JP2012502047A5 - - Google Patents
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- Publication number
- JP2012502047A5 JP2012502047A5 JP2011526201A JP2011526201A JP2012502047A5 JP 2012502047 A5 JP2012502047 A5 JP 2012502047A5 JP 2011526201 A JP2011526201 A JP 2011526201A JP 2011526201 A JP2011526201 A JP 2011526201A JP 2012502047 A5 JP2012502047 A5 JP 2012502047A5
- Authority
- JP
- Japan
- Prior art keywords
- ranolazine
- amiodarone
- per day
- administered
- combination according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- XKLMZUWKNUAPSZ-UHFFFAOYSA-N Ranolazine Chemical compound COC1=CC=CC=C1OCC(O)CN1CCN(CC(=O)NC=2C(=CC=CC=2C)C)CC1 XKLMZUWKNUAPSZ-UHFFFAOYSA-N 0.000 claims description 46
- 229960000213 ranolazine Drugs 0.000 claims description 46
- IYIKLHRQXLHMJQ-UHFFFAOYSA-N Amiodarone Chemical compound CCCCC=1OC2=CC=CC=C2C=1C(=O)C1=CC(I)=C(OCCN(CC)CC)C(I)=C1 IYIKLHRQXLHMJQ-UHFFFAOYSA-N 0.000 claims description 42
- 229960005260 Amiodarone Drugs 0.000 claims description 42
- 239000000203 mixture Substances 0.000 claims description 35
- 230000002195 synergetic Effects 0.000 claims description 14
- 238000009472 formulation Methods 0.000 claims description 6
- 230000002459 sustained Effects 0.000 claims description 6
- 231100000486 side effect Toxicity 0.000 claims description 3
- 206010003658 Atrial fibrillation Diseases 0.000 claims description 2
- 230000002401 inhibitory effect Effects 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims description 2
- 230000001629 suppression Effects 0.000 description 1
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US9435908P | 2008-09-04 | 2008-09-04 | |
US61/094,359 | 2008-09-04 | ||
US10877608P | 2008-10-27 | 2008-10-27 | |
US61/108,776 | 2008-10-27 | ||
PCT/US2009/055924 WO2010028173A2 (en) | 2008-09-04 | 2009-09-03 | Method of treating atrial fibrillation |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2012502047A JP2012502047A (ja) | 2012-01-26 |
JP2012502047A5 true JP2012502047A5 (de) | 2012-10-18 |
Family
ID=41421639
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2011526201A Pending JP2012502047A (ja) | 2008-09-04 | 2009-09-03 | 心房細動を治療する方法 |
Country Status (5)
Country | Link |
---|---|
US (1) | US20100056536A1 (de) |
EP (1) | EP2337559A2 (de) |
JP (1) | JP2012502047A (de) |
CA (1) | CA2735653A1 (de) |
WO (1) | WO2010028173A2 (de) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1505977B1 (de) * | 2002-05-21 | 2014-09-10 | Gilead Sciences, Inc. | Verabreichung eines partiellen fettsäure oxidationshemmers wie ranolazin zur behandlung von diabetes |
US20100292217A1 (en) * | 2009-05-14 | 2010-11-18 | Gilead Palo Alto, Inc. | Ranolazine for the treatment of cns disorders |
PL2464645T3 (pl) * | 2009-07-27 | 2017-12-29 | Gilead Sciences, Inc. | Skondensowane heterocykliczne związki jako modulatory kanałów jonowych |
TWI508726B (zh) | 2009-12-21 | 2015-11-21 | Gilead Sciences Inc | 治療心房纖維性顫動之方法 |
CN103096977B (zh) | 2010-07-02 | 2017-02-15 | 吉利德科学公司 | 作为离子通道调节剂的稠杂环化合物 |
MX361350B (es) | 2011-05-10 | 2018-12-04 | Gilead Sciences Inc | Compuestos heterocíclicos fusionados como moduladores del canal de sodio. |
TW201837023A (zh) | 2011-07-01 | 2018-10-16 | 美商基利科學股份有限公司 | 作為離子通道調節劑之稠合雜環化合物 |
NO3175985T3 (de) | 2011-07-01 | 2018-04-28 | ||
US20140364417A1 (en) * | 2013-05-03 | 2014-12-11 | Gilead Sciences, Inc. | Method of treating atrial fibrillation |
ES2691541T3 (es) | 2013-12-19 | 2018-11-27 | Gilead Sciences, Inc. | Compuestos heterocíclicos condensados como moduladores de canales iónicos |
US20190119236A1 (en) | 2016-02-23 | 2019-04-25 | Portola Pharmaceuticals, Inc. | Compounds for binding proprotein convertase subtilisin/kexin type 9 (pcsk9) |
WO2017152062A1 (en) | 2016-03-04 | 2017-09-08 | Gilead Sciences, Inc. | Compositions and combinations of autotaxin inhibitors |
Family Cites Families (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030077229A1 (en) * | 1997-10-01 | 2003-04-24 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing cardiovascular or renal drugs |
WO2000041688A1 (en) * | 1999-01-11 | 2000-07-20 | The Board Of Regents Of The University And Community College System Of Nevada | Use of an amiodarone compound as antifungal agent |
US20030220344A1 (en) * | 2002-04-04 | 2003-11-27 | Luiz Belardinelli | Method of treating arrhythmias |
US20090111826A1 (en) * | 2007-02-13 | 2009-04-30 | Louis Lange | Use of ranolazine for the treatment of cardiovascular diseases |
JP2010518169A (ja) * | 2007-02-13 | 2010-05-27 | ギリアード・パロ・アルト・インコーポレイテッド | 心血管疾患の処置のためのラノラジンの使用 |
-
2009
- 2009-09-03 WO PCT/US2009/055924 patent/WO2010028173A2/en active Application Filing
- 2009-09-03 EP EP09792242A patent/EP2337559A2/de not_active Withdrawn
- 2009-09-03 JP JP2011526201A patent/JP2012502047A/ja active Pending
- 2009-09-03 CA CA2735653A patent/CA2735653A1/en not_active Abandoned
- 2009-09-03 US US12/553,841 patent/US20100056536A1/en not_active Abandoned
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