptibility |
-
2009
- 2009-09-25 AU AU2009296393A patent/AU2009296393A1/en not_active Abandoned
- 2009-09-25 US US12/567,669 patent/US20100099101A1/en not_active Abandoned
- 2009-09-25 MX MX2011003273A patent/MX2011003273A/es unknown
- 2009-09-25 CA CA2736373A patent/CA2736373A1/fr not_active Abandoned
- 2009-09-25 EP EP09816951A patent/EP2344674A4/fr not_active Withdrawn
- 2009-09-25 BR BRPI0913778A patent/BRPI0913778A2/pt not_active IP Right Cessation
- 2009-09-25 WO PCT/US2009/058478 patent/WO2010036960A2/fr active Application Filing
- 2009-09-25 KR KR1020117006867A patent/KR20110081161A/ko not_active Application Discontinuation
- 2009-09-25 JP JP2011529281A patent/JP2012503985A/ja active Pending
- 2009-09-25 CN CN200980146949XA patent/CN102224258A/zh active Pending
-
2011
- 2011-02-28 IL IL211462A patent/IL211462A0/en unknown
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